Scholars@Duke
Harry Rissler Phillips III

Harry Rissler Phillips III

Professor Emeritus of Medicine
Medicine, Cardiology
phill014@mc.duke.edu
Duke Box 3126, Durham, NC 27710
8662A HAFS Building, Durham, NC 27710

Selected Publications

Relationship Between HCAHPS Scores and Survey Response Rate Is Linked to Hospital Size.

Journal Article J Patient Exp · December 2020 Patient experience is an important dimension of health care quality and is assessed using the standard Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey for inpatients. The HCAHPS scores may vary based on survey response rate ... Full text Link to item Cite

Analysis of geographic variations in the diagnosis and treatment of patients with aortic stenosis in North Carolina.

Journal Article Am J Cardiol · June 1, 2014 Despite advances in the treatment of aortic stenosis (AS), many patients with AS remain untreated. Barriers to accessing cardiovascular surgical care may play a role in this undertreatment. We sought to examine whether there are geographic variations in th ... Full text Link to item Cite

Detailed analysis of polymer response to delivery balloon expansion of drug-eluting stents versus bare metal stents.

Journal Article EuroIntervention · July 2013 AIMS: We sought to describe the response of the polymer surface of drug-eluting stents (DES) to delivery balloon expansion, including quantitation of any resulting detached microparticles. METHODS AND RESULTS: We expanded the US Food and Drug Administratio ... Full text Link to item Cite

Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia.

Journal Article Am J Physiol Heart Circ Physiol · December 15, 2012 Myocardial ischemia (MI) activates innate cardioprotective mechanisms, enhancing cardiomyocyte tolerance to ischemia. Here, we report a MI-activated liver-dependent mechanism for myocardial protection. In response to MI in the mouse, hepatocytes exhibited ... Full text Link to item Cite

Ischemia change in stable coronary artery disease is an independent predictor of death and myocardial infarction.

Journal Article JACC Cardiovasc Imaging · July 2012 OBJECTIVES: The aim of this study was to evaluate the independent prognostic significance of ischemia change in stable coronary artery disease (CAD). BACKGROUND: Recent randomized trials in stable CAD have suggested that revascularization does not improve ... Full text Link to item Cite

Comparison of Clinical characteristics and long-term outcomes of patients with ischemic cardiomyopathy with versus without angina pectoris (from the Duke Databank for Cardiovascular Disease).

Journal Article Am J Cardiol · May 1, 2012 Myocardial ischemic origin is a significant independent predictor of mortality in patients with heart failure (HF). The implications of angina pectoris (AP) in HF are less well characterized. The aim of this study was to compare the clinical characteristic ... Full text Link to item Cite

Long-term survival of patients with ischemic cardiomyopathy treated by coronary artery bypass grafting versus medical therapy.

Journal Article Ann Thorac Surg · February 2012 BACKGROUND: We prospectively applied the Surgical Treatment of Ischemic Cardiomyopathy trial entry criteria to an observational database to determine whether coronary artery bypass grafting (CABG) decreases mortality compared with medical therapy (MED) for ... Full text Link to item Cite

Trends in the use of diagnostic coronary angiography, percutaneous coronary intervention, and coronary artery bypass graft surgery across North Carolina.

Journal Article Am Heart J · November 2011 BACKGROUND: Although variation in use of invasive coronary procedures has been shown, the relationship between invasive diagnostic cardiac catheterization (Cath) and subsequent revascularization with percutaneous coronary intervention (PCI) or coronary art ... Full text Link to item Cite

Preliminary observations using optical coherence tomography to assess neointimal coverage of a metal stent in a porcine model.

Journal Article Cardiovasc Revasc Med · 2009 BACKGROUND: Concerns surrounding late stent thrombosis have prompted the development of novel imaging techniques to assess neointimal coverage. Recent clinical studies have evaluated optical coherence tomography (OCT) to evaluate neointimal coverage, but p ... Full text Link to item Cite

Vulnerable plaque intervention: State of the art.

Journal Article Catheter Cardiovasc Interv · February 15, 2008 Progressive atherosclerotic disease is responsible for many of the late adverse clinical events that detract from the high procedural and clinical success of percutaneous coronary intervention. Despite recent advances in catheter based technology for the t ... Full text Link to item Cite

Revascularization for heart failure.

Journal Article Am Heart J · April 2007 Coronary artery disease is the most common underlying cause of heart failure, yet there is little consensus on the role of revascularization in the management of patients with ischemic cardiomyopathy. The concept of recovery of dysfunctional but viable myo ... Full text Link to item Cite

Mycophenolate mofetil and cardiovascular disease

Journal Article Lupus · November 1, 2006 Lupus is proving a fertile ground for research into mechanisms of accelerated atheroma. Often referred to as 'the new diabetes', lupus has a relative risk of myocardial infarction way in excess of, for example, other inflammatory diseases such as rheumatoi ... Full text Cite

Clinical implications of vulnerable plaque.

Journal Article Future Cardiol · November 2006 In many individuals, the first indicator of atherosclerosis is an acute heart attack, which is often fatal. Despite innovations in medical therapy and interventional cardiology techniques, coronary artery disease continues to be the leading cause of death ... Full text Link to item Cite

Late thrombosis following treatment of in-stent restenosis with drug-eluting stents after discontinuation of antiplatelet therapy.

