Scholars@Duke
Richard Edward Moon

Richard Edward Moon

Professor of Anesthesiology
Anesthesiology, General, Vascular, High Risk Transplant & Critical Care
richard.moon@duke.edu
Box 3094 Med Ctr, Durham, NC
5676 Hafs Bldg, Durham, NC 27710

Selected Publications

Pushing Scuba to New Heights: Approach, Decompression, and Logistical Considerations for High-Altitude Diving.

Journal Article High Alt Med Biol · October 8, 2024 There is interest among technical, expedition, commercial, and military divers in expanding diving operations to high altitude. However, altitude diving presents unique challenges including acclimatization, increased decompression sickness (DCS) risk, and ... Full text Link to item Cite

Prediction of central nervous system oxygen toxicity symptoms using electrodermal activity and machine learning

Journal Article Biocybernetics and Biomedical Engineering · April 1, 2024 Objective: Breathing elevated oxygen partial pressures (PO2) prior to SCUBA diving increases the risk of developing central nervous system oxygen toxicity (CNS-OT), which could impair performance or result in seizure and subsequent drowning. We aimed to st ... Full text Cite

Effects of submersion on VO2: comparing maximum aerobic exertion on land and underwater.

Journal Article Undersea Hyperb Med · 2024 INTRODUCTION: Submersion results in blood redistribution into the pulmonary circulation, causing changes in pulmonary compliance and increased cardiac preload. Few studies have compared incremental exercise to exhaustion (VO2 max testing) in a dry environm ... Link to item Cite

Arterial blood gases in SCUBA divers at depth

Journal Article Frontiers in Marine Science · January 1, 2024 Background: Current diving physiology postulates that SCUBA divers’ arterial blood gas (ABG) levels vary proportionally to environmental pressure, but, to date, ABGs have only been obtained during simulated dives. Also, recent evidence supports the use of ... Full text Cite

Relative hypoxemia at depth during breath-hold diving investigated through arterial blood gas analysis and lung ultrasound.

Journal Article J Appl Physiol (1985) · October 1, 2023 Pulmonary gas exchange in breath-hold diving (BHD) consists of a progressive increase in arterial partial pressures of oxygen ([Formula: see text]) and carbon dioxide ([Formula: see text]) during descent. However, recent findings have demonstrated that [Fo ... Full text Link to item Cite

Effect of Anesthetic Carrier Gas on In Vivo Circulation Times of Intravenously Administered Phospholipid Oxygen Microbubbles in Rats.

Journal Article Ultrasound Med Biol · August 2023 OBJECTIVE: For the treatment of tumor hypoxia, microbubbles comprising oxygen as a majority component of the gas core with a stabilizing shell may be used to deliver and release oxygen locally at the tumor site through ultrasound destruction. Previous work ... Full text Link to item Cite

Deep Learning-Based Venous Gas Emboli Grade Classification in Doppler Ultrasound Audio Recordings.

Journal Article IEEE Trans Biomed Eng · May 2023 OBJECTIVE: Doppler ultrasound (DU) is used to detect venous gas emboli (VGE) post dive as a marker of decompression stress for diving physiology research as well as new decompression procedure validation to minimize decompression sickness risk. In this art ... Full text Link to item Cite

Volume 50: The UHM Journal celebrates a milestone with the publication of this issue.

Journal Article Undersea Hyperb Med · 2023 As the UHMS observes the distinguished anniversary of the publication of 50 volumes of the Undersea and Hyperbaric Medicine Journal, two of our past editors take a look at the evolution of our flagship publications. ... Full text Link to item Cite

An open-source framework for synthetic post-dive Doppler ultrasound audio generation.

Journal Article PloS one · January 2023 Doppler ultrasound (DU) measurements are used to detect and evaluate venous gas emboli (VGE) formed after decompression. Automated methodologies for assessing VGE presence using signal processing have been developed on varying real-world datasets of limite ... Full text Cite

Erratum: The effect of hyperbaric oxygen therapy on bladder symptoms of female patients with overactive bladder (Undersea Hyperb Med (2022) 49: 3 (383-390) DOI: 10.22462/05.06.2022.13)

Journal Article Undersea and Hyperbaric Medicine · January 1, 2023 The abstract in the above-named paper, which appeared on page 383 of the 49(3) issue, contained an error. It read: “The mean changes in the ICIQ-SF, OAB-V8, and IIQ-7 scores in the third month of treatment in Group 1 were 4.12 ±...” This first number shoul ... Full text Cite

Development of a graphical user interface for automatic separation of human voice from Doppler ultrasound audio in diving experiments.

Journal Article PLoS One · 2023 Doppler ultrasound (DU) is used in decompression research to detect venous gas emboli in the precordium or subclavian vein, as a marker of decompression stress. This is of relevance to scuba divers, compressed air workers and astronauts to prevent decompre ... Full text Link to item Cite

Safety evaluation of carbon tetrafluoride as an inert hyperbaric breathing gas in Sprague-Dawley rats.

Journal Article Toxicol Appl Pharmacol · June 1, 2022 Carbon tetrafluoride (CF4) is an inert gas with higher molecular weight and lower water solubility than commonly used hyperbaric breathing gases. These inert gas properties decrease time required to decompress and avoid decompression sickness after deep di ... Full text Link to item Cite

Decompression Sickness and Arterial Gas Embolism.

