Scholars@Duke
Shivanand Lad

Shivanand Lad

Professor of Neurosurgery
Neurosurgery
nandan.lad@duke.edu
DUMC 3807, Durham, NC 27710
200 Trent Drive, Blue Zone, Su, Durham, NC 27710

Selected Publications

Maximal Analgesic Effect Attained by the Use of Objective Neurophysiological Measurements With Closed-Loop Spinal Cord Stimulation.

Journal Article Neuromodulation · December 2024 OBJECTIVES: Spinal cord stimulation (SCS) has been challenged by the lack of neurophysiologic data to guide therapy optimization. Current SCS programming by trial-and-error results in suboptimal and variable therapeutic effects. A novel system with a physi ... Full text Link to item Cite

High-Frequency 10-kHz Spinal Cord Stimulation Provides Long-term (24-Month) Improvements in Diabetes-Related Pain and Quality of Life for Patients with Painful Diabetic Neuropathy.

Journal Article J Diabetes Sci Technol · October 6, 2024 BACKGROUND: The SENZA-PDN study evaluated high-frequency 10-kHz spinal cord stimulation (SCS) for the treatment of painful diabetic neuropathy (PDN). Over 24 months, 10-kHz SCS provided sustained pain relief and improved health-related quality of life. Thi ... Full text Link to item Cite

Four-tract tractography: multiparametric direct targeting of the dentatorubrothalamic tract.

Journal Article Neurosurg Focus Video · October 2024 This video article presents a case study of a 70-year-old male with medically refractory essential tremor treated with magnetic resonance-guided focused ultrasound (MRgFUS). Following an initial successful ablation of the right thalamus, the patient underw ... Full text Link to item Cite

Gender Differences in Operative Autonomy Using the Surgical Autonomy Program: A Multicenter Study.

Journal Article J Grad Med Educ · October 2024 Background The proportion of women surgeons is increasing, but studies show that women in surgical residency are granted less autonomy than men. Objective We utilized the Surgical Autonomy Program (SAP), an educational framework, to evaluate gender differe ... Full text Link to item Cite

Five-Year Longitudinal Follow-Up of Restorative Neurostimulation Shows Durability of Effectiveness in Patients With Refractory Chronic Low Back Pain Associated With Multifidus Muscle Dysfunction.

Journal Article Neuromodulation · July 2024 BACKGROUND: Adults with refractory, mechanical chronic low back pain associated with impaired neuromuscular control of the lumbar multifidus muscle have few treatment options that provide long-term clinical benefit. This study hypothesized that restorative ... Full text Link to item Cite

Disparities in the treatment of movement disorders using deep brain stimulation.

Journal Article J Neurosurg · July 1, 2024 OBJECTIVE: Deep brain stimulation (DBS) is a well-established treatment for Parkinson's disease (PD) and essential tremor (ET). Although the prevalence of PD and ET can vary by sex and race, little is known about the accessibility of neurosurgical treatmen ... Full text Link to item Cite

Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor in a patient with von Willebrand disease: perioperative optimization for patients with coagulopathies. Illustrative case.

Journal Article J Neurosurg Case Lessons · June 10, 2024 BACKGROUND: Essential tremor (ET) is one of the most common movement disorders worldwide. In medically refractory ET, deep brain stimulation (DBS) of the ventral intermediate nucleus of the thalamus is the current standard of care. However, DBS carries an ... Full text Link to item Cite

Disparities in Access to Deep Brain Stimulation and Responsive Neurostimulation Approaches to Drug-Resistant Epilepsy.

Journal Article Neuromodulation : journal of the International Neuromodulation Society · June 2024 BackgroundEpilepsy affects 1% to 2% of the global population, and those who are resistant to medical treatment may be candidates for neuromodulation. In select populations, brain stimulation approaches including deep brain stimulation (DBS) and re ... Full text Cite

Nationwide Analysis of Risk Factors Related to Opioid Weaning Following Lumbar Decompression Surgery - A Retrospective Database Study.

Journal Article World Neurosurg · June 2024 BACKGROUND: Opioids are often prescribed for patients who eventually undergo lumbar decompression. Given the potential for opioid-related morbidity and mortality, postoperative weaning is often a goal of surgery. The purpose of this study was to examine th ... Full text Link to item Cite

Healthcare Economics of High Frequency Spinal Cord Stimulation for Painful Diabetic Peripheral Neuropathy.

Journal Article J Diabetes Sci Technol · May 2024 BACKGROUND: Painful diabetic peripheral neuropathy (pDPN) is a debilitating complication of long-term diabetes. High-frequency spinal cord stimulation (HF-SCS) was recently shown to be an effective treatment option, but the associated healthcare resource u ... Full text Link to item Cite

Pushing the Limits of Minimally Invasive Spine Surgery-From Preoperative to Intraoperative to Postoperative Management.

Journal Article J Clin Med · April 20, 2024 The introduction of minimally invasive surgery ushered in a new era of spine surgery by minimizing the undue iatrogenic injury, recovery time, and blood loss, among other complications, of traditional open procedures. Over time, technological advancements ... Full text Open Access Link to item Cite

Healthcare resource utilization for chronic low back pain among high-utilizers.

Journal Article Spine J · April 2024 BACKGROUND: Chronic low back pain is a leading cause of morbidity and is among the largest cost drivers for the healthcare system. Research on healthcare resource utilization of patients with low back pain who are not surgical candidates is limited, and fe ... Full text Link to item Cite

Digital Health Platforms for Breast Cancer Care: A Scoping Review.

Journal Article J Clin Med · March 27, 2024 Breast cancer is a significant global health concern affecting millions of women each year. Digital health platforms are an easily accessible intervention that can improve patient care, though their efficacy in breast cancer care is unknown. This scoping r ... Full text Link to item Cite

Red Blood Cells in the Cerebrospinal Fluid Compartment After Subarachnoid Haemorrhage: Significance and Emerging Therapeutic Strategies.

Journal Article Transl Stroke Res · February 29, 2024 Subarachnoid haemorrhage (SAH) is a subtype of stroke that predominantly impacts younger individuals. It is associated with high mortality rates and can cause long-term disabilities. This review examines the contribution of the initial blood load and the d ... Full text Link to item Cite

Durable responses at 24 months with high-frequency spinal cord stimulation for nonsurgical refractory back pain.

Journal Article J Neurosurg Spine · February 1, 2024 OBJECTIVE: The objective of this study was to evaluate the 24-month durability of pain relief, function, quality of life, and safety outcomes for patients with nonsurgical refractory back pain (NSRBP) treated with high-frequency spinal cord stimulation (SC ... Full text Link to item Cite

Digital Health for Patients Undergoing Spine Surgery: A Systematic Review.

Journal Article World Neurosurg · February 2024 OBJECTIVE: Digital health tools, including smartphone applications (apps), websites, and online search engines, are increasingly being utilized for health data collection and patient education. Studies have shown that these tools can help disseminate infor ... Full text Link to item Cite

Real World Characterization of Chronic Pain, Success Rates and Implant Rates: Evidence from a Digital Health Platform of Patients Undergoing Spinal Cord Stimulation Evaluations.

Journal Article The journal of pain · December 2023 Spinal cord stimulation is an effective treatment for those experiencing chronic back and leg pain but requires a temporary evaluation period (SCSeval) before permanent implantation. We present real-world data from 7,000 patients who underwent SCSeval whil ... Full text Cite

High-resolution neural recordings improve the accuracy of speech decoding.

Journal Article Nat Commun · November 6, 2023 Patients suffering from debilitating neurodegenerative diseases often lose the ability to communicate, detrimentally affecting their quality of life. One solution to restore communication is to decode signals directly from the brain to enable neural speech ... Full text Link to item Cite

Short-Term Health Care Costs of High-Frequency Spinal Cord Stimulation for the Treatment of Postsurgical Persistent Spinal Pain Syndrome.

Journal Article Neuromodulation · October 2023 OBJECTIVE: High-frequency spinal cord stimulation (HF-SCS) is a treatment option for postsurgical persistent spinal pain syndrome (type 2 PSPS). We aimed to determine the health care costs associated with this therapy in a nationwide cohort. MATERIALS AND ... Full text Link to item Cite

Long-term efficacy of high-frequency (10 kHz) spinal cord stimulation for the treatment of painful diabetic neuropathy: 24-Month results of a randomized controlled trial.

Journal Article Diabetes Res Clin Pract · September 2023 AIMS: To evaluate the long-term efficacy of high-frequency (10 kHz) spinal cord stimulation (SCS) for treating refractory painful diabetic neuropathy (PDN). METHODS: The SENZA-PDN study was a prospective, multicenter, randomized controlled trial that compa ... Full text Link to item Cite

Health care resource utilization and costs in patients with painful diabetic neuropathy treated with 10 kHz spinal cord stimulation therapy.

Journal Article J Manag Care Spec Pharm · September 2023 BACKGROUND: Diabetic peripheral neuropathy, a common comorbidity of diabetes, is a neurodegenerative disorder that targets sensory, autonomic, and motor nerves frequently associated with painful diabetic neuropathy (PDN). PDN carries an economic burden as ... Full text Link to item Cite

Digital Health for Patients Undergoing Cardiac Surgery: A Systematic Review

Journal Article Healthcare (Switzerland) · September 1, 2023 Digital health interventions have shown promise in improving patient outcomes and experiences in various healthcare settings. However, their effectiveness in the context of cardiac surgery remains uncertain. This systematic review aims to evaluate the exis ... Full text Cite

Improving patient outcomes with a mobile digital health platform for patients undergoing transcatheter aortic valve replacement.

Journal Article J Invasive Cardiol · September 2023 PURPOSE: ManageMySurgery (MMS) is a digital health application (app) for patients undergoing surgery, including Transcatheter Aortic Valve Replacement (TAVR). Patients using MMS review procedure-specific education, view FAQs, and report patient-reported ou ... Full text Link to item Cite

Assessment of Health Care Costs and Total Baclofen Use Associated With Targeted Drug Delivery for Spasticity.