Journal Article Catheter Cardiovasc Interv · August 2005 Drug-eluting stent usage has become commonplace for the percutaneous treatment of de novo coronary lesions, but the safety and efficacy profile for their evolving usage in restenotic lesions is largely unknown. We report three cases of angiographically con ... Full text Link to item Cite

Outcomes following elective percutaneous coronary intervention without on-site surgical backup in a community hospital.

Journal Article Am J Cardiol · May 1, 2005 Despite guidelines to the contrary, limited numbers of elective percutaneous coronary intervention (PCI) procedures without on-site surgical backup are being performed, particularly in Europe and Canada. In the United States, many hospitals are considering ... Full text Link to item Cite

The complementary use of glycoprotein IIb/IIIa inhibitors and drug-eluting stents in contemporary percutaneous coronary intervention.

Journal Article J Invasive Cardiol · December 2002 The percutaneous treatment of symptomatic, obstructive coronary artery disease continues to undergo evolutionary changes that have led to an increase in the number of procedures performed each year. Studies on the adjunctive use of thienopyridines and glyc ... Link to item Cite

Inflammation, platelets, and glycoprotein IIb/IIIa inhibitors.

Journal Article J Invasive Cardiol · December 2002 Atherosclerosis, with its thromboembolic complications (including sudden cardiac death, myocardial infarction, and other ischemic organ damage such as stroke and ischemic renovascular disease), represents by far the major cause of death, morbidity, and dis ... Link to item Cite

Relationship between activated clotting time during percutaneous intervention and subsequent bleeding complications.

Journal Article Am Heart J · September 2002 BACKGROUND: Approximately 50% of percutaneous coronary interventions in the United States are performed with unfractionated heparin and no IIb/IIIa agent. The operator must weigh the risks and benefits of more intensive anticoagulation during these percuta ... Full text Link to item Cite

Primary renal artery stenting: characteristics and outcomes after 363 procedures.

Journal Article Am Heart J · August 2001 BACKGROUND: Stenting improves the acute results of percutaneous balloon angioplasty for atherosclerotic renal artery stenosis. Predictors of benefit and angiographic restenosis are not well understood. We describe the technical and clinical success of rena ... Full text Link to item Cite

Comparison of medicine alone, coronary angioplasty, and left internal mammary artery-coronary artery bypass for one-vessel proximal left anterior descending coronary artery disease.

Journal Article Am J Cardiol · December 15, 2000 Despite the deleterious and sometimes catastrophic consequences of proximal left anterior descending (LAD) artery occlusion, there is a paucity of data to guide the treatment of patients with such disease. Our aim was to describe outcomes with medical ther ... Full text Link to item Cite

Local delivery of heparin post-PTCA: a multicenter randomized pilot study.

Journal Article Catheter Cardiovasc Interv · April 2000 Bailout stenting for major dissection and threatened closure has high rates of ischemic complications. We performed a randomized trial of local heparin delivery using the infusion sleeve before bailout stenting for suboptimal angioplasty results. In phase ... Full text Link to item Cite

A comparison of ionic versus nonionic contrast medium during primary percutaneous transluminal coronary angioplasty for acute myocardial infarction (GUSTO IIb). Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes.

Journal Article Am J Cardiol · March 15, 2000 The clinical impact of contrast medium selection during primary percutaneous transluminal coronary angioplasty for acute myocardial infarction (AMI) has not been studied. We compared the clinical outcomes of patients who received ionic versus nonionic low ... Full text Link to item Cite

Efficacy of abciximab readministration in coronary intervention.

Journal Article Am J Cardiol · February 15, 2000 Abciximab, an Fab monoclonal antibody fragment that blocks the platelet glycoprotein IIb/IIIa receptor, is increasingly used as an adjunct to coronary intervention. Little is known, however, about the efficacy and safety of readministration of abciximab. T ... Full text Link to item Cite

Treatment of Palmaz-Schatz in-stent restenosis: 6-Month clinical follow-up

Journal Article Journal of Interventional Cardiology · January 1, 2000 To identify predictors of Palmaz-Schatz in-stent restenosis and determine outcomes of treatment, we assessed 6-month outcomes in 402 patients who had coronary intervention with stent placement; 60 (15%) developed angiographic and clinical evidence of reste ... Full text Cite

Local drug delivery of argatroban from a polymeric-metallic composite stent reduces platelet deposition in a swine coronary model.

Journal Article Catheter Cardiovasc Interv · April 1999 Thrombus formation after intracoronary stent implantation provides a stimulus for neointimal hyperplasia and if excessive can result in stent thrombosis. We tested the hypothesis that local delivery of an antithrombin drug from a polymeric-metallic stent i ... Full text Link to item Cite

Acute hemodynamic changes during carotid artery stenting.

Journal Article Am J Cardiol · November 1, 1998 To determine the clinical significance of acute hemodynamic disturbances during stenting in the carotid sinus region, we assessed the relation between intraprocedural changes in heart rate (HR) and blood pressure (BP) and adverse neurologic and cardiac out ... Full text Link to item Cite

Progression of renal artery stenosis in patients undergoing cardiac catheterization.

Journal Article Am Heart J · November 1998 BACKGROUND: Renal artery stenosis is potentially correctable by either revascularization surgery or percutaneous methods. However, appropriate use of these techniques has been hampered by a lack of data on the natural history of this disease. This study as ... Full text Link to item Cite

Prognostic value of congestive heart failure history in patients undergoing percutaneous coronary interventions.