Journal Article N Engl J Med · March 31, 2022 Full text Link to item Cite

Immersion-Induced Mitral Regurgitation: A Novel Risk Factor for Swimming-Induced Pulmonary Edema.

Journal Article Chest · March 2022 Immersion pulmonary edema, more commonly referred to as swimming-induced pulmonary edema (SIPE), is a well-documented condition believed to be a result of immersion physiologic condition that is characterized by a peripheral-to-central redistribution of bl ... Full text Link to item Cite

Blood gas analyses in hyperbaric and underwater environments: a systematic review.

Journal Article J Appl Physiol (1985) · February 1, 2022 Pulmonary gas exchange during diving or in a dry hyperbaric environment is affected by increased breathing gas density and possibly water immersion. During free diving, there is also the effect of apnea. Few studies have published blood gas data in underwa ... Full text Link to item Cite

Anesthesia and Surgery in Space: Comment.

Journal Article Anesthesiology · February 1, 2022 Full text Link to item Cite

The Dewey Monitor: Pulse Oximetry can Warn of Hypoxia in an Immersed Rebreather Diver in Multiple Scenarios.

Journal Article Ann Biomed Eng · February 2022 Divers who wish to prolong their time underwater while carrying less equipment often use devices called rebreathers, which recycle the gas expired after each breath instead of discarding it as bubbles. However, rebreathers' need to replace oxygen used by b ... Full text Link to item Cite

The Dewey Monitor: Pulse Oximetry can Warn of Hypoxia in an Immersed Rebreather Diver in Multiple Scenarios.

Journal Article Annals of biomedical engineering · February 2022 Divers who wish to prolong their time underwater while carrying less equipment often use devices called rebreathers, which recycle the gas expired after each breath instead of discarding it as bubbles. However, rebreathers' need to replace oxygen used by b ... Full text Cite

Effects of high-intensity interval training with hyperbaric oxygen.

Journal Article Front Physiol · 2022 Hyperbaric Oxygen (HBO2) has been proposed as a pre-conditioning method to enhance exercise performance. Most prior studies testing this effect have been limited by inadequate methodologies. Its potential efficacy and mechanism of action remain unknown. We ... Full text Open Access Link to item Cite

International Multicenter Registry for Hyperbaric Oxygen Therapy: Results through June 2021.

Journal Article Undersea Hyperb Med · 2022 INTRODUCTION: The International Multicenter Registry for Hyperbaric Oxygen Therapy (International Report Registered Identifier DERR1-10.2196/18857) was established in 2011 to capture outcomes and complications data for both Undersea and Hyperbaric Medical ... Link to item Cite

Physiological responses during ascent to high altitude and the incidence of acute mountain sickness.

Journal Article Physiol Rep · April 2021 Acute mountain sickness (AMS) occurs when there is failure of acclimatisation to high altitude. The aim of this study was to describe the relationship between physiological variables and the incidence of AMS during ascent to 5300 m. A total of 332 lowland- ... Full text Link to item Cite

Randomized controlled trial of 7, 28, vs 42 day stored red blood cell transfusion on oxygen delivery (VO2 max) and exercise duration.

Journal Article Transfusion · March 2021 BACKGROUND: Few studies have rigorously assessed the impact of red blood cell (RBC) transfusion on oxygen delivery. Several large trials demonstrated no clinical outcome differences between transfusion of shorter-storage vs prolonged-storage RBCs. These tr ... Full text Link to item Cite

Ultrasound in decompression research: fundamentals, considerations, and future technologies.

Journal Article Undersea Hyperb Med · 2021 It is widely accepted that bubbles are a necessary but insufficient condition for the development of decompression sickness. However, open questions remain regarding the precise formation and behavior of these bubbles after an ambient pressure reduction (d ... Full text Link to item Cite

A fully automated method for late ventricular diastole frame selection in post-dive echocardiography without ECG gating.

Journal Article Undersea Hyperb Med · 2021 Venous gas emboli (VGE) are often quantified as a marker of decompression stress on echocardiograms. Bubble-counting has been proposed as an easy to learn method, but remains time-consuming, rendering large dataset analysis impractical. Computer automation ... Full text Link to item Cite

Hyperbaric oxygen for intracranial abscess.

Journal Article Undersea Hyperb Med · 2021 The term "intracranial abscess" (ICA) includes cerebral abscess, subdural empyema, and epidural empyema, which share many diagnostic and therapeutic similarities and, frequently, very similar etiologies. Infection may occur and spread from a contiguous inf ... Full text Link to item Cite

Physiologic and biochemical rationale for treating COVID-19 patients with hyperbaric oxygen.

Journal Article Undersea Hyperb Med · 2021 The SARS-Cov-2 (COVID-19) pandemic remains a major worldwide public health issue. Initially, improved supportive and anti-inflammatory intervention, often employing known drugs or technologies, provided measurable improvement in management. We have recentl ... Full text Link to item Cite

Hyperbaric oxygen for decompression sickness.

Journal Article Undersea Hyperb Med · 2021 Decompression sickness (DCS, "bends") is caused by formation of bubbles in tissues and/or blood when the sum of dissolved gas pressures exceeds ambient pressure (supersaturation). This may occur when ambient pressure is reduced during any of the following: ... Open Access Link to item Cite

Diving

Chapter · January 1, 2021 Humans are poorly adapted to the underwater environment. Breath-hold diving is limited by limits on the capacity of the thorax to compress during descent, and ability to withstand hyperoxia and hypercapnia. Using compressed gas technology humans can breath ... Full text Cite

Cardio-Respiratory tolerability of perfluoropropaneEnhanced MRI of pulmonary ventilation

Conference Journal of Lung, Pulmonary & Respiratory Research · December 30, 2020 Rationale: Recent advances in perfluoropropane magnetic resonance imaging of the lung have provided the means to assess pulmonary ventilation and gas distribution throughout the pulmonary airways and acini in a non-invasive manner. Objectives: The ... Full text Cite

Reply to Drs. Wang et al.

