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Margaret Bush

Clinical Professor in the School of Nursing
School of Nursing
311 Trent Drive, Clipp Research Building, Rm 1056, Durham, NC 27710

Selected Publications


A scoping review of surface wipe sampling for antineoplastic drug contamination in patient care areas.

Journal Article Journal of occupational and environmental hygiene · June 2025 Antineoplastic drug (AD) exposure can cause adverse health effects for healthcare workers. AD contamination on surfaces persists despite interventions to reduce it. The United States Pharmacopeial Convention recommends surface sampling as a measure of expo ... Full text Cite

The Use of Plastic-Backed Pads to Reduce Hazardous Drug Contamination.

Journal Article Clinical journal of oncology nursing · May 2025 Toilet plume aerosols are a source of hazardous drug (HD) contamination in patient bathrooms; however, using plastic-backed pads to reduce contamination has not been tested within the clinical setting. This study tested wheth. ... Full text Cite

Assessing Etoposide and Cyclophosphamide Contamination and Current Cleaning Practices in Patient Bathrooms.

Journal Article Clinical journal of oncology nursing · March 2025 BackgroundAntineoplastic drug (AD) exposure presents severe risks to healthcare workers. Previous studies have demonstrated that patient bathrooms are highly contaminated and have led to concern for excreta as a source of environmental contaminati ... Full text Cite

Implementation of Supplemental Small-Group Sessions in an Online Clinical Pharmacology Course

Conference The Journal of Pharmacology and Experimental Therapeutics · June 2024 Full text Cite

Evaluation of current practice for penicillin allergy labeling using the PEN-FAST tool.

Journal Article Antimicrobial stewardship & healthcare epidemiology : ASHE · January 2024 Inaccurate penicillin allergy labeling may deter healthcare providers from initiating appropriate therapy and contribute to antibiotic resistance. In a rural urgent care setting, the current practice of penicillin allergy labeling was evaluated using the P ... Full text Cite

Reducing Inappropriate Antibiotic Prescribing for Upper Respiratory Infections

Journal Article Journal for Nurse Practitioners · March 1, 2022 Acute upper respiratory infections account for most urgent care visits, and most do not require antibiotics. A quality improvement project was conducted at an urgent care clinic in Texas over a 1-month period with the intent of improving antibiotic prescri ... Full text Cite

Transitioning your course to online: High-yield modifications for success.

Journal Article Currents in pharmacy teaching & learning · September 2021 IntroductionFaculty everywhere are struggling to transition their on-campus courses to an online format due to the COVID-19 pandemic. We transitioned our graduate pathophysiology and clinical pharmacology courses for advanced practice providers fr ... Full text Cite

Degradation of endothelial glycocalyx in Tanzanian children with falciparum malaria.

Journal Article FASEB J · September 2021 A layer of glycocalyx covers the vascular endothelium serving important protective and homeostatic functions. The objective of this study was to determine if breakdown of the endothelial glycocalyx (eGC) occurs during malaria infection in children. Measure ... Full text Link to item Cite

Endocrine therapy for breast cancer

Journal Article Journal for Nurse Practitioners · February 1, 2021 Full text Cite

Vascular Dysfunction in Malaria: Understanding the Role of the Endothelial Glycocalyx.

Journal Article Front Cell Dev Biol · 2021 Malaria caused by Plasmodium falciparum results in over 400,000 deaths annually, predominantly affecting African children. In addition, non-falciparum species including vivax and knowlesi cause significant morbidity and mortality. Vascular dysfunction is a ... Full text Link to item Cite

Increasing Medication Access by Promoting Appropriate Use of Multi-dose Vials.

Journal Article Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses · October 2020 Medication shortage is a problem that affects patients, providers, and institutions of all sizes and scope across the United States. The objective of this quality improvement project was to promote the appropriate use of multi-dose vials (MDVs) by anesthes ... Full text Cite

Surface Contamination With Antineoplastic Drugs on Two Inpatient Oncology Units.

Journal Article Oncol Nurs Forum · May 1, 2020 OBJECTIVES: To measure surface contamination with antineoplastic drugs on inpatient oncology units and to characterize nursing staff personal protective equipment (PPE) use and factors that predict this use. SAMPLE & SETTING: A descriptive pilot study ... Full text Link to item Cite

Immunotherapy and Targeted Drugs for Common Cancers

Journal Article Journal for Nurse Practitioners · March 1, 2020 Treatment of cancer has shifted dramatically over the past 2 decades. Targeted agents are used to block pathways known to drive tumor growth. Immunotherapy agents work by reversing cancer's ability to evade immune checkpoints, resulting in effective immune ... Full text Cite

Old Drugs, New Concerns

Journal Article Journal for Nurse Practitioners · March 1, 2020 Full text Cite

Glycocalyx breakdown is increased in African children with cerebral and uncomplicated falciparum malaria.

Journal Article FASEB J · December 2019 Cerebral malaria (CM) from Plasmodium falciparum infection is associated with endothelial dysfunction and parasite sequestration. The glycocalyx (GCX), a carbohydrate-rich layer lining the endothelium, is crucial in vascular homeostasis. To evaluate the ro ... Full text Link to item Cite

Glycocalyx Breakdown Is Associated With Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria.