Journal Article J Am Coll Cardiol · October 1998 OBJECTIVES: We sought to determine the prognostic significance of a history of congestive heart failure above that provided by baseline ejection fraction in patients undergoing percutaneous coronary interventions. BACKGROUND: Left ventricular function is a ... Full text Link to item Cite

Kissing stents in the aortic bifurcation.

Journal Article Am Heart J · October 1998 BACKGROUND: We report the first series of simultaneously delivered stents used to treat stenosis of the aortic bifurcation. Surgical treatment of aortoiliac occlusive disease carries up to a 3% mortality rate. Percutaneous balloon techniques to treat aorti ... Full text Link to item Cite

Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries.

Journal Article Am J Cardiol · September 1, 1998 We compared the effect on platelet deposition of the glycoprotein IIb/IIIa receptor antagonist L-703,081, administered locally via a drug delivery stent, with that of a standard metal stent in a canine coronary model. There was a significant reduction in p ... Full text Link to item Cite

Diagnosing coronary arterial stent thrombosis and arterial closure.

Journal Article Am J Cardiol · September 1, 1998 This single-center review of a consecutive series of patients requiring reexamination by angiography within 1 week of a coronary stent placement due to chest pain reveals that patients treated with a poststent anticoagulation regimen of warfarin and aspiri ... Full text Link to item Cite

Internal mammary artery graft angioplasty: acute and long-term outcome.

Journal Article Cathet Cardiovasc Diagn · June 1998 Secondary to the low attrition rate of internal mammary artery grafts, limited data are available on the clinical and angiographic outcome of patients who have undergone balloon angioplasty of an internal mammary artery stenosis. This study examined a cons ... Full text Link to item Cite

A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction.

Journal Article N Engl J Med · June 5, 1997 BACKGROUND: Among physicians who treat patients with acute myocardial infarction, there is controversy about the magnitude of the clinical benefit of primary (i.e., immediate) coronary angioplasty as compared with thrombolytic therapy. METHODS: As part of ... Full text Link to item Cite

The natural history of single-vessel chronic coronary occlusion: a 25-year experience.

Journal Article Am Heart J · April 1997 To determine the natural history of patients with a total occlusion of a single coronary artery, we searched the Duke Databank for Cardiovascular Disease to find all patients who underwent a first coronary angiogram >2 days after a symptomatic myocardial i ... Full text Link to item Cite

Economic implications of the prophylactic use of intraaortic balloon counterpulsation in the setting of acute myocardial infarction. The Randomized IABP Study Group. Intraaortic Balloon Pump.

Journal Article Am J Cardiol · March 1, 1997 Intraaortic balloon counterpulsation (IABP) has been shown to improve coronary artery patency and reduce the rates of recurrent myocardial ischemia and its sequelae in selected patients when used within 24 hours of acute myocardial infarction. The economic ... Full text Link to item Cite

Antiplatelet versus warfarin therapy: Platelet, neutrophil, and thrombus deposition for intracoronary stents in a porcine model

Journal Article Journal of Interventional Cardiology · January 1, 1997 Antiplatelet therapy may offer an advantage over warfarin in reducing adverse clinical events after intracoronary stent implantation. The mechanism of this effect has not been elucidated but platelet adhesion may play a predominant role in the process of s ... Full text Cite

A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes.

Journal Article N Engl J Med · September 12, 1996 BACKGROUND: Thrombin has a pivotal role in the pathogenesis of acute coronary thrombosis. We compared the clinical efficacy of a potent, direct thrombin inhibitor, recombinant hirudin, with that of heparin (an indirect antithrombin agent) in patients with ... Full text Link to item Cite

Long-term survival benefits of coronary artery bypass grafting and percutaneous transluminal angioplasty in patients with coronary artery disease.

Journal Article J Thorac Cardiovasc Surg · May 1996 The purpose of this study was to evaluate long-term survival benefits of bypass surgery and angioplasty versus medical therapy in 9263 patients at Duke University Medical Center between 1984 and 1990 with coronary artery disease confirmed by cardiac cathet ... Full text Link to item Cite

A polymer-metal composite stent.

Journal Article Semin Interv Cardiol · March 1996 Link to item Cite

Relation between activated clotting time during angioplasty and abrupt closure.

Journal Article Circulation · February 15, 1996 BACKGROUND: The purpose of this study was to determine whether the degree of heparin anticoagulation during coronary angioplasty, as measured by the activated clotting time, is related to the risk of abrupt vessel closure. METHODS AND RESULTS: Sixty-two ca ... Full text Link to item Cite

Percutaneous revascularization of chronic coronary occlusions: an overview.

Journal Article J Am Coll Cardiol · July 1995 Patients with a chronic coronary occlusion often undergo coronary angiography after weeks to months of occlusion. The published reports underestimate the extent of this problem because such patients are often arbitrarily assigned to receive medical therapy ... Full text Link to item Cite

Intravascular ultrasound in the management of acute coronary artery dissection: a case report.

Journal Article Cathet Cardiovasc Diagn · March 1995 Crossing total occlusions is frequently difficult. The guidewire may enter a false lumen, thereby preventing successful balloon dilatations. We present a case of an acute arterial dissection following attempted angioplasty of a totally occluded right coron ... Full text Link to item Cite

Effect of cigarette smoking on outcome after thrombolytic therapy for myocardial infarction.