Journal Article J Appl Physiol (1985) · October 1, 2020 Full text Link to item Cite

Arterial gas embolism breathing compressed air in 1.2 metres of water.

Journal Article Diving Hyperb Med · September 30, 2020 Arterial gas embolism (AGE) may result when diving while breathing compressed gas and ascending rapidly or with a closed glottis. Pulmonary over-pressurisation can result in lung stretch injury with entry of bubbles into the pulmonary venous circulation an ... Full text Link to item Cite

A methodology to explore ventilatory chemosensitivity and opioid-induced respiratory depression risk.

Journal Article J Appl Physiol (1985) · September 1, 2020 Reported incidence of postoperative opioid-induced respiratory depression (OIRD) ranges from 0.5-41% and is not reliably predicted by traditional risk factors. This study tests a new methodology to investigate ventilatory chemosensitivity as a new potentia ... Full text Link to item Cite

Arterial blood gases in divers at surface after prolonged breath-hold.

Journal Article Eur J Appl Physiol · February 2020 PURPOSE: Adaptations during voluntary breath-hold diving have been increasingly investigated since these athletes are exposed to critical hypoxia during the ascent. However, only a limited amount of literature explored the pathophysiological mechanisms und ... Full text Open Access Link to item Cite

Hyperbaric oxygen as a treatment for COVID-19 infection?

Journal Article Undersea Hyperb Med · 2020 Recently the internet has been abuzz with new ideas to treat COVID-19, including hyperbaric oxygen (HBO2) therapy, undoubtedly driven by the fact that until recently there have been few therapeutic options for this highly contagious and often lethal infect ... Full text Open Access Link to item Cite

Using the Electronic Medical Record to Improve Preoperative Identification of Patients at Risk for Obstructive Sleep Apnea.

Journal Article J Perianesth Nurs · February 2019 PURPOSE: Obstructive sleep apnea (OSA) is a breathing disorder found in surgical patients and associated with complications in the postoperative period. The implementation of a preoperative universal screening process using the STOP-BANG questionnaire to i ... Full text Open Access Link to item Cite

Blue Vision (Cyanopsia) Associated With TURP Syndrome: A Case Report.

Journal Article A A Pract · November 15, 2018 There have been many complications associated with transurethral resection of the prostate (TURP), known as TURP syndrome. Of the various irrigation fluids used for TURP, glycine irrigant has been historically popular given its relatively low cost. It is a ... Full text Open Access Link to item Cite

Pharmacologic Targeting of Red Blood Cells to Improve Tissue Oxygenation.

Journal Article Clin Pharmacol Ther · September 2018 Disruption of microvascular blood flow is a common cause of tissue hypoxia in disease, yet no therapies are available that directly target the microvasculature to improve tissue oxygenation. Red blood cells (RBCs) autoregulate blood flow through S-nitroso- ... Full text Open Access Link to item Cite

The Smell of Hypoxia: using an electronic nose at altitude and proof of concept of its role in the prediction and diagnosis of acute mountain sickness.

Journal Article Physiol Rep · September 2018 Electronic nose (e-nose) devices may be used to identify volatile organic compounds (VOCs) in exhaled breath. VOCs generated via metabolic processes are candidate biomarkers of (patho)physiological pathways. We explored the feasibility of using an e-nose t ... Full text Link to item Cite

Pulmonary Delivery of Therapeutic and Diagnostic Gases.

Journal Article J Aerosol Med Pulm Drug Deliv · April 2018 The 21st Congress for the International Society for Aerosols in Medicine included, for the first time, a session on Pulmonary Delivery of Therapeutic and Diagnostic Gases. The rationale for such a session within ISAM is that the pulmonary delivery of gaseo ... Full text Open Access Link to item Cite

Otorhinolaryngology and Diving-Part 2: Otorhinolaryngological Fitness for Compressed Gas Scuba Diving: A Review.

Journal Article JAMA Otolaryngol Head Neck Surg · March 1, 2018 IMPORTANCE: Self-contained underwater breathing apparatus (scuba) diving has become increasingly popular with millions of people diving each year. Otorhinolaryngologists are often consulted either by patients or diving physicians regarding fitness to dive, ... Full text Link to item Cite

Otorhinolaryngology and Diving-Part 1: Otorhinolaryngological Hazards Related to Compressed Gas Scuba Diving: A Review.

Journal Article JAMA Otolaryngol Head Neck Surg · March 1, 2018 IMPORTANCE: Scuba diving is becoming increasingly popular. However, scuba diving is associated with specific risks; 80% of adults and 85% of juvenile divers (aged 6-17 years) have been reputed to have an ear, nose, or throat complaint related to diving at ... Full text Open Access Link to item Cite

Environmental Physiology and Diving Medicine.

Journal Article Front Psychol · 2018 Man's experience and exploration of the underwater environment has been recorded from ancient times and today encompasses large sections of the population for sport enjoyment, recreational and commercial purpose, as well as military strategic goals. Knowle ... Full text Open Access Link to item Cite

Can my patient dive after a first episode of primary spontaneous pneumothorax? A systematic review of the literature.