Journal Article Neuromodulation · August 2023 BACKGROUND: Chronic spasticity causes significant impairment and financial burden. Oral baclofen, the first-line therapy, can have intolerable, dose-dependent side effects. Targeted drug delivery (TDD) through intrathecal baclofen delivers smaller amounts ... Full text Link to item Cite

Quantifying the Opportunity Cost of Neurosurgical Resident Education.

Journal Article World Neurosurg · July 2023 BACKGROUND/OBJECTIVE: Education is at the core of neurosurgical residency, but little research in to the cost of neurosurgical education exists. This study aimed to quantify costs of resident education in an academic neurosurgery program using traditional ... Full text Link to item Cite

A Nationwide Analysis of Aneurysmal Subarachnoid Hemorrhage Mortality, Complications, and Health Economics in the USA.

Journal Article Transl Stroke Res · June 2023 Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating neurological condition. Endovascular coiling or surgical clipping have equivocal success rates, but relatively little is known regarding the health economics and complications of these procedures a ... Full text Link to item Cite

From Their Eyes: What Constitutes Quality Formative Written Feedback for Neurosurgery Residents.

Journal Article J Surg Educ · March 2023 BACKGROUND: The characteristics of quality feedback from the neurosurgery resident's perspective are not fully elucidated. The Surgical Autonomy Program is an intraoperative assessment tool based on Vygotsky's Zone of Proximal Development (ZPD). SAP facili ... Full text Link to item Cite

Cost-effectiveness of 10-kHz spinal cord stimulation therapy compared with conventional medical management over the first 12 months of therapy for patients with nonsurgical back pain: randomized controlled trial.

Journal Article J Neurosurg Spine · February 1, 2023 OBJECTIVE: This analysis evaluated if spinal cord stimulation (SCS) at 10 kHz plus conventional medical management (CMM) is cost-effective compared with CMM alone for the treatment of nonsurgical refractory back pain (NSRBP). METHODS: NSRBP subjects were r ... Full text Link to item Cite

Long-Term Outcomes of Restorative Neurostimulation in Patients With Refractory Chronic Low Back Pain Secondary to Multifidus Dysfunction: Two-Year Results of the ReActiv8-B Pivotal Trial.

Journal Article Neuromodulation · January 2023 BACKGROUND: Impaired neuromuscular control and degeneration of the multifidus muscle have been linked to the development of refractory chronic low back pain (CLBP). An implantable restorative-neurostimulator system can override the underlying multifidus in ... Full text Link to item Cite

Health Care Resource Utilization of High-Frequency Spinal Cord Stimulation for Treatment of Chronic Refractory Low Back Pain.

Journal Article Neuromodulation · January 2023 INTRODUCTION: Chronic refractory low back pain (CRLBP) is a diagnosis characterized by chronic low back pain in patients who are poor candidates for surgery and fail conservative management. High-frequency spinal cord stimulation (HF-SCS) is a new advance ... Full text Link to item Cite

Three-Year Durability of Restorative Neurostimulation Effectiveness in Patients With Chronic Low Back Pain and Multifidus Muscle Dysfunction.

Journal Article Neuromodulation : journal of the International Neuromodulation Society · January 2023 BackgroundRestorative neurostimulation is a rehabilitative treatment for patients with refractory chronic low back pain (CLBP) associated with dysfunction of the lumbar multifidus muscle resulting in impaired neuromuscular control. The ReActiv8-B ... Full text Cite

Treatment Patterns and Health Care Resource Utilization of Iatrogenic Spinal Cerebrospinal Fluid Leaks in the United States.

Journal Article Clin Spine Surg · November 1, 2022 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: We aimed to characterize the treatment patterns and the associated costs in patients with cerebrospinal fluid (CSF) leak after spine procedures in the United States. BACKGROUND: CSF leak is a common comp ... Full text Link to item Cite

Outcomes With a Mobile Digital Health Platform for Patients Undergoing Spine Surgery: Retrospective Analysis.

Journal Article JMIR Perioper Med · October 26, 2022 BACKGROUND: Digital health solutions have been shown to enhance outcomes for individuals with chronic medical illnesses, but few have been validated for surgical patients. The digital health platform ManageMySurgery (MMS) has been validated for spine surge ... Full text Link to item Cite

Treatment of nonsurgical refractory back pain with high-frequency spinal cord stimulation at 10 kHz: 12-month results of a pragmatic, multicenter, randomized controlled trial.

Journal Article J Neurosurg Spine · August 1, 2022 OBJECTIVE: Spinal cord stimulation (SCS) at 10 kHz (10-kHz SCS) is a safe and effective therapy for treatment of chronic low-back pain. However, it is unclear from existing evidence whether these findings can be generalized to patients with chronic back pa ... Full text Link to item Cite

Machine Learning to Predict Successful Opioid Dose Reduction or Stabilization After Spinal Cord Stimulation.

Journal Article Neurosurgery · August 1, 2022 BACKGROUND: Spinal cord stimulation (SCS) effectively reduces opioid usage in some patients, but preoperatively, there is no objective measure to predict who will most benefit. OBJECTIVE: To predict successful reduction or stabilization of opioid usage aft ... Full text Link to item Cite

Construct validity of the Surgical Autonomy Program for the training of neurosurgical residents.

Journal Article Neurosurg Focus · August 2022 OBJECTIVE: There is no standard way in which physicians teach or evaluate surgical residents intraoperatively, and residents are proving to not be fully competent at core surgical procedures upon graduating. The Surgical Autonomy Program (SAP) is a novel e ... Full text Link to item Cite

Initial Clinical Outcome With Bilateral, Dual-Target Deep Brain Stimulation Trial in Parkinson Disease Using Summit RC + S.

Journal Article Neurosurgery · July 1, 2022 BACKGROUND: Deep brain stimulation (DBS) is an effective therapy in advanced Parkinson disease (PD). Although both subthalamic nucleus (STN) and globus pallidus (GP) DBS show equivalent efficacy in PD, combined stimulation may demonstrate synergism. OBJECT ... Full text Open Access Link to item Cite

Feasibility study of a novel digital health platform for patients undergoing transcatheter aortic valve replacement.

Journal Article J Card Surg · July 2022 INTRODUCTION: Despite abundant evidence indicating that digital health solutions improve outcomes in chronic medical conditions, there are few validated solutions for acute surgical episodes. Transcatheter aortic valve replacement (TAVR) is a less invasive ... Full text Link to item Cite

Palliative Care Consultations in Patients with Severe Traumatic Brain Injury: Who Receives Palliative Care Consultations and What Does that Mean for Utilization?

Journal Article Neurocrit Care · June 2022 BACKGROUND: Palliative care has the potential to improve goal-concordant care in severe traumatic brain injury (sTBI). Our primary objective was to illuminate the demographic profiles of patients with sTBI who receive palliative care encounters (PCEs), wit ... Full text Open Access Link to item Cite

Intraoperative microseizure detection using a high-density micro-electrocorticography electrode array.

Journal Article Brain Commun · 2022 One-third of epilepsy patients suffer from medication-resistant seizures. While surgery to remove epileptogenic tissue helps some patients, 30-70% of patients continue to experience seizures following resection. Surgical outcomes may be improved with more ... Full text Open Access Link to item Cite

Inpatient mortality and healthcare resource utilization of nontraumatic intracerebral hemorrhage complications in the US.

Journal Article J Neurosurg · October 1, 2021 OBJECTIVE: Nontraumatic, primary intracerebral hemorrhage (ICH) accounts for 2 million strokes worldwide annually and has a 1-year survival rate of 50%. Recent studies examining functional outcomes from ICH evacuation have been performed, but limited work ... Full text Link to item Cite

An implantable restorative-neurostimulator for refractory mechanical chronic low back pain: a randomized sham-controlled clinical trial.

Journal Article Pain · October 2021 AbstractChronic low back pain can be caused by impaired control and degeneration of the multifidus muscles and consequent functional instability of the lumbar spine. Available treatment options have limited effectiveness and prognosis is unfavorab ... Full text Cite

Mobile Health Application for Patients Undergoing Breast Cancer Surgery: Feasibility Study.

Journal Article JCO oncology practice · September 2021 PurposeContemporary breast cancer surgery often requires hospital stays of 1 day or less, presenting challenges to delivery of high-quality care. Without sufficient time for proper education and guidance, patients may delay seeking care, experienc ... Full text Cite

A high-resolution interactive atlas of the human brainstem using magnetic resonance imaging.

Journal Article Neuroimage · August 15, 2021 Conventional atlases of the human brainstem are limited by the inflexible, sparsely-sampled, two-dimensional nature of histology, or the low spatial resolution of conventional magnetic resonance imaging (MRI). Postmortem high-resolution MRI circumvents the ... Full text Link to item Cite

Flexible, high-resolution thin-film electrodes for human and animal neural research.

Journal Article J Neural Eng · June 17, 2021 Objective.Brain functions such as perception, motor control, learning, and memory arise from the coordinated activity of neuronal assemblies distributed across multiple brain regions. While major progress has been made in understanding the function of indi ... Full text Link to item Cite

Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy: A Randomized Clinical Trial.

Journal Article JAMA Neurol · June 1, 2021 IMPORTANCE: Many patients with diabetic peripheral neuropathy experience chronic pain and inadequate relief despite best available medical treatments. OBJECTIVE: To determine whether 10-kHz spinal cord stimulation (SCS) improves outcomes for patients with ... Full text Link to item Cite

Impact of US hospital center and interhospital transfer on spinal cord injury management: An analysis of the National Trauma Data Bank.

Journal Article J Trauma Acute Care Surg · June 1, 2021 BACKGROUND: Traumatic spinal cord injury (SCI) is a serious public health problem. Outcomes are determined by severity of immediate injury, mitigation of secondary downstream effects, and rehabilitation. This study aimed to understand how the center type a ... Full text Open Access Link to item Cite

Outcomes and Health Care Resource Utilization of Adult Bacterial Meningitis in the United States.

Journal Article Neurol Clin Pract · April 2021 OBJECTIVE: To examine the longitudinal health care resource utilization, in-hospital mortality, and incidence of downstream complications of bacterial meningitis in the United States. METHODS: Using IBM MarketScan, we retrieved data on adult patients with ... Full text Link to item Cite

The Surgical Autonomy Program: A Pilot Study of Social Learning Theory Applied to Competency-Based Neurosurgical Education.