Journal Article Clin Infect Dis · October 30, 2019 BACKGROUND: Interactions between the endothelium and infected erythrocytes play a major role in the pathogenesis of falciparum malaria, with microvascular dysfunction and parasite sequestration associated with worsening outcomes. The glycocalyx is a carboh ... Full text Link to item Cite

Improving Patient Experience and Treatment Adherence in the Adult, Outpatient Hemodialysis Population.

Journal Article Journal of nursing care quality · October 2019 BackgroundThe commonly employed medication reconciliation process leaves room for mismanagement of medications in the complex end-stage renal disease patient population.PurposeThe purpose of this quality improvement project was to impleme ... Full text Cite

Considerations for Developing a Student Evaluation of Teaching Form

Journal Article Teaching and Learning in Nursing · April 1, 2018 Student evaluations of teaching (SET) provide feedback to nursing faculty for improving courses and teaching and to administrators for making personnel decisions affecting faculty. We surveyed the literature to better understand the content of and types of ... Full text Cite

Student evaluations of teaching (SET): Guidelines for their use.

Journal Article Nurs Forum · January 18, 2018 Student evaluations of teaching (SET) provide a structured way of collecting feedback from students about the course and teacher's effectiveness. We reviewed literature describing use of SET across a broad range of disciplines in undergraduate and graduate ... Full text Link to item Cite

Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity.

Journal Article Sci Rep · July 7, 2016 We earlier established that nitric oxide (NO) is protective against severe malaria and that arginine and NO levels are reduced in malaria patients. We now show that an M2-like blood monocyte phenotype is significantly associated with hypoargininemia, NO in ... Full text Link to item Cite

Cultivating a Culture of Medication Safety in Prelicensure Nursing Students.

Journal Article Nurse educator · July 2015 Safety education in nursing has traditionally focused at the level of individual nurse-patient interactions. Students and novice clinicians lack clinical experience to create context and understand the complexity of the health care system and safety scienc ... Full text Cite

Overview of biotechnology.

Journal Article Journal of Pharmacy Practice · 1998 Cite

Pharmacotherapeutics of biotechnology-derived products.

Journal Article Journal of Pharmacy Practice · 1998 Cite

The L-arginine-nitric oxide-cyclic GMP pathway mediates inhibitory nonadrenergic-noncholinergic neurotransmission in the corpus cavernosum of human and rabbit

Journal Article Circulation · January 1, 1993 The objective of this study was to compare the effects of nonadrenergic-noncholinergic (NANC) stimulation and nitric oxide (NO) on isolated strips of corpus cavernosum from human and rabbit penis. Authentic NO and electrical field stimulation (EFS) caused ... Cite

Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum.

Journal Article Biochemical and biophysical research communications · July 1992 The objective of this study was to determine whether a constitutive isoform of nitric oxide (NO) synthase is present in rabbit corpus cavernosum that could account for the involvement of the L-arginine-NO pathway in neurogenically-elicited relaxation of th ... Cite

Nitric oxide as a mediator of relaxation of the corpus cavernosum.

Journal Article The New England journal of medicine · June 1992 Full text Cite

Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine.

Journal Article Biochemical and biophysical research communications · June 1992 This study examined whether constitutive nitric oxide (NO) synthase from rat cerebellum catalyzes the formation of equimolar amounts of NO plus citrulline from L-arginine under various conditions. Citrulline was determined by monitoring the formation of 3H ... Cite

Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum.

Journal Article The Journal of urology · June 1992 Nitric oxide (NO) caused a potent, marked, and transient relaxation of precontracted strips of corpus cavernosum isolated from humans and rabbits. The relaxation response elicited by NO was very similar to the relaxation evoked by electrical field stimulat ... Cite

Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission.

Journal Article The New England journal of medicine · January 1992 BACKGROUND: Nitric oxide has been identified as an endothelium-derived relaxing factor in blood vessels. We tried to determine whether it is involved in the relaxation of the corpus cavernosum that allows penile erection. The relaxation of this smooth musc ... Full text Cite

Neurotransmitter identity doubt.

Journal Article Nature · September 1990 BACKGROUND: Nitric oxide has been identified as an endothelium-derived relaxing factor in blood vessels. We tried to determine whether it is involved in the relaxation of the corpus cavernosum that allows penile erection. The relaxation of this smooth musc ... Full text Cite

Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle.

Journal Article Biochemical and biophysical research communications · July 1990 In the presence of functional adrenergic and cholinergic blockade, electrical field stimulation relaxes corpus cavernosum smooth muscle by unknown mechanisms. We report here that electrical field stimulation of isolated strips of rabbit corpus cavernosum p ... Full text Cite

Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation.

Journal Article Biochemical and biophysical research communications · October 1989 This study examined the influence of lowered arterial levels of L-arginine on endothelium-dependent relaxation of isolated rings of bovine pulmonary artery. Incubation of arterial rings under tension for 24 hr in oxygenated Krebs bicarbonate solution at 37 ... Full text Cite