Journal Article Undersea Hyperb Med · 2018 INTRODUCTION: Patients with prior primary spontaneous pneumothorax (PSP) frequently seek clearance to dive. Despite wide consensus in precluding compressed-air diving in this population, there is a paucity of data to support this decision. We reviewed the ... Open Access Link to item Cite

Arterial Blood Gas Analysis in Breath-Hold Divers at Depth.

Journal Article Front Physiol · 2018 The present study aimed to evaluate the partial pressure of arterial blood gases in breath-hold divers performing a submersion at 40 m. Eight breath-hold divers were enrolled for the trials held at "Y-40 THE DEEP JOY" pool (Montegrotto Terme, Padova, Italy ... Full text Open Access Link to item Cite

Anesthesiology

Chapter · January 1, 2018 Cite

Sildenafil: Possible Prophylaxis against Swimming-induced Pulmonary Edema.

Journal Article Med Sci Sports Exerc · September 2017 Featured Publication Swimming-induced pulmonary edema (SIPE) occurs during swimming and scuba diving, usually in cold water, in susceptible healthy individuals, especially military recruits and triathletes. We have previously demonstrated that pulmonary artery (PA) pressure an ... Full text Open Access Link to item Cite

Successful treatment of pneumatosis intestinalis with associated pneumoperitoneum and ileus with hyperbaric oxygen therapy.

Journal Article BMJ Case Rep · May 30, 2017 Pneumatosis intestinalis (PI), or the presence of air in the bowel wall, is a rare disorder that is associated with a variety of underlying diseases, including connective tissue disorders. PI presents on a spectrum from asymptomatic to bowel obstruction an ... Full text Open Access Link to item Cite

Marriage and mortality after noncardiac surgery.

Journal Article J Surg Res · April 2017 BACKGROUND: Marriage is linked to substantial societal and economic benefits, and it has been associated with improved outcomes following acute illness. However, it is not known if being married confers benefit to patients undergoing noncardiac surgical pr ... Full text Link to item Cite

A randomized controlled pilot study of VO2 max testing: a potential model for measuring relative in vivo efficacy of different red blood cell products.

Journal Article Transfusion · March 2017 BACKGROUND: Randomized trials, for example, RECESS, comparing "young" (median, 7-day) versus "middle-aged" (median, 28-day) red blood cells (RBCs), showed no difference in outcome. These data are important; however, they do not inform us about the safety a ... Full text Link to item Cite

Spontaneous Absorption of Cerebral Air Emboli.

Journal Article J Cerebrovasc Endovasc Neurosurg · March 2017 Full text Link to item Cite

Another perspective on ACEP policy on critical issues in carbon monoxide poisoning: Invited commentary.

Journal Article Undersea Hyperb Med · 2017 The American College of Emergency Physicians (ACEP) recently published its official policy on the evaluation and management of patients with acute carbon monoxide (CO) poisoning [1], an update of the policy previously published in 2008. Three questions reg ... Full text Link to item Cite

Non-dysbaric arterial gas embolism associated with chronic necrotizing pneumonia, bullae and coughing: a case report.

Journal Article Undersea Hyperb Med · 2017 Arterial gas embolism (AGE) can be clinically devastating, and is most often associated with exposure to changes in ambient pressure, medical procedure or congenital malformation. Here we report a case of AGE in a 78-year-old male without these traditional ... Full text Link to item Cite

Hypercapnia in diving: a review of COâ‚‚ retention in submersed exercise at depth.

Journal Article Undersea Hyperb Med · 2017 Carbon dioxide (COâ‚‚) retention, or hypercapnia, is a known risk of diving that can cause mental and physical impairments leading to life-threatening accidents. Often, such accidents occur due to elevated inspired carbon dioxide. For instance, in cases of C ... Full text Open Access Link to item Cite

Diagnosis of Swimming Induced Pulmonary Edema-A Review.

Journal Article Front Physiol · 2017 Featured Publication Swimming induced pulmonary edema (SIPE) is a complication that can occur during exercise with the possibility of misdiagnosis and can quickly become life threatening; however, medical literature infrequently describes SIPE. Therefore, the aim of this revie ... Full text Open Access Link to item Cite

Enhanced recovery protocols for colorectal surgery and postoperative renal function: a retrospective review.

Journal Article Perioper Med (Lond) · 2017 BACKGROUND: While enhanced recovery protocols (ERPs) reduce physiologic stress and improve outcomes in general, their effects on postoperative renal function have not been directly studied. METHODS: Patients undergoing major colorectal surgery under ERP (F ... Full text Open Access Link to item Cite

An Undiagnosed Paraganglioma in a 58-Year-Old Female Who Underwent Tumor Resection.

Journal Article Case Rep Anesthesiol · 2017 Paragangliomas and pheochromocytomas are rare neuroendocrine tumors that can have high morbidity and mortality if undiagnosed. Here we report a case of an undiagnosed paraganglioma in a 58-year-old female who underwent tumor resection. The patient became s ... Full text Open Access Link to item Cite

The Dewey monitor: Pulse oximetry can independently detect hypoxia in a rebreather diver.

