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Michael Alan Babyak

Professor Emeritus in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
Box 2969 Med Ctr, Durham, NC 27710
Room 4072 South Hospital, DUMC Box 2969, Durham, NC 27710

Selected Publications


Change in body image flexibility and correspondence with outcomes in a digital early intervention for eating disorders based on acceptance and commitment therapy.

Journal Article Body Image · March 2023 Body image flexibility (BIF) has been suggested as a transdiagnostic process of change in eating disorder (ED) interventions, but data remain sparse. The current study examined the relationship between BIF and treatment effects in a randomized controlled t ... Full text Link to item Cite

Seasonality of Pediatric Mental Health Emergency Department Visits, School, and COVID-19.

Journal Article Pediatr Emerg Care · December 1, 2022 OBJECTIVES: The aim of this study was to explore how the academic calendar, and by extension school-year stressors, contributes to the seasonality of pediatric mental health emergency department (ED) visits. METHODS: The authors reviewed all pediatric ment ... Full text Open Access Link to item Cite

Confounding, Mediation, Moderation, and General Considerations in Regression Modeling

Chapter · January 1, 2022 Although causation cannot be established solely by statistical methods, multivariable modeling can be a useful tool in illuminating hypotheses about causal processes. In the present chapter, we discuss several concepts that are vital to exploiting multivar ... Full text Cite

Exercise Prescription Practices to Improve Mental Health.

Journal Article J Psychiatr Pract · July 28, 2021 OBJECTIVE: There is growing evidence that higher levels of physical activity are associated with better mental health. Furthermore, interventional studies have shown that exercise may improve symptoms in a number of psychiatric conditions. Despite this evi ... Full text Link to item Cite

"Pain is Subjective": A Mixed-Methods Study of Provider Attitudes and Practices Regarding Pain Management in Sickle Cell Disease Across Three Countries.

Journal Article J Pain Symptom Manage · March 2021 CONTEXT: Sickle cell disease (SCD), an autosomal recessive blood disorder, affects millions of people worldwide. Approximately 80% of all cases are located in Africa. OBJECTIVES: This cross-national, interdisciplinary, collaborative study investigated prov ... Full text Link to item Cite

The role of comorbid anxiety in exercise and depression trials: Secondary analysis of the SMILE-II randomized clinical trial.

Journal Article Depress Anxiety · February 2021 OBJECTIVES: To explore the anxiolytic effects of a 4-month randomized, placebo-controlled trial of exercise and antidepressant medication in patients with major depressive disorder (MDD), and to examine the potential modifying effects of anxiety in treatin ... Full text Link to item Cite

Sex and race differences of cerebrospinal fluid metabolites in healthy individuals.

Journal Article Metabolomics · January 18, 2021 INTRODUCTION: Analyses of cerebrospinal fluid (CSF) metabolites in large, healthy samples have been limited and potential demographic moderators of brain metabolism are largely unknown. OBJECTIVE: Our objective in this study was to examine sex and race dif ... Full text Link to item Cite

An open trial of app-assisted acceptance and commitment therapy (iACT) for eating disorders in type 1 diabetes.

Journal Article J Eat Disord · January 6, 2021 BACKGROUND: Eating disorders (EDs) among individuals with type 1 diabetes (T1D) increase the risk of early and severe diabetes-related medical complications and premature death. Conventional eating disorder (ED) treatments have been largely ineffective for ... Full text Link to item Cite

Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.

Journal Article Transl Psychiatry · October 20, 2020 In prior work, we identified a novel gene-by-stress association of EBF1's common variation (SNP rs4704963) with obesity (i.e., hip, waist) in Whites, which was further strengthened through multiple replications using our synthetic stress measure. We now ex ... Full text Open Access Link to item Cite

Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Previous studies have demonstrated that aerobic exercise (AE) and the Dietary Approaches to Stop Hypertension (DASH) diet can improve neurocognition. However, the mechanisms by which lifestyle improves neurocognition have not been widely studie ... Full text Link to item Cite

Systolic Blood Pressure and Socioeconomic Status in a large multi-study population.

Journal Article SSM Popul Health · December 2019 The present study used harmonized data from eight studies (N = 28,891) to examine the association between socioeconomic status (SES) and resting systolic blood pressure (SBP). The study replicates and extends our prior work on this topic by examining poten ... Full text Open Access Link to item Cite

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Journal Article Anesthesiology · June 2019 BACKGROUND: Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury. I ... Full text Open Access Link to item Cite

Real-time predictors and consequences of binge eating among adults with type 1 diabetes.

Journal Article J Eat Disord · 2019 BACKGROUND: Objective binge eating (OBE) is common among individuals with type 1 diabetes (T1D) and may have negative consequences for glycemic control. Recent studies have suggested that diabetes distress (i.e., emotional distress specific to diabetes and ... Full text Link to item Cite

Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.

Journal Article J Alzheimers Dis · 2019 BACKGROUND: Greater body weight has been associated impairments in neurocognition and greater dementia risk, although the mechanisms linking weight and neurocognition have yet to be adequately delineated. OBJECTIVE: To examine metabolic mechanisms underlyi ... Full text Link to item Cite

Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients: Results of the OCEAN Trial.

Journal Article JACC Heart Fail · October 2018 OBJECTIVES: The goal of this study was to test the effects of long-chain omega-3 fatty acid supplementation on omega-3 levels, depressive symptoms, and other psychosocial factors, as well as other chronic heart failure (CHF)-related functional measures. BA ... Full text Link to item Cite

Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses.

Journal Article BMC Res Notes · July 24, 2018 OBJECTIVES: Among many challenges in cardiovascular disease (CVD) risk prediction are interactions of genes with stress, race, and/or sex and developing robust estimates of these interactions. Improved power with larger sample size contributed by the accum ... Full text Link to item Cite

Change in body image flexibility and correspondence with outcomes in a digital early intervention for eating disorders based on acceptance and commitment therapy.

Journal Article Body Image · March 2023 Body image flexibility (BIF) has been suggested as a transdiagnostic process of change in eating disorder (ED) interventions, but data remain sparse. The current study examined the relationship between BIF and treatment effects in a randomized controlled t ... Full text Link to item Cite

Seasonality of Pediatric Mental Health Emergency Department Visits, School, and COVID-19.

Journal Article Pediatr Emerg Care · December 1, 2022 OBJECTIVES: The aim of this study was to explore how the academic calendar, and by extension school-year stressors, contributes to the seasonality of pediatric mental health emergency department (ED) visits. METHODS: The authors reviewed all pediatric ment ... Full text Open Access Link to item Cite

Confounding, Mediation, Moderation, and General Considerations in Regression Modeling

Chapter · January 1, 2022 Although causation cannot be established solely by statistical methods, multivariable modeling can be a useful tool in illuminating hypotheses about causal processes. In the present chapter, we discuss several concepts that are vital to exploiting multivar ... Full text Cite

Exercise Prescription Practices to Improve Mental Health.

Journal Article J Psychiatr Pract · July 28, 2021 OBJECTIVE: There is growing evidence that higher levels of physical activity are associated with better mental health. Furthermore, interventional studies have shown that exercise may improve symptoms in a number of psychiatric conditions. Despite this evi ... Full text Link to item Cite

"Pain is Subjective": A Mixed-Methods Study of Provider Attitudes and Practices Regarding Pain Management in Sickle Cell Disease Across Three Countries.

Journal Article J Pain Symptom Manage · March 2021 CONTEXT: Sickle cell disease (SCD), an autosomal recessive blood disorder, affects millions of people worldwide. Approximately 80% of all cases are located in Africa. OBJECTIVES: This cross-national, interdisciplinary, collaborative study investigated prov ... Full text Link to item Cite

The role of comorbid anxiety in exercise and depression trials: Secondary analysis of the SMILE-II randomized clinical trial.

Journal Article Depress Anxiety · February 2021 OBJECTIVES: To explore the anxiolytic effects of a 4-month randomized, placebo-controlled trial of exercise and antidepressant medication in patients with major depressive disorder (MDD), and to examine the potential modifying effects of anxiety in treatin ... Full text Link to item Cite

Sex and race differences of cerebrospinal fluid metabolites in healthy individuals.

Journal Article Metabolomics · January 18, 2021 INTRODUCTION: Analyses of cerebrospinal fluid (CSF) metabolites in large, healthy samples have been limited and potential demographic moderators of brain metabolism are largely unknown. OBJECTIVE: Our objective in this study was to examine sex and race dif ... Full text Link to item Cite

An open trial of app-assisted acceptance and commitment therapy (iACT) for eating disorders in type 1 diabetes.

Journal Article J Eat Disord · January 6, 2021 BACKGROUND: Eating disorders (EDs) among individuals with type 1 diabetes (T1D) increase the risk of early and severe diabetes-related medical complications and premature death. Conventional eating disorder (ED) treatments have been largely ineffective for ... Full text Link to item Cite

Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.

Journal Article Transl Psychiatry · October 20, 2020 In prior work, we identified a novel gene-by-stress association of EBF1's common variation (SNP rs4704963) with obesity (i.e., hip, waist) in Whites, which was further strengthened through multiple replications using our synthetic stress measure. We now ex ... Full text Open Access Link to item Cite

Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Previous studies have demonstrated that aerobic exercise (AE) and the Dietary Approaches to Stop Hypertension (DASH) diet can improve neurocognition. However, the mechanisms by which lifestyle improves neurocognition have not been widely studie ... Full text Link to item Cite

Systolic Blood Pressure and Socioeconomic Status in a large multi-study population.

Journal Article SSM Popul Health · December 2019 The present study used harmonized data from eight studies (N = 28,891) to examine the association between socioeconomic status (SES) and resting systolic blood pressure (SBP). The study replicates and extends our prior work on this topic by examining poten ... Full text Open Access Link to item Cite

Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.

Journal Article Anesthesiology · June 2019 BACKGROUND: Cognitive decline after cardiac surgery occurs frequently and persists in a significant proportion of patients. Preclinical studies and human trials suggest that intravenous lidocaine may confer protection in the setting of neurologic injury. I ... Full text Open Access Link to item Cite

Real-time predictors and consequences of binge eating among adults with type 1 diabetes.

Journal Article J Eat Disord · 2019 BACKGROUND: Objective binge eating (OBE) is common among individuals with type 1 diabetes (T1D) and may have negative consequences for glycemic control. Recent studies have suggested that diabetes distress (i.e., emotional distress specific to diabetes and ... Full text Link to item Cite

Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.

Journal Article J Alzheimers Dis · 2019 BACKGROUND: Greater body weight has been associated impairments in neurocognition and greater dementia risk, although the mechanisms linking weight and neurocognition have yet to be adequately delineated. OBJECTIVE: To examine metabolic mechanisms underlyi ... Full text Link to item Cite

Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients: Results of the OCEAN Trial.

Journal Article JACC Heart Fail · October 2018 OBJECTIVES: The goal of this study was to test the effects of long-chain omega-3 fatty acid supplementation on omega-3 levels, depressive symptoms, and other psychosocial factors, as well as other chronic heart failure (CHF)-related functional measures. BA ... Full text Link to item Cite

Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses.

Journal Article BMC Res Notes · July 24, 2018 OBJECTIVES: Among many challenges in cardiovascular disease (CVD) risk prediction are interactions of genes with stress, race, and/or sex and developing robust estimates of these interactions. Improved power with larger sample size contributed by the accum ... Full text Link to item Cite

Time of Day When Type 1 Diabetes Patients With Eating Disorder Symptoms Most Commonly Restrict Insulin.

Journal Article Psychosom Med · 2018 OBJECTIVE: Restricting insulin to lose weight is a significant problem in the clinical management of type 1 diabetes (T1D). Little is known about this behavior or how to effectively intervene. Identifying when insulin restriction occurs could allow clinici ... Full text Link to item Cite

Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies.

Journal Article Front Genet · 2018 The serotonin receptor 5-HTR2C is thought to be involved in the function of multiple brain structures. Consequently, the HTR2C gene has been studied extensively with respect to its association with a variety of phenotypes. One coding variant in the HTR2C g ... Full text Open Access Link to item Cite

Usefulness of Myocardial Annular Velocity Change During Mental Stress to Predict Cardiovascular Outcome in Patients With Coronary Artery Disease (From the Responses of Mental Stress-Induced Myocardial Ischemia to Escitalopram Treatment Trial).

Journal Article Am J Cardiol · November 1, 2017 Mental stress-induced myocardial ischemia is common and a prognostic factor of adverse cardiovascular outcomes in patients with coronary artery disease (CAD). The present study aimed at examining associations between mental stress-induced myocardial annula ... Full text Link to item Cite

Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort.

Journal Article Am Heart J · August 2017 BACKGROUND: The rs6265 (Val66Met) single-nucleotide polymorphism in the BDNF gene has been related to a number of endophenotypes that have in turn been shown to confer risk for atherosclerotic cardiovascular disease (CVD). To date, however, very few studie ... Full text Link to item Cite

Building research in diet and cognition: The BRIDGE randomized controlled trial.

Journal Article Contemp Clin Trials · August 2017 Obesity has been linked to cognitive impairment, cognitive decline and dementia. Given that 38.5% of U.S. adults 60years and older are obese and these numbers are rapidly increasing, strategies to decouple obesity from cognitive decline are needed. Innovat ... Full text Link to item Cite

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.

Journal Article Psychoneuroendocrinology · May 2017 Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been associated with cortisol responses to stress with gender differences reported, although the findings are not entirely consistent. To evaluate the role of Val66Met genotype and gender o ... Full text Link to item Cite

Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients.

Journal Article Eur J Prev Cardiol · April 2017 Aims Mental stress-induced myocardial ischemia (MSIMI) occurs in up to 70% of patients with clinically stable ischemic heart disease and is associated with increased risk of adverse prognosis. We aimed to examine the prognostic value of indices of MSIMI an ... Full text Link to item Cite

Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence.

Journal Article Am Heart J · March 2017 UNLABELLED: Based on prior research finding the 5HTTLPR L allele associated with increased cardiovascular reactivity to laboratory stressors and increased risk of myocardial infarction, we hypothesized that the 5HTTLPR L allele will be associated with incr ... Full text Link to item Cite

Treatment of anxiety in patients with coronary heart disease: Rationale and design of the UNderstanding the benefits of exercise and escitalopram in anxious patients WIth coroNary heart Disease (UNWIND) randomized clinical trial.

Journal Article Am Heart J · June 2016 BACKGROUND: Anxiety is highly prevalent among patients with coronary heart disease (CHD), and there is growing evidence that high levels of anxiety are associated with worse prognosis. However, few studies have evaluated the efficacy of treating anxiety in ... Full text Link to item Cite

Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial.

Journal Article Psychosom Med · 2016 OBJECTIVE: To examine the prognostic value of select biobehavioral factors in patients with chronic obstructive pulmonary disease (COPD) in a secondary analysis of participants from the INSPIRE-II trial. METHODS: Three hundred twenty-six outpatients with C ... Full text Link to item Cite

Psychosocial Predictors of Mortality Following Lung Transplantation.

Journal Article Am J Transplant · January 2016 Lung transplantation has become an increasingly common treatment for patients with end-stage lung disease. Few studies have examined psychosocial risk factors for mortality in transplant recipients, despite evidence suggesting that elevated levels of negat ... Full text Link to item Cite

Lifestyle modification for resistant hypertension: The TRIUMPH randomized clinical trial.

Journal Article Am Heart J · November 2015 BACKGROUND: Resistant hypertension (RH) is a growing health burden in this country affecting as many as 1 in 5 adults being treated for hypertension. Resistant hypertension is associated with increased risk of adverse cardiovascular disease (CVD) events an ... Full text Link to item Cite

Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene.

Journal Article Genet Epidemiol · September 2015 Chronic psychosocial stress adversely affects health and is associated with the development of disease [Williams, 2008]. Systematic epidemiological and genetic studies are needed to uncover genetic variants that interact with stress to modify metabolic res ... Full text Link to item Cite

Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.

Journal Article Eur J Hum Genet · June 2015 We performed gene-environment interaction genome-wide association analysis (G × E GWAS) to identify SNPs whose effects on metabolic traits are modified by chronic psychosocial stress in the Multi-Ethnic Study of Atherosclerosis (MESA). In Whites, the G × E ... Full text Open Access Link to item Cite

Prognostic significance of depression in blacks with heart failure: insights from Heart Failure: a Controlled Trial Investigating Outcomes of Exercise Training.

Journal Article Circ Heart Fail · May 2015 BACKGROUND: Although studies have shown that depression is associated with worse outcomes in patients with heart failure, most studies have been in white patients. The impact of depression on outcomes in blacks with heart failure has not been studied. METH ... Full text Link to item Cite

Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group.

Journal Article Ann Am Thorac Soc · March 2015 RATIONALE: The 2011 combined Global Initiative for Chronic Obstructive Lung Disease (GOLD) assessment incorporates symptoms, exacerbation history, and spirometry in discriminating risk of exacerbations in patients with chronic obstructive pulmonary disease ... Full text Link to item Cite

A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.

Journal Article Biol Psychol · December 2014 Previously we have shown that a functional nonsynonymous single nucleotide polymorphism (SNP), rs6318 on the HTR2C gene located on the X-chromosome, is associated with hypothalamic-pituitary-adrenal axis response to a laboratory stress recall task. The pre ... Full text Link to item Cite

The effects of a telehealth coping skills intervention on outcomes in chronic obstructive pulmonary disease: primary results from the INSPIRE-II study.

Journal Article Psychosom Med · October 2014 OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is associated with increased morbidity and mortality and reduced quality of life (QoL). Novel interventions are needed to improve outcomes in COPD patients. The present study assessed the effects of a ... Full text Link to item Cite

DRD2 SNP RS4586205, CHD METABOLIC RISK FACTORS IN NORMALS AND CLINICAL COURSE IN CHD PATIENTS

Conference INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE · August 1, 2014 Link to item Cite

The long-term effects of lifestyle change on blood pressure: One-year follow-up of the ENCORE study.

Journal Article Am J Hypertens · May 2014 BACKGROUND: There is a paucity of data describing the sustained benefits of lifestyle interventions on health behaviors and blood pressure (BP). METHODS: We examined the persistence of changes in health habits and BP in the ENCORE study, a trial in which 1 ... Full text Link to item Cite

The relationship between pain and eating among overweight and obese individuals with osteoarthritis: an ecological momentary study.

Journal Article Pain Res Manag · 2014 BACKGROUND: Osteoarthritis (OA) patients who are overweight or obese report higher levels of pain compared with their normal-weight OA counterparts. Evidence suggests that overweight or obese OA patients also experience pain relief from eating foods high i ... Full text Link to item Cite

A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.

Journal Article PLoS One · 2014 Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response to stress may be one of a number of biological mechanisms that links psychological stress to depressive symptoms, although the precise caus ... Full text Open Access Link to item Cite

Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples.

Journal Article Biol Psychol · April 2013 TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride level ... Full text Link to item Cite

DEPRESSION AND EXERCISE TRAINING IN PATIENTS WITH CHRONIC HEART FAILURE

Conference ANNALS OF BEHAVIORAL MEDICINE · March 1, 2013 Link to item Cite

Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms.

Journal Article J Psychiatr Res · February 2013 BACKGROUND: BDNF Val66Met by chronic stress interaction has been studied using childhood stress as a moderator, but has not been widely studied using chronic stress in adulthood. METHODS: Two independent samples were used: Duke-CG (238 Caucasians) and MESA ... Full text Link to item Cite

A functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events.

Journal Article PLoS One · 2013 Previously we have shown that a functional nonsynonymous single nucleotide polymorphism (rs6318) of the 5HTR2C gene located on the X-chromosome is associated with hypothalamic-pituitary-adrenal axis response to a stress recall task, and with endophenotypes ... Full text Open Access Link to item Cite

Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial.

Journal Article Contemp Clin Trials · January 2013 BACKGROUND: Risk factors for cardiovascular disease (CVD) not only increase the risk for clinical CVD events, but also are associated with a cascade of neurophysiologic and neuroanatomic changes that increase the risk of cognitive impairment and dementia. ... Full text Link to item Cite

Association of anxiety and depression with pulmonary-specific symptoms in chronic obstructive pulmonary disease.

Journal Article Int J Psychiatry Med · 2013 OBJECTIVES: To examine the association of anxiety and depression with pulmonary-specific symptoms of Chronic Obstructive Pulmonary Disease (COPD), and to determine the extent to which disease severity and functional capacity modify this association. METHOD ... Full text Link to item Cite

Socioeconomic indices as independent correlates of C-reactive protein in the National Longitudinal Study of Adolescent Health.

Journal Article Psychosom Med · 2013 OBJECTIVES: To examine the association between socioeconomic status (SES) and C-reactive protein (CRP) to understand how SES may increase the risk of cardiovascular disease and thus identify targets for prevention measures. METHODS: Path models were used t ... Full text Link to item Cite

Determinants and consequences of adherence to the dietary approaches to stop hypertension diet in African-American and white adults with high blood pressure: results from the ENCORE trial.

Journal Article J Acad Nutr Diet · November 2012 BACKGROUND: Although the Dietary Approaches to Stop Hypertension (DASH) diet is an accepted nonpharmacologic treatment for hypertension, little is known about what patient characteristics affect dietary adherence and what level of adherence is needed to re ... Full text Link to item Cite

Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: results from the UPBEAT (Understanding the Prognostic Benefits of Exercise and Antidepressant Therapy) study.

Journal Article J Am Coll Cardiol · September 18, 2012 OBJECTIVES: The aim of this study was to assess the efficacy of exercise and antidepressant medication in reducing depressive symptoms and improving cardiovascular biomarkers in depressed patients with coronary heart disease. BACKGROUND: Although there is ... Full text Link to item Cite

Changes in neurocognitive functioning following lung transplantation.

Journal Article Am J Transplant · September 2012 Although neurocognitive impairment is relatively common among patients with advanced lung disease, little is known regarding changes in neurocognition following lung transplantation. We therefore administered 10 tests of neurocognitive functioning before a ... Full text Link to item Cite

Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial.

Journal Article JAMA · August 1, 2012 CONTEXT: Depression is common in patients with cardiac disease, especially in patients with heart failure, and is associated with increased risk of adverse health outcomes. Some evidence suggests that aerobic exercise may reduce depressive symptoms, but to ... Full text Link to item Cite

Pain coping skills training and lifestyle behavioral weight management in patients with knee osteoarthritis: a randomized controlled study.

Journal Article Pain · June 2012 Overweight and obese patients with osteoarthritis (OA) experience more OA pain and disability than patients who are not overweight. This study examined the long-term efficacy of a combined pain coping skills training (PCST) and lifestyle behavioral weight ... Full text Link to item Cite

Linkages Between Facial Expressions of Anger and Transient Myocardial Ischemia in Men with Coronary Artery Disease

Journal Article · March 22, 2012 This chapter examines linkages between spontaneous facial expressions of emotion and ischemia and examines the relative contributions of hostility and anger to a coronary heart disease-relevant outcome. The dynamic linkages between facial expressions of an ... Full text Cite

Systolic blood pressure and adiposity: examination by race and gender in a nationally representative sample of young adults.

Journal Article Am J Hypertens · February 2012 BACKGROUND: Adiposity, or more specifically, underlying body fat distribution, has been associated with systolic blood pressure (SBP), and it has been suggested that these associations vary between whites and blacks, as well as by gender. METHODS: Here, we ... Full text Link to item Cite

Stress and coping in caregivers of patients awaiting solid organ transplantation.

Journal Article Clin Transplant · 2012 Caregivers for patients undergoing solid organ transplantation play an essential role in the process of transplantation. However, little is known about stress and coping among these caregivers. Six hundred and twenty-one primary caregivers of potential can ... Full text Link to item Cite

Cortisol responses to emotional stress in men: association with a functional polymorphism in the 5HTR2C gene.

Journal Article Biol Psychol · January 2012 The serotonin 5HTR2C receptor has been shown to mediate HPA axis activation during stress. We hypothesized that a functional polymorphism (rs6318) of the 5HTR2C gene would be associated with HPA axis response to a laboratory stress protocol. The present sa ... Full text Link to item Cite

Systolic blood pressure, socioeconomic status, and biobehavioral risk factors in a nationally representative US young adult sample.

Journal Article Hypertension · August 2011 In the National Longitudinal Study of Adolescent Health, a US longitudinal study of >15 000 young adults, we examined the extent to which socioeconomic status is linked to systolic blood pressure (SBP) and whether biobehavioral risk factors mediate the ass ... Full text Link to item Cite

Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · June 2011 BACKGROUND: Inclusion of a measure of left ventricular diastolic dysfunction (LVDD) may improve risk prediction after cardiac surgery. Current LVDD grading guidelines rely on echocardiographic variables that are not always available or aligned to allow gra ... Full text Link to item Cite

Association of vascular health and neurocognitive performance in overweight adults with high blood pressure.

Journal Article J Clin Exp Neuropsychol · June 2011 The relationship between vascular health--including flow-mediated dilation (FMD) and intima medial thickness (IMT)--and neurocognitive performance was examined in a sample of 124 sedentary, middle-aged adults with high blood pressure (systolic blood pressu ... Full text Link to item Cite

Positive emotion is associated with 6-year change in functional status in individuals aged 60 and older

Journal Article Journal of Positive Psychology · May 1, 2011 Analyses examined both positive emotion (PE) at baseline and change in PE from baseline to follow up as predictors of change in functional status (FS). Initial models examined baseline PE, and change in PE, as predictors of change in FS adjusted for baseli ... Full text Cite

Coping effectively with heart failure (COPE-HF): design and rationale of a telephone-based coping skills intervention.

Journal Article J Card Fail · March 2011 BACKGROUND: Coping Effectively with Heart Failure (COPE-HF) is an ongoing randomized clinical trial funded by the National Institutes of Health to evaluate if a coping skills training (CST) intervention will result in improved health status and quality of ... Full text Link to item Cite

The DASH diet and insulin sensitivity.

Journal Article Curr Hypertens Rep · February 2011 Lifestyle modifications, including adoption of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern, weight loss in individuals who are overweight or obese, and physical activity, are effective in the prevention and treatment of hypertension. ... Full text Link to item Cite

Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.

Journal Article Psychosom Med · 2011 OBJECTIVE: To examine a 1-year follow-up of a 4-month, controlled clinical trial of exercise and antidepressant medication in patients with major depressive disorder (MDD). METHODS: In the original study, 202 sedentary adults with MDD were randomized to: a ... Full text Link to item Cite

Cerebrovascular risk factors and cerebral hyperintensities among middle-aged and older adults with major depression.

Journal Article Am J Geriatr Psychiatry · September 2010 OBJECTIVES: To examine the association between cerebral hyperintensities and cerebrovascular risk factors (CVRF) among middle-aged and older adults with major depressive disorder (MDD). METHODS: Thirty patients (aged 55-77 years) with MDD and no history of ... Full text Link to item Cite

Phobic anxiety and increased risk of mortality in coronary heart disease.

Journal Article Psychosom Med · September 2010 OBJECTIVES: To evaluate whether phobic anxiety is associated with increased risk of cardiac mortality in individuals with established coronary heart disease (CHD) and to examine the role of reduced heart rate variability (HRV) in mediating this risk. Previ ... Full text Open Access Link to item Cite

Confirmatory factor analysis: an introduction for psychosomatic medicine researchers.

Journal Article Psychosom Med · July 2010 We present an introduction to the basic concepts essential to understanding confirmatory factor analysis (CFA). We initially discuss the underlying mathematical model and its graphical representation. We then show how parameters are estimated for the CFA m ... Full text Link to item Cite

Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.

Journal Article Hypertension · June 2010 High blood pressure increases the risks of stroke, dementia, and neurocognitive dysfunction. Although aerobic exercise and dietary modifications have been shown to reduce blood pressure, no randomized trials have examined the effects of aerobic exercise co ... Full text Open Access Link to item Cite

Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids.

Journal Article Hypertension · May 2010 This study examined the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on insulin sensitivity and lipids. In a randomized control trial, 144 overweight (body mass index: 25 to 40) men (n=47) and women (n=97) with high blood pressure (13 ... Full text Link to item Cite

Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study.

Journal Article Arch Intern Med · January 25, 2010 BACKGROUND: Although the DASH (Dietary Approaches to Stop Hypertension) diet has been shown to lower blood pressure (BP) in short-term feeding studies, it has not been shown to lower BP among free-living individuals, nor has it been shown to alter cardiova ... Full text Link to item Cite

Cardiovascular disease risk, vascular health and erectile dysfunction among middle-aged, clinically depressed men.

Journal Article Int J Impot Res · 2010 Erectile dysfunction (ED) is especially common in men with major depressive disorder (MDD). This study examined the extent to which risk factors for cardiovascular disease (CVD) and vascular endothelial dysfunction were associated with ED severity in MDD p ... Full text Link to item Cite

Prognosis after change in left ventricular ejection fraction during mental stress testing in patients with stable coronary artery disease.

Journal Article Am J Cardiol · January 1, 2010 Previous studies of patients with stable coronary artery disease have demonstrated that decreases in the left ventricular ejection fraction (LVEF) during acute mental stress are predictive of adverse clinical outcomes. The aim of the present study was to e ... Full text Link to item Cite

Enhancing standard cardiac rehabilitation with stress management training: background, methods, and design for the enhanced study.

Journal Article J Cardiopulm Rehabil Prev · 2010 PURPOSE: Enhancing Standard Cardiac Rehabilitation with Stress Management Training in Patients with Heart Disease (ENHANCED) is a randomized clinical trial funded by the National Heart Lung and Blood Institute to evaluate the effects of stress management t ... Full text Link to item Cite

Understanding confounding and mediation.

Journal Article Evid Based Ment Health · August 2009 Full text Link to item Cite

Effects of aerobic exercise on sexual functioning in depressed adults

Journal Article Mental Health and Physical Activity · June 1, 2009 Objective: Exercise appears to be generally comparable to antidepressant medication in reducing depressive symptoms. The current study examines the effects of aerobic exercise, compared to antidepressant medication and placebo pill, on sexual function amon ... Full text Cite

Association between n-3 fatty acid consumption and ventricular ectopy after myocardial infarction.

Journal Article Am J Clin Nutr · May 2009 BACKGROUND: n-3 (omega-3) Fatty acids are associated with a reduced risk of cardiovascular disease; however, the relation between dietary intake of n-3 fatty acids and ventricular arrhythmias has not been investigated among acute post-myocardial infarction ... Full text Link to item Cite

Caregiver-assisted coping skills training for patients with COPD: background, design, and methodological issues for the INSPIRE-II study.

Journal Article Clin Trials · April 2009 BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a progressive illness characterized by airflow obstruction and dyspnea that afflicts over 12 million people and represents a leading cause of death in the United States. Not surprisingly, COPD is ... Full text Link to item Cite

Intima-media thickness and age of first depressive episode.

Journal Article Biol Psychol · March 2009 BACKGROUND: Late life depression, including patients with vascular depression, has been associated with higher levels of intima-media thickness (IMT). Although individuals with vascular depression tend to report a later onset of depression, the relationshi ... Full text Link to item Cite

Ethnic differences in the treatment of depression in patients with ischemic heart disease.

Journal Article Am Heart J · January 2009 OBJECTIVE: The aim of this study is to examine ethnic differences in depressive symptoms and antidepressant treatment in a cohort of patients undergoing diagnostic coronary angiography. BACKGROUND: Coronary heart disease (CHD) is the leading cause of morta ... Full text Link to item Cite

Dimensions of social support and depression in patients at increased psychosocial risk recovering from myocardial infarction.

Journal Article Int J Behav Med · 2009 BACKGROUND: There is considerable evidence that depression and low social support are associated with increased morbidity and mortality for patients with coronary heart disease (CHD). However, there is a lack of consensus regarding the measurement of socia ... Full text Link to item Cite

Baseline 6-min walk distance predicts survival in lung transplant candidates.

Journal Article Am J Transplant · July 2008 In a large, prospectively followed, two-center cohort of patients listed for lung transplantation (n = 376), we used Cox proportional hazards models to determine the importance of baseline 6-min walk distance (6MWD) in predicting patient survival. 6MWD use ... Full text Link to item Cite

Coping and quality of life in patients awaiting lung transplantation.

Journal Article J Psychosom Res · July 2008 OBJECTIVE: Patients with end-stage lung disease (ESLD) experience significant decrements in quality of life (QOL). Although coping strategies are related to QOL in patients with ESLD, the extent to which specific native lung disease moderates this relation ... Full text Link to item Cite

Exercise fails to improve neurocognition in depressed middle-aged and older adults.

Journal Article Med Sci Sports Exerc · July 2008 PURPOSE: Although cross-sectional studies have demonstrated an association between higher levels of aerobic fitness and improved neurocognitive function, there have been relatively few interventional studies investigating this relationship, and results hav ... Full text Link to item Cite

Response to letters to the editor [3]

Journal Article Psychosomatic Medicine · February 1, 2008 Full text Cite

In Response

Journal Article Health Psychology · January 1, 2008 Full text Cite

Effects of exercise and weight loss on depressive symptoms among men and women with hypertension.

Journal Article J Psychosom Res · November 2007 OBJECTIVE: This study aimed to investigate changes in depressive symptoms in hypertensive individuals participating in an exercise and weight loss intervention. METHODS: This study involved 133 sedentary men and women with high blood pressure (BP; 130-180 ... Full text Link to item Cite

Social support and prognosis in patients at increased psychosocial risk recovering from myocardial infarction.

Journal Article Health Psychol · July 2007 OBJECTIVE: To compare the impact of network support and different types of perceived functional support on all-cause mortality or nonfatal reinfarction for patients with a recent acute myocardial infarction (AMI). DESIGN: Participants were recruited from t ... Full text Link to item Cite

Donepezil for cognitive decline following coronary artery bypass surgery: a pilot randomized controlled trial.

Journal Article Psychopharmacol Bull · 2007 OBJECTIVE: To study the effect of donepezil in treating patients with cognitive decline following coronary artery bypass graft (CABG) surgery. METHODS: Forty-four patients, with at least a 0.5 SD decline at 1 year post-CABG on at least one cognitive domain ... Link to item Cite

Spirituality, religion, and clinical outcomes in patients recovering from an acute myocardial infarction.

Journal Article Psychosom Med · 2007 OBJECTIVE: To assess the prospective relationship between spiritual experiences and health in a sample of patients surviving an acute myocardial infarction (AMI) with depression or low social support. METHODS: A subset of 503 patients participating in the ... Full text Link to item Cite

Exercise and pharmacotherapy in the treatment of major depressive disorder.

Journal Article Psychosom Med · 2007 OBJECTIVE: To assess whether patients receiving aerobic exercise training performed either at home or in a supervised group setting achieve reductions in depression comparable to standard antidepressant medication (sertraline) and greater reductions in dep ... Full text Link to item Cite

Ventricular ectopy: impact of self-reported stress after myocardial infarction.

Journal Article Am Heart J · January 2007 BACKGROUND: Although psychologic stress has been implicated in the pathogenesis of ventricular arrhythmias, the relationship between self-reported stress and ventricular ectopy has not been evaluated under naturalistic conditions in acute post-myocardial i ... Full text Link to item Cite

Understanding prognostic benefits of exercise and antidepressant therapy for persons with depression and heart disease: the UPBEAT study--rationale, design, and methodological issues.

Journal Article Clin Trials · 2007 BACKGROUND: Depression is relatively common in patients with coronary heart disease (CHD) and is associated with worse prognosis. Recently there has been interest in evaluating the impact of treating depression on clinical outcomes. Anti-depressant medicat ... Full text Link to item Cite

Cerebrovascular risk factors, vascular disease, and neuropsychological outcomes in adults with major depression.

Journal Article Psychosom Med · 2007 OBJECTIVE: To investigate the relationship of cerebrovascular risk factors (CVRFs), endothelial function, carotid artery intima medial thickness (IMT), and neuropsychological performance in a sample of 198 middle-aged and older individuals with major depre ... Full text Link to item Cite

Telephone-based coping skills training for patients awaiting lung transplantation.

Journal Article J Consult Clin Psychol · June 2006 Impaired quality of life is associated with increased mortality in patients with advanced lung disease. Using a randomized controlled trial with allocation concealment and blinded outcome assessment at 2 tertiary care teaching hospitals, the authors random ... Full text Link to item Cite

NEO personality domains and gender predict levels and trends in body mass index over 14 years during midlife

Journal Article Journal of Research in Personality · June 1, 2006 Mixed models were used to examine NEO-PI scores as predictors of body mass index (BMI) over a 14 year period during midlife. Average BMI levels during midlife were positively related to Neuroticism and negatively related to Openness, Agreeableness, and Con ... Full text Cite

Successful bilateral lung transplant outcomes in recipients 61 years of age and older.

Journal Article Transplantation · March 27, 2006 BACKGROUND: Controversy exists regarding the optimal use of bilateral lung transplant (BLT) in older recipients in diseases where either single or bilateral transplant is appropriate. International Society for Heart and Lung Transplant (ISHLT) guidelines s ... Full text Link to item Cite

Associations among perceptions of social support, negative affect, and quality of sleep in caregivers and noncaregivers.

Journal Article Health Psychol · March 2006 The authors used structural equation modeling to examine associations among perceptions of negative affect, social support, and quality of sleep in a sample of caregivers (n = 175) and noncaregiver control participants (n = 169). The authors hypothesized t ... Full text Link to item Cite

Phobic anxiety, depression, and risk of ventricular arrhythmias in patients with coronary heart disease.

Journal Article Psychosom Med · 2006 OBJECTIVE: Findings of an association between phobic anxiety and elevated risks of sudden cardiac death suggest that phobic anxiety may be related to increased risk of ventricular arrhythmias. The purpose of this study was to examine whether phobic anxiety ... Full text Link to item Cite

Association between hot flashes, sleep complaints, and psychological functioning among healthy menopausal women.

Journal Article Int J Behav Med · 2006 Self-report data suggest that sleep hot flashes among menopausal women are associated with sleep problems and in turn impaired psychological functioning. However, few studies have examined these relations with physiologic hot flash measures. A total of 41 ... Full text Link to item Cite

Emotional distress and quality of life in caregivers of patients awaiting lung transplant.

Journal Article J Psychosom Res · July 2005 OBJECTIVE: The aims of this study are to characterize the levels of emotional distress and quality of life among caregivers of lung transplant candidates and to examine the relation of coping styles and perceived caregiver burden to caregivers' self-report ... Full text Link to item Cite

Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial.

Journal Article JAMA · April 6, 2005 CONTEXT: Observational studies have shown that psychosocial factors are associated with increased risk for cardiovascular morbidity and mortality, but the effects of behavioral interventions on psychosocial and medical end points remain uncertain. OBJECTIV ... Full text Link to item Cite

Statistical guidelines for Psychosomatic Medicine

Journal Article Psychosomatic Medicine · March 1, 2005 Full text Cite

Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease.

Journal Article Psychosom Med · 2005 OBJECTIVE: This study examined the relationship between cognitive functioning and the severity of underlying lung disease in patients awaiting lung transplantation. METHODS: Ninety-four patients with end-stage lung disease completed a test battery to asses ... Full text Link to item Cite

Perceived social support as a predictor of mortality in coronary patients: effects of smoking, sedentary behavior, and depressive symptoms.

Journal Article Psychosom Med · 2005 OBJECTIVE: Numerous studies have shown network assessments of social contact predict mortality in patients with coronary artery disease (CAD). Fewer studies have demonstrated an association between perceived social support and longevity in patient samples. ... Full text Link to item Cite

Social support and coronary heart disease: epidemiologic evidence and implications for treatment.

Journal Article Psychosom Med · 2005 OBJECTIVE: The present paper reviews theories of social support and evidence for the role of social support in the development and progression of coronary heart disease (CHD). METHODS: Articles for the primary review of social support as a risk factor were ... Full text Link to item Cite

Emotional antecedents of hot flashes during daily life.

Journal Article Psychosom Med · 2005 OBJECTIVE: Hot flashes are among the most frequently reported menopausal symptoms. However, little is known about factors associated with their occurrence. Moreover, despite the wide use of self-report hot flash measures, little is known about their concor ... Full text Link to item Cite

Association between exercise capacity and left ventricular geometry in overweight patients with mild systemic hypertension.

Journal Article Am J Cardiol · November 15, 2004 The purpose of this study was to determine the relation between left ventricular (LV) geometry and exercise capacity in unmedicated, hypertensive patients. Analysis of the data revealed peak oxygen consumption (ml kg(-1) min(-1)) for concentric hypertrophy ... Full text Link to item Cite

Effects of daily stress on autonomic cardiac control in patients with coronary artery disease.

Journal Article Am J Cardiol · May 15, 2004 Emotional stress has been implicated in the development and progression of coronary artery disease, with 1 proposed causal pathway being changes in cardiac autonomic tone. One hundred thirty-five patients with coronary artery disease underwent 48 hours of ... Full text Link to item Cite

Exercise, depression, and mortality after myocardial infarction in the ENRICHD trial.

Journal Article Med Sci Sports Exerc · May 2004 PURPOSE: The large and well-characterized population of acute myocardial infarction (AMI) patients studied in the recently completed Enhancing Recovery in Coronary Heart Disease (ENRICHD) multicenter clinical trial provides a unique opportunity to examine ... Full text Link to item Cite

Prospective study of perceived stress in cardiac patients.

Journal Article Ann Behav Med · February 2004 BACKGROUND: Psychological stress is known to have a negative effect on the health and well-being of coronary artery disease (CAD) patients. Although the study of stress CAD samples has received considerable attention, few studies have examined the effects ... Full text Link to item Cite

Relationship between exercise systolic blood pressure and left ventricular geometry in overweight, mildly hypertensive patients.

Journal Article J Hypertens · February 2004 OBJECTIVE: To examine the association between the graded exercise systolic blood pressure (SBP) response and left ventricular (LV) geometric structure in patients with untreated mild hypertension. PARTICIPANTS: The study included 80 sedentary, overweight p ... Full text Link to item Cite

Depression as a risk factor for coronary artery disease: evidence, mechanisms, and treatment.

Journal Article Psychosom Med · 2004 OBJECTIVE: The present paper reviews the evidence that depression is a risk factor for the development and progression of coronary artery disease (CAD). METHODS: MEDLINE searches and reviews of bibliographies were used to identify relevant articles. Articl ... Full text Link to item Cite

What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models.

Journal Article Psychosom Med · 2004 Statistical models, such as linear or logistic regression or survival analysis, are frequently used as a means to answer scientific questions in psychosomatic research. Many who use these techniques, however, apparently fail to appreciate fully the problem ... Full text Link to item Cite

Cerebral embolization during cardiac surgery: impact of aortic atheroma burden.

Other Br J Anaesth · November 2003 BACKGROUND: Aortic atheromatous disease is known to be associated with an increased risk of perioperative stroke in the setting of cardiac surgery. In this study, we sought to determine the relationship between cerebral microemboli and aortic atheroma burd ... Full text Link to item Cite

Psychiatric disorder and quality of life in patients awaiting lung transplantation.

Journal Article Chest · November 2003 STUDY OBJECTIVE: To examine the relationship between psychiatric comorbidity and quality of life in patients awaiting lung transplantation. SETTING: Duke University Medical Center/Lung Transplantation Program. PARTICIPANTS: One hundred patients with end-st ... Full text Link to item Cite

Effects of exercise and weight loss on cardiac risk factors associated with syndrome X.

Journal Article Arch Intern Med · September 8, 2003 BACKGROUND: Patients with high blood pressure (BP) often exhibit syndrome X, an aggregation of abnormalities in carbohydrate and lipoprotein metabolism associated with increased risk of coronary heart disease (CHD). The present study evaluated the effects ... Full text Link to item Cite

Effect of smoking and sedentary behavior on the association between depressive symptoms and mortality from coronary heart disease.

Journal Article Am J Cardiol · September 1, 2003 It has been suggested that one of the mechanisms linking depression with elevated mortality risk is the association between depressive symptoms and other established coronary artery disease (CAD) risk factors, such as smoking and failure to exercise. The p ... Full text Link to item Cite

Depression as a risk factor for mortality after coronary artery bypass surgery.

Journal Article Lancet · August 23, 2003 BACKGROUND: Studies that have shown clinical depression to be a risk factor for cardiac events after coronary artery bypass graft (CABG) surgery have had small sample sizes, short follow-up, and have not had adequate power to assess mortality. We sought to ... Full text Link to item Cite

Depression and increased myocardial ischemic activity in patients with ischemic heart disease.

Journal Article Am Heart J · July 2003 BACKGROUND: Depression is relatively common in patients with ischemic heart disease (IHD) and is associated with increased risk of mortality and morbidity. However, the mechanisms by which depression adversely affects clinical outcomes of patients with IHD ... Full text Link to item Cite

Exercise therapy for depression in middle-aged and older adults: predictors of early dropout and treatment failure.

Journal Article Health Psychol · November 2002 Psychosocial factors predicting treatment dropout or failure to benefit from treatment were identified in a randomized trial of exercise therapy and pharmacotherapy for major depression. One hundred fifty-six men and women over age 50 diagnosed with major ... Link to item Cite

Effects of a telephone-based psychosocial intervention for patients awaiting lung transplantation.

Journal Article Chest · October 2002 STUDY OBJECTIVES: To test the efficacy of a tailored telephone-based intervention consisting of supportive counseling and cognitive behavioral techniques for individuals awaiting lung transplantation on measures of quality of life and general well-being. M ... Full text Link to item Cite

Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction.

Other Anesth Analg · July 2002 UNLABELLED: Renal dysfunction is common after coronary artery bypass graft (CABG) surgery. We have previously shown that CABG procedures complicated by stroke have a threefold greater peak serum creatinine level relative to uncomplicated surgery. However, ... Full text Link to item Cite

Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension.

Journal Article Arch Intern Med · June 24, 2002 BACKGROUND: Hypertrophy and concentric remodeling of the left ventricle are important manifestations of hypertension that are associated with increased morbidity and mortality. Although lifestyle interventions are efficacious in lowering blood pressure, ev ... Full text Link to item Cite

Usefulness of psychosocial treatment of mental stress-induced myocardial ischemia in men.

Journal Article Am J Cardiol · January 15, 2002 This study examined the effects of exercise and stress management training on clinical outcomes and medical expenditures over a 5-year follow-up period in 94 male patients with established coronary artery disease (CAD) and evidence of ambulatory or mental ... Full text Link to item Cite

Predictors of smoking cessation in patients with a diagnosis of coronary artery disease.

Journal Article J Cardiopulm Rehabil · 2002 PURPOSE: This study aimed to examine demographic, psychosocial, and clinical variables as predictors of smoking cessation in patients with coronary artery disease. METHODS: Smoking status and psychosocial variables were obtained at baseline. Participants w ... Full text Link to item Cite

The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery.

Other Anesth Analg · January 2002 UNLABELLED: Neurocognitive dysfunction is a common complication after cardiac surgery. We evaluated in this prospective study the effect of rewarming rate on neurocognitive outcome after hypothermic cardiopulmonary bypass (CPB). After IRB approval and info ... Full text Link to item Cite

Relationship of clinic, ambulatory, and laboratory stress blood pressure to left ventricular mass in overweight men and women with high blood pressure.

Journal Article Psychosom Med · 2002 OBJECTIVE: This study was designed to evaluate the relationship between left ventricular (LV) mass and blood pressure (BP) recorded in the following contexts: in the clinic, using standard auscultatory procedures, during a typical day using ambulatory BP m ... Full text Link to item Cite

Binge eating disorder and night eating syndrome: psychological and behavioral characteristics.

Journal Article Int J Eat Disord · September 2001 OBJECTIVE: The present study was designed to examine the psychological and behavioral characteristics associated with both night eating syndrome (NES) and binge eating disorder (BED) in 42 males and 41 females who were enrolled in a university-based weight ... Full text Link to item Cite

Linkages between facial expressions of anger and transient myocardial ischemia in men with coronary artery disease.

Journal Article Emotion · June 2001 The authors examined whether facial expressions of emotion would predict changes in heart function. One hundred fifteen male patients with coronary artery disease underwent the Type A Structured Interview, during which time measures of transient myocardial ... Full text Link to item Cite

Effects of exercise training on cognitive functioning among depressed older men and women

Journal Article Journal of Aging and Physical Activity · January 1, 2001 The effects of a structured exercise program on the cognitive functioning of 84 clinically depressed middle-aged and older adults (mean age = 57 years) were examined. Participants were randomized to either 4 months of aerobic exercise (n = 42) or antidepre ... Full text Cite

Enhancing Recovery in Coronary Heart Disease (ENRICHD) study intervention: rationale and design.

Journal Article Psychosom Med · 2001 OBJECTIVE: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social su ... Link to item Cite

Temperature during coronary artery bypass surgery affects quality of life.

Journal Article Ann Thorac Surg · January 2001 BACKGROUND: The objective of this study was to examine the effects of temperature on a variety of indices of psychologic adjustment and quality of life. METHODS: A total of 209 patients randomly received normothermic (warm) or hypothermic (cold) conditions ... Full text Link to item Cite

Effects of exercise and weight loss on mental stress-induced cardiovascular responses in individuals with high blood pressure.

Journal Article Hypertension · August 2000 The purpose of this study was to determine the effects of exercise and weight loss on cardiovascular responses during mental stress in mildly to moderately overweight patients with elevated blood pressure. Ninety-nine men and women with high normal or unme ... Full text Link to item Cite

Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning.

Journal Article Arch Intern Med · July 10, 2000 BACKGROUND: Lifestyle modifications have been recommended as the initial treatment strategy for lowering high blood pressure (BP). However, evidence for the efficacy of exercise and weight loss in the management of high BP remains controversial. METHODS: O ... Full text Link to item Cite

Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months.

Journal Article Psychosom Med · 2000 OBJECTIVE: The purpose of this study was to assess the status of 156 adult volunteers with major depressive disorder (MDD) 6 months after completion of a study in which they were randomly assigned to a 4-month course of aerobic exercise, sertraline therapy ... Full text Link to item Cite

Effects of exercise training on older patients with major depression.

Journal Article Arch Intern Med · October 25, 1999 BACKGROUND: Previous observational and interventional studies have suggested that regular physical exercise may be associated with reduced symptoms of depression. However, the extent to which exercise training may reduce depressive symptoms in older patien ... Full text Link to item Cite

Emotional responsivity and transient myocardial ischemia.

Journal Article J Consult Clin Psychol · August 1999 This study examined the relationship between "emotional responsivity" (i.e., individuals who exhibit relatively large variations of self-reported tension levels) and myocardial ischemia. One hundred thirty-six patients with coronary artery disease underwen ... Full text Link to item Cite

Perception of cognitive function in older adults following coronary artery bypass surgery.

Journal Article Health Psychol · May 1999 This study examined the effects of coronary artery bypass grafting (CABG) on objective and subjective measures of neurocognitive functioning. Participants were 170 older patients (127 men and 43 women; mean age = 61 years) undergoing CABG. Measures of neur ... Full text Link to item Cite

The association between physical activity and depression in older depressed adults

Journal Article Journal of Aging and Physical Activity · January 1, 1999 Previous studies of younger, healthy individuals have demonstrated an inverse relationship between physical activity and depression. The present study addressed the relation between self-reported physical activity and symptoms of depression in 146 men and ... Full text Cite

Predicting peak oxygen uptake among older patients with chronic illness.

Journal Article J Cardiopulm Rehabil · 1999 PURPOSE: To compare three equations developed to predict VO2 among patients diagnosed with one of two chronic diseases: essential hypertension (HTN), and fibromyalgia (FM). The equations included the American College of Sports Medicine (ACSM) equation, the ... Full text Link to item Cite

METHODOLOGY IN PSYCHOSOMATIC RESEARCH

Journal Article Psychosomatic Medicine · 1999 Full text Cite

Personality predictors of mood related to dieting.

Journal Article J Consult Clin Psychol · December 1998 The clinical utility of a model of normal emotional functioning (vs. psychopathology) and the moderating effects of neuroticism (N) and extraversion (E) on mood were examined during a 6-week weight-loss trial. Participants were 40 obese women who completed ... Full text Link to item Cite

A Monte Carlo Investigation of Methods for Controlling Type I Errors with Specification Searches in Structural Equation Modeling.

Journal Article Multivariate Behav Res · July 1, 1998 A standard strategy in structural equation modeling is to conduct multiple Lagrange multiplier (LM) tests after rejection of an initial model. Controlling for Type 1 error across these tests minimizes the likelihood of including unnecessary additional para ... Full text Link to item Cite

Measures of hostility as predictors of facial affect during social interaction: evidence for construct validity.

Journal Article Ann Behav Med · 1998 We assessed the construct validity of several self-report measures and an interview-based measure of hostility (Interpersonal Hostility Assessment Technique [IHAT]) by evaluating their associations with a behavioral indicator of hostile emotions (facial ex ... Full text Link to item Cite

Social support and hostility as predictors of depressive symptoms in cardiac patients one month after hospitalization: a prospective study.

Journal Article Psychosom Med · 1998 OBJECTIVE: Hospitalization for cardiac disease is associated with an increased risk for depression, which itself confers a poorer prognosis. Few prospective studies have examined the determinants of depression after hospitalization in cardiac patients, and ... Full text Link to item Cite

Stress management and exercise training in cardiac patients with myocardial ischemia. Effects on prognosis and evaluation of mechanisms.

Journal Article Archives of internal medicine · October 1997 BackgroundPrevious studies have demonstrated that myocardial ischemia can be elicited by mental stress in the laboratory and during daily life and that ischemia induced by mental stress is associated with an increased risk for future cardiac event ... Full text Cite

Effects of mental stress on myocardial ischemia during daily life.

Journal Article JAMA · May 21, 1997 OBJECTIVE: To determine the relative risk of myocardial ischemia triggered by specific emotions during daily life. DESIGN AND SETTING: Relative risk was calculated by the recently developed case-crossover method, in which the frequency of a presumed trigge ... Link to item Cite

Metabolic and behavioral effects of a high-sucrose diet during weight loss.

Journal Article Am J Clin Nutr · April 1997 In response to evidence linking obesity and high amounts of dietary fat, the food industry has developed numerous reduced-fat and nonfat food items. These items frequently derive a relatively large percentage of their energy from sugars and the effect of t ... Full text Link to item Cite

Control of Type I Errors with Multiple Tests of Constraints in Structural Equation Modeling.

Journal Article Multivariate Behav Res · January 1, 1997 Two contrasting views toward the evaluation of multiple tests of constraints and control of Type 1 errors in structural equation modeling are presented. (a) Exploring; data helps researchers make decisions about inclusion of relevant model parameters and c ... Full text Link to item Cite

Social dominance and 22-year all-cause mortality in men.

Journal Article Psychosom Med · 1997 OBJECTIVE: Research findings suggest that, in addition to hostility, social dominance-related variables may be related to morbidity and mortality. The purposes of the present study were to evaluate a) whether pressured social dominance (defined as a patter ... Full text Link to item Cite

Mental stress--induced myocardial ischemia and cardiac events.

Journal Article JAMA · June 5, 1996 OBJECTIVE: To assess the clinical significance of mental stress-induced myocardial ischemia in patients with coronary artery disease (CAD). DESIGN AND SETTING: Cohort study in outpatients in a tertiary care teaching hospital assessed at baseline and follow ... Full text Link to item Cite

Development and validation of the State Hope Scale.

Journal Article J Pers Soc Psychol · February 1996 Defining hope as a cognitive set comprising agency (belief in one's capacity to initiate and sustain actions) and pathways (belief in one's capacity to generate routes) to reach goals, the Hope Scale was developed and validated previously as a dispositiona ... Full text Link to item Cite

Mental stress-induced ischemia in the laboratory and ambulatory ischemia during daily life. Association and hemodynamic features.

Journal Article Circulation · October 15, 1995 BACKGROUND: The purpose of this study was to determine the correspondence of mental stress-induced ischemia in the laboratory with ambulatory ischemia and to assess the relationship between hemodynamic responses to mental stress and the occurrence of ische ... Full text Link to item Cite

PSYCHOLOGICAL EFFECTS OF LIPID-LOWERING DRUGS

Journal Article PSYCHOSOMATIC MEDICINE · March 1, 1994 Link to item Cite

Psychometric properties of the hope scale: A confirmatory factor analysis

Journal Article Journal of Research in Personality · January 1, 1993 Confirmatory factor analysis was employed to test several psychometric hypotheses regarding the Hope Scale. Across four large samples of college students, a two-factor (agency and pathways) model of hope reproduced the observed data consistently better tha ... Full text Cite