Journal Article Circulation · January 15, 1995 BACKGROUND: Smoking is known to be a strong risk factor for premature atherosclerosis, myocardial infarction, and sudden cardiac death. Unexpectedly, in the reperfusion era, investigators have reported that patients who smoke have a more favorable prognosi ... Full text Link to item Cite

Use of the perfusion balloon as a primary dilation device.

Journal Article J Invasive Cardiol · 1995 The development of more user-friendly and versatile perfusion balloon catheters has increased the use of prolonged dilations as a primary catheter treatment for coronary artery disease. In a multicenter randomized trial, the use of these devices to prolong ... Link to item Cite

Development of a new technique for reducing pressure pulse generation during 308-nm excimer laser coronary angioplasty.

Journal Article Cathet Cardiovasc Diagn · January 1995 Despite expectations that excimer laser ablation would result in a low incidence of coronary dissection, studies have documented a 15-20% incidence of dissection (including a 4-6% incidence of clinically significant dissection) during excimer interventions ... Full text Link to item Cite

Current status of biodegradable stents.

Journal Article Cardiol Clin · November 1994 Coronary angioplasty remains limited by abrupt closure and restenosis. Metallic stents are useful for suboptimal PTCA results or threatened closure and can reduce restenosis in de novo lesions. However, they are permanent devices that are used to treat a s ... Link to item Cite

Transluminal extraction coronary atherectomy.

Journal Article Cardiol Clin · November 1994 The TEC is a forward-cutting atherectomy catheter that has the unique potential to excise and aspirate atheroma, especially intraluminal thrombus. This device has been under clinical investigation for more than 6 years and received final marketing approval ... Link to item Cite

The impact of autoperfusion on quantitative electrocardiographic parameters of ischemia severity, extent, and "burden" during salvage of elective coronary angioplasty.

Journal Article J Invasive Cardiol · September 1994 Long angioplasty inflations have been reported using an autoperfusion system that delivers oxygenated blood distal to the balloon segment. The safety and efficacy of this system has been demonstrated in anatomically selected patients. The clinical use, how ... Link to item Cite

The role of angioplasty after successful thrombolysis for acute myocardial infarction.

Journal Article Coron Artery Dis · May 1994 Soon after the efficacy of thrombolytic agents in recanalizing totally occluded arteries in the setting of AMI was shown, angiographic studies revealed a residual high-grade stenosis in a majority of these patients. To improve clinical outcome further, the ... Full text Link to item Cite

Continuing evolution of therapy for coronary artery disease. Initial results from the era of coronary angioplasty.

Journal Article Circulation · May 1994 BACKGROUND: Survival after coronary artery bypass graft surgery (CABG) and medical therapy in patients with coronary artery disease (CAD) has been studied in both randomized trials and observational treatment comparisons. Over the past decade, the use of c ... Full text Link to item Cite

Treatment of long coronary artery narrowings with long angioplasty balloon catheters.

Journal Article Am J Cardiol · June 1, 1993 Balloon angioplasty of long coronary artery narrowings has been associated with a lower rate of acute success, and a higher rate of acute complications and restenosis than that observed for short narrowings. Angioplasty catheters with longer length balloon ... Full text Link to item Cite

In vivo validation of compensatory enlargement of atherosclerotic coronary arteries.

Journal Article Am J Cardiol · March 15, 1993 Necropsy examinations and epicardial ultrasound studies have suggested that atherosclerotic coronary arteries undergo compensatory enlargement. This increase in vessel size may be an important mechanism for maintaining myocardial blood flow. It also is of ... Full text Link to item Cite

Unrecognized left main coronary artery disease in patients undergoing interventional procedures.

Journal Article Am J Cardiol · January 15, 1993 Selective, coronary arteriographic, catheter-based, intravascular ultrasound images were obtained to determine the presence and extent of angiographically undetected or underestimated left main (LM) coronary arterial narrowing in patients receiving coronar ... Full text Link to item Cite

Thermal-perfusion balloon coronary angioplasty: in vivo evaluation.

Journal Article Am Heart J · January 1993 The goal of this study was to develop and test a new radio frequency thermal balloon system to allow longer balloon inflations at lower temperature levels than have been used with standard (laser) thermal balloon angioplasty. Radio frequency thermal capabi ... Full text Link to item Cite

Prognosis in cardiogenic shock after acute myocardial infarction in the interventional era.

Journal Article J Am Coll Cardiol · December 1992 OBJECTIVES: The purpose of this study is to describe the outcome in cardiogenic shock treated with aggressive reperfusion therapy and to identify factors predictive of in-hospital and long-term mortality. BACKGROUND: Cardiogenic shock is the most common ca ... Full text Link to item Cite

Intracoronary ultrasound predictors of adverse outcomes after coronary artery interventions.

Journal Article J Am Coll Cardiol · November 15, 1992 OBJECTIVES: The purpose of this study was to determine the association between qualitative and quantitative lesion characteristics as assessed by intracoronary ultrasound imaging and adverse outcomes after coronary artery interventions. BACKGROUND: Resteno ... Full text Link to item Cite

Early and late outcome following deployment of a new flexible tantalum intracoronary stent in dogs.