Journal Article Undersea Hyperb Med · 2017 Rebreather diving has one of the highest fatality rates per man hour of any diving activity in the world. The leading cause of death is hypoxia, typically from equipment or procedural failures. Hypoxia causes very few symptoms prior to causing loss of cons ... Full text Open Access Link to item Cite

Assessment of the interaction of hyperbaric N2, CO2, and O2 on psychomotor performance in divers.

Journal Article J Appl Physiol (1985) · October 1, 2016 Diving narcosis results from the complex interaction of gases, activities, and environmental conditions. We hypothesized that these interactions could be separated into their component parts. Where previous studies have tested single cognitive tasks sequen ... Full text Link to item Cite

Follow-up to Nonfatal Opioid Overdoses.

Journal Article Ann Intern Med · September 6, 2016 Full text Link to item Cite

Iatrogenic cerebral gas embolism.

Journal Article Diving Hyperb Med · June 2016 Link to item Cite

Swimming-Induced Pulmonary Edema: Pathophysiology and Risk Reduction With Sildenafil.

Journal Article Circulation · March 8, 2016 BACKGROUND: Swimming-induced pulmonary edema (SIPE) occurs during swimming or scuba diving, often in young individuals with no predisposing conditions, and its pathophysiology is poorly understood. This study tested the hypothesis that pulmonary artery and ... Full text Open Access Link to item Cite

Did the crew of the submarine H.L. Hunley suffocate?

Journal Article Forensic Sci Int · March 2016 On the evening of February 17th, 1864, the Confederate submarine H.L. Hunley attacked the Union ship USS Housatonic outside Charleston, South Carolina and became the first submarine in history to successfully sink an enemy ship in combat. One hypothesis fo ... Full text Link to item Cite

Association between Serum IGF-I levels and Postoperative Delirium in Elderly Subjects Undergoing Elective Knee Arthroplasty.

Journal Article Sci Rep · February 5, 2016 Evidence is mixed for an association between serum insulin-like growth factor-I (IGF-I) levels and postoperative delirium (POD). The current study assessed preoperative serum IGF-I levels as a predictor of incident delirium in non-demented elderly elective ... Full text Link to item Cite

Deaths in triathletes: immersion pulmonary oedema as a possible cause.

Journal Article BMJ Open Sport Exerc Med · 2016 BACKGROUND/AIM: To address the question as to whether immersion pulmonary oedema (IPO) may be a common cause of death in triathlons, markers of swimming-induced pulmonary oedema (SIPO) susceptibility were sought in triathletes' postmortem examinations. MET ... Full text Open Access Link to item Cite

Don’t dive cold when you don’t have to

Journal Article Diving and Hyperbaric Medicine · December 1, 2015 Cite

The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle.

Journal Article Am J Physiol Lung Cell Mol Physiol · October 15, 2015 The heme oxygenase-1 (HO-1)/carbon monoxide (CO) system induces mitochondrial biogenesis, but its biological impact in human skeletal muscle is uncertain. The enzyme system generates CO, which stimulates mitochondrial proliferation in normal muscle. Here w ... Full text Link to item Cite

Human Physiology in an Aquatic Environment.

Journal Article Compr Physiol · September 20, 2015 Water covers over 70% of the earth, has varying depths and temperatures and contains much of the earth's resources. Head-out water immersion (HOWI) or submersion at various depths (diving) in water of thermoneutral (TN) temperature elicits profound cardior ... Full text Link to item Cite

Cerebral Arterial Gas Embolism During Upper Endoscopy.

Journal Article A A Case Rep · September 15, 2015 Arterial gas embolism can be caused by direct entry of gas into systemic arteries or indirectly by venous-to-arterial shunting. Although arterial gas embolism is rare, most documented cases are iatrogenic, resulting from the entry of gas during procedures ... Full text Link to item Cite

Oxygen in Acute Illness: More or Less?

Journal Article Crit Care Med · July 2015 Full text Link to item Cite

Immersion pulmonary edema and comorbidities: case series and updated review.

Journal Article Med Sci Sports Exerc · June 2015 PURPOSE: Immersion pulmonary edema (IPE) occurs in swimmers (especially triathletes) and scuba divers. Its pathophysiology and risk factors are incompletely understood. This study was designed to establish the prevalence of preexisting comorbidities in ind ... Full text Link to item Cite

Don't dive cold when you don't have to.

Journal Article Diving Hyperb Med · March 2015 Link to item Cite

Research report: Charcoal type used for hookah smoking influences CO production.

Journal Article Undersea Hyperb Med · 2015 A hookah smoker who was treated for severe carbon monoxide poisoning with hyperbaric oxygen reported using a different type of charcoal prior to hospital admission, i.e., quick-light charcoal. This finding led to a study aimed at determining whether CO pro ... Open Access Link to item Cite

Short Term Repeatability Of Perfluorinated Gas Imaging In A Series Of Subjects With Asthma (mild And Moderate/severe)

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Textbook plagiarism reform.

Journal Article Anesth Analg · September 2014 Full text Link to item Cite

Effects of elevated oxygen and carbon dioxide partial pressures on respiratory function and cognitive performance.

Journal Article J Appl Physiol (1985) · August 15, 2014 Hyperoxia during diving has been suggested to exacerbate hypercapnic narcosis and promote unconsciousness. We tested this hypothesis in male volunteers (12 at rest, 10 at 75 W cycle ergometer exercise) breathing each of four gases in a hyperbaric chamber. ... Full text Link to item Cite

A prospective comparison of a noninvasive cardiac output monitor versus esophageal Doppler monitor for goal-directed fluid therapy in colorectal surgery patients.

