Muath Bishawi

Journal Article J Thorac Cardiovasc Surg · May 2024 OBJECTIVES: Right heart failure remains a serious complication of left ventricular assist device therapy. Many patients presenting for left ventricular assist device implantation have significant tricuspid regurgitation. It remains unknown whether concurre ... Full text Link to item Cite

Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts.

Journal Article J Cardiovasc Transl Res · June 2023 The porcine intra-abdominal heterotopic heart transplantation model allows for the assessment of immunologic effects on cardiac transplantation without relying on the allograft to maintain hemodynamic support for the animal. Historically, allograft functio ... Full text Link to item Cite

Variation among organ procurement organizations in experience and practice of heart donation after circulatory death.

Journal Article JTCVS Open · June 2023 Full text Link to item Cite

Ex Vivo Gene Delivery to Porcine Cardiac Allografts Using a Myocardial-Enhanced Adeno-Associated Viral Vector.

Journal Article Hum Gene Ther · April 2023 Transplantation, the gold standard intervention for organ failure, is a clinical field that is ripe for applications of gene therapy. One of the major challenges in applying gene therapy to this field is the need for a method that achieves consistent and r ... Full text Link to item Cite

An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.

Journal Article Cell Stem Cell · January 5, 2023 The efficacy and safety of gene-therapy strategies for indications like tissue damage hinge on precision; yet, current methods afford little spatial or temporal control of payload delivery. Here, we find that tissue-regeneration enhancer elements (TREEs) i ... Full text Link to item Cite

Improved Outcomes in Severe Primary Graft Dysfunction After Heart Transplantation Following Donation After Circulatory Death Compared With Donation After Brain Death.

Journal Article J Card Fail · January 2023 BACKGROUND: Primary graft dysfunction (PGD), the leading cause of early mortality after heart transplantation, is more common following donation after circulatory death (DCD) than donation after brain death (DBD). We conducted a single-center, retrospectiv ... Full text Link to item Cite

A Porcine Model of Acute Rejection for Cardiac Transplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2023 Cite

Health-related quality of life impacts upon 5-year survival after coronary artery bypass surgery.

Journal Article Journal of cardiac surgery · December 2022 BackgroundPoor preoperative health-related quality of life (HRQoL) has been associated with reduced short-term survival after coronary artery bypass graft (CABG) surgery; however, its impact on long-term mortality is unknown. This study's objectiv ... Full text Cite

Restrictive Mitral Annuloplasty: Patient Selection Is the Key.

Journal Article Ann Thorac Surg · November 2022 Full text Link to item Cite

Late Durability of Mitral Repair for Ischemic Versus Nonischemic Functional Mitral Regurgitation.

Journal Article Ann Thorac Surg · October 2022 BACKGROUND: Concerns regarding long-term durability of surgical repair for functional mitral regurgitation are based on short-term data, with few comparisons of ischemic mitral regurgitation (IMR) versus nonischemic functional mitral regurgitation (NIFMR) ... Full text Link to item Cite

Novel Use of Mobile Ex-Vivo Lung Perfusion in Donation After Circulatory Death Lung Transplantation.

Journal Article Progress in transplantation (Aliso Viejo, Calif.) · June 2022 Full text Cite

An engineering approach to mitral valve mechanics and function

Journal Article Applications in Engineering Science · June 1, 2022 Full text Cite

Incidence and Diagnostic Challenges of Bowel Ischemia after Continuous-flow Left Ventricular Assist Device Therapy.

Journal Article ASAIO J · May 1, 2022 Long-term continuous-flow left ventricular assist device (CFLVAD) therapy is limited by complications. Compared with stroke and renal dysfunction, post-CFLVAD bowel ischemia is poorly characterized. Adult patients who underwent first-time durable CFLVAD im ... Full text Link to item Cite

Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.

Journal Article iScience · April 15, 2022 The complex and inaccessible space radiation environment poses an unresolved risk to astronaut cardiovascular health during long-term space exploration missions. To model this risk, healthy male c57BL/6 mice aged six months (corresponding to an astronaut o ... Full text Link to item Cite

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft.

