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George Staples Leight Jr.

Professor of Surgery
Surgical Oncology
Box 3513 Med Ctr, Durham, NC
101 Bell Bldg, Durham, NC

Selected Publications


Surgeon-performed ultrasound is superior to 99Tc-sestamibi scanning to localize parathyroid adenomas in patients with primary hyperparathyroidism: results in 516 patients over 10 years.

Journal Article J Am Coll Surg · April 2011 BACKGROUND: Surgeon-performed cervical ultrasound (SUS) and 99Tc-sestamibi scanning (MIBI) are both useful in patients with primary hyperparathyroidism (PHPT). We sought to determine the relative contributions of SUS and MIBI to accurately predict adenoma ... Full text Link to item Cite

Improved surgical outcomes for breast cancer patients receiving neoadjuvant aromatase inhibitor therapy: results from a multicenter phase II trial.

Journal Article J Am Coll Surg · May 2009 BACKGROUND: Neoadjuvant aromatase inhibitor therapy has been reported to improve surgical outcomes for postmenopausal women with clinical stage II or III hormone receptor-positive breast cancer. A multicenter phase II clinical trial was conducted to invest ... Full text Link to item Cite

Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism.

Journal Article Surgery · December 2007 BACKGROUND: Successful parathyroidectomy for sporadic primary hyperparathyroidism (pHPT) is predicted by a 50% drop in PTH intra-operatively. Vitamin D is a known inhibitor of PTH secretion and is associated with secondary HPT following adenoma resection. ... Full text Link to item Cite

Progress in the operative management of sporadic primary hyperparathyroidism over 34 years.

Journal Article Ann Surg · May 2004 BACKGROUND: Progress in the diagnosis, localization of abnormal parathyroids, and intraoperative management of primary hyperparathyroidism has been observed over the past 34 years. The goal of this study is to report the outcome of patients undergoing 2 di ... Full text Link to item Cite

The impact of minimally invasive parathyroidectomy on the way endocrinologists treat primary hyperparathyroidism.

Conference Surgery · December 2003 BACKGROUND: Minimally-invasive parathyroidectomy (MIP) appears to be changing preoperative treatment and referral patterns for sporadic, nonfamilial, non-multiple endocrine neoplasia, primary hyperparathyroidism (PHPT). METHODS: The American Association of ... Full text Link to item Cite

Increased sectioning of pathologic specimens with ductal carcinoma in situ of the breast: are there clinical consequences?

Journal Article Clin Breast Cancer · August 2003 To assess if there has been increased sectioning of pathologic specimens with ductal carcinoma in situ (DCIS), identify sources of this change, and consider the clinical consequences, pathologic data from patients who underwent initial excisional biopsies ... Full text Link to item Cite

Surgical management of secondary hyperparathyroidism.

Journal Article Adv Ren Replace Ther · July 2002 Featured Publication Most patients with renal failure maintained on chronic dialysis have elevated parathyroid hormone (PTH) levels and PTH-mediated bone disease (secondary hyperparathyroidism [sHPT]). Elevated PTH production in this setting represents a progressive, exaggerat ... Full text Link to item Cite

Final results of the Department of Defense multicenter breast lymphatic mapping trial.

Journal Article Ann Surg Oncol · April 2002 BACKGROUND: Lymphatic mapping and sentinel lymph node (SLN) biopsy have the potential to become the standard of care for nodal staging in breast cancer patients, but their widespread utility outside of university-based centers has not been determined. This ... Full text Link to item Cite

The role of lymphoscintigraphy in the management of the patient with breast cancer.

Journal Article Ann Surg Oncol · May 2001 Featured Publication INTRODUCTION: Regional nodal status is the most powerful predictor of recurrence and survival in women with breast cancer. Lymphatic mapping and sentinel lymph node (SLN) biopsy have been found to accurately predict the regional nodal status. Preoperative ... Full text Link to item Cite

Complementary nature of radiotracer parathyroid imaging and intraoperative parathyroid hormone assays in the surgical management of primary hyperparathyroid disease: case report and review.

Journal Article Clin Nucl Med · March 2000 Featured Publication PURPOSE: This article illustrates the complementary nature of preoperative radionuclide parathyroid imaging and intraoperative rapid parathyroid hormone (PTH) assays in primary hyperparathyroid disease. The authors review the literature on these procedures ... Full text Link to item Cite

Initial experience with intraoperative PTH determinations in the surgical management of 130 consecutive cases of primary hyperparathyroidism.