Journal Article Anesth Analg · May 2014 BACKGROUND: Goal-directed fluid therapy (GDFT) is associated with improved outcomes after surgery. The esophageal Doppler monitor (EDM) is widely used, but has several limitations. The NICOM, a completely noninvasive cardiac output monitor (Cheetah Medical ... Full text Open Access Link to item Cite

Reduced length of hospital stay in colorectal surgery after implementation of an enhanced recovery protocol.

Journal Article Anesth Analg · May 2014 BACKGROUND: Enhanced recovery after surgery (ERAS) is a multimodal approach to perioperative care that combines a range of interventions to enable early mobilization and feeding after surgery. We investigated the feasibility, clinical effectiveness, and co ... Full text Open Access Link to item Cite

Neurology and diving.

Journal Article Handb Clin Neurol · 2014 Diving exposes a person to the combined effects of increased ambient pressure and immersion. The reduction in pressure when surfacing can precipitate decompression sickness (DCS), caused by bubble formation within tissues due to inert gas supersaturation. ... Full text Link to item Cite

Hyperbaric oxygen treatment for air or gas embolism

Journal Article Undersea and Hyperbaric Medicine · January 1, 2014 Gas can enter arteries (arterial gas embolism) due to alveolar-capillary disruption (caused by pulmonary overpressurization, e.g., breath-hold ascent by divers) or veins (venous gas embolism, VGE) as a result of tissue bubble formation due to decompression ... Cite

Hyperbaric oxygen treatment for air or gas embolism.

Journal Article Undersea Hyperb Med · 2014 Gas can enter arteries (arterial gas embolism) due to alveolar-capillary disruption (caused by pulmonary overpressurization, e.g., breath-hold ascent by divers) or veins (venous gas embolism, VGE) as a result of tissue bubble formation due to decompression ... Link to item Cite

Hyperbaric oxygen treatment for decompression sickness.

Journal Article Undersea Hyperb Med · 2014 Decompression sickness (DCS) is a clinical syndrome occurring usually within 24 hours of a reduction in ambient pressure. DCS occurs most commonly in divers ascending from a minimum depth of 20 feet (6 meters) of sea water, but can also occur during rapid ... Link to item Cite

Perfluoropropane gas as a magnetic resonance lung imaging contrast agent in humans.

Journal Article Chest · October 2013 BACKGROUND: Fluorine-enhanced MRI is a relatively inexpensive and straightforward technique that facilitates regional assessments of pulmonary ventilation. In this report, we assess its suitability through the use of perfluoropropane (PFP) in a cohort of h ... Full text Link to item Cite

Multi-Breath Steady-State Ventilation Distribution Via 19fluorine-Enhanced Mri

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

In reply.

Journal Article Anesthesiology · December 2012 Full text Link to item Cite

Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample.

Journal Article Intensive Care Med · July 2012 PURPOSE: Necrotising soft tissue infection (NSTI) is a deadly disease associated with a significant risk of mortality and long-term disability from limb and tissue loss. The aim of this study was to determine the effect of hyperbaric oxygen (HBO(2)) therap ... Full text Link to item Cite

What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics.

Journal Article J Oral Maxillofac Surg · July 2012 PURPOSE: This study tested hyperbaric oxygen (HBO) as an adjunct to surgery and antibiotics in the treatment of bisphosphonate-related osteonecrosis of the jaw (ONJ) and evaluated its effects on gingival healing, pain, and quality of life. MATERIALS AND ME ... Full text Link to item Cite

Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly.

Journal Article Anesthesiology · April 2012 BACKGROUND: Postoperative delirium, a common complication in the elderly, can occur following any type of surgery and is associated with increased morbidity and mortality; it may also be associated with subsequent cognitive problems. Effective therapy for ... Full text Link to item Cite

Safe administration of hyperbaric oxygen after bleomycin: a case series of 15 patients.

Journal Article Undersea Hyperb Med · 2012 INTRODUCTION: Supplemental oxygen has been reported to cause pulmonary complications after bleomycin. We describe the safe administration of hyperbaric oxygen (HBO2) after bleomycin in 15 patients. METHODS: Paper and electronic records were reviewed for bl ... Link to item Cite

Recommendations for rescue of a submerged unresponsive compressed-gas diver.

Journal Article Undersea Hyperb Med · 2012 The Diving Committee of the Undersea and Hyperbaric Medical Society has reviewed available evidence in relation to the medical aspects of rescuing a submerged unresponsive compressed-gas diver. The rescue process has been subdivided into three phases, and ... Link to item Cite

Hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss.

Journal Article Undersea Hyperb Med · 2012 Idiopathic sudden sensorineural hearing loss (ISSHL) is the newest indication approved by the Undersea and Hyperbaric Medical Society's Hyperbaric Oxygen Therapy Committee. Idiopathic sudden sensorineural hearing loss appears to be characterized by hypoxia ... Link to item Cite

Risk factors for immersion pulmonary edema: hyperoxia does not attenuate pulmonary hypertension associated with cold water-immersed prone exercise at 4.7 ATA.

Journal Article J Appl Physiol (1985) · March 2011 Hyperoxia has been shown to attenuate the increase in pulmonary artery (PA) pressure associated with immersed exercise in thermoneutral water, which could serve as a possible preventive strategy for the development of immersion pulmonary edema (IPE). We te ... Full text Link to item Cite

Decompression illness.