Journal Article Am Heart J · October 1992 A new radiopaque, highly flexible balloon-expandable tantalum stent was tested. Thirty-six of 40 stents were successfully deployed percutaneously in the coronary arteries of 31 dogs. The dogs were given aspirin before, intravenous heparin during, and aspir ... Full text Link to item Cite

Coronary angioplasty performed with gradual and prolonged inflation using a perfusion balloon catheter: procedural success and restenosis rate.

Journal Article Am Heart J · September 1992 The results of routine coronary angioplasty using gradual and prolonged balloon inflation with a perfusion balloon catheter were evaluated. One hundred forty patients were treated with inflation of the balloon to 6 atm over 3 minutes, with a median inflati ... Full text Link to item Cite

Prospective analysis of possible myocardial damage or hemolysis occurring as a result of prolonged autoperfusion angioplasty in humans.

Journal Article J Am Coll Cardiol · September 1992 OBJECTIVES: The purpose of this study was to further explore the procedural safety of prolonged (15-min) dilation using an autoperfusion coronary angioplasty balloon by assessing the degree of myocardial damage or hemolysis, if any, occurring as a result o ... Full text Link to item Cite

Outcome after prolonged balloon inflations of greater than 20 minutes for initially unsuccessful percutaneous transluminal coronary angioplasty.

Journal Article Am J Cardiol · June 1, 1992 Prolonged balloon inflation with or without autoperfusion techniques is a common initial approach to major dissection or abrupt occlusion after percutaneous transluminal coronary angioplasty (PTCA). To assess such a strategy in the setting of unsuccessful ... Full text Link to item Cite

Renal artery stenosis: prevalence and associated risk factors in patients undergoing routine cardiac catheterization.

Journal Article J Am Soc Nephrol · May 1992 The purposes of this study were to determine the prevalence of angiographically significant renal artery stenosis in a patient population referred for diagnostic cardiac catheterization and to develop a model that predicts the highest-risk subset of patien ... Full text Link to item Cite

“Over The Shoulder” Guidewire Manipulation Through An Angulated Stenosis Adjacent To A Coronary Aneurysm During High Risk Percutaneous Transluminal Angioplasty

Journal Article Journal of Interventional Cardiology · January 1, 1992 Angioplasty in the setting of poor left ventricular function may involve coronary anatomy with special challenges to the technique of the operator and the safety of the patient. Spontaneous coronary aneurysms involve a disruption of the tissue of the vesse ... Full text Cite

A computerized method for the application of coronary artery disease risk classification models to a large patient population

Conference Proceedings Computers in Cardiology Cic 1992 · January 1, 1992 We have developed a flexible and powerful coronary anatomy classification system which can be applied to the development and evaluation of qualitative and quantitative methods for assessing myocardium in jeopardy on the basis of the severity and location o ... Full text Cite

Determinants of the need for early acute intervention in patients treated conservatively after thrombolytic therapy for acute myocardial infarction. TAMI-5 Study Group.

Journal Article J Am Coll Cardiol · December 1991 This study sought to determine whether clinical variables can be used to identify patients at high risk of recurrent spontaneous myocardial ischemia or hemodynamic compromise during the 1st 4 days after intravenous thrombolysis for acute myocardial infarct ... Full text Link to item Cite

Intracoronary ultrasound evaluation of interventional technologies.

Journal Article Am J Cardiol · November 15, 1991 The feasibility and applicability of intravascular ultrasound (IVUS) of the coronary arteries were evaluated in 65 patients undergoing 70 coronary interventional procedures. Morphologic and quantitative analyses were performed with a mechanically rotated I ... Full text Link to item Cite

"Hugging balloons" through a single 8-French guide: salvage angioplasty with lytic therapy in the infarct vessel of a 40-year-old man.

Journal Article Cathet Cardiovasc Diagn · September 1991 We report the a case of hugging balloons through an 8-French guiding catheter to stabilize an ectatic right coronary artery following failed thrombolytic therapy in the setting of acute myocardial infarction. Angiographic follow-up at 1 wk and 6 mo reveale ... Full text Link to item Cite

Evaluation of combination thrombolytic therapy and timing of cardiac catheterization in acute myocardial infarction. Results of thrombolysis and angioplasty in myocardial infarction--phase 5 randomized trial. TAMI Study Group.

Journal Article Circulation · May 1991 Recent trials of myocardial reperfusion using single-agent thrombolytic therapy and sequential cardiac catheterization have supported a conservative approach to the patient with acute myocardial infarction. To evaluate combination thrombolytic therapy and ... Full text Link to item Cite

Effectiveness of high-dose urokinase for acute myocardial infarction

Journal Article Cardiology Board Review · January 1, 1991 Cite

Coronary transluminal extraction-endarterectomy.

Journal Article J Invasive Cardiol · 1991 Link to item Cite

Usefulness of a pericardial friction rub after thrombolytic therapy during acute myocardial infarction in predicting amount of myocardial damage. The TAMI Study Group.

Journal Article Am J Cardiol · December 15, 1990 To evaluate the clinical incidence and outcomes of patients with pericarditis after thrombolytic therapy, 810 patients were prospectively studied during acute myocardial infarction (AMI). Pericarditis was defined as the presence of a pericardial friction r ... Full text Link to item Cite

A rapid, effective technique for retrograde crossing of valvular aortic stenosis using standard coronary catheters.