Journal Article Neurosurgery · March 15, 2021 Over the last decade, strict duty hour policies, pressure for increased work related value units from faculty, and the apprenticeship model of education have coalesced to make opportunities for intraoperative teaching more challenging. Evidence is emerging ... Full text Link to item Cite

High-Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Nonsurgical Refractory Back Pain: Design of a Pragmatic, Multicenter, Randomized Controlled Trial.

Journal Article Pain Pract · February 2021 BACKGROUND: Spinal cord stimulation (SCS) has been shown to provide pain relief for chronic back and leg pain due to failed back surgery syndrome. But many patients with chronic back pain have not had major back surgery or are not good candidates for surge ... Full text Link to item Cite

Paediatric bacterial meningitis in the USA: outcomes and healthcare resource utilization of nosocomial versus community-acquired infection.

Journal Article Journal of medical microbiology · January 2021 Introduction. Paediatric bacterial meningitis remains a costly disease, both financially and clinically.Hypothesis/Gap Statement. Previous epidemiological and cost studies of bacterial meningitis (BM) have largely focused on adult populations ... Full text Cite

Impact of Spinal Cord Stimulation on Opioid Dose Reduction: A Nationwide Analysis.

Journal Article Neurosurgery · December 15, 2020 BACKGROUND: Opioid misuse in the USA is an epidemic. Utilization of neuromodulation for refractory chronic pain may reduce opioid-related morbidity and mortality, and associated economic costs. OBJECTIVE: To assess the impact of spinal cord stimulation (SC ... Full text Open Access Link to item Cite

Health care resource utilization and treatment of leptomeningeal carcinomatosis in the United States.

Journal Article Neurooncol Pract · December 2020 BACKGROUND: The economic burden of cancer in the United States is substantial, and better understanding it is essential in informing health care policy and innovation. Leptomeningeal carcinomatosis (LC) represents a late complication of primary cancer spre ... Full text Link to item Cite

Spinal cord stimulation and rehabilitation in an individual with chronic complete L1 paraplegia due to a conus medullaris injury: motor and functional outcomes at 18 months.

Journal Article Spinal Cord Ser Cases · October 16, 2020 INTRODUCTION: Epidural electrical stimulation of the conus medullaris has helped facilitate native motor recovery in individuals with complete cervicothoracic spinal cord injuries (SCI). A theorized mechanism of clinical improvement includes supporting cen ... Full text Link to item Cite

A Smartphone App With a Digital Care Pathway for Patients Undergoing Spine Surgery: Development and Feasibility Study.

Journal Article JMIR Perioper Med · October 16, 2020 BACKGROUND: There is a great unmet clinical need to provide patients undergoing spinal surgery and their caregivers with ongoing, high-quality care before and after surgery in an efficiency-focused health care environment. OBJECTIVE: The objective of this ... Full text Open Access Link to item Cite

Health Care Resource Utilization and Management of Chronic, Refractory Low Back Pain in the United States.

Journal Article Spine (Phila Pa 1976) · October 15, 2020 STUDY DESIGN:: Retrospective analysis of inpatient and outpatient medical insurance claims data from a database containing over 100 million individuals. OBJECTIVE:: To quantify the healthcare resource utilization (HCRU) of non-surgical treatments in the fi ... Full text Link to item Cite

Withdrawal of Life-supporting Treatment in Severe Traumatic Brain Injury.

Journal Article JAMA Surg · August 1, 2020 IMPORTANCE: There are limited data on which factors affect the critical and complex decision to withdraw life-supporting treatment (LST) in patients with severe traumatic brain injury (sTBI). OBJECTIVE: To determine demographic and clinical factors associa ... Full text Link to item Cite

Enhancing Reality: A Systematic Review of Augmented Reality in Neuronavigation and Education.

Journal Article World Neurosurg · July 2020 OBJECTIVE: Augmented reality (AR) is increasingly being explored as an adjunct to conventional neuronavigation systems. AR affords the ability to superimpose 3-dimensional images onto the real environment. A natural extension of this technology is to help ... Full text Link to item Cite

31-LB: Neuromodulation for Treatment of Painful Diabetic Neuropathy: A Multicenter Randomized Controlled Trial

Conference Diabetes · June 1, 2020 Background: Six million adults in the U.S. are living with painful diabetic neuropathy (PDN) and current treatments are ineffective for many. Preliminary data suggest 10 kHz spinal cord stimulation (SCS) relieves pain and may improve sensation in r ... Full text Cite

In vitro and numerical simulation of blood removal from cerebrospinal fluid: comparison of lumbar drain to Neurapheresis therapy.

Journal Article Fluids Barriers CNS · March 16, 2020 BACKGROUND: Blood removal from cerebrospinal fluid (CSF) in post-subarachnoid hemorrhage patients may reduce the risk of related secondary brain injury. We formulated a computational fluid dynamics (CFD) model to investigate the impact of a dual-lumen cath ... Full text Link to item Cite

The longitudinal health economic impact of viral encephalitis in the United States.

Journal Article J Med Microbiol · February 2020 Introduction. Previous studies of viral encephalitis have focused on acute costs, estimating incidence at 7.3 per 100 000 and total US annual charges at $2 billion in 2010.Aim. We aim to quantify the most updated longitudinal health economic impact of vira ... Full text Link to item Cite

Impact of Neurapheresis System on Intrathecal Cerebrospinal Fluid Dynamics: A Computational Fluid Dynamics Study.

Journal Article J Biomech Eng · February 1, 2020 It has been hypothesized that early and rapid filtration of blood from cerebrospinal fluid (CSF) in postsubarachnoid hemorrhage patients may reduce hospital stay and related adverse events. In this study, we formulated a subject-specific computational flui ... Full text Link to item Cite

Painful diabetic peripheral neuropathy: Health care costs and complications from 2010 to 2015.

Journal Article Neurol Clin Pract · February 2020 OBJECTIVE: To quantify health care resource utilization and risk of complications in painful diabetic peripheral neuropathy (pDPN). METHODS: Adult patients diagnosed with diabetes mellitus or diabetic peripheral neuropathy (DPN) were identified in MarketSc ... Full text Link to item Cite

Evaluation of neurapheresis therapy in vitro: a novel approach for the treatment of leptomeningeal metastases.

Journal Article Neurooncol Adv · 2020 BACKGROUND: Leptomeningeal metastases (LM), late-stage cancer when malignant cells migrate to the subarachnoid space (SAS), have an extremely poor prognosis. Current treatment regimens fall short in effectively reducing SAS tumor burden. Neurapheresis ther ... Full text Link to item Cite

Prevalence and Cost Analysis of Chronic Pain After Hernia Repair: A Potential Alternative Approach With Neurostimulation.

Journal Article Neuromodulation · December 2019 OBJECTIVES: Chronic pain (CP) affects a significant number of patients following hernia repair, ranging from 11 to 54% in the literature. The aim of this study was to assess the prevalence, overall costs, and health care utilization associated with CP afte ... Full text Link to item Cite

Healthcare Economics of Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage in the United States.

Journal Article Transl Stroke Res · December 2019 Hydrocephalus is one of the most common sequelae after aneurysmal subarachnoid hemorrhage (aSAH), and it is a large contributor to the condition's high rates of readmission and mortality. Our objective was to quantify the healthcare resource utilization (H ... Full text Link to item Cite

Structural mapping with fiber tractography of the human cuneate fasciculus at microscopic resolution in cervical region.

Journal Article Neuroimage · August 1, 2019 Human spinal white matter tract anatomy has been mapped using post mortem histological information with the help of molecular tracing studies in animal models. This study used 7 Tesla diffusion MR tractography on a human cadaver that was harvested 24 hours ... Full text Link to item Cite

Multicolumn spinal cord stimulation for predominant back pain in failed back surgery syndrome patients: a multicenter randomized controlled trial.

Journal Article Pain · June 2019 Despite optimal medical management (OMM), low back pain (LBP) can be disabling, particularly after spinal surgery. Spinal cord stimulation (SCS) is effective in reducing neuropathic leg pain; however, evidence is limited for LBP. This prospective, open-lab ... Full text Open Access Link to item Cite

Simultaneous Recording and Stimulation Instrumentation for Closed Loop Spinal Cord Stimulation

Conference International IEEE/EMBS Conference on Neural Engineering, NER · May 16, 2019 Chronic neuropathic pain is a debilitating disorder. Many patients receive pain relief when implanted with a Spinal Cord Stimulation (SCS) system. However, there is currently no way to automatically determine the most effective parameters to use in stimula ... Full text Cite

Novel Dual Lumen Catheter and Filtration Device for Removal of Subarachnoid hemorrhage: First Case Report.

Journal Article Oper Neurosurg (Hagerstown) · May 1, 2019 BACKGROUND AND IMPORTANCE: The amount of subarachnoid blood and the presence of toxic blood breakdown products in the cerebrospinal fluid (CSF) have long been associated with poor outcomes in aneurysmal subarachnoid hemorrhage. The Neurapheresis™ system (M ... Full text Link to item Cite

The assassination of Robert F. Kennedy: an analysis of the senator's injuries and neurosurgical care.

Journal Article J Neurosurg · May 1, 2019 On June 5, 1968, having won the Democratic Party presidential primary in California, Senator Robert F. Kennedy delivered a victory speech to supporters at the Ambassador Hotel in downtown Los Angeles. Just after 12:15 am (Pacific daylight savings time), a ... Full text Link to item Cite

Independent Associations With 30- and 90-Day Unplanned Readmissions After Elective Lumbar Spine Surgery: A National Trend Analysis of 144 123 Patients.

Journal Article Neurosurgery · March 1, 2019 BACKGROUND: Unplanned hospital readmissions contribute significantly to soaring national healthcare expenditures. To alleviate this burden, Centers for Medicare and Medicaid Services implemented initiatives to penalize hospitals for unplanned 30-d hospital ... Full text Link to item Cite

Toward Functional Restoration of the Central Nervous System: A Review of Translational Neuroscience Principles.

Journal Article Neurosurgery · January 1, 2019 Injury to the central nervous system (CNS) can leave patients with devastating neurological deficits that may permanently impair independence and diminish quality of life. Recent insights into how the CNS responds to injury and reacts to critically timed i ... Full text Link to item Cite

Nonawake vs Awake Placement of Spinal Cord Stimulators: A Prospective, Multicenter Study Comparing Safety and Efficacy.

Journal Article Neurosurgery · January 1, 2019 BACKGROUND: Spinal cord stimulation (SCS) is a common intervention for managing intractable pain. Generally, leads are implanted in a minimally invasive procedure with verbal feedback regarding the location and nature of generated paresthesias by active st ... Full text Link to item Cite

Spinal Cord Stimulation for Restless Legs Syndrome: Case Series and Mechanistic Hypothesis.

Journal Article Stereotact Funct Neurosurg · 2019 BACKGROUND: Spinal cord stimulation (SCS) is a well-established therapy for chronic pain syndromes, with growing applicability to other conditions. Restless legs syndrome (RLS) is a widespread, chronic movement disorder managed primarily and incompletely b ... Full text Link to item Cite

Review of Neurosurgery Medical Professional Liability Claims in the United States.

Journal Article Neurosurgery · November 1, 2018 BACKGROUND: Due to disparaging costs and rates of malpractice claims in neurosurgery, there has been significant interest in identifying high-risk specialties, types of malpractice claims, and characteristics of claim-prone physicians. OBJECTIVE: To charac ... Full text Link to item Cite

Novel Treatment of Cryptococcal Meningitis via Neurapheresis Therapy.

Journal Article J Infect Dis · August 24, 2018 Cryptococcal meningitis (CM) has emerged as the most common life-threatening fungal meningitis worldwide. Current management involves a sequential, longitudinal regimen of antifungals; despite a significant improvement in survival compared with uniform mor ... Full text Open Access Link to item Cite

Prevalence and Cost Analysis of Complex Regional Pain Syndrome (CRPS): A Role for Neuromodulation.

Journal Article Neuromodulation · July 2018 OBJECTIVE: The diagnosis and treatment of complex regional pain syndrome (CRPS) is challenging and there is a paucity of data describing its overall cost burden and quantifying its impact on the US healthcare system. The aim of this study was to assess the ... Full text Link to item Cite

Influence of racial disparities on patient-reported satisfaction and short- and long-term perception of health status after elective lumbar spine surgery.

Journal Article J Neurosurg Spine · July 2018 OBJECTIVE In spine surgery, racial disparities have been shown to impact various aspects of surgical care. Previous studies have associated racial disparities with inferior surgical outcomes, including increased complication and 30-day readmission rates af ... Full text Link to item Cite

Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States.

Journal Article J Med Microbiol · February 2018 PURPOSE: Previous epidemiological and cost studies of fungal meningitis have largely focused on single pathogens, leading to a poor understanding of the disease in general. We studied the largest and most diverse group of fungal meningitis patients to date ... Full text Link to item Cite

Drivers and Risk Factors of Unplanned 30-Day Readmission Following Spinal Cord Stimulator Implantation.

Journal Article Neuromodulation · January 2018 OBJECTIVES: Unplanned 30-day readmission rates contribute significantly to growing national healthcare expenditures. Drivers of unplanned 30-day readmission after spinal cord stimulator (SCS) implantation are relatively unknown. The aim of this study was t ... Full text Link to item Cite

Postmortem diffusion MRI of the entire human spinal cord at microscopic resolution.

Journal Article Neuroimage Clin · 2018 The human spinal cord is a central nervous system structure that plays an important role in normal motor and sensory function, and can be affected by many debilitating neurologic diseases. Due to its clinical importance, the spinal cord is frequently the s ... Full text Link to item Cite

Leptomeningeal disease: current diagnostic and therapeutic strategies.

Journal Article Oncotarget · September 22, 2017 Leptomeningeal disease has become increasingly prevalent as novel therapeutic interventions extend the survival of cancer patients. Although a majority of leptomeningeal spread occurs secondary to breast cancer, lung cancer, and melanoma, a wide variety of ... Full text Link to item Cite

Increasing Rates of Imaging in Failed Back Surgery Syndrome Patients: Implications for Spinal Cord Stimulation.

Journal Article Pain Physician · September 2017 BACKGROUND: Failed back surgery syndrome (FBSS) has a high incidence following spinal surgery, is notoriously refractory to treatment, and results in high health care utilization. Spinal cord stimulation (SCS) is a well-accepted modality for pain relief in ... Link to item Cite

Long-term Cost Utility of Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome.

Journal Article Pain Physician · September 2017 BACKGROUND: Failed back surgery syndrome (FBSS) is a cause of significant morbidity for up to 40% of patients following spine surgery, and is estimated to cost almost $20 billion. Treatment options for these patients currently include conventional medical ... Link to item Cite

Explantation Rates and Healthcare Resource Utilization in Spinal Cord Stimulation.

Journal Article Neuromodulation · June 2017 OBJECTIVES: Certain patients ultimately undergo explantation of their spinal cord stimulation (SCS) devices. Understanding the predictors and rates of SCS explantation has important implications for healthcare resource utilization (HCRU) and pain managemen ... Full text Link to item Cite

Impact of Insurance Provider on Overall Costs in Failed Back Surgery Syndrome: A Cost Study of 122,827 Patients.

Journal Article Neuromodulation · June 2017 OBJECTIVES: Failed back surgery syndrome (FBSS) affects 40% of patients following spine surgery with estimated costs of $20 billion to the US health care system. The aim of this study was to assess the cost differences across the different insurance provid ... Full text Link to item Cite

Specialty-Based Variations in Spinal Cord Stimulation Success Rates for Treatment of Chronic Pain.

Journal Article Neuromodulation · June 2017 OBJECTIVES: Spinal cord stimulation (SCS) has emerged as an appropriate modality of treatment for intractable chronic pain. The present study examines variations in SCS trial-to-permanent conversion rates based on provider types performing the procedure. M ... Full text Link to item Cite

The Volume-Outcome Effect: Impact on Trial-to-Permanent Conversion Rates in Spinal Cord Stimulation.

Journal Article Neuromodulation · April 2017 OBJECTIVES: Conversion rates from trial leads to permanent spinal cord stimulation (SCS) systems have important implications for healthcare resource utilization (HCRU) and pain management. We hypothesized that there is a volume-outcome effect, with chronic ... Full text Link to item Cite

Comparing outcomes of early, late, and non-surgical management of intraspinal abscess.

Journal Article J Clin Neurosci · February 2017 Intraspinal abscesses (ISAs) are rare lesions that are often neurologically devastating. Current treatment paradigms vary widely including early surgical decompression, drainage, and systemic antibiotics, delayed surgery, and sole medical management. The N ... Full text Link to item Cite

Prevalence of Specific Types of Pain Diagnoses in a Sample of United States Adults.

Journal Article Pain Physician · February 2017 BACKGROUND: Patients with pain conditions place significant demands on health care services globally. Health economists have reported the annual economic cost of pain in the United States as high as $635 billion. A common challenge in treating patients suf ... Link to item Cite

Racial, Socioeconomic, and Gender Disparities in the Presentation, Treatment, and Outcomes of Adult Chiari I Malformations.

Journal Article World Neurosurg · January 2017 OBJECTIVE: To examine the influence of race, gender, and socioeconomic factors on presentations and outcomes of adult Chiari I malformations. METHODS: The charts of 638 adult patients with Chiari I malformations were reviewed, and 287 patients were include ... Full text Link to item Cite

The Neurostimulation Appropriateness Consensus Committee (NACC) Safety Guidelines for the Reduction of Severe Neurological Injury.

Journal Article Neuromodulation · January 2017 INTRODUCTION: Neurostimulation involves the implantation of devices to stimulate the brain, spinal cord, or peripheral or cranial nerves for the purpose of modulating the neural activity of the targeted structures to achieve specific therapeutic effects. S ... Full text Link to item Cite

The Neurostimulation Appropriateness Consensus Committee (NACC) Recommendations for Infection Prevention and Management.

Journal Article Neuromodulation · January 2017 INTRODUCTION: The use of neurostimulation for pain has been an established therapy for many decades and is a major tool in the arsenal to treat neuropathic pain syndromes. Level I evidence has recently been presented to substantiate the therapy, but this i ... Full text Link to item Cite

The Neurostimulation Appropriateness Consensus Committee (NACC): Recommendations on Bleeding and Coagulation Management in Neurostimulation Devices.

Journal Article Neuromodulation · January 2017 INTRODUCTION: The Neurostimulation Appropriateness Consensus Committee (NACC) was formed by the International Neuromodulation Society (INS) in 2012 to evaluate the evidence to reduce the risk of complications and improve the efficacy of neurostimulation. T ... Full text Link to item Cite

The Effect of Propofol vs. Isoflurane Anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine Levels: Results from a Randomized Trial.

Journal Article Front Immunol · 2017 INTRODUCTION: Aside from direct effects on neurotransmission, inhaled and intravenous anesthetics have immunomodulatory properties. In vitro and mouse model studies suggest that propofol inhibits, while isoflurane increases, neuroinflammation. If these fin ... Full text Link to item Cite

Local Fields in Human Subthalamic Nucleus Track the Lead-up to Impulsive Choices.

Journal Article Front Neurosci · 2017 The ability to adaptively minimize not only motor but cognitive symptoms of neurological diseases, such as Parkinson's Disease (PD) and obsessive-compulsive disorder (OCD), is a primary goal of next-generation deep brain stimulation (DBS) devices. On the b ... Full text Link to item Cite

Longer Delay From Chronic Pain to Spinal Cord Stimulation Results in Higher Healthcare Resource Utilization.

Journal Article Neuromodulation · July 2016 INTRODUCTION: A shorter delay time from chronic pain diagnosis to spinal cord stimulation (SCS) implantation may make it more likely to achieve lasting therapeutic efficacy with SCS. The objective of this analysis was to determine the impact of pain-to-SCS ... Full text Link to item Cite

Surgical Options for Atypical Facial Pain Syndromes.

Journal Article Neurosurg Clin N Am · July 2016 Atypical neuropathic facial pain is a syndrome of intractable and unremitting facial pain that is secondary to nociceptive signaling in the trigeminal system. These syndromes are often recalcitrant to pharmacotherapy and other common interventions, includi ... Full text Link to item Cite

The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.

Journal Article J Alzheimers Dis · April 15, 2016 BACKGROUND: Preclinical studies have found differential effects of isoflurane and propofol on the Alzheimer's disease (AD)-associated markers tau, phosphorylated tau (p-tau) and amyloid-β (Aβ). OBJECTIVE: We asked whether isoflurane and propofol have diffe ... Full text Open Access Link to item Cite

Implantable Neurostimulation for Headache Disorders: Effect on Healthcare Utilization and Expenditures.

Journal Article Neuromodulation · April 2016 OBJECTIVES: Chronic daily headache is a considerable source of morbidity for patients and also carries an enormous economic burden. Patients who fail standard medication regimens lack well-defined therapies, and neurostimulation is an emerging option for t ... Full text Link to item Cite

Inferior Vena Cava Filter Thrombosis in the Postoperative Neurosurgical Setting: Case Report and Review of the Literature.

Journal Article Cureus · March 10, 2016 There are no definitive treatment guidelines for caval-filter thrombosis in the postoperative setting. Clinical management for partial or complete postoperative inferior vena cava (IVC) occlusion relies solely on expert opinion, anecdotal evidence, and sma ... Full text Link to item Cite

Impact of Increasing Age on Outcomes of Spinal Fusion in Adult Idiopathic Scoliosis.

Journal Article World Neurosurg · March 2016 OBJECTIVE: To investigate the role of advancing age on postoperative complications and revision surgery after fusion for scoliosis. METHODS: A retrospective, cohort study was performed using the Thomson Reuters MarketScan database, examining patients with ... Full text Link to item Cite

Thoracic Nerve Root Entrapment by Intrathecal Catheter Coiling: Case Report and Review of the Literature.

Journal Article Pain Physician · March 2016 BACKGROUND: Intrathecal catheter placement has long-term therapeutic benefits in the management of chronic, intractable pain. Despite the diverse clinical applicability and rising prevalence of implantable drug delivery systems in pain medicine, the spectr ... Link to item Cite

Comparison of Bilateral vs. Staged Unilateral Deep Brain Stimulation (DBS) in Parkinson's Disease in Patients Under 70 Years of Age.

Journal Article Neuromodulation · January 2016 OBJECTIVE: The most popular surgical method for deep brain stimulation (DBS) in Parkinson's disease (PD) is simultaneous bilateral DBS. However, some centers conduct a staged unilateral approach advocating that reduced continuous intraoperative time reduce ... Full text Link to item Cite

The Incidence of Spinal Cord Injury in Implantation of Percutaneous and Paddle Electrodes for Spinal Cord Stimulation.

Journal Article Neuromodulation · January 2016 OBJECTIVE: Spinal cord stimulation (SCS) has been proven effective for multiple chronic pain syndromes. Over the past 40 years of use, the complication rates of SCS have been well defined in the literature; however, the incidence of one of the most devasta ... Full text Link to item Cite

Comparative Analysis of Inpatient and Outpatient Interspinous Process Device Placement for Lumbar Spinal Stenosis.

Journal Article J Neurol Surg A Cent Eur Neurosurg · November 2015 PURPOSE: To compare reoperations, health care utilization, and costs in lumbar spinal stenosis (LSS) patients undergoing interspinous process (ISP) device placement in an inpatient versus outpatient setting. METHODS: The MarketScan database (2007-2009) was ... Full text Link to item Cite

Postmortem diffusion MRI of the human brainstem and thalamus for deep brain stimulator electrode localization.

Journal Article Hum Brain Mapp · August 2015 Deep brain stimulation (DBS) is an established surgical therapy for medically refractory tremor disorders including essential tremor (ET) and is currently under investigation for use in a variety of other neurologic and psychiatric disorders. There is grow ... Full text Link to item Cite

Differences in the outcomes of anterior versus posterior interbody fusion surgery of the lumbar spine: a propensity score-controlled cohort analysis of 10,941 patients.

Journal Article J Clin Neurosci · May 2015 Few studies have measured outcome differences between the various available spinal fusion techniques. We compare long-term outcomes of anterior versus posterior lumbar interbody fusion. Using the MarketScan database (Truven Health Analytics, Ann Arbor, MI, ... Full text Link to item Cite

Impact of advancing age on post-operative complications of deep brain stimulation surgery for essential tremor.

Journal Article J Clin Neurosci · May 2015 Essential tremor (ET) was the original indication for deep brain stimulation (DBS), with USA Food and Drug Administration approval since 1997. Despite the efficacy of DBS, it is associated with surgical complications that cause sub-optimal clinical outcome ... Full text Link to item Cite

Effect of insurance and racial disparities on outcomes in traumatic brain injury.

Journal Article J Neurol Surg A Cent Eur Neurosurg · May 2015 INTRODUCTION: We evaluated outcome and resource utilization disparities between commercially insured, Medicaid, and Medicare patients. We further analyzed racial disparities in a subset cohort. METHODS: We reviewed the MarketScan database (2000-2009) for a ... Full text Link to item Cite

Outcomes after cervical laminectomy with instrumented fusion versus expansile laminoplasty: a propensity matched study of 3185 patients.

Journal Article J Clin Neurosci · March 2015 The aim of this study was to compare reoperation, complication rates, and healthcare resource utilization of expansile laminectomies with instrumented fusion versus laminoplasty. Using the MarketScan database (Truven Health Analytics, Ann Arbor, MI, USA), ... Full text Link to item Cite

A national survey of spinal cord stimulation trial-to-permanent conversion rates.

Journal Article Neuromodulation · February 2015 OBJECTIVES: Conversion rates from trial leads to permanent spinal cord stimulation (SCS) systems have recently come under scrutiny. Our goal was to examine the rate of conversion from trial lead to permanent system placement as well as identify factors ass ... Full text Link to item Cite

Comments

Journal Article Neuromodulation · February 1, 2015 Full text Cite

Comments

Journal Article Neuromodulation · February 1, 2015 Full text Cite

Experience with intrawound vancomycin powder for posterior cervical fusion surgery.

Journal Article J Neurosurg Spine · January 2015 OBJECT: Recent studies have reported that the local delivery of vancomycin powder is associated with a decrease in spinal surgical site infection. This retrospective cohort study compares posterior cervical fusion cases before and after the routine applica ... Full text Link to item Cite

In reply

Journal Article JAMA Neurology · January 1, 2015 Cite

Neurostimulation: Stimulation of the Cranium and Head: Stimulation of the Deep Brain for the Treatment of Chronic Pain

Chapter · January 1, 2015 Deep brain stimulation (DBS) is a therapy that has been used for more than half a century to treat chronic pain. The first use of these treatments occurred in the 1950s when neurosurgeons stimulated the septal region nuclei in patients with psychiatric dis ... Full text Cite

Stimulation of the Motor Cortex to Treat Chronic Pain

Chapter · January 1, 2015 Motor cortex stimulation (MCS) is a technique that allows physicians to offer treatment to many individuals who would otherwise have no treatment options. The increasing use of this modality is a reflection on the safety, perceived good outcome, and surpri ... Full text Cite

Stimulation of the Spinal Cord by Placement of Surgical-Based Paddle Leads

Chapter · January 1, 2015 Spinal cord stimulation can be achieved through various methods. One of the least invasive and most popular options is percutaneous lead placement via a needle in the epidural space and passing a cylindrical lead into the desired epidural location, produci ... Full text Cite

Morbidity, mortality, and health care costs for patients undergoing spine surgery following the ACGME resident duty-hour reform: Clinical article.

Journal Article J Neurosurg Spine · October 2014 OBJECT: The Accreditation Council for Graduate Medical Education (ACGME) implemented resident duty-hour restrictions on July 1, 2003, in concern for patient and resident safety. Whereas studies have shown that duty-hour restrictions have increased resident ... Full text Link to item Cite

Effect of advancing age on outcomes of deep brain stimulation for Parkinson disease.

Journal Article JAMA Neurol · October 2014 IMPORTANCE: Deep brain stimulation (DBS) is a well-established modality for the treatment of advanced Parkinson disease (PD). Recent studies have found DBS plus best medical therapy to be superior to best medical therapy alone for patients with PD and earl ... Full text Link to item Cite

Response

Journal Article Journal of Neurosurgery: Spine · October 1, 2014 Full text Cite

Preoperative serum albumin level as a predictor of postoperative complication after spine fusion.

Journal Article Spine (Phila Pa 1976) · August 15, 2014 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To investigate the association between preoperative baseline serum albumin and postoperative surgical complication. SUMMARY OF BACKGROUND DATA: The prevalence of malnutrition in the hospitalized patient ... Full text Link to item Cite

Worse outcomes for patients undergoing brain tumor and cerebrovascular procedures following the ACGME resident duty-hour restrictions.

Journal Article J Neurosurg · August 2014 OBJECT: On July 1, 2003, the Accreditation Council for Graduate Medical Education (ACGME) implemented duty-hour restrictions for resident physicians due to concerns for patient and resident safety. Though duty-hour restrictions have increased resident qual ... Full text Link to item Cite

Interspinous device versus laminectomy for lumbar spinal stenosis: a comparative effectiveness study.

Journal Article Spine J · August 1, 2014 BACKGROUND CONTEXT: Currently no studies directly compare effectiveness between interspinous devices (IDs) and laminectomy in lumbar spinal stenosis (LSS) patients. PURPOSE: To compare reoperations, complications, and costs between LSS patients undergoing ... Full text Link to item Cite

The appropriate use of neurostimulation of the spinal cord and peripheral nervous system for the treatment of chronic pain and ischemic diseases: the Neuromodulation Appropriateness Consensus Committee.

Journal Article Neuromodulation · August 2014 INTRODUCTION: The Neuromodulation Appropriateness Consensus Committee (NACC) of the International Neuromodulation Society (INS) evaluated evidence regarding the safety and efficacy of neurostimulation to treat chronic pain, chronic critical limb ischemia, ... Full text Link to item Cite

The appropriate use of neurostimulation: stimulation of the intracranial and extracranial space and head for chronic pain. Neuromodulation Appropriateness Consensus Committee.