Journal Article Lancet · January 8, 2011 Featured Publication Decompression illness is caused by intravascular or extravascular bubbles that are formed as a result of reduction in environmental pressure (decompression). The term covers both arterial gas embolism, in which alveolar gas or venous gas emboli (via cardia ... Full text Link to item Cite

Cerebral air embolism following removal of central venous catheter

Journal Article Military Medicine · September 1, 2010 Cite

Effects of hyperoxia on ventilation and pulmonary hemodynamics during immersed prone exercise at 4.7 ATA: possible implications for immersion pulmonary edema.

Journal Article J Appl Physiol (1985) · July 2010 Featured Publication Immersion pulmonary edema (IPE) can occur in otherwise healthy swimmers and divers, likely because of stress failure of pulmonary capillaries secondary to increased pulmonary vascular pressures. Prior studies have revealed progressive increase in ventilati ... Full text Link to item Cite

Gas Embolism

Chapter · January 1, 2010 Full text Cite

Breath-hold diving and cerebral decompression illness.

Journal Article Undersea Hyperb Med · 2010 Featured Publication Link to item Cite

Treatment of arterial gas embolism.

Journal Article Mil Med · December 2009 Link to item Cite

Untitled

Journal Article MILITARY MEDICINE · December 1, 2009 Link to item Cite

Letters to the editor

Journal Article Military Medicine · December 1, 2009 Cite

Multimodality surgical and hyperbaric management of mandibular osteoradionecrosis.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2009 PURPOSE: To elucidate long-term outcomes in 65 consecutive patients meeting a uniform definition of mandibular osteoradionecrosis (ORN) treated with multimodality therapy including hyperbaric oxygen (HBO). METHODS AND MATERIALS: Pretreatment, post-treatmen ... Full text Link to item Cite

Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans.

Journal Article Am J Physiol Heart Circ Physiol · July 2009 Given that the physiology of heme oxygenase-1 (HO-1) encompasses mitochondrial biogenesis, we tested the hypothesis that the HO-1 product, carbon monoxide (CO), activates mitochondrial biogenesis in skeletal muscle and enhances maximal oxygen uptake (Vo(2m ... Full text Link to item Cite

Adjunctive therapy for decompression illness: a review and update.

Journal Article Diving Hyperb Med · June 2009 Therapeutic interventions may augment the outcome or provide temporizing support pending recompression. Effective measures include first aid (surface) oxygen therapy, fluid resuscitation, non-steroidal anti-inflammatory drugs and avoidance of fever. Lignoc ... Link to item Cite

Pulmonary gas exchange in diving.

Journal Article J Appl Physiol (1985) · February 2009 Featured Publication Diving-related pulmonary effects are due mostly to increased gas density, immersion-related increase in pulmonary blood volume, and (usually) a higher inspired Po(2). Higher gas density produces an increase in airways resistance and work of breathing, and ... Full text Link to item Cite

Effects of head and body cooling on hemodynamics during immersed prone exercise at 1 ATA.

Journal Article J Appl Physiol (1985) · February 2009 Featured Publication Immersion pulmonary edema (IPE) is a condition with sudden onset in divers and swimmers suspected to be due to pulmonary arterial or venous hypertension induced by exercise in cold water, although it does occur even with adequate thermal protection. We tes ... Full text Link to item Cite

Discussion: Diving Researcher Recruitment

Conference FUTURE OF DIVING:100 YEARS OF HALANE AND BEYOND · January 1, 2009 Link to item Cite

Discussion: Decompression Physiology and Methodology

Conference FUTURE OF DIVING:100 YEARS OF HALANE AND BEYOND · January 1, 2009 Link to item Cite

Predictors of increased PaCO2 during immersed prone exercise at 4.7 ATA.

Journal Article J Appl Physiol (1985) · January 2009 Featured Publication During diving, arterial Pco(2) (Pa(CO(2))) levels can increase and contribute to psychomotor impairment and unconsciousness. This study was designed to investigate the effects of the hypercapnic ventilatory response (HCVR), exercise, inspired Po(2), and ex ... Full text Link to item Cite

Environmental Physiology of the Future

Conference FUTURE OF DIVING:100 YEARS OF HALANE AND BEYOND · January 1, 2009 Link to item Cite

Hyperoxia-induced decrease in organ blood flow [10]

Journal Article Anesthesiology · January 1, 2008 Full text Cite

In reply (Anesthesiology (2008) 108, (169-170))

Journal Article Anesthesiology · January 1, 2008 Cite

Decompression Sickness

Journal Article · January 1, 2008 Full text Cite

Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series.

Journal Article J Oral Maxillofac Surg · July 2007 PURPOSE: Bisphosphonate (BP)-associated osteonecrosis of the jaw (ONJ) is an emerging problem with few therapeutic options. Our pilot study of BP-ONJ investigated a possible role for hyperbaric oxygen (HBO(2)) therapy. PATIENTS AND METHODS: A total of 16 p ... Full text Link to item Cite

Hyperoxia-induced tissue hypoxia: a danger?

Journal Article Anesthesiology · May 2007 Featured Publication Full text Link to item Cite

First aid normobaric oxygen for the treatment of recreational diving injuries.