Journal Article Cathet Cardiovasc Diagn · September 1990 Retrograde crossing of valvular aortic stenosis can be challenging even to experienced angiographers. In 446 of 447 consecutive patients with aortic stenosis catheterized during the past 3 years, a technique using a standard Judkins right coronary catheter ... Full text Link to item Cite

Serial evaluation of right ventricular dysfunction associated with acute inferior myocardial infarction.

Journal Article Am Heart J · April 1990 Right ventricular (RV) function was evaluated serially by multigated blood pool imaging in 18 patients with RV dysfunction associated with acute inferior myocardial infarction. Radionuclide ventriculograms were performed on all patients within 18 hours of ... Full text Link to item Cite

Results of high dose intravenous urokinase for acute myocardial infarction.

Journal Article Am J Cardiol · January 15, 1990 To determine the outcome of patients after treatment with high-dose intravenous urokinase (3 million U) 102 patients were prospectively evaluated in the setting of acute myocardial infarction. The first 61 patients received intravenous urokinase as a conti ... Full text Link to item Cite

Pharmacodynamics of thrombolysis with recombinant tissue-type plasminogen activator. Correlation with characteristics of and clinical outcomes in patients with acute myocardial infarction. The TAMI Study Group.

Journal Article Circulation · November 1989 Coagulation analysis was performed on blood samples from 386 patients with acute myocardial infarction drawn before, during, and after a continuous intravenous infusion of 150 mg recombinant tissue-type plasminogen activator (rt-PA) (Activase). Plasma rt-P ... Full text Link to item Cite

Repeat percutaneous transluminal coronary angioplasty and predictors of recurrent restenosis.

Journal Article Am J Cardiol · February 15, 1989 One hundred seventeen consecutive patients undergoing repeat percutaneous transluminal coronary angioplasty (PTCA) were studied to assess procedural success and recurrent restenosis rates. Clinical, anatomic and procedural variables were examined as predic ... Full text Link to item Cite

Peripheral artery atherectomy: description of technique and report of initial results.

Journal Article Radiology · December 1988 Percutaneous transluminal atherectomy has been developed for treatment of peripheral artery stenoses. The atherectomy catheter is inserted through a sheath, and the resection window of the catheter is positioned adjacent to the vascular stenosis. The ballo ... Full text Link to item Cite

Administration of thrombolytic therapy in the community hospital: established principles and unresolved issues.

Journal Article J Am Coll Cardiol · December 1988 In patients with acute myocardial infarction presenting to community hospitals, thrombolytic therapy should be initiated as rapidly as possible under the supervision of a physician. Paramedic or nurse-initiated pre-hospital therapy is currently investigati ... Full text Link to item Cite

Myocardial protection during coronary angioplasty with an autoperfusion balloon catheter in humans.

Journal Article Circulation · November 1988 An autoperfusion balloon catheter was developed to allow passive myocardial perfusion during inflation through a central lumen and multiple side holes in the shaft proximal and distal to the balloon. We report its safety and efficacy in 11 patients undergo ... Full text Link to item Cite

Survival and cardiac event rates in the first year after emergency coronary angioplasty for acute myocardial infarction.

Journal Article J Am Coll Cardiol · June 1988 One year survival and event-free survival rates were analyzed in 342 patients with acute myocardial infarction who were consecutively enrolled in a treatment protocol of early intravenous thrombolytic therapy followed by emergency coronary angioplasty. Nin ... Full text Link to item Cite

Perfusion balloon catheter.

Journal Article Am J Cardiol · May 9, 1988 An autoperfusion balloon catheter was developed to allow passive myocardial perfusion during balloon inflation, through a central lumen and multiple side holes in the shaft proximal and distal to the balloon. This report reviews preliminary experimental an ... Full text Link to item Cite

Transluminal intracoronary reperfusion catheter: a device to maintain coronary perfusion between failed coronary angioplasty and emergency coronary bypass surgery.

Journal Article J Am Coll Cardiol · May 1988 The reperfusion catheter is a 4.3F catheter with 30 holes over its distal 10 cm. It is used to maintain coronary blood flow in patients awaiting emergency coronary bypass surgery after failed coronary angioplasty. The insertion of the reperfusion catheter ... Full text Link to item Cite

The risk for systemic embolization associated with percutaneous balloon valvuloplasty in adults. A prospective comprehensive evaluation.

Journal Article Ann Intern Med · April 1988 STUDY OBJECTIVE: To prospectively investigate the evidence for embolic phenomena associated with percutaneous mitral and aortic valvuloplasty. DESIGN: Prospective, consecutive case series before and after balloon valvuloplasty. SETTING: Referral center hos ... Full text Link to item Cite

Late restenosis after emergent coronary angioplasty for acute myocardial infarction: comparison with elective coronary angioplasty.

Journal Article J Am Coll Cardiol · April 1988 The late restenosis rate after emergent percutaneous transluminal coronary angioplasty for acute myocardial infarction was assessed by performing outpatient follow-up cardiac catheterization in 79 (87%) of 91 consecutive patients who had been discharged fr ... Full text Link to item Cite

Helicopter transport of patients during acute myocardial infarction.

Journal Article Am J Cardiol · April 1, 1988 Initial experience with a regional system of emergency helicopter transport of patients with acute myocardial infarction (AMI) referred for emergent cardiac catheterization and percutaneous transluminal coronary angioplasty (PTCA) is described. Two hundred ... Full text Link to item Cite

Hemodynamic effects of intravenous pirmenol.

Journal Article Angiology · March 1988 The hemodynamic effects of intravenous pirmenol were studied in 21 subjects instrumented with peripheral arterial, pulmonary artery, and left ventricular catheters. Baseline measurements of heart rate, cardiac output, pulmonary artery pressure, systemic ar ... Link to item Cite

Coronary perfusion during acute myocardial infarction with a combined therapy of coronary angioplasty and high-dose intravenous streptokinase.

Journal Article Circulation · January 1988 Two hundred and sixteen patients with acute myocardial infarction were treated with immediate infusion of high-dose (1.5 million units) intravenous streptokinase followed by emergency coronary angioplasty. The infarct lesion was crossed and dilated in 99% ... Full text Link to item Cite

Interventional Cardiac Catheterization at Duke Medical Center - The Duke Interventional Cardiac Catheterization Program

Journal Article American Journal of Cardiology · January 1, 1988 Clinical perspective: Cardiac revascularization in a wide range of patients with coronary artery disease is the underlying mission of Duke University's Interventional Cardiac Catheterization Program, one of the largest of its kind in the United States. Und ... Cite

New international technology: The autoperfusion balloon catheter

Journal Article American Journal of Cardiology · January 1, 1988 Clinical perspective: Balloon angioplasty reduces mortality and morbidity in AMI and coronary artery disease patients, but the procedure has major limitations. Acute failure requiring an emergency response is not uncommon, and the restenosis rate is greate ... Cite

Limitations of balloon angioplasty: Possible causes of restenosis

Journal Article American Journal of Cardiology · January 1, 1988 Clinical perspective: Much needs to be learned about the precise physiologic and biochemical actions and effects of thrombolytic therapy and PTCA in various settings. In particular, the factors influencing restenosis must be elucidated. ... Cite

Balloon angioplasty in acute myocardial infarction - Limitations of thrombolytic therapy when used alone

Journal Article American Journal of Cardiology · 1988 Clinical perspective: Although thrombolytic therapy offers important, often life-preserving benefits to many AMI patients, its effectiveness is limited in several crucial respects: it does not achieve reperfusion in a substantial percentage of patients, no ... Cite

Hemodynamic effects of intravenous pirmenol

Journal Article Angiology · January 1, 1988 The hemodynamic effects of intravenous pirmenol were studied in 21 subjects instrumented with peripheral arterial, pulmonary artery, and left ventricular catheters. Baseline measurements of heart rate, cardiac output, pulmonary artery pressure, systemic ar ... Cite

Validation of in vivo two-dimensional echocardiographic dimension measurements using myocardial mass estimates in dogs.

Journal Article Am Heart J · March 1987 The accuracy of in vivo measurements of left ventricular wall thickness and chamber size by means of two-dimensional echocardiography was investigated by comparing left ventricular mass estimates obtained at end diastole in 15 closed-chest dogs with a wide ... Full text Link to item Cite

Isotretinoin and Staphylococcus aureus infection. A possible association.

Journal Article Arch Dermatol · July 1986 The use of isotretinoin (13-cis-retinoic acid) in the treatment of numerous dermatologic disorders, as well as the side effects encountered with use of the drug, have increased remarkably since its release. We encountered a case of Staphylococcus aureus en ... Link to item Cite

Interventional cardiac catheterization.

Journal Article Invest Radiol · July 1985 Full text Link to item Cite

Prognostic value of a coronary artery jeopardy score.

Journal Article J Am Coll Cardiol · May 1985 The prognostic value of a coronary artery jeopardy score was evaluated in 462 consecutive nonsurgically treated patients with significant coronary artery disease, but without significant left main coronary stenosis. The jeopardy score is a simple method fo ... Full text Link to item Cite

Evaluation of a QRS scoring system for estimating myocardial infarct size. IV. Correlation with quantitative anatomic findings for posterolateral infarcts.

Journal Article Am J Cardiol · March 1, 1984 This study correlated the location and size of posterolateral myocardial infarcts (MIs) measured anatomically with that estimated by quantitative criteria derived from the standard 12-lead ECG. Twenty patients were studied who had autopsy-proved, single, p ... Full text Link to item Cite

The natural history and recommended management of patients with traumatic coronary artery fistulas.

Journal Article Ann Thorac Surg · September 1983 Traumatic coronary artery fistulas are reported less often than other complications resulting from both penetrating and blunt trauma to the heart. We describe a 50-year-old man in whom the natural history of a traumatic coronary fistula is well documented. ... Full text Link to item Cite

A noninvasive radiographic technique for evaluation of exercise-induced changes in cardiac function.

Journal Article J Am Coll Cardiol · August 1983 An electrocardiographic-triggered radiographic technique for obtaining a single image of the heart at both end-systole and end-diastole was used in conjunction with upright bicycle exercise to detect stress-induced changes in 1) systolic and diastolic card ... Full text Link to item Cite

Functional improvement of jeopardized myocardium following intracoronary streptokinase infusion in acute myocardial infarction.

Journal Article J Clin Invest · July 1983 The effect of reperfusion on regional left ventricular performance following acute myocardial infarction in man was determined. Intracoronary streptokinase was administered in 24 patients within 6 h of the onset of symptoms. 15 patients (62%) were successf ... Full text Link to item Cite

Serial thallium-201 imaging at rest in patients with unstable and stable angina pectoris: relationship of myocardial perfusion at rest to presenting clinical syndrome.

Journal Article Am Heart J · July 1983 In order to determine whether there are differences in myocardial perfusion at rest among patients with various unstable and stable angina syndromes, serial thallium-201 imaging was performed at rest in 19 patients presenting with rapidly worsening exertio ... Full text Link to item Cite

Adverse effects of nifedipine therapy on hypertrophic obstructive cardiomyopathy.

Journal Article Chest · April 1983 A 62-year-old man with obstructive hypertrophic cardiomyopathy was given sublingual nifedipine, 10 mg, during invasive hemodynamic monitoring. After 15 minutes, his left ventricular outflow gradient increased from 22 to 80 mm Hg while arterial pressure fel ... Full text Link to item Cite

Outcome in one-vessel coronary artery disease.

Journal Article Circulation · February 1983 We analyzed the clinical outcomes in 688 patients with isolated stenosis of one major coronary artery. The survival rate among patients with disease of the right coronary artery (RCA) was higher than that among patients with left anterior descending (LAD) ... Full text Link to item Cite

Evaluation of a QRS scoring system for estimating myocardial infarct size. III. Correlation with quantitative anatomic findings for inferior infarcts.

Journal Article Am J Cardiol · February 1983 This study evaluated by quantitative autopsy correlation a previously developed scoring system for estimating the size of myocardial infarcts based on the QRS complex of the electrocardiogram. This system was tested using electrocardiograms from patients w ... Full text Link to item Cite

Serial changes in left ventricular ejection fraction in the early hours after aortocoronary bypass grafting.

Journal Article Chest · January 1983 To determine the course of left ventricular ejection fraction (LVEF) in the early hours after aortocoronary bypass grafting, 24 patients underwent serial gated bloodpool scanning. Twenty-two had received propranolol until the day of surgery. ECGs showed no ... Full text Link to item Cite

Anatomic and prognostic implications of an early positive treadmill exercise test.

Journal Article Am J Cardiol · October 1982 Eighty men (group A) with clinical coronary artery disease underwent coronary angiography regardless of symptoms and previous therapy because they had a positive treadmill exercise test in stage I or II of the Bruce protocol. Thirty-four other men (group B ... Full text Link to item Cite

Hemodynamic effects of the antiarrhythmic drug pirmenol.

Journal Article Clin Pharmacol Ther · August 1982 We examined the hemodynamic effects of pirmenol, a new antiarrhythmic drug, for the first time in man. Right and left heart pressures, Fick cardiac output, and radionuclide ejection fraction were measured before and during infusion of pirmenol in 10 patien ... Full text Link to item Cite

Subvalvular thrombotic obstruction of an aortic porcine heterograft.

Journal Article Chest · June 1982 A 48-year-old man had angina pectoris and symptoms of heart failure. Cardiac catheterization showed severe aortic stenosis and regurgitation, and he underwent aortic valve replacement in 1976 with a 23-mm Carpentier-Edwards aortic porcine heterograft. Init ... Full text Link to item Cite

Evaluation of a QRS scoring system for estimating myocardial infarct size. II. Correlation with quantitative anatomic findings for anterior infarcts.

Journal Article Am J Cardiol · May 1982 The ability of an independently developed QRS point score to estimate the size of infarcts predominantly within the anterior third of the left ventricular was evaluated by quantitative pathologic-electrocardiographic correlation. The study was limited to 2 ... Full text Link to item Cite

A techniqe to inject microspheres into the left atrium of awake dogs without thoracotomy

Journal Article American Journal of Physiology - Heart and Circulatory Physiology · January 1, 1982 A technique to inject radioactive microspheres into the left atrium of awake dogs without prior thoracotomy was developed and tested. Twelve dogs were studied and evaluated: the interatrial septum was crossed and a catheter placed in the left atrium in all ... Cite

Mitral valve replacement for isolated mitral regurgitation: analysis of clinical course and late postoperative left ventricular ejection fraction.

Journal Article Am J Cardiol · October 1981 One hundred five patients underwent mitral valve replacement for relief of isolated mitral regurgitation between 1974 and 1979. There were 4 in-hospital deaths (4 percent) and 12 late deaths giving an 82 percent predicted 5 year survival rate. An age of 60 ... Full text Link to item Cite

The effect of pulsatile perfusion on preservation of left ventricular function after aortocoronary bypass grafting.

Journal Article Circulation · August 1981 Pulsatile perfusion has been reported to be of value in intraoperative myocardial protection. To evaluate this technique, we studied 26 patients undergoing aortocoronary bypass grafting. Ejection fraction determinations from multigated cardiac blood pool s ... Link to item Cite

Aortocoronary bypass grafting in patients without left main stenosis. Relation of risk factors to early and late survival.

Journal Article Br Heart J · May 1981 Three-hundred and thirty-five patients without left main stenosis or recent acute myocardial infarction underwent isolated aortocoronary bypass grafting during 1974 and 1975. The hospital mortality was 2 per cent for the four-year predicted survival is 94 ... Full text Link to item Cite

Evaluation of vectorcardiographic criteria for the diagnosis of myocardial infarction in the presence of left ventricular hypertrophy.

Journal Article Circulation · February 1976 Vectorcardiograms (VCG) from a consecutive group of 77 patients with significant aortic valve disease were analyzed. All of the patients had complete left and right heart catheterization with normal coronary arteriograms and normal left ventricular contrac ... Full text Link to item Cite