Journal Article Neuromodulation · August 2014 INTRODUCTION: The International Neuromodulation Society (INS) has identified a need for evaluation and analysis of the practice of neurostimulation of the brain and extracranial nerves of the head to treat chronic pain. METHODS: The INS board of directors ... Full text Link to item Cite

Spinal surgery: variations in health care costs and implications for episode-based bundled payments.

Journal Article Spine (Phila Pa 1976) · July 1, 2014 STUDY DESIGN: Retrospective, observational. OBJECTIVE: To simulate what episodes of care in spinal surgery might look like in a bundled payment system and to evaluate the associated costs and characteristics. SUMMARY OF BACKGROUND DATA: Episode-based payme ... Full text Link to item Cite

Utilization of spinal cord stimulation in patients with failed back surgery syndrome.

Journal Article Spine (Phila Pa 1976) · May 20, 2014 STUDY DESIGN: Retrospective analysis of a population-based insurance claims data set. OBJECTIVE: To evaluate the use of spinal cord stimulation (SCS) and lumbar reoperation for the treatment of failed back surgery syndrome (FBSS), and examine their associa ... Full text Link to item Cite

Surgery for spinal stenosis: long-term reoperation rates, health care cost, and impact of instrumentation.

Journal Article Spine (Phila Pa 1976) · May 20, 2014 STUDY DESIGN: Retrospective cohort analysis. OBJECTIVE: To examine the complications, reoperation rates, and resource use after each of the surgical approaches for the treatment of spinal stenosis. SUMMARY OF BACKGROUND DATA: There are no uniform guideline ... Full text Link to item Cite

Effectiveness of radiotherapy for elderly patients with anaplastic gliomas.

Journal Article J Clin Neurosci · May 2014 Postoperative radiotherapy (RT) is utilized routinely in the management of anaplastic World Health Organization Grade III gliomas (AG), including anaplastic astrocytoma (AA) and anaplastic oligodendroglioma (AO). However, the optimal role of RT in elderly ... Full text Link to item Cite

Radiological evidence of spontaneous spinal arthrodesis in patients with lower lumbar spondylolisthesis.

Journal Article Spine (Phila Pa 1976) · April 15, 2014 STUDY DESIGN: Retrospective review of a consecutive series of patients with radiological evidence of spondylolisthesis. OBJECTIVE: To establish the incidence and characteristics of spontaneous spinal arthrodesis in the setting of lower lumbar spondylolisth ... Full text Link to item Cite

SEER insights.

Journal Article J Neurosurg · February 2014 Full text Link to item Cite

Experience with intrawound vancomycin powder for spinal deformity surgery.

Journal Article Spine (Phila Pa 1976) · January 15, 2014 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To evaluate the ability of local vancomycin powder to prevent deep wound infection after thoracolumbar and lumbar spinal fusion for open deformity cases. SUMMARY OF BACKGROUND DATA: Recent studies report ... Full text Open Access Link to item Cite

In reply.

Journal Article Neurosurgery · January 2014 Full text Link to item Cite

Comments

Journal Article Neuromodulation · January 1, 2014 Full text Cite

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Journal Article Neuromodulation · January 1, 2014 Full text Cite

Evaluation of intradural stimulation efficiency and selectivity in a computational model of spinal cord stimulation.

Journal Article PLoS One · 2014 Spinal cord stimulation (SCS) is an alternative or adjunct therapy to treat chronic pain, a prevalent and clinically challenging condition. Although SCS has substantial clinical success, the therapy is still prone to failures, including lead breakage, lead ... Full text Open Access Link to item Cite

Comparison of vertebroplasty, kyphoplasty, and nonsurgical management of vertebral compression fractures and impact on us healthcare resource utilization

Journal Article Asian Spine Journal · January 1, 2014 Study Design: Retrospective propensity score-matched cohort analysis of the Thomson Reuters MarketScan database. Purpose: To compare the outcomes of vertebral compression fracture (VCF) treatment options, with an emphasis on reoperation, complications, cos ... Full text Cite

Complications, reoperation rates, and health-care cost following surgical treatment of lumbar spondylolisthesis.

Journal Article J Bone Joint Surg Am · November 6, 2013 BACKGROUND: Surgery remains the mainstay for management of lumbar spondylolisthesis and is considered an effective therapeutic modality following unsuccessful nonoperative treatment. Surgical procedures include decompression, decompression with instrumente ... Full text Link to item Cite

Trend and geographic analysis for traumatic brain injury mortality and cost based on MarketScan database.

Journal Article J Neurotrauma · October 15, 2013 The objective of the current research was to examine the current epidemiology of traumatic brain injury (TBI); to determine the effects of geographic region, co-morbidities, year of injury, injury severity, and demographics on hospital costs, length of sta ... Full text Link to item Cite

Comments

Journal Article Neuromodulation · September 1, 2013 Full text Cite

Cancer after spinal fusion: the role of bone morphogenetic protein.

Journal Article Neurosurgery · September 2013 BACKGROUND: Bone morphogenetic protein (BMP) is used in tens of thousands of spinal fusions each year. A trial evaluating a high-dose BMP formulation demonstrated that its use may be associated with an increased risk of cancer. OBJECTIVE: To evaluate wheth ... Full text Link to item Cite

Long-term economic impact of coiling vs clipping for unruptured intracranial aneurysms.

Journal Article Neurosurgery · June 2013 BACKGROUND: : Treatment of unruptured intracranial aneurysms (UIAs) involves endovascular coiling or aneurysm clipping. While many studies have compared these treatment modalities with respect to various clinical outcomes, few studies have investigated the ... Full text Link to item Cite

Disparities in the outcomes of lumbar spinal stenosis surgery based on insurance status.

Journal Article Spine (Phila Pa 1976) · June 1, 2013 STUDY DESIGN: Retrospective cohort study using Thomson Reuter's MarketScan database. OBJECTIVE: To evaluate the extent to which Medicaid versus commercial insurance status affects outcomes after lumbar stenosis surgery. SUMMARY OF BACKGROUND DATA: The Affo ... Full text Link to item Cite

Racial disparities in outcomes of spinal surgery for lumbar stenosis.

Journal Article Spine (Phila Pa 1976) · May 15, 2013 STUDY DESIGN: A retrospective, cross-sectional study. OBJECTIVE: To evaluate racial disparities in outcomes of lumbar stenosis surgery. SUMMARY OF BACKGROUND DATA: Racial inequalities have been described in the outcomes of cardiovascular and orthopedic pro ... Full text Link to item Cite

Timing of tracheostomy after anterior cervical spine fixation.

Journal Article J Trauma Acute Care Surg · April 2013 BACKGROUND: Patients with cervical spinal cord injury frequently undergo early anterior cervical spine fixation (ACSF) and tracheostomy procedures to reduce further deterioration, to reduce risk of pulmonary complications, and to improve patient mobilizati ... Full text Link to item Cite

Racial disparities in outcomes after spinal cord injury.

Journal Article J Neurotrauma · March 15, 2013 Spinal Cord Injury (SCI) is an acute trauma to the neural elements resulting in temporary or permanent sensory and motor deficit. Studies have indicated that although 66% of SCI occur in Caucasians, there are a growing number of other racial groups affecte ... Full text Link to item Cite

Thickness of subcutaneous fat as a risk factor for infection in cervical spine fusion surgery.

Journal Article J Bone Joint Surg Am · February 20, 2013 BACKGROUND: Surgical site infections increase the incidence of morbidity and mortality as well as health-care expenses. The cost of care increases threefold to fourfold as a consequence of surgical site infection after spinal surgery. The aim of the presen ... Full text Link to item Cite

Urinary tract infections in meningioma patients: analysis of risk factors and outcomes.

Journal Article J Hosp Infect · February 2013 BACKGROUND: Urinary tract infections (UTIs) account for about 35% of all nosocomial infections and 75% are associated with the use of urethral catheters. AIM: The goal of this study was to evaluate preoperative factors associated with the risk of UTI and t ... Full text Link to item Cite

Outcomes of percutaneous and paddle lead implantation for spinal cord stimulation: a comparative analysis of complications, reoperation rates, and health-care costs.

Journal Article Neuromodulation · 2013 OBJECTIVES: Spinal cord stimulation (SCS) is a well-established modality for the treatment of chronic pain, and can utilize percutaneous or paddle leads. While percutaneous leads are less invasive, they have been shown to have higher lead migration rates. ... Full text Link to item Cite

Complete visual recovery after incipient crao due to ocular hypoperfusion in a patient with moyamoya disease.

Journal Article Retin Cases Brief Rep · 2013 PURPOSE: The purpose of this study was to report a case of an impending central retinal artery occlusion with hypoperfusion in a moyamoya patient. METHODS: A young, surgically revascularized moyamoya patient experienced severe unilateral vision loss from 2 ... Full text Link to item Cite

Effectiveness of radiotherapy for elderly patients with anaplastic gliomas

Journal Article Journal of Clinical Neuroscience · 2013 Cite

Racial disparities in Medicaid patients after brain tumor surgery.

Journal Article J Clin Neurosci · January 2013 The presence of healthcare-related disparities is an ongoing, widespread, and well-documented societal and health policy issue. We investigated the presence of racial disparities among post-operative patients either with meningioma or malignant, benign, or ... Full text Link to item Cite

Insurance disparities in the outcomes of spinal cord stimulation surgery.

Journal Article Neuromodulation · 2013 OBJECTIVES: The Affordable Care Act aims to expand health insurance and to help narrow existing health care disparities. Medicaid patients have previously been noted to be at an increased risk for impaired access to health care, delayed medical treatment, ... Full text Link to item Cite

Neurosurgical interventions for spondyloepiphyseal dysplasia congenita: clinical presentation and assessment of the literature.

Journal Article World Neurosurg · 2013 BACKGROUND: Spondyloepiphyseal dysplasia (SED) is a rare disease that causes vertebral abnormalities and short-trunk dwarfism. The two forms of SED are congenita and tarda. Each form arises in a genetically distinct fashion and manifests with a different s ... Full text Link to item Cite

Fungal infection of a ventriculoperitoneal shunt: histoplasmosis diagnosis and treatment.

Journal Article World Neurosurg · 2013 BACKGROUND: Histoplasmosis is a fungal disease caused by Histoplasma capsulatum, commonly found in the Americas, and Histoplasma duboisii, located in Africa. In the United States, H. capsulatum is prevalent in the Ohio and Mississippi river valleys. In rar ... Full text Link to item Cite

Orbital fractures: national inpatient trends and complications.

Journal Article Ophthalmic Plast Reconstr Surg · 2013 PURPOSE: The present study aimed to examine cost, demographics, and short-term complications associated with orbital fractures and their surgical repair in the inpatient population in the United States over a 7-year period. METHODS: A retrospective cohort ... Full text Link to item Cite

Trends in surgical use and associated patient outcomes in the treatment of acoustic neuroma.

Journal Article World Neurosurg · 2013 OBJECTIVE: To investigate recent trends in surgical volume and associated patient outcomes in the treatment of acoustic neuromas. METHODS: A retrospective analysis was performed using the Nationwide Inpatient Sample database from 2000-2007; cases from 2005 ... Full text Link to item Cite

Comments

Journal Article Neuromodulation · January 1, 2013 Full text Cite

A population-based study of inpatient outcomes after operative management of nontraumatic intracerebral hemorrhage in the United States.

Journal Article World Neurosurg · December 2012 BACKGROUND: In the United States, data on patient outcomes after operative management of nontraumatic intracerebral hemorrhage (ICH) have been largely derived from tertiary care academic institutions. Given that outcomes of patients treated at these specia ... Full text Link to item Cite

Venous thromboembolism after thoracic/thoracolumbar spinal fusion.

Journal Article World Neurosurg · November 2012 OBJECTIVE: Venous thromboembolism (VTE), which includes deep venous thrombosis and pulmonary embolism, is a serious and potentially fatal surgical complication. The goal of our study was to examine preoperative characteristics, incidence, and outcomes of p ... Full text Link to item Cite

Retrospective, propensity score-matched cohort study examining timing of fracture fixation for traumatic thoracolumbar fractures.

Journal Article J Neurotrauma · August 10, 2012 The timing of surgery in patients with traumatic thoracic/thoracolumbar fractures, with or without spinal cord injury, remains controversial. The objective of this study was to determine the importance of the timing of surgery for complications and resourc ... Full text Link to item Cite

134 BMP and Cancer Risk

Conference Neurosurgery · August 2012 Full text Cite

Racial and gender disparities and the role of primary tumor type on inpatient outcomes following craniotomy for brain metastases.

Journal Article Ann Surg Oncol · August 2012 BACKGROUND: Race and gender disparities in outcomes have been documented in many cancers. Our study evaluated the role of race, gender, and tumor primary site in predicting in-hospital mortality, discharge disposition, and complications among patients with ... Full text Link to item Cite

Incidental aneurysms in temporal lobe epilepsy surgery: report of three cases and a review of the literature.

Journal Article Br J Neurosurg · February 2012 OBJECTIVE AND IMPORTANCE: In rare instances, patients who are undergoing evaluation for temporal lobe epilepsy surgery will also be found to have an incidental aneurysm adjacent to the temporal lobe. Although busy epilepsy centers will eventually come acro ... Full text Link to item Cite

Proteomic biomarker discovery in cerebrospinal fluid for cerebral vasospasm following subarachnoid hemorrhage.

Journal Article J Stroke Cerebrovasc Dis · January 2012 Currently, there are no established biomarkers for diagnosing preclinical vasospasm or monitoring its progression. Two areas of extensive biomarker research are neuroimaging and biochemical markers in body fluids, such as cerebrospinal fluid (CSF). We perf ... Full text Link to item Cite

Hospital costs, incidence, and inhospital mortality rates of traumatic subdural hematoma in the United States.

Journal Article J Neurosurg · November 2011 OBJECT: This study provides the first US national data regarding frequency, cost, and mortality rate of traumatic subdural hematoma (SDH), and identifies demographic factors affecting morbidity and death in patients with traumatic SDH undergoing surgical d ... Full text Link to item Cite

Trends in the use of bone morphogenetic protein as a substitute to autologous iliac crest bone grafting for spinal fusion procedures in the United States.

Journal Article Spine (Phila Pa 1976) · February 15, 2011 STUDY DESIGN: Analysis of Nationwide Inpatient Sample (NIS) database for data related to spinal fusion procedures. OBJECTIVE: To identify trends in the use of bone morphogenetic protein (BMP) versus iliac crest bone grafts in various spinal fusion procedur ... Full text Link to item Cite

Comments

Journal Article Neurosurgery · December 1, 2010 Full text Cite

A socioeconomic survey of spinal cord stimulation (SCS) surgery.

Journal Article Neuromodulation · October 2010 OBJECTIVE: We evaluated trends in inpatient spinal cord stimulation (SCS) for the 14-year period from 1993 to 2006. MATERIALS AND METHODS: We utilized the Nationwide Inpatient Sample data base from the Healthcare Cost and Utilization Project, Agency for He ... Full text Link to item Cite

Socioeconomic trends in hospitalization for multiple sclerosis.

Journal Article Neuroepidemiology · August 2010 OBJECTIVES: Multiple sclerosis (MS) is a neurological disorder with a high burden on patient quality of life and medical rehabilitation services. Little is known about the acute hospitalization costs and characteristics. We examined the trends in MS hospit ... Full text Link to item Cite

Socioeconomic Trends in Deep Brain Stimulation (DBS) Surgery.

Journal Article Neuromodulation · July 2010 OBJECTIVE:   We evaluated trends in deep brain stimulation (DBS) for the 14-year period from 1993 to 2006. MATERIALS AND METHODS:   We utilized the Nationwide Inpatient Sample data base from the Healthcare Cost and Utilization Project, Agency for Healthcar ... Full text Link to item Cite

Craniotomy for resection of meningioma in the elderly: a multicentre, prospective analysis from the National Surgical Quality Improvement Program.

Journal Article J Neurol Neurosurg Psychiatry · May 2010 OBJECT: Whether there is an increased surgical risk in elderly patients who undergo craniotomy for meningioma resection remains a point of controversy. Utilising multicentre, prospective data from the National Surgical Quality Improvement Program, the pres ... Full text Link to item Cite

Trends in median, ulnar, radial, and brachioplexus nerve injuries in the United States.

Journal Article Neurosurgery · May 2010 UNLABELLED: significant constraints on an individual's quality of life. OBJECTIVE: To promote efforts to reduce exposure to injury risk factors and to utilize effective therapies when damage does occur, it is important to understand historical trends in bo ... Full text Link to item Cite

Orbital recurrence of B-progenitor acute lymphoblastic leukemia in a child.

Journal Article J Pediatr Ophthalmol Strabismus · 2010 Orbital mass is an exceedingly rare presentation of acute lymphoblastic leukemia. This report describes a 12-year-old boy with recurrent orbital pre-B-cell acute lymphoblastic leukemia and reviews the literature on the incidence, presentation, prognosis, a ... Full text Link to item Cite

Deep Brain Stimulation (DBS) Surgery: National Trends

Conference JOURNAL OF NEUROSURGERY · August 1, 2009 Link to item Cite

Risk factors for postoperative spinal wound infections after spinal decompression and fusion surgeries.

Journal Article Spine (Phila Pa 1976) · August 1, 2009 STUDY DESIGN: This is a multivariate analysis of a prospectively collected database. OBJECTIVE: To determine preoperative, intraoperative, and patient characteristics that contribute to an increased risk of postoperative wound infection in patients undergo ... Full text Link to item Cite

National trends in vertebral augmentation procedures for the treatment of vertebral compression fractures.

Journal Article Surg Neurol · May 2009 BACKGROUND: Vertebral compression fractures represent a serious health care problem. Vertebroplasty and kyphoplasty have been gaining popularity in the treatment of symptomatic compression fractures that are often secondary to osteoporosis or neoplasia. ME ... Full text Link to item Cite

National trends in spinal arteriovenous malformations.

Journal Article Neurosurg Focus · January 2009 OBJECT: Spinal arteriovenous malformations (AVMs) are rare and understudied vascular lesions that cause neurological insult by mass effect, venous obstruction, and vascular steal. These lesions are challenging entities to treat because of their complicated ... Full text Link to item Cite

National trends in spinal fusion for cervical spondylotic myelopathy.

Journal Article Surg Neurol · January 2009 BACKGROUND: The objective of this study is to provide a retrospective analysis using an NIS database to examine national trends in outcomes for CSM from 1993 to 2002. METHODS: Data for CSM admissions (n = 138792) were extracted from the 1993 to 2002 NIS da ... Full text Link to item Cite

Cervical corpectomy: complications and outcomes.

Journal Article Neurosurgery · October 2008 OBJECTIVE: Previously, information on cervical corpectomy complication rates has been obtained from retrospective analysis of single-institution data. The aim of this study was to report 30-day mortality and complication rates after cervical corpectomy usi ... Full text Link to item Cite

Visual loss after spine surgery: a population-based study.

Journal Article Spine (Phila Pa 1976) · June 1, 2008 STUDY DESIGN: Retrospective cohort study using National inpatient sample administrative data. OBJECTIVE: To determine national estimates of visual impairment and ischemic optic neuropathy after spine surgery. SUMMARY OF BACKGROUND DATA: Loss of vision afte ... Full text Link to item Cite

Effects of age and comorbidities on complication rates and adverse outcomes after lumbar laminectomy in elderly patients.

Journal Article Spine (Phila Pa 1976) · May 15, 2008 STUDY DESIGN: This is a retrospective cohort study using the National Inpatient Sample database. OBJECTIVE: The objective is to report mortality and complications after lumbar laminectomy in the elderly. SUMMARY OF BACKGROUND DATA: As the population contin ... Full text Link to item Cite

Complications and outcomes after spinal cord tumor resection in the United States from 1993 to 2002.

Journal Article Spinal Cord · May 2008 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: Data on patient outcomes after surgery for spinal cord tumors have been derived from single-institution series. The objective of this study is to report inpatient complications, mortality and outcomes on ... Full text Link to item Cite

Visual loss after spine surgery: A population based study

Conference JOURNAL OF NEUROSURGERY · April 1, 2008 Full text Link to item Cite

Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling.

Journal Article Mol Immunol · April 2008 The mitochondrial anti-viral signaling protein (MAVS), also known as CARDIF, IPS-1, KIAA1271 and VISA, is a mitochondria associated protein that regulates type I interferon production through coordinated activation of NF-kappaB and IRF3. The N-terminal CAR ... Full text Link to item Cite

Laminectomy and fusion after spinal cord injury: national inpatient complications and outcomes.

Journal Article J Neurotrauma · March 2008 There is little information about national in-hospital complication rates, adverse outcomes, and mortality after spinal fusion for spinal cord injury (SCI). The National Inpatient Sample (NIS) was utilized to identify 31,381 admissions of acute spinal cord ... Full text Link to item Cite

Cervical spondylotic myelopathy: complications and outcomes after spinal fusion.

Journal Article Neurosurgery · February 2008 OBJECTIVE: There is little information about in-hospital complication rates, adverse outcomes, and mortality after spinal fusion for cervical spondylotic myelopathy (CSM). The aim of this study was to report inpatient mortality, complications, and outcomes ... Full text Link to item Cite

Late recurrences of Cushing's disease after initial successful transsphenoidal surgery.

Journal Article J Clin Endocrinol Metab · February 2008 CONTEXT: Few studies have systematically analyzed the long-term recurrence rates of Cushing's disease after initial successful transsphenoidal surgery. SETTING: This was a retrospective review of patients treated at the University of Virginia Medical Cente ... Full text Link to item Cite

Intracranial hypotension from intrathecal baclofen pump insertion. A case report and review of the literature.

Journal Article Stereotact Funct Neurosurg · 2008 Intracranial hypotension is a syndrome of low cerebrospinal fluid pressure with a variable clinical presentation ranging from postural headaches to coma. A number of neuroradiologic techniques are now available to aid in the diagnosis of this syndrome (CT, ... Full text Link to item Cite

Inpatient complications, mortality, and discharge disposition after surgical correction of idiopathic scoliosis: a national perspective.

Journal Article Spine J · 2008 BACKGROUND CONTEXT: Information about complications and mortality after surgery for correction of idiopathic scoliosis has been largely derived from single-institution series. Regional or national studies have been lacking. PURPOSE: To report inpatient mor ... Full text Link to item Cite

Trends in pathological vertebral fractures in the United States: 1993 to 2004.

Journal Article J Neurosurg Spine · September 2007 OBJECT: Pathological vertebral fractures (PVFs) are an increasingly important cause of disability and have many clinical and economic implications. The authors examined trends in epidemiology and surgical management of pathological vertebral fractures in t ... Full text Link to item Cite

National inpatient complications and outcomes after surgery for spinal metastasis from 1993-2002.

Journal Article Cancer · August 1, 2007 BACKGROUND: Information regarding patient outcomes, complications, and mortality after surgery for spinal metastasis has previously been derived from single-institution series. The aim of this study was to report inpatient mortality, complications, and out ... Full text Link to item Cite

Cyberknife targeting the pterygopalatine ganglion for the treatment of chronic cluster headaches.

Journal Article Neurosurgery · March 2007 OBJECTIVE: Cluster headache (CH) is a severe unilateral and periorbital facial pain syndrome that is often associated with autonomic symptoms, including ipsilateral lacrimation, nasal congestion, conjunctival injection, miosis, ptosis, and eyelid edema. We ... Full text Link to item Cite

Efficacy and safety of CyberKnife radiosurgery for acromegaly.

Journal Article Pituitary · 2007 OBJECTIVE: Acromegaly is a disease characterized by GH hypersecretion, and is typically caused by a pituitary somatotroph adenoma. The primary mode of therapy is surgery, and radiotherapy is utilized as an adjuvant strategy to treat persistent disease. The ... Full text Link to item Cite

Brain atrophy and cognitive deficits in Cushing's disease.

Journal Article Neurosurg Focus · 2007 Cushing's disease is associated with brain atrophy and cognitive deficits. Excess glucocorticoids cause retraction and simplification of dendrites in the hippocampus, and this morphological change probably accounts for the hippocampal volume loss. Mechanis ... Full text Link to item Cite

CyberKnife rhizotomy for facetogenic back pain: a pilot study.

Journal Article Neurosurg Focus · 2007 OBJECT: By targeting the medial branches of the dorsal rami, radiofrequency ablation and facet joint injections can provide temporary amelioration of facet joint-producing (or facetogenic) back pain. The authors used CyberKnife radiosurgery to denervate af ... Full text Link to item Cite

National trends, complications, and outcomes following transsphenoidal surgery for Cushing's disease from 1993 to 2002.

Journal Article Neurosurg Focus · 2007 OBJECT: Information about complications, patient outcomes, and mortality rate after transsphenoidal surgery (TSS) for Cushing's disease has been derived largely from single-institution series. In this study the authors report on inpatient death, morbidity, ... Full text Link to item Cite

Hippocrates' influence on the origins of neurosurgery.

Journal Article Neurosurg Focus · 2007 Hippocrates is widely considered the father of medicine. His contributions revolutionized the practice of medicine and laid the foundation for modern-day neurosurgery. He inspired several generations to follow his vision, by pioneering the rigorous clinica ... Full text Link to item Cite

The role of inferior petrosal sinus sampling in the diagnostic localization of Cushing's disease.

Journal Article Neurosurg Focus · 2007 Cushing's syndrome can present a complex problem of differential diagnosis. Of cases in which hypercortisolemia results from an adrenocorticotropic hormone (ACTH)-dependent process, approximately 80% are due to a pituitary adenoma (Cushing's disease [CD]), ... Full text Link to item Cite

Tethered cord syndrome: nationwide inpatient complications and outcomes.

Journal Article Neurosurgical focus · January 1, 2007 OBJECT: Previous investigations of health outcome after spinal surgery for tethered cord syndrome (TCS) have been single-institution studies. The aim of this study was to report inpatient complications and outcomes on a nationwide level. METHODS: The Natio ... Full text Cite

Motor cortex stimulation and neuropathic facial pain.

Journal Article Neurosurg Focus · December 15, 2006 Trigeminal neuropathic pain is a syndrome of severe, constant facial pain related to disease of or injury to the trigeminal nerve or ganglion. Causes of this type of pain can include injury from sinus or dental surgery, skull and/or facial trauma, or inten ... Full text Link to item Cite

Cerebral perfusion imaging in vasospasm.

Journal Article Neurosurg Focus · September 15, 2006 Vasospasm following cerebral aneurysm rupture is one of the most devastating sequelae and the most common cause of delayed ischemic neurological deficit (DIND). Because vasospasm also is the most common cause of morbidity and mortality in patients who surv ... Full text Link to item Cite

Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment.

Journal Article J Neuropathol Exp Neurol · June 2006 Alterations in synaptic protein stoichiometry may contribute to neocortical synaptic dysfunction in Alzheimer disease (AD). Whether perturbations in synaptic protein expression occur during the earliest stages of cognitive decline remain unclear. We examin ... Full text Link to item Cite

Carotid and vertebral rete mirabile in man presenting with intraparenchymal hemorrhage: a case report.

Journal Article J Stroke Cerebrovasc Dis · 2006 Carotid and vertebral rete mirabile is an unusual segmental regression of both the cavernous carotid artery and transdural vertebral arteries with a network of collateral vessels seen rarely in human beings. We present a 57-year-old woman with carotid and ... Full text Link to item Cite

Munchausen's syndrome in neurosurgery: report of two cases and review of the literature.

Journal Article Neurosurgery · December 2004 OBJECTIVE AND IMPORTANCE: Munchausen's syndrome is a rare psychiatric condition, in which patients seek medical treatment for factitious or self-induced medical problems. Reports in the literature of postoperative Munchausen's syndrome are extremely rare. ... Link to item Cite

Munchausen's syndrome in neurosurgery: Report of two cases

Journal Article Neurosurgery · December 1, 2004 OBJECTIVE and IMPORTANCE: Munchausen's syndrome is a rare psychiatric condition, in which patients seek medical treatment for factitious or self-induced medical problems. Reports in the literature of postoperative Munchausen's syndrome are extremely rare. ... Full text Cite

Nerve growth factor: structure, function and therapeutic implications for Alzheimer's disease.

Journal Article Curr Drug Targets CNS Neurol Disord · October 2003 Over the past decade, neurotrophic factors have generated much excitement for their potential as therapy for neurological disorders. In this regard, nerve growth factor (NGF), the founding member of the neurotrophin family, has generated great interest as ... Full text Link to item Cite

Activation of the mitogen-activated protein kinase pathway through p75NTR: a common mechanism for the neurotrophin family.

Journal Article J Neurosci Res · September 1, 2003 Neurotrophins interact with two distinct classes of cell-surface receptors, the Trk receptor tyrosine kinase family and the common neurotrophin receptor p75(NTR). For many years, the biological role of p75(NTR) remained obscure, being relegated to modulati ... Full text Link to item Cite

Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site.

Journal Article J Biol Chem · July 4, 2003 A long-standing question in neurotrophin signal transduction is whether heteromeric TrkA-p75NTR complexes possess signaling capabilities that are significantly different from homo-oligomeric TrkA or p75NTR alone. To address this issue, various combinations ... Full text Link to item Cite

Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor.

Journal Article J Neurosci Res · January 1, 2001 The common neurotrophin receptor p75(NTR) (low affinity nerve growth factor receptor) participates in the high-affinity binding with the TrkA nerve growth factor (NGF) receptor, may mediate apoptosis, and may signal independently in a cell-specific manner. ... Full text Link to item Cite

Emerging roles for telomerase in neuronal development and apoptosis.

Journal Article J Neurosci Res · January 1, 2001 Telomerase is an enzyme consisting of a reverse transcriptase called TERT and an RNA component that adds repeats of a DNA sequence (TTAGGG) to the ends of chromosomes, thereby preventing their shortening and cell cycle arrest. Telomerase levels are high in ... Full text Link to item Cite