Journal Article Surgery · December 1999 Featured Publication BACKGROUND: Successful surgical management of primary hyperparathyroidism (1 degree HPT) historically has required bilateral neck exploration. The intraoperative parathyroid hormone (IO-PTH) assay allows a more limited procedure by confirming complete remo ... Full text Link to item Cite

Follicular neoplasms: The role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery

Journal Article Seminars in Surgical Oncology · December 1, 1999 The diagnosis and management of follicular carcinoma of the thyroid gland remains a controversial topic. Fine needle aspiration, although very sensitive with other types of thyroid cancer, has limited accuracy with follicular lesions. The role of suppressi ... Cite

Follicular neoplasms: the role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery.

Journal Article Semin Surg Oncol · 1999 Featured Publication The diagnosis and management of follicular carcinoma of the thyroid gland remains a controversial topic. Fine needle aspiration, although very sensitive with other types of thyroid cancer, has limited accuracy with follicular lesions. The role of suppressi ... Full text Link to item Cite

Complications of axillary lymph node dissection for carcinoma of the breast: a report based on a patient survey.

Journal Article Cancer · October 1, 1998 BACKGROUND: Axillary lymph node dissection is commonly performed as part of the primary management of breast carcinoma. Its value in patient management, however, has recently been questioned. Few studies exist that document long term complications. METHODS ... Full text Link to item Cite

Use of paravertebral block anesthesia in the surgical management of breast cancer: experience in 156 cases.

Journal Article Ann Surg · April 1998 Featured Publication OBJECTIVE: To assess safety and efficacy of the regional anesthetic technique paravertebral block for operative treatment of breast cancer, and to compare postoperative pain, nausea, vomiting, and length of hospital stay in patients undergoing breast surge ... Full text Link to item Cite

Surgeon-performed ultrasound is superior to 99Tc-sestamibi scanning to localize parathyroid adenomas in patients with primary hyperparathyroidism: results in 516 patients over 10 years.

Journal Article J Am Coll Surg · April 2011 BACKGROUND: Surgeon-performed cervical ultrasound (SUS) and 99Tc-sestamibi scanning (MIBI) are both useful in patients with primary hyperparathyroidism (PHPT). We sought to determine the relative contributions of SUS and MIBI to accurately predict adenoma ... Full text Link to item Cite

Improved surgical outcomes for breast cancer patients receiving neoadjuvant aromatase inhibitor therapy: results from a multicenter phase II trial.

Journal Article J Am Coll Surg · May 2009 BACKGROUND: Neoadjuvant aromatase inhibitor therapy has been reported to improve surgical outcomes for postmenopausal women with clinical stage II or III hormone receptor-positive breast cancer. A multicenter phase II clinical trial was conducted to invest ... Full text Link to item Cite

Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism.

Journal Article Surgery · December 2007 BACKGROUND: Successful parathyroidectomy for sporadic primary hyperparathyroidism (pHPT) is predicted by a 50% drop in PTH intra-operatively. Vitamin D is a known inhibitor of PTH secretion and is associated with secondary HPT following adenoma resection. ... Full text Link to item Cite

Progress in the operative management of sporadic primary hyperparathyroidism over 34 years.

Journal Article Ann Surg · May 2004 BACKGROUND: Progress in the diagnosis, localization of abnormal parathyroids, and intraoperative management of primary hyperparathyroidism has been observed over the past 34 years. The goal of this study is to report the outcome of patients undergoing 2 di ... Full text Link to item Cite

The impact of minimally invasive parathyroidectomy on the way endocrinologists treat primary hyperparathyroidism.

Conference Surgery · December 2003 BACKGROUND: Minimally-invasive parathyroidectomy (MIP) appears to be changing preoperative treatment and referral patterns for sporadic, nonfamilial, non-multiple endocrine neoplasia, primary hyperparathyroidism (PHPT). METHODS: The American Association of ... Full text Link to item Cite

Increased sectioning of pathologic specimens with ductal carcinoma in situ of the breast: are there clinical consequences?

Journal Article Clin Breast Cancer · August 2003 To assess if there has been increased sectioning of pathologic specimens with ductal carcinoma in situ (DCIS), identify sources of this change, and consider the clinical consequences, pathologic data from patients who underwent initial excisional biopsies ... Full text Link to item Cite

Surgical management of secondary hyperparathyroidism.

Journal Article Adv Ren Replace Ther · July 2002 Featured Publication Most patients with renal failure maintained on chronic dialysis have elevated parathyroid hormone (PTH) levels and PTH-mediated bone disease (secondary hyperparathyroidism [sHPT]). Elevated PTH production in this setting represents a progressive, exaggerat ... Full text Link to item Cite

Final results of the Department of Defense multicenter breast lymphatic mapping trial.

Journal Article Ann Surg Oncol · April 2002 BACKGROUND: Lymphatic mapping and sentinel lymph node (SLN) biopsy have the potential to become the standard of care for nodal staging in breast cancer patients, but their widespread utility outside of university-based centers has not been determined. This ... Full text Link to item Cite

The role of lymphoscintigraphy in the management of the patient with breast cancer.

Journal Article Ann Surg Oncol · May 2001 Featured Publication INTRODUCTION: Regional nodal status is the most powerful predictor of recurrence and survival in women with breast cancer. Lymphatic mapping and sentinel lymph node (SLN) biopsy have been found to accurately predict the regional nodal status. Preoperative ... Full text Link to item Cite

Complementary nature of radiotracer parathyroid imaging and intraoperative parathyroid hormone assays in the surgical management of primary hyperparathyroid disease: case report and review.

Journal Article Clin Nucl Med · March 2000 Featured Publication PURPOSE: This article illustrates the complementary nature of preoperative radionuclide parathyroid imaging and intraoperative rapid parathyroid hormone (PTH) assays in primary hyperparathyroid disease. The authors review the literature on these procedures ... Full text Link to item Cite

Initial experience with intraoperative PTH determinations in the surgical management of 130 consecutive cases of primary hyperparathyroidism.

Journal Article Surgery · December 1999 Featured Publication BACKGROUND: Successful surgical management of primary hyperparathyroidism (1 degree HPT) historically has required bilateral neck exploration. The intraoperative parathyroid hormone (IO-PTH) assay allows a more limited procedure by confirming complete remo ... Full text Link to item Cite

Follicular neoplasms: The role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery

Journal Article Seminars in Surgical Oncology · December 1, 1999 The diagnosis and management of follicular carcinoma of the thyroid gland remains a controversial topic. Fine needle aspiration, although very sensitive with other types of thyroid cancer, has limited accuracy with follicular lesions. The role of suppressi ... Cite

Follicular neoplasms: the role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery.

Journal Article Semin Surg Oncol · 1999 Featured Publication The diagnosis and management of follicular carcinoma of the thyroid gland remains a controversial topic. Fine needle aspiration, although very sensitive with other types of thyroid cancer, has limited accuracy with follicular lesions. The role of suppressi ... Full text Link to item Cite

Complications of axillary lymph node dissection for carcinoma of the breast: a report based on a patient survey.

Journal Article Cancer · October 1, 1998 BACKGROUND: Axillary lymph node dissection is commonly performed as part of the primary management of breast carcinoma. Its value in patient management, however, has recently been questioned. Few studies exist that document long term complications. METHODS ... Full text Link to item Cite

Use of paravertebral block anesthesia in the surgical management of breast cancer: experience in 156 cases.

Journal Article Ann Surg · April 1998 Featured Publication OBJECTIVE: To assess safety and efficacy of the regional anesthetic technique paravertebral block for operative treatment of breast cancer, and to compare postoperative pain, nausea, vomiting, and length of hospital stay in patients undergoing breast surge ... Full text Link to item Cite

Quantitative analysis of the calcium-sensing receptor messenger RNA in parathyroid adenomas.

Journal Article Surgery · December 1997 BACKGROUND: In primary hyperparathyroidism, hypercalcemia fails to suppress adequately secretion of parathyroid hormone by the parathyroid gland, which may result from failure of the cell-surface calcium receptor (CaR) to sense calcium correctly. Quantific ... Full text Link to item Cite

Intraoperative parathyroid hormone monitoring during parathyroidectomy for secondary hyperparathyroidism.

Journal Article Surgery · December 1997 Featured Publication BACKGROUND: The surgical management of secondary hyperparathyroidism by experienced surgeons is associated with excellent results. The presence of supernumerary glands and inadequate initial parathyroidectomy can lead to reoperations for recurrence. Intrao ... Full text Link to item Cite

The complementary roles of fast spin-echo MR imaging and double-phase 99m Tc-sestamibi scintigraphy for localization of hyperfunctioning parathyroid glands.

Journal Article AJR Am J Roentgenol · December 1996 OBJECTIVE: Our purpose was to evaluate and compare prospectively fast spin-echo MR imaging and double-phase technetium-99m-sestamibi scintigraphy for preoperative localization of hyperfunctioning parathyroid glands in high-risk surgical patients. SUBJECTS ... Full text Link to item Cite

Incidence of multiglandular disease in primary hyperparathyroidism determined by parathyroid hormone secretion.

Journal Article Surgery · December 1996 BACKGROUND: Successful parathyroidectomy depends on recognition and excision of all hyperfunctioning parathyroid glands. Because histologic definition is limited, multiglandular disease (MGD) is usually determined grossly by means of estimation of gland si ... Full text Link to item Cite

Uremic leontiasis ossea: "bighead" disease in humans? Radiologic, clinical, and pathologic features.

Journal Article Radiology · April 1996 PURPOSE: To describe the clinical, radiologic, and pathologic findings in patients with uremic leontiasis ossea (ULO). MATERIALS AND METHODS: Five patients with renal osteodystrophy developed marked hyperostosis of the facial and cranial bones. Radiologic ... Full text Link to item Cite

Hyperparathyroidism in high-risk surgical patients: evaluation with double-phase technetium-99m sestamibi imaging.

Journal Article Radiology · December 1995 PURPOSE: To evaluate the accuracy of technetium-99m sestamibi as a single agent in the detection and localization of hyperfunctioning parathyroid tissue in patients who underwent prior neck exploration or who otherwise are high surgical risks. MATERIALS AN ... Full text Link to item Cite

QUANTITATIVE-ANALYSIS OF THE CALCIUM-SENSING RECEPTOR BY COMPETITIVE RT-PCR

Conference JOURNAL OF BONE AND MINERAL RESEARCH · August 1, 1995 Link to item Cite

Hyperparathyroidism of multiple endocrine neoplasia type 1: Candidate gene and parathyroid calcium sensing protein expression

Journal Article Surgery · 1995 Background. Hyperparathyroidism affects most patients with multiple endocrine neoplasia type 1 (MEN 1). This study investigates expression of the candidate MEN 1 gene phospholipase C β3 (PLC β 3) and expression and function of a putative calcium sensing pr ... Full text Cite

Surgical treatment of primary hyperaldosteronism.

Journal Article Ann Surg · April 1994 OBJECTIVE: A retrospective review of patients with primary hyperaldosteronism treated at the Duke University Medical Center was performed. SUMMARY BACKGROUND DATA: The management of patients with primary hyperaldosteronism has changed dramatically in the p ... Full text Link to item Cite

Local failure and margin status in early-stage breast carcinoma treated with conservation surgery and radiation therapy.

Journal Article Ann Surg · July 1993 OBJECTIVE: The authors determined whether microscopically positive surgical margins are detrimental to the outcome of early stage breast cancer patients treated with conservation surgery and radiation therapy. SUMMARY BACKGROUND DATA: The optimal extent of ... Full text Link to item Cite

CT in the diagnosis of primary aldosteronism: sensitivity in 29 patients.

Journal Article AJR Am J Roentgenol · February 1993 OBJECTIVE: The most common cause of primary aldosteronism is a small aldosterone-secreting adrenal adenoma. With improvements in CT technology, smaller adrenal lesions can now be detected. We reviewed our experience with 29 patients with primary aldosteron ... Full text Link to item Cite

Preoperative endocrine tumor localization utilizing a cost-effective approach.

Journal Article Curr Opin Gen Surg · 1993 Endocrine tumors commonly produce characteristic clinical signs, and laboratory tests lead to accurate diagnosis in a high percentage of cases. The successful management of these tumors usually requires complete surgical resection. A large number of preope ... Link to item Cite

Management of pheochromocytomas in patients with multiple endocrine neoplasia type 2 syndromes

Journal Article Annals of Surgery · 1993 Objective: The authors sought to determine the optimal surgical management of pheochromocytomas that develop in patients with multiple endocrine neoplasia (MEN) type 2 syndromes. Summary Background data: The performance of empirical bilateral adrenalectomy ... Cite

Non-autonomy of parathyroid hormone secretion in acute primary hyperparathyroidism.

Journal Article Clin Endocrinol (Oxf) · December 1992 A patient with acute primary hyperparathyroidism treated with mithramycin preoperatively, underwent neck exploration and two enlarged parathyroid glands were excised: one huge adenoma (6g) and another smaller gland. Mithramycin was administered preoperativ ... Full text Link to item Cite

The role of circulating N-terminal parathyroid hormone fragments in the early postparathyroid adenomectomy period.

Journal Article Surgery · December 1991 Calcium metabolism and hormonal control after parathyroid adenomectomy are poorly understood. During the first postoperative hours, biologically active intact parathyroid hormone (PTH) (hPTH 1-84) levels are subnormal and, in spite of down-regulation of PT ... Link to item Cite

Iodine 131-labeled metaiodobenzylguanidine scintigraphy and biochemical analyses in suspected pheochromocytoma.

Journal Article Arch Intern Med · July 1991 Detection of abnormal catecholamine levels and localization of tumor mass are important factors in the diagnosis and treatment of pheochromocytoma. Iodine 131-labeled metaiodobenzylguanidine scintigraphy was performed in 64 patients with suspected pheochro ... Link to item Cite

The role of resection in the management of melanoma metastatic to the adrenal gland.

Journal Article Surgery · February 1991 Melanoma metastatic to the adrenal gland diagnosed before death was exceedingly rare before the development of computed tomographic (CT) scanning. The records of 28 patients with melanoma metastatic to the adrenal gland seen since 1975 were reviewed. Eight ... Link to item Cite

Parathyroid hormone secretion and target organ response in experimental acute pancreatitis.

Journal Article Arch Surg · February 1991 To determine changes in parathyroid hormone secretion and target organ response caused by acute pancreatitis before the development of systemic toxic conditions, experimental acute pancreatitis was induced in rats with a choline-deficient, ethionine-supple ... Full text Link to item Cite

Function in athymic nude mice of parathyroid heterografts from patients with primary hyperparathyroidism and secondary hyperparathyroidism.

Journal Article Surgery · December 1990 Heterotransplantation of adenomatous parathyroid glandular tissue from humans with primary hyperparathyroidism into athymic nude mice creates a unique animal model of this disease. The mice manifest high concentrations of both midregion/C-terminal human pa ... Link to item Cite

Long-term prognostic implications of sex-steroid receptors in human cancer.

Journal Article Prog Clin Biol Res · 1990 Progesterone receptor analysis has been used to enhance the prognostic usefulness of estrogen receptor analysis in breast cancer. Immunocytochemical assays for both steroid receptors have been shown to correlate with established biochemical techniques but ... Link to item Cite

Circadian rhythms for calcium, inorganic phosphorus, and parathyroid hormone in primary hyperparathyroidism: functional and practical considerations.

Journal Article Surgery · December 1989 We obtained serial serum and urine samples from 14 patients with primary hyperparathyroidism both before and 3 to 9 months after excision of their parathyroid adenomas to (1) determine whether the circadian rhythms for calcium, phosphorus, and parathyroid ... Link to item Cite

Primary hyperparathyroidism: a new experimental animal model.

Journal Article Surgery · December 1989 Although potentially useful in the understanding of hypercalcemic states, a satisfactory animal model of primary hyperparathyroidism has not been developed. Models that use transplants of supernumerary parathyroid (PT) glands or chronic parathyroid hormone ... Link to item Cite

MR evaluation of adrenal masses at 1.5 T.

Journal Article AJR Am J Roentgenol · August 1989 We retrospectively studied the value of MR imaging at 1.5 T to distinguish between nonadenomatous (n = 17) and adenomatous (n = 15) adrenal masses on the basis of (1) signal-intensity ratios on T1- and T2-weighted spin-echo images, (2) T2 relaxation times, ... Full text Link to item Cite

Cystosarcoma phyllodes. Effective therapy with cisplatin and etoposide chemotherapy.

Journal Article Cancer · June 1, 1989 Cystosarcoma phyllodes is an unusual breast neoplasm that rarely metastasizes. Most series report chemotherapy, radiation, and hormonal therapy to be ineffective. Three patients were treated with cisplatin and etoposide combination chemotherapy with effect ... Full text Link to item Cite

Cell dissociation techniques in human breast cancer--variations in tumor cell viability and DNA ploidy.

Journal Article Breast Cancer Res Treat · March 1989 Approximately 70% of breast cancers contain cell populations with hyperdiploid (greater than G0/G1) DNA content; however, cells cultured from breast cancers have only diploid DNA contents and karyotypes. Mechanically dissociated cells rarely, if ever, grow ... Full text Link to item Cite

Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods.

Journal Article Cancer Res · February 15, 1989 Biochemical quantitation of estrogen receptors has been used to predict prognosis in breast cancer. Immunocytochemical analysis of estrogen receptors correlates with biochemical analysis but has very few follow-up studies in the literature to validate it a ... Link to item Cite

Benign retroperitoneal schwannoma.

Journal Article Urology · April 1988 A case of benign retroperitoneal Schwannoma is presented, with special attention to clarification of often confused pathologic nomenclature. The radiologic diagnosis and the literature on this rare tumor are reviewed. ... Full text Link to item Cite

Estrogen receptor determination by monoclonal antibody in fine needle aspiration breast cancer cytologies: a marker of hormone response.

Journal Article Breast Cancer Res Treat · December 1987 A monoclonal antibody (H222) prepared against purified estrogen receptor has been demonstrated to be highly specific and sensitive in an immunohistochemical assay for the detection and quantification of estrogen receptor in human breast carcinoma biopsy sp ... Full text Link to item Cite

What is the clinical significance of bone loss in primary hyperparathyroidism?

Journal Article Arch Intern Med · November 1987 To help determine the clinical significance of the bone loss associated with primary hyperparathyroidism, we studied the prevalence of vertebral fractures in a group of patients with this disorder. From a registry of parathyroidectomies, 206 cases were rev ... Link to item Cite

Inflammatory breast carcinoma. Effective multimodal approach.

Journal Article Arch Surg · November 1987 Twenty-two patients with inflammatory breast carcinoma received preoperative chemotherapy consisting of weekly administration of cyclophosphamide, doxorubicin hydrochloride, fluorouracil, and vincristine sulfate for six weeks. Postoperative therapy consist ... Full text Link to item Cite

Benign adrenal lesions mimicking malignancy on MR imaging: report of two cases.

Journal Article Radiology · June 1987 Two cases of nonmalignant adrenal masses with prolonged T2 relaxation time and increased adrenal/liver signal ratios are reported. These two cases, one a functioning adenoma with small areas of hemorrhage and the other tuberculosis, emphasize that increase ... Full text Link to item Cite

TUMOR-CELL VIABILITY IN SUBPOPULATIONS OF HUMAN-BREAST CANCER

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1987 Link to item Cite

MR imaging with surface coils in primary hyperparathyroidism.

Journal Article J Comput Assist Tomogr · 1987 The use of magnetic resonance (MR) to preoperatively evaluate patients with primary hyperparathyroidism was assessed using a 1.5 T system and surface coil reception. Twenty-five patients with primary hyperparathyroidism were studied before surgical explora ... Full text Link to item Cite

TUMOR-CELL VIABILITY OF HUMAN-BREAST CANCER

Conference BREAST CANCER RESEARCH AND TREATMENT · January 1, 1987 Link to item Cite

Malignant teratoma in the thyroid gland of an adult: a case report and a review of the literature.

Journal Article Surgery · November 1986 Teratomas in the neck are rare neoplasms. Most occur in the neonate and are benign. In contrast, cervical teratomas in adults are malignant and carry a poor prognosis. Fourteen adult cases have been reported in the world literature, and 11 of these were st ... Link to item Cite

Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors

Journal Article Cancer Research · October 15, 1986 A monoclonal antibody to human estrogen receptor protein (H222 Spγ), amplified via immunoperoxidase techniques, was used in the analysis of estrogen receptor in 452 breast carcinomas, 100 endometrial carcinomas, and 15 melanomas. Immunohistochemical evalua ... Cite

MRI with surface coils for parathyroid tumors: preliminary investigation.

Journal Article AJR Am J Roentgenol · September 1986 The ability of MRI to detect parathyroid gland enlargement was assessed using 1.5-T systems and surface coil reception. Nine patients with primary hyperparathyroidism were studied before surgical neck exploration. Five-millimeter-thick axial images were ob ... Full text Link to item Cite

Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors.

Journal Article Cancer Res · August 1986 A monoclonal antibody to human estrogen receptor protein (H222 Sp gamma), amplified via immunoperoxidase techniques, was used in the analysis of estrogen receptor in 452 breast carcinomas, 100 endometrial carcinomas, and 15 melanomas. Immunohistochemical e ... Link to item Cite

Intraluminal thrombus and bowel obstruction in acute leukemia due to bleeding Meckel's diverticulum.

Journal Article Am J Med · June 1986 Gastrointestinal bleeding from Meckel's diverticulum resulted in small bowel obstruction by thrombus in two patients with acute myelogenous leukemia during bone marrow aplasia and recovery from induction chemotherapy. Although gastrointestinal symptoms and ... Full text Link to item Cite

Familial medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity.

Journal Article Br J Surg · April 1986 In an evaluation of 213 patients from 15 kindreds with familial medullary thyroid carcinoma (MTC), we detected 41 subjects from two kindreds (L and O) who had MTC but no extra-thyroidal manifestations (hyperparathyroidism, phaeochromocytomas or mucosal neu ... Full text Link to item Cite

Stimulation of insulin secretion by a rapid intravenous calcium infusion in patients with beta-cell neoplasms of the pancreas.

Journal Article J Clin Endocrinol Metab · January 1986 The effects of calcium on fasting plasma insulin and glucose levels were compared in 16 normal subjects and 11 patients with beta-cell neoplasms of the pancreas. Calcium was administered iv either as a rapid calcium infusion (RCI; 2 mg/kg in 1 min) or as a ... Full text Link to item Cite

Fluoxymesterone stimulation of tumor marker secretion in patients with breast carcinoma.

Journal Article Breast Cancer Res Treat · 1986 The gross cystic disease fluid protein of 15,000 MW (GCDFP-15) has been demonstrated to be a circulating glycoprotein tumor marker for breast carcinoma in approximately 40% of patients with advanced disease. A recent retrospective analysis of plasma GCDFP- ... Full text Link to item Cite

Hyperparathyroidism associated with the enlargement of two or three parathyroid glands.

Journal Article Ann Surg · November 1985 Eighty-five (23%) of 375 patients undergoing surgery for primary hyperparathyroidism were found to have enlargement (greater than 50 mg) of two or three parathyroid glands. Of 76 patients followed from 12 to 140 months after surgery, eight (10.5%) develope ... Full text Link to item Cite

Parathyroid hormone secretion from dispersed human hyperparathyroid cells: increased secretion in cells from hyperplastic glands versus adenomas.

Journal Article J Clin Endocrinol Metab · May 1985 The in vitro secretion of PTH by dispersed human parathyroid cells was examined under conditions of low and high extracellular Ca+2 using tissue from patients with primary hyperparathyroidism and hyperparathyroidism resulting from chronic renal failure (CR ... Full text Link to item Cite

Malignant teratoma of the thyroid in an adult: CT appearance.

Journal Article J Comput Assist Tomogr · 1985 A case of malignant teratoma of the thyroid gland is presented. Computed tomography identified an inhomogeneous mass with dense calcifications involving the thyroid gland and compressing the upper airway. Enlarged, peripherally enhancing lymph nodes in the ... Full text Link to item Cite

Granular cell tumors of the breast. Steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S100 protein.

Journal Article Arch Pathol Lab Med · November 1984 Granular cell tumors occur in a variety of sites, including the breast (6%). Origins from histiocytic, myogenic, fibroblastic, and neurogenic elements have been proposed. Female predominance suggests that estrogenic hormones are involved. Four granular cel ... Link to item Cite

Sex steroid receptor concentration in breast carcinoma tissue: effect of devascularization during mastectomy.

Journal Article Surgery · March 1984 The accurate determination of sex steroid receptors at the time of mastectomy (MX) for breast carcinoma is important for the determination of subsequent therapy of patients who develop metastases in inaccessible sites. The estrogen (E) and progesterone (P) ... Link to item Cite

Divergent effects of forskolin on 3',5' cyclic adenosine monophosphate production and parathyroid hormone secretion.

Journal Article Calcif Tissue Int · January 1984 Forskolin, a diterpene which directly stimulates adenylate cyclase, markedly stimulated cAMP production in intact rat parathyroid glands and dispersed cells from hyperplastic and adenomatous human parathyroid tissues. Stimulation of cAMP production in huma ... Full text Link to item Cite

Clinical response to hormone therapy correlated with estrogen receptor analyses. Biochemical v histochemical methods.

Journal Article Arch Pathol Lab Med · January 1984 Estrogen receptor (ER) analysis by sucrose density gradient analysis (SDGA) was compared with histochemical localization of estrogen binding using 6-carbomethoxy-bovine serum albumin-fluorescein isothiocyanode-estradiol (E2-6-CMO-BSA-FITC) (6FE), 17-thiose ... Link to item Cite

Comparison of four provocative tests for the diagnosis of gastrinoma.

Journal Article Ann Surg · May 1983 In an attempt to determine the best provocative test for the diagnosis of gastrinoma, ten normal subjects, 13 patients with known gastrinoma, and one patient with presumed gastrinoma were administered four regimens: (1) rapid calcium infusion (2 mg Ca++/kg ... Full text Link to item Cite

Relationship of age and menopausal status to estrogen receptor content in primary carcinoma of the breast.

Journal Article Ann Surg · February 1983 The cytosolic estrogen receptor (CER) content of 1037 primary breast carcinomas was evaluated by sucrose density gradient analysis. Tumor specimens from premenopausal patients had significantly lower levels of CER (14.6 +/- 1.5 (mean +/- SEM) 8S binding fm ... Full text Link to item Cite

Androgen stimulation of gross cystic disease fluid protein and carcinoembryonic antigen in patients with metastatic breast carcinoma.

Journal Article J Natl Cancer Inst · January 1983 Plasma levels of carcinoembryonic antigen (CEA) and the 15,000 molecular weight gross cystic disease fluid protein (GCDFP-15) were determined in 30 patients with metastatic breast carcinoma before, during, and after treatment with fluoxymesterone. Within 2 ... Link to item Cite

The importance of early diagnosis in patients with hereditary medullary thyroid carcinoma.

Journal Article Ann Surg · May 1982 Ninety-two patients from 12 kindreds with hereditary medullary thyroid carcinoma (MTC) were evaluated. We sought to determine if the stimulated plasma calcitonin (CT) level at the time of diagnosis was of prognostic significance. The patients were divided ... Full text Link to item Cite

Quantitation of response to therapy in patients with metastatic breast carcinoma by serial analysis of plasma gross cystic disease fluid protein and carcinoembryonic antigen.

Journal Article Cancer · March 15, 1982 The maximum percent change (MPC) of plasma carcinoembryonic antigen (CEA) and gross cystic disease fluid protein (CDP) were correlated with response to therapy in 92 metastatic breast carcinoma patients. In patients treated with hormone therapy MPC values ... Full text Link to item Cite

Androgen stimulation of breast cyst fluid antigen levels in plasma of patients with metastatic breast carcinoma

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1982 Cite

ANDROGEN STIMULATION OF BREAST CYST FLUID ANTIGEN LEVELS IN PLASMA OF PATIENTS WITH METASTATIC BREAST-CARCINOMA

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1982 Link to item Cite

DETERMINATION OF ESTROGEN-RECEPTOR STATUS

Journal Article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · January 1, 1982 Link to item Cite

A communication-cognition program for elderly nursing home residents

Journal Article Gerontologist · 1981 The intellectual and communicative declines which are prevalent among nursing home residents can be counteracted. A program is presented which has helped elderly persons to achieve greater independence while increasing both their cognitive and expressive f ... Cite

Beta-adrenergic effects on parathyroid (PTH) release

Journal Article British Journal of Surgery · January 1, 1981 Cite

BETA-ADRENERGIC EFFECTS ON PARATHYROID-HORMONE RELEASE

Journal Article SURGICAL FORUM · January 1, 1981 Link to item Cite

BETA-ADRENERGIC EFFECTS ON PARATHYROID (PTH) RELEASE

Conference BRITISH JOURNAL OF SURGERY · January 1, 1981 Link to item Cite

Primary hyperparathyroidism.

Journal Article Curr Probl Surg · August 1980 Link to item Cite

Long-term evaluation of patients with primary parathyroid hyperplasia managed by total parathyroidectomy and heterotopic autotransplantation.

Journal Article Ann Surg · 1980 Since 1973, we have performed total parathyroidectomy and forearm parathyroid autotransplantation in 36 patients with generalized (four gland) primary parathyroid hyperplasia. Twenty (56%) patients had nonfamilial parathyroid hyperplasia (NFPH) and 16 (44% ... Full text Link to item Cite

Primary hyperparathyroidism

Journal Article Current Problems in Surgery · January 1, 1980 Full text Cite

EFFECT OF CHEMOTHERAPY ON CALCITONIN (CT) LEVELS IN PATIENTS WITH METASTATIC MEDULLARY-THYROID CARCINOMA (MTC)

Conference PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1980 Link to item Cite

Transplantation in miniature swine. VI. Factors influencing survival of renal allografts.

Journal Article Transplantation · July 1979 Renal allografts were performed between and among animals from three herds of miniature swine that were selectively inbred to homozygosity at the major histocompatibility complex, MSLA. The results suggest several genetic factors which influence the surviv ... Link to item Cite

Experimental cryopreservation and autotransplantation of parathyroid glands: technique and demonstration of function.

Journal Article Ann Surg · July 1978 A canine model for cryopreservation and autotransplantation of parathyroid glands was developed as a prototype for cryopreservation of human parathyroid glands; Each of 18 dogs had two parathyroids removed, sectioned, and cooled at a controlled rate to -80 ... Full text Link to item Cite

Transplantation in miniature swine.

Journal Article Transplant Proc · March 1977 Link to item Cite

Transplantation in miniature swine. II. In vitro parameters of histocompatibility in MSLA homozygous minipigs.

Journal Article Transplantation · March 1977 A selective breeding program based on serological techniques was used to establish three herds of miniature swine, each homozygous for a different allele at the major histocompatibility complex, termed MSLA. By selective immunization of these swine, high-t ... Link to item Cite

Transplantation in miniature swine. I. Fixation of the major histocompatibility complex.

Journal Article Transplantation · December 1976 Three strains of miniature swine, each homozygous for a different allele of the major histocompatibility locus (MHC), have been developed by a selective breeding scheme based on tissue typing of the offspring of each generation. Prior to breeding, the orig ... Full text Link to item Cite

Pneumocystis pneumonia: the importance of early open lung biopsy.

Journal Article Ann Surg · March 1976 Pulmonary infection due to Pneumocystis carinii is now recognized as the leading cause of death from infection in patients with a hematologic malignancy who are in remission. Effective treatment requires suspicion of the infection in susceptible patients a ... Full text Link to item Cite