Journal Article J Vis Exp · February 14, 2022 Cardiac transplantation is the gold standard treatment for end-stage heart failure. However, it remains limited by the number of available donor hearts and complications such as primary graft dysfunction and graft rejection. The recent clinical use of an e ... Full text Link to item Cite

The outcome of mitral repair for degenerative versus ischemic mitral regurgitation using a single complete ring.

Journal Article J Card Surg · February 2022 BACKGROUND: The durability of surgical repair for degenerative versus ischemic mitral regurgitation (MR) is thought to be markedly different. We, therefore, examined late outcomes and durability for mitral repair in a large cohort of patients receiving a s ... Full text Link to item Cite

Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.

Journal Article Front Cardiovasc Med · 2022 BACKGROUND: The optimal delivery route to enhance effectiveness of regenerative therapeutics to the human heart is poorly understood. Direct intra-myocardial (IM) injection is the gold standard, however, it is relatively invasive. We thus compared targeted ... Full text Link to item Cite

Evaluation of U-Net Based Architectures for Automatic Aortic Dissection Segmentation

Journal Article ACM Transactions on Computing for Healthcare · January 1, 2022 Segmentation and reconstruction of arteries is important for a variety of medical and engineering fields, such as surgical planning and physiological modeling. However, manual methods can be laborious and subject to a high degree of human variability. In t ... Full text Cite

Patient- and Ventilator-Specific Modeling to Drive the Use and Development of 3D Printed Devices for Rapid Ventilator Splitting During the COVID-19 Pandemic

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2022 In the early days of the COVID-19 pandemic, there was a pressing need for an expansion of the ventilator capacity in response to the COVID19 pandemic. Reserved for dire situations, ventilator splitting is complex, and has previously been limited to patient ... Full text Cite

Cardiac-Enhanced Adeno-Associated Viral Vector Achieves Long-Term Transgene Expression in Transplanted Porcine Hearts When Administered During Ex Vivo Perfusion

Conference CIRCULATION · 2022 Cite

Surgical Treatment of Tricuspid Valve Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation: Interim analysis of the TVVAD trial.

Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts.

Variation among organ procurement organizations in experience and practice of heart donation after circulatory death.

Journal Article JTCVS Open · June 2023 Full text Link to item Cite

Ex Vivo Gene Delivery to Porcine Cardiac Allografts Using a Myocardial-Enhanced Adeno-Associated Viral Vector.

An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.

Improved Outcomes in Severe Primary Graft Dysfunction After Heart Transplantation Following Donation After Circulatory Death Compared With Donation After Brain Death.

A Porcine Model of Acute Rejection for Cardiac Transplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2023 Cite

Health-related quality of life impacts upon 5-year survival after coronary artery bypass surgery.

Restrictive Mitral Annuloplasty: Patient Selection Is the Key.

Journal Article Ann Thorac Surg · November 2022 Full text Link to item Cite

Late Durability of Mitral Repair for Ischemic Versus Nonischemic Functional Mitral Regurgitation.

Novel Use of Mobile Ex-Vivo Lung Perfusion in Donation After Circulatory Death Lung Transplantation.

Journal Article Progress in transplantation (Aliso Viejo, Calif.) · June 2022 Full text Cite

An engineering approach to mitral valve mechanics and function

Journal Article Applications in Engineering Science · June 1, 2022 Full text Cite

Incidence and Diagnostic Challenges of Bowel Ischemia after Continuous-flow Left Ventricular Assist Device Therapy.

Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft.

The outcome of mitral repair for degenerative versus ischemic mitral regurgitation using a single complete ring.

Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.

Evaluation of U-Net Based Architectures for Automatic Aortic Dissection Segmentation

Patient- and Ventilator-Specific Modeling to Drive the Use and Development of 3D Printed Devices for Rapid Ventilator Splitting During the COVID-19 Pandemic

Cardiac-Enhanced Adeno-Associated Viral Vector Achieves Long-Term Transgene Expression in Transplanted Porcine Hearts When Administered During Ex Vivo Perfusion

Conference CIRCULATION · 2022 Cite

Surgical features of malignant cardiac tumors

Chapter · January 1, 2022 Malignant primary cardiac tumors are rare and generally present at a young age. Multimodal imaging (CT, Cardiac MRI, and Echo) represents the current gold standard for diagnosis, staging, and surgical planning. Unique considerations include tumor involveme ... Full text Cite

Influence of peritoneal dialysis catheter type on complications and long-term outcomes: an updated systematic review and meta-analysis.

Journal Article J Nephrol · December 2021 BACKGROUND: There is currently no consensus regarding the optimal type of peritoneal dialysis catheter (PDC). We compared the outcomes of PDCs according to the number of cuffs, intercuff and intraperitoneal segment shape, and presence of a weighted tip. ME ... Full text Link to item Cite

Surgical versus percutaneous catheter placement for peritoneal dialysis: an updated systematic review and meta-analysis.

Journal Article J Nephrol · October 2021 BACKGROUND: No consensus currently exists regarding the optimal approach for peritoneal dialysis catheter placement. We aimed to compare the outcomes of percutaneous and surgical peritoneal dialysis catheter placement. METHODS: A systematic review of the l ... Full text Link to item Cite

New-onset postoperative atrial fibrillation impact on 5-year clinical outcomes and costs.

Journal Article The Journal of thoracic and cardiovascular surgery · May 2021 ObjectiveThe impact of new-onset postoperative atrial fibrillation (POAF) following coronary artery bypass grafting (CABG) surgery on long-term clinical outcomes and costs is not known. This subanalysis of the Veterans Affairs "Randomized On/Off B ... Full text Cite

Characteristics of strokes associated with centrifugal flow left ventricular assist devices.

Journal Article Sci Rep · January 18, 2021 Stroke is a devastating complication of left ventricular assist device (LVAD) therapy. Understanding the characteristics, risk factors and outcomes of strokes associated with the centrifugal flow LVADs is important to devise better strategies for managemen ... Full text Link to item Cite

Predicting aneurysmal degeneration of type B aortic dissection with computational fluid dynamics

Conference Proceedings of the 12th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, BCB 2021 · January 18, 2021 Stanford Type B aortic dissection (TBAD) is a deadly cardiovascular disease with mortality rates as high as 50% in complicated cases. Patients with TBAD are often medically managed, but in ∼20-40% of cases, patients experience aneurysmal degeneration in th ... Full text Cite

PD-1 and PD-L1 expression in cardiac transplantation.

Journal Article Cardiovasc Pathol · 2021 Programmed death-ligand 1 (PD-L1), a transmembrane protein and member of the CD28 T cell family is associated with lymphocyte activation.1 PD-L1 expression is upregulated on activated antigen presenting cells such as monocytes, myeloid and dendritic cells. ... Full text Link to item Cite

Targeted Intra-Coronary Delivery versus Intra-Myocardial Injection of Therapeutics for Myocardial Recovery: A Nanoparticle Image Guided Porcine Study

Conference CIRCULATION · 2021 Cite

Treatment of Perioperative Ischemia, Infarction, and Ventricular Failure in Cardiac Surgery

Chapter · January 1, 2021 An increasing number of high-risk patients are undergoing cardiac surgery. Despite this trend, advances in surgical techniques, myocardial preservation, anesthesia, and perioperative care have resulted in reduced morbidity and mortality. Positive outcomes ... Full text Cite

The Role of Neoadjuvant Chemotherapy in Patients With Resectable Malignant Pleural Mesothelioma-An Institutional and National Analysis.

Journal Article J Natl Cancer Inst · November 1, 2020 BACKGROUND: There is no standard of care with respect to the use of neoadjuvant chemotherapy (NAC) in resectable malignant pleural mesothelioma (MPM). We performed an intention-to-treat analysis with data from a single institution and the National Cancer D ... Full text Link to item Cite

Cloud Computing for COVID-19: Lessons Learned From Massively Parallel Models of Ventilator Splitting.

Journal Article Computing in science & engineering · November 2020 A patient-specific airflow simulation was developed to help address the pressing need for an expansion of the ventilator capacity in response to the COVID-19 pandemic. The computational model provides guidance regarding how to split a ventilator between tw ... Full text Cite

Surgical infection prophylaxis prior to left ventricular assist device implantation: A survey of clinical practice.

Journal Article J Card Surg · October 2020 BACKGROUND: Short duration, antimicrobial prophylaxis that includes antistaphylococcal activity is recommended at the time of left ventricular assist device (LVAD) implantation to reduce infection-related complications. There continues to be wide variabili ... Full text Link to item Cite

Modeling early stage atherosclerosis in a primary human vascular microphysiological system.

Journal Article Nature communications · October 2020 Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compression. TEB ... Full text Cite

Failure to rescue in the era of the lung allocation score: The impact of center volume.

Journal Article American journal of surgery · September 2020 BackgroundFailure to Rescue (FTR) is a valuable surgical quality improvement metric. The aim of this study is to assess the relationship between center volume and FTR following lung transplantation.MethodsUsing the database of the United ... Full text Cite

Shared Ventilation: Toward Safer Ventilator Splitting in Resource Emergencies.

Journal Article Anesthesiology · September 2020 Full text Open Access Link to item Cite

Incidence and Prognostic Impact of Incomplete Revascularization Documented by Coronary Angiography 1 Year After Coronary Artery Bypass Grafting.

Journal Article The American journal of cardiology · September 2020 Complete revascularization (CR) at the time of coronary artery bypass graft (CABG) surgery improves long-term cardiac outcomes. No studies have previously reported angiographically confirmed CR rates post-CABG. This study's aim was to assess the impact upo ... Full text Cite

Cardiovascular Implantable Electronic Device Surgery Following Left Ventricular Assist Device Implantation.

Journal Article JACC Clin Electrophysiol · September 2020 OBJECTIVES: This study sought to determine the indications, characteristics, and outcomes of cardiovascular implantable electronic device (CIED) surgery in patients with LVAD. BACKGROUND: Many patients with a left ventricular assist device (LVAD) will requ ... Full text Link to item Cite

Rapid Ventilator Splitting During COVID-19 Pandemic Using 3D Printed Devices and Numerical Modeling of 200 Million Patient Specific Air Flow Scenarios.

Journal Article Res Sq · August 12, 2020 There has been a pressing need for an expansion of the ventilator capacity in response to the recent COVID19 pandemic. To address this need, we present a system to enable rapid and efficacious splitting between two or more patients with varying lung compli ... Full text Link to item Cite

The use of an inexpensive processing aid device (the Mouse PAD) to facilitate rodent tissue banking.

Journal Article Biotechniques · July 2020 The generation of an experimental animal model often requires considerable investment of both time and money. Typically, investigators are interested in specific organs and when experimental animals are euthanized, tissues that are not the focus of the res ... Full text Link to item Cite

Aortic valve repair with a newly approved geometric annuloplasty ring in patients undergoing proximal aortic repair: early results from a single-centre experience.

Journal Article Eur J Cardiothorac Surg · June 1, 2020 OBJECTIVES: Aortic insufficiency (AI) is common in patients with proximal aortic disease, but limited options exist to facilitate aortic valve repair (AVr) in this population. This study reports 'real-world' early results of AVr using newly FDA-approved tr ... Full text Link to item Cite

Lead Extraction for Cardiovascular Implantable Electronic Device Infection in Patients With Left Ventricular Assist Devices.

Journal Article JACC Clin Electrophysiol · June 2020 OBJECTIVES: The goal of this study was to assess the utility of transvenous lead extraction for cardiovascular implantable electronic device (CIED) infection in patients with a left ventricular assist device (LVAD). BACKGROUND: The use of transvenous lead ... Full text Link to item Cite

Variability in donor organ offer acceptance and lung transplantation survival.

Journal Article J Heart Lung Transplant · April 2020 BACKGROUND: Lung transplantation offers a survival benefit for patients with end-stage lung disease. When suitable donors are identified, centers must accept or decline the offer for a matched candidate on their waitlist. The degree to which variability in ... Full text Link to item Cite

Successful Gene Delivery to Cardiac Allograft with Adeno-Associated Viral Vector Using Ex Vivo Storage Perfusion Platform

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Cardiac gene therapy remains limited by inefficient transgene delivery with currently available methods (intravenous infusion, transcatheter coronary artery infusion, direct myocardial injection). We previously demonstrated in a porcine heterotopi ... Full text Cite

Impact of Tricuspid Valve Repair for Moderate Tricuspid Regurgitation at the Time of Left Ventricular Assist Device Implantation on the Occurrence of Right Heart Failure

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Significant tricuspid regurgitation (TR) in patients undergoing durable left ventricular assist device (LVAD) implantation has been associated with increased incidence of right heart failure (RHF). There is great surgical practice variability rela ... Full text Cite

The HeartMate 6.

Journal Article ASAIO J · March 2020 The need for biventricular support poses significant challenges for patients who require a mechanical bridge to transplantation. Recent improvements in ventricular assist device (VAD) technology has made possible the use of two centrifugal flow VADs as a t ... Full text Link to item Cite

Stroke risk following implantation of current generation centrifugal flow left ventricular assist devices.

Journal Article J Card Surg · February 2020 BACKGROUND AND AIM: Stroke remains a significant complication of left ventricular assist device (LVAD) therapy. We performed a single-center retrospective study evaluating patients undergoing first-time HeartWare HVAD (Medtronic Inc) or HeartMate 3 (Abbott ... Full text Link to item Cite

Durability and Efficacy of Tricuspid Valve Repair in Patients Undergoing Left Ventricular Assist Device Implantation.

Journal Article JACC Heart Fail · February 2020 OBJECTIVES: This study sought to determine the durability of tricuspid valve repair (TVr) performed concurrently with left ventricular assist device (LVAD) implantation and its association with the development of late right heart failure (RHF). BACKGROUND: ... Full text Open Access Link to item Cite

Failure to Rescue Contributes to Center-Level Differences in Mortality After Lung Transplantation.

Journal Article Ann Thorac Surg · January 2020 BACKGROUND: The clinical response to postoperative complications after lung transplantation (LTx) may contribute to mortality differences among transplantation centers. The ability to avoid mortality after a complication-failure to rescue (FTR)-may be an e ... Full text Link to item Cite

Simultaneous Heart Kidney Transplant Benefits are Concentrated in the Dialysis Dependent Population

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2020 Cite

STROKE-RELATED MORBIDITY AND MORTALITY IN PATIENTS WITH NEW GENERATION LEFT VENTRICULAR ASSIST DEVICES

Conference INTERNATIONAL JOURNAL OF STROKE · 2020 Cite

Pre- Versus Post-Procedure Health Care Resource Utilization in Patients Undergoing Commercial Transcatheter Mitral Valve Repair.

Journal Article JACC Cardiovasc Interv · December 9, 2019 OBJECTIVES: The aim of this study was to assess the real-world impact of transcatheter mitral valve repair (TMVR) on hospitalizations and Medicare costs pre- versus post-TMVR. BACKGROUND: TMVR is effective in degenerative mitral regurgitation (MR) and appr ... Full text Link to item Cite

Single lung transplantation in patients with severe secondary pulmonary hypertension.

Journal Article J Heart Lung Transplant · September 2019 BACKGROUND: The optimal transplant strategy for patients with end-stage lung disease complicated by secondary pulmonary hypertension (PH) is controversial. The aim of this study is to define the role of single lung transplantation in this population. METHO ... Full text Link to item Cite

Controlling axillary intra-aortic balloon pump inflation is a viable option for turning an acute heart failure patient into a chronic one.

Journal Article Artif Organs · July 2019 Intra-aortic balloon pump (IABP) is often used to support patients in decompensated heart failure. Placement of the IABP via the axillary artery facilitates long-term support with the device and may allow for the conversion of an acute heart failure (HF) p ... Full text Link to item Cite

Circulating mitochondria in organ donors promote allograft rejection.

Journal Article Am J Transplant · July 2019 The innate immune system is a critical regulator of the adaptive immune responses that lead to allograft rejection. It is increasingly recognized that endogenous molecules released from tissue injury and cell death are potent activators of innate immunity. ... Full text Link to item Cite

Outcomes After Extracorporeal Right Ventricular Assist Device Combined With Durable Left Ventricular Assist Device Support.

Journal Article Ann Thorac Surg · June 2019 BACKGROUND: Right heart failure occurs in 9% to 44% of left ventricular assist device (LVAD) implants, of which less than 10% require right ventricular assist device (RVAD) support either concurrently with the LVAD or staged, as a delayed procedure. We hav ... Full text Link to item Cite

A normothermic ex vivo organ perfusion delivery method for cardiac transplantation gene therapy.

Journal Article Sci Rep · May 29, 2019 Clinically, both percutaneous and surgical approaches to deliver viral vectors to the heart either have resulted in therapeutically inadequate levels of transgene expression or have raised safety concerns associated with extra-cardiac delivery. Recent deve ... Full text Link to item Cite

Tricuspid Valve Regurgitation Immediately After Heart Transplant and Long-Term Outcomes.

Journal Article Ann Thorac Surg · May 2019 BACKGROUND: Tricuspid valve regurgitation (TR) is a common finding immediately after cardiac transplantation. However, there is a scarcity of data regarding its implication if left untreated on long-term outcomes and the role of early surgical repair. METH ... Full text Link to item Cite

Outcomes of Laparoscopic Cholecystectomy in Patients Supported with a Left Ventricular Assist Device.

Journal Article J Laparoendosc Adv Surg Tech A · April 2019 BACKGROUND: An increasing number of end-stage heart failure patients are supported with left ventricular assist device (LVAD) implantation and must be maintained on consistent anticoagulation. These patients are experiencing prolonged survival and, in some ... Full text Link to item Cite

Clinical and Angiographic Predictors of Patient-Reported Angina 1 Year After Coronary Artery Bypass Graft Surgery.

Journal Article Circulation. Cardiovascular quality and outcomes · April 2019 BackgroundStudies of the relationship between patient self-reported angina symptoms using the Seattle Angina Questionnaire (SAQ) and angiographic findings after coronary artery bypass grafting surgery (CABG) are lacking. Nested within a randomized ... Full text Cite

Outcomes of carotid-subclavian bypass performed in the setting of thoracic endovascular aortic repair.

Journal Article J Vasc Surg · March 2019 BACKGROUND: Subclavian artery revascularization is frequently performed in the setting of thoracic endovascular aortic repair (TEVAR). However, there is little information on the short- and long-term outcomes of patients undergoing carotid to subclavian ar ... Full text Link to item Cite

Implications of declining donor offers with increased risk of disease transmission on waiting list survival in lung transplantation.

Journal Article J Heart Lung Transplant · March 2019 BACKGROUND: Donors with characteristics that may increase the likelihood of disease transmission with transplantation are noted as increased risk via Public Health Service criteria. This study aimed to establish the implications of declining an increased-r ... Full text Link to item Cite

PRE- VERSUS POST-PROCEDURE CLINICAL EVENT RATES AND ASSOCIATED HEALTHCARE RESOURCE UTILIZATION IN PATIENTS UNDERGOING COMMERCIAL MITRACLIP PLACEMENT

Conference Journal of the American College of Cardiology · March 2019 Full text Cite

Costs Five Years After Off-Pump or On-Pump Coronary Artery Bypass Surgery.

Journal Article The Annals of thoracic surgery · January 2019 BackgroundCoronary artery bypass grafting (CABG) is a common surgical treatment for ischemic heart disease. Little is known about the long-term costs of conducting the surgery on-pump or off-pump.MethodsAs part of the Randomized On/Off By ... Full text Cite

Off-Pump Versus On-Pump Impact: Diabetic Patient 5-Year Coronary Artery Bypass Clinical Outcomes.

Journal Article The Annals of thoracic surgery · January 2019 BackgroundFor diabetic patients who require coronary artery bypass graft (CABG) operation, controversy persists whether an off-pump or an on-pump approach may be advantageous. This US-based, multicenter, randomized, controlled trial, Department of ... Full text Cite

Implications of blood group on lung transplantation rates: A propensity-matched registry analysis.

Journal Article J Heart Lung Transplant · January 2019 BACKGROUND: Blood type O lung allografts may be allocated to blood type identical (type O) or compatible (non-O) candidates. We tested the hypothesis that the current organ allocation schema in the United States-based on the Lung Allocation Score-prejudice ... Full text Link to item Cite

Mitochondria Released by Apoptotic Cell Death Initiate Innate Immune Responses.

Journal Article ImmunoHorizons · January 2019 Full text Cite

Early RHF Post Tricuspid Valve Repair Performed Concurrent With LVAD Implantation is Not Associated With Late RHF

Conference CIRCULATION · 2019 Cite

Stroke Following Current Generation Ventricular Assist Devices: A Systematic Review of Incidence and Outcomes

Conference CIRCULATION · 2019 Cite

Extracellular Mitochondrial DNA and N-Formyl Peptides in Trauma and Critical Illness: A Systematic Review.

Journal Article Crit Care Med · December 2018 OBJECTIVES: Extracellular mitochondrial DNA and N-formyl peptides released following tissue damage may contribute to systemic inflammation through stimulation of the innate immune system. In this review, we evaluate existing in vivo human data regarding a ... Full text Link to item Cite

The Perioperative Management of Ascending Aortic Dissection.

Journal Article Anesth Analg · December 2018 Acute aortic syndromes are a distinct group of pathologies involving the wall of the aorta that present acutely and can be potentially fatal unless treated in a timely fashion. The syndrome is dominated by aortic dissections, which comprise ≥95% of all suc ... Full text Link to item Cite

Mitochondria Released by Apoptotic Cell Death Initiate Innate Immune Responses.

Journal Article Immunohorizons · December 2018 In solid organ transplantation, cell death arising from ischemia/reperfusion leads to the release of several damage-associated molecular patterns derived from mitochondria. Mitochondrial damage-associated molecular patterns (mtDAMPs) initiate proinflammato ... Full text Link to item Cite

Decline of Increased Risk Donor Offers on Waitlist Survival in Heart Transplantation.

Journal Article J Am Coll Cardiol · November 6, 2018 Full text Link to item Cite

Outcomes of Planned Two-Stage Hybrid Aortic Repair With Dacron-Replaced Proximal Landing Zone.

Journal Article Ann Thorac Surg · October 2018 BACKGROUND: Results of hybrid arch repair (HAR) using the native zone 0 proximal landing zone (PLZ) have been unsatisfactory in many series, especially in the setting of ascending aortic dilation (>4.0 cm). This study reports early and late outcomes of pla ... Full text Link to item Cite

Management of Patients With Left Ventricular Assist Devices Requiring Teeth Extraction: Is Halting Anticoagulation Appropriate?

Journal Article J Oral Maxillofac Surg · September 2018 PURPOSE: An increasing number of patients with end-stage heart failure are supported with left ventricular assist device (LVAD) implantation and must be maintained on a consistent anticoagulation regimen. Pre-emptive extraction of carious teeth in these pa ... Full text Link to item Cite

Is Functional Independence Associated With Improved Long-Term Survival After Lung Transplantation?

Journal Article Ann Thorac Surg · July 2018 BACKGROUND: Existing research demonstrates superior short-term outcomes (length of stay, 1-year survival) after lung transplantation in patients with preoperative functional independence. The aim of this study was to determine whether advantages remain sig ... Full text Link to item Cite

Risk factors for stroke on left ventricular assist devices.

Journal Article J Card Surg · June 2018 BACKGROUND: Patients with end-stage heart failure on left ventricular assist devices (LVADs) are predisposed to a high incidence of stroke. Preoperative factors associated with increased stroke risk are poorly understood. METHODS: We performed a single-cen ... Full text Link to item Cite

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart.

Journal Article J Vis Exp · May 11, 2018 Featured Publication Mechanical circulatory support (MCS) has been introduced as a viable alternative to heart transplantation primarily through the use of intracorporeal ventricular assist devices (VADs) for support of the left ventricle. However, certain clinical scenarios w ... Full text Link to item Cite

Single- Versus Multicenter Surgeons' Risk-Adjusted Coronary Artery Bypass Graft Procedural Outcomes.

Journal Article Ann Thorac Surg · May 2018 Featured Publication BACKGROUND: Since 2010, 460+ hospital mergers have occurred in the United States, rerouting historical coronary artery bypass graft (CABG) referral patterns. The goals of this study were: (1) to compare risk-adjusted CABG outcomes between single-center ver ... Full text Link to item Cite

Wide Spread Adenoviral Vector Delivery to a Cardiac Allograft Utilizing an Ex Vivo Perfusion Storage Strategy

Conference MOLECULAR THERAPY · May 1, 2018 Featured Publication Link to item Cite

Preoperative factors associated with worsening in health-related quality of life following coronary artery bypass grafting in the Randomized On/Off Bypass (ROOBY) trial.

Journal Article American heart journal · April 2018 For advanced coronary disease, coronary artery bypass graft (CABG) surgery generally improves patients' symptoms and long-term survival. Unfortunately, some patients experience worse health-related quality of life (HRQL) after CABG. The objective of this s ... Full text Cite