Journal Article Undersea Hyperb Med · 2007 INTRODUCTION: First aid oxygen (FAO2) has been widely used as an emergency treatment for diving injuries, but there are few studies supporting its efficacy. METHODS: 2,231 sequential diving injury reports collected by the Divers Alert Network (DAN) Injury ... Link to item Cite

Fractal response of physiological signals to stress conditions, environmental changes, and neurodegenerative diseases

Journal Article Complexity · January 1, 2007 In the past two decades the biomedical community has witnessed several applications of nonlinear system theory to the analysis of biomedical time series and the development of nonlinear dynamic models. The development of this area of medicine can best be d ... Full text Cite

Skeletal muscle mitochondrial biogenesis induced by carbon monoxide

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2007 Link to item Cite

Nitroglycerine: relief from the heartache of decompression sickness?

Journal Article J Appl Physiol (1985) · December 2006 Featured Publication Full text Link to item Cite

Medical qualification of a commercial spaceflight participant: not your average astronaut.

Journal Article Aviat Space Environ Med · May 2006 BACKGROUND: Candidates for commercial spaceflight may be older than the typical astronaut and more likely to have medical problems that place them at risk during flight. Since the effects of microgravity on many medical conditions are unknown, physicians h ... Link to item Cite

Diving

Chapter · January 1, 2006 Humans are poorly adapted to the underwater environment. Breath-hold diving is limited by limits on the capacity of the thorax to compress during descent, and ability to withstand hyperoxia and hypercapnia. Using compressed gas technology humans can breath ... Full text Cite

DIVING

Chapter · January 1, 2006 Humans are poorly adapted to the underwater environment. Breath-hold diving is limited by limits on the capacity of the thorax to compress during descent, and ability to withstand hyperoxia and hypercapnia. Using compressed gas technology humans can breath ... Full text Cite

Bubbles in the brain: what to do for arterial gas embolism?

Journal Article Crit Care Med · April 2005 Featured Publication Full text Link to item Cite

The independently fractal nature of respiration and heart rate during exercise under normobaric and hyperbaric conditions.

Journal Article Respir Physiol Neurobiol · February 15, 2005 To test the hypothesis that the fractal character of breathing and heart rate are independent, inter-breath intervals (IBI) and R-R intervals (RRI) were measured during rest and two levels of exercise at 1 and 2.8 ATA in a hyperbaric chamber in 18 male and ... Full text Link to item Cite

Plasma glucose responses in recreational divers with insulin-requiring diabetes.

Journal Article Undersea Hyperb Med · 2004 Insulin-requiring diabetes mellitus (IRDM) is commonly described as an absolute contraindication to scuba diving. A 1993 Divers Alert Network survey, however, identified many active IRDM divers. We report on the plasma glucose response to recreational divi ... Link to item Cite

Cigarette smoking and decompression illness severity: a retrospective study in recreational divers.

Journal Article Aviat Space Environ Med · December 2003 BACKGROUND: Severe decompression illness (DCI) could be more likely in cigarette smokers because of airway obstruction or vascular disease. The present study evaluated the severity of DCI as a function of cigarette smoking in recreational divers. METHODS: ... Link to item Cite

The relationship between ionized and total serum magnesium concentrations during abdominal surgery.

Journal Article J Clin Anesth · June 2003 STUDY OBJECTIVE: To determine the necessity for ionized magnesium (iMg) assay by evaluating the effect of abdominal surgery without massive transfusion on total magnesium (Mg) and iMg concentrations. DESIGN: Prospective, observational study. SETTING: Opera ... Full text Link to item Cite

Effects of age and exercise on physiological dead space during simulated dives at 2.8 ATA.

Journal Article J Appl Physiol (1985) · February 2003 Featured Publication Physiological dead space (Vds), end-tidal CO(2) (Pet(CO(2))), and arterial CO(2) (Pa(CO(2))) were measured at 1 and 2.8 ATA in a dry hyperbaric chamber in 10 older (58-74 yr) and 10 younger (19-39 yr) air-breathing subjects during rest and two levels of up ... Full text Link to item Cite

Treatment of Decompression Illness

Journal Article · January 1, 2003 Full text Cite

Drowning and near-drowning.

Journal Article Emerg Med (Fremantle) · December 2002 Water immersion is a frequent cause of accidental death and hospital admission. This article outlines the pathogenesis and principles of treatment. Drowning is defined as death by asphyxia due to submersion in a liquid medium. Near-drowning is defined as i ... Full text Link to item Cite

Nitric oxide in the human respiratory cycle.

Journal Article Nat Med · July 2002 Interactions of nitric oxide (NO) with hemoglobin (Hb) could regulate the uptake and delivery of oxygen (O(2)) by subserving the classical physiological responses of hypoxic vasodilation and hyperoxic vasconstriction in the human respiratory cycle. Here we ... Full text Link to item Cite

Blood glucose meter performance under hyperbaric oxygen conditions.

Journal Article Clin Chim Acta · March 2001 This study evaluated the accuracy of the Precision PCx (PCx) against another bedside blood glucose meter SureStepPro (SSP), which has been shown to be unaffected by high P(O(2)). Human blood samples were used to prepare plasma glucose (PG) concentrations o ... Full text Link to item Cite

Nitric oxide in the respiratory cycle in human health and disease

Journal Article FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2001 Link to item Cite

Measurement of plasma glucose under hyperbaric oxygen conditions

Journal Article South Pacific Underwater Medicine Society Journal · December 1, 2000 This study was designed to evaluate the accuracy of the bedside glucometer SureStepPro (SSP, LifeScan Inc; Milpitas, California) against a standard laboratory instrument (Yellow Springs Instruments [YSI] 2300 STAT PLUS; Yellow Springs, