Scholars@Duke
Michael Durheim

Michael Durheim

Research Scholar
Medicine
michael.durheim@duke.edu
DUMC 102355, Durham, NC 27710
DUMC 102355, Durham, NC 27710

Selected Publications

Predicting the risk of subsequent progression in patients with systemic sclerosis-associated interstitial lung disease with progression: a multicentre observational cohort study.

Journal Article The Lancet. Rheumatology · July 2025 BackgroundIn patients with systemic sclerosis, it is common practice to treat interstitial lung disease (ILD) in patients in whom progression has already occurred. We sought to clarify whether observed progression of systemic sclerosis-associated ... Full text Cite

Validation of a semi-quantitative method to assess interstitial lung disease severity and progression in systemic sclerosis by standard and low-dose HRCT scans.

Journal Article RMD open · February 2025 BackgroundWhile the presence of distinct imaging abnormalities by high-resolution CT (HRCT) defines interstitial lung disease (ILD), there is a relative lack of validated methods to quantify these abnormalities in clinical practice, limiting ILD s ... Full text Cite

Evaluation of sex inequity in lung-cancer-specific survival.

Journal Article Acta oncologica (Stockholm, Sweden) · May 2024 BackgroundWhether sex is an independent prognostic factor in lung cancer survival is the subject of ongoing debate. Both large national registries and single hospital studies have shown conflicting findings. In this study, we explore the impact of ... Full text Cite

Trajectory of cardiac troponin T following moderate-to-severe COVID-19 and the association with cardiac abnormalities.

Journal Article BMC cardiovascular disorders · April 2024 BackgroundCOVID-19 has been associated with cardiac troponin T (cTnT) elevations and changes in cardiac structure and function, but the link between cardiac dysfunction and high-sensitive cardiac troponin T (hs-cTnT) in the acute and convalescent ... Full text Cite

Updated Prevalence of Lymphangioleiomyomatosis in Europe.

Journal Article American journal of respiratory and critical care medicine · February 2024 Full text Cite

Pulmonary fibrosis

Journal Article Ers Monograph · January 1, 2024 Pulmonary fibrosis (PF) comprises a group of chronic fibrotic ILDs that carry a substantial risk of progressive respiratory failure and death. As such, PF represents an important indication for LTx. Specific ILD subtypes may be idiopathic, related to rheum ... Full text Cite

Comparison of different reference values for lung function: implications of inconsistent use among centers.

Journal Article BMC pulmonary medicine · April 2023 BackgroundFor interpretation of pulmonary function tests (PFTs), reference values based on sex, age, height and ethnicity are needed. In Norway, the European Coal and Steel Community (ECSC) reference values remain widely used, in spite of recommen ... Full text Cite

A prospective study of pulmonary outcomes and chest computed tomography in the first year after COVID-19.

Journal Article ERJ open research · March 2023 COVID-19 primarily affects the respiratory system. We aimed to evaluate how pulmonary outcomes develop after COVID-19 by assessing participants from the first pandemic wave prospectively 3 and 12 months following hospital discharge. Pulmonary outcomes incl ... Full text Cite

A role for the terminal C5-C9 complement pathway in idiopathic pulmonary fibrosis.

Journal Article Frontiers in medicine · January 2023 Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by damage to the alveolar epithelium, leading to fibrosis and excessive accumulation of extracellular matrix in the interstitium of the lung. In the presen ... Full text Cite

The course and determinants of post-traumatic stress over 12 months after hospitalization for COVID-19.

Journal Article Frontiers in psychiatry · January 2022 ObjectiveTo assess the trajectory of symptoms and symptom-defined post-traumatic stress disorder (PTSD) from 1.5 to 12 months after hospitalization for COVID-19 and determine risk factors for persistent symptoms and PTSD.MethodsThis was a ... Full text Cite

Outcomes of patients with advanced idiopathic pulmonary fibrosis treated with nintedanib or pirfenidone in a real-world multicentre cohort.

Journal Article Respirology (Carlton, Vic.) · October 2021 Background and objectiveAntifibrotic therapy with nintedanib or pirfenidone slows disease progression and reduces mortality in patients with idiopathic pulmonary fibrosis (IPF). However, patients with advanced IPF, as defined by forced vital capac ... Full text Cite

Effect of high-intensity training on bone health and body composition in lung transplant recipients: A secondary analysis of a randomized controlled trial.

Journal Article Clinical transplantation · August 2021 BackgroundLoss of bone mineral and skeletal muscle mass is common after lung transplantation (LTx), and physical activity (PA) may prevent further deterioration. We aimed to assess the effects of 20-week high-intensity training (HIT) on body compo ... Full text Cite

Effect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial.

Journal Article JAMA · May 11, 2021 IMPORTANCE: Alteration in lung microbes is associated with disease progression in idiopathic pulmonary fibrosis. OBJECTIVE: To assess the effect of antimicrobial therapy on clinical outcomes. DESIGN, SETTING, AND PARTICIPANTS: Pragmatic, randomized, unblin ... Full text Link to item Cite

Dyspnoea, lung function and CT findings 3 months after hospital admission for COVID-19.

Journal Article The European respiratory journal · April 2021 The long-term pulmonary outcomes of coronavirus disease 2019 (COVID-19) are unknown. We aimed to describe self-reported dyspnoea, quality of life, pulmonary function and chest computed tomography (CT) findings 3 months following hospital admission for COVI ... Full text Cite

Relation of sputum neutrophilia to the development of chronic lung allograft dysfunction after lung transplantation.

Journal Article Clinical transplantation · March 2021 Chronic lung allograft dysfunction (CLAD) is a serious complication after lung transplantation (LuTx) and is associated with elevated proportions of neutrophils in bronchoalveolar lavage (BAL). Induced sputum is a less-invasive sampling method than BAL and ... Full text Cite

Predictors of long intensive care need after lung transplantation.

Journal Article Clinical transplantation · January 2021 BackgroundWhile expected need for intensive care after lung transplantation (LTx) does not normally affect organ allocation, it would be useful to estimate whether intensive care capacity is limited. The aim of this study was to assess factors ava ... Full text Cite

Toward Realizing the Full Potential of Registries in Interstitial Lung Disease.

Journal Article Annals of the American Thoracic Society · December 2020 Full text Cite

A retrospective study of in-hospital mortality in patients with idiopathic pulmonary fibrosis between 2015 and 2018.

Journal Article Medicine (Baltimore) · November 20, 2020 Hospitalizations are common in patients with idiopathic pulmonary fibrosis (IPF) and are associated with high mortality. We used data from the Premier Healthcare Database to determine in-hospital mortality rates and the factors associated with in-hospital ... Full text Link to item Cite

Effect of high-intensity training on peak oxygen uptake and muscular strength after lung transplantation: A randomized controlled trial.

Journal Article The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · September 2020 BackgroundPeak oxygen uptake (VO2peak) remains low after lung transplantation (LTx). We evaluated the effect of high-intensity interval training (HIIT) on VO2peak, muscular strength, health-related quality of life (HRQOL), pu ... Full text Cite

ILD-specific health-related quality of life in systemic sclerosis-associated ILD compared with IPF.

Journal Article BMJ open respiratory research · June 2020 IntroductionIdiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) are fibrotic ILDs with divergent disease populations. Little is known about health-related quality of life (HRQL) in SSc-ILD rela ... Full text Cite

Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy - the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial.

Journal Article Respir Res · March 12, 2020 Compelling data have linked disease progression in patients with idiopathic pulmonary fibrosis (IPF) with lung dysbiosis and the resulting dysregulated local and systemic immune response. Moreover, prior therapeutic trials have suggested improved outcomes ... Full text Link to item Cite

Cardiorespiratory Fitness and Physical Activity following Lung Transplantation: A National Cohort Study.

Journal Article Respiration; international review of thoracic diseases · January 2020 BackgroundLow cardiorespiratory fitness and inactivity are common after lung transplantation (LTx). The causes of exercise intolerance are incompletely understood.ObjectivesThe aim of this study was to objectively assess cardiorespiratory ... Full text Cite

Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency-Features of CT and 18F-FDG Positron Emission Tomography/CT in Clinically Progressive Disease.

Journal Article Frontiers in immunology · January 2020 Common variable immunodeficiency (CVID) is characterized not only by recurrent bacterial infections, but also autoimmune and inflammatory complications including interstitial lung disease (ILD), referred to as granulomatous-lymphocytic interstitial lung di ... Full text Cite

In-Hospital Mortality in Patients with Idiopathic Pulmonary Fibrosis: A US Cohort Study.

Journal Article Lung · December 2019 PURPOSE: In patients with idiopathic pulmonary fibrosis (IPF), hospitalizations are associated with high mortality. We sought to determine in-hospital mortality rates and factors associated with in-hospital mortality in patients with IPF. METHODS: Patients ... Full text Link to item Cite

Effect of high intensity training after lung transplantation

Conference Transplantation · September 28, 2019 Full text Cite

Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants.

Journal Article Chest · September 2019 BACKGROUND: Pulmonary fibrosis (PF) is the most common disease indication for lung transplantation. Our recent work implicated an excess of rare genetic variants in the telomere-related genes TERT, RTEL1, and PARN in PF disease risk. The impact of such var ... Full text Link to item Cite

Effect of Donor Age on Outcome of Lung Transplantation Stratified by Recipient Diagnosis: A Nordic Multicenter Study.

Journal Article Transplantation · April 2019 BackgroundOrgans from older donors are increasingly used in lung transplantation, and studies have demonstrated that this could be safe in selected recipients. However, which recipient groups that have the largest benefit of older organs are uncle ... Full text Cite

Characteristics and outcomes of adults with chronic obstructive pulmonary disease and atrial fibrillation.

Journal Article Heart · November 2018 OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is associated with the development of atrial fibrillation (AF), and may complicate treatment of AF. We examined the association between COPD and symptoms, quality of life (QoL), treatment and outcomes ... Full text Link to item Cite

Cardiopulmonary response to exercise after lung transplantation

Conference Transplantation · September 15, 2018 Full text Cite

A Nordic Multicenter Study on Size Mismatch in Bilateral Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Use of Silicon Stents for Stenotic Airway Complications in Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Mortality and Respiratory Failure After Thoracoscopic Lung Biopsy for Interstitial Lung Disease.

Journal Article Ann Thorac Surg · August 2017 BACKGROUND: Surgical lung biopsy contributes to establishing a specific diagnosis among many patients with interstitial lung disease (ILD). The risks of death and respiratory failure associated with elective thoracoscopic surgical lung biopsy, and patient ... Full text Link to item Cite

An Exome Sequencing Study to Assess the Role of Rare Genetic Variation in Pulmonary Fibrosis.

Journal Article Am J Respir Crit Care Med · July 1, 2017 RATIONALE: Idiopathic pulmonary fibrosis (IPF) is an increasingly recognized, often fatal lung disease of unknown etiology. OBJECTIVES: The aim of this study was to use whole-exome sequencing to improve understanding of the genetic architecture of pulmonar ... Full text Link to item Cite

Survival Benefit of Lung Transplantation in the Modern Era of Lung Allocation.

Journal Article Ann Am Thorac Soc · February 2017 RATIONALE: Lung transplantation is an accepted and increasingly employed treatment for advanced lung diseases, but the anticipated survival benefit of lung transplantation is poorly understood. OBJECTIVES: To determine whether and for which patients lung t ... Full text Link to item Cite

Depressive symptoms and early mortality following lung transplantation: A pilot study.

Journal Article Clin Transplant · February 2017 BACKGROUND: Impaired psychological function is common among lung transplant candidates and may affect clinical outcomes following transplantation. Although numerous studies have examined the relationship between pretransplant depression, quality of life (Q ... Full text Link to item Cite

Changes In Dyspnea Following Lung Transplantation: A Pooled Cohort Study

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Association Of COPD With Cardiovascular Events In Adults With Atrial Fibrillation: Insights From The Orbit-Af Registry

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Pulmonary function and adverse cardiovascular outcomes: Can cardiac function explain the link?

Journal Article Respir Med · December 2016 BACKGROUND: The complex interaction between pulmonary function, cardiac function and adverse cardiovascular events has only been partially described. We sought to describe the association between pulmonary function with left heart structure and function, a ... Full text Link to item Cite

Human Leukocyte Antigen (HLA) Mismatch Impact on Lung transplants outcomes.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · June 1, 2016 Link to item Cite

Depression, Quality of Life, and Mortality Early Following Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2016 Full text Cite

Chronic obstructive pulmonary disease in patients with atrial fibrillation: Insights from the ARISTOTLE trial.

Journal Article Int J Cardiol · January 1, 2016 BACKGROUND: Comorbid chronic obstructive pulmonary disease (COPD) is associated with poor outcomes among patients with cardiovascular disease. The risks of stroke and mortality associated with COPD among patients with atrial fibrillation are not well under ... Full text Link to item Cite

Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial.

Journal Article Psychosom Med · 2016 OBJECTIVE: To examine the prognostic value of select biobehavioral factors in patients with chronic obstructive pulmonary disease (COPD) in a secondary analysis of participants from the INSPIRE-II trial. METHODS: Three hundred twenty-six outpatients with C ... Full text Link to item Cite

Rationale for and design of the Idiopathic Pulmonary Fibrosis-PRospective Outcomes (IPF-PRO) registry.

Journal Article BMJ Open Respir Res · 2016 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterised by progressive loss of lung function. Its clinical course is variable but ultimately fatal. There is a need for a multicentre patient registry incorporatin ... Full text Link to item Cite

Disease Severity And Quality Of Life In Newly Diagnosed Idiopathic Pulmonary Fibrosis Patients

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Early and Long-term Outcomes of Older Adults after Acute Care Encounters for Chronic Obstructive Pulmonary Disease Exacerbation.

Journal Article Ann Am Thorac Soc · December 2015 RATIONALE: Older patients are at high risk of death and rehospitalization after hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AE-COPD). Emergency department visits comprise a substantial portion of acute care encounters ... Full text Link to item Cite

Association of hospital admission and forced vital capacity endpoints with survival in patients with idiopathic pulmonary fibrosis: analysis of a pooled cohort from three clinical trials.

Journal Article Lancet Respir Med · May 2015 BACKGROUND: Mortality is an impractical primary endpoint for clinical trials in patients with idiopathic pulmonary fibrosis who have mild-to-moderate physiological impairment because event rates are low. Change in forced vital capacity (FVC) is widely acce ... Full text Link to item Cite

Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group.

Journal Article Ann Am Thorac Soc · March 2015 RATIONALE: The 2011 combined Global Initiative for Chronic Obstructive Lung Disease (GOLD) assessment incorporates symptoms, exacerbation history, and spirometry in discriminating risk of exacerbations in patients with chronic obstructive pulmonary disease ... Full text Link to item Cite

Delirium affects length of hospital stay after lung transplantation.

Journal Article J Crit Care · February 2015 BACKGROUND: Delirium is relatively common after lung transplantation, although its prevalence and prognostic significance have not been systematically studied. The purpose of the present study was to examine pretransplant predictors of delirium and the sho ... Full text Link to item Cite

Associations Between Hospitalization And Forced Vital Capacity Endpoints And Survival In Idiopathic Pulmonary Fibrosis

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Neurocognitive changes after lung transplantation.

Journal Article Ann Am Thorac Soc · December 2014 RATIONALE: Neurocognitive impairments are associated with reduced quality of life and may adversely affect medical compliance, but their prevalence after lung transplantation has not been extensively studied. OBJECTIVES: To examine the frequency of neuroco ... Full text Link to item Cite

The effects of a telehealth coping skills intervention on outcomes in chronic obstructive pulmonary disease: primary results from the INSPIRE-II study.

Journal Article Psychosom Med · October 2014 OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is associated with increased morbidity and mortality and reduced quality of life (QoL). Novel interventions are needed to improve outcomes in COPD patients. The present study assessed the effects of a ... Full text Link to item Cite

Effects of exercise training intensity on pancreatic beta-cell function.

Journal Article Diabetes Care · October 2009 OBJECTIVE: Insulin resistance and beta-cell dysfunction both are important contributors to the pathogenesis of type 2 diabetes. Exercise training improves insulin sensitivity, but its effects on beta-cell function are less well studied. RESEARCH DESIGN AND ... Full text Link to item Cite

Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise.

Journal Article Physiol Genomics · February 2, 2009 Endurance exercise (EE) leads to beneficial alterations in skeletal muscle lipid metabolism in overweight and obese individuals; however, the mechanisms of these improvements are poorly understood. The primary goal of the current investigation was to test ... Full text Link to item Cite

Relationships between exercise-induced reductions in thigh intermuscular adipose tissue, changes in lipoprotein particle size, and visceral adiposity.

Journal Article Am J Physiol Endocrinol Metab · August 2008 Small LDL and HDL particle size are characteristic of a proatherogenic lipoprotein profile. Aerobic exercise increases these particle sizes. Although visceral adipose tissue (VAT) has been strongly linked with dyslipidemia, the importance of intermuscular ... Full text Link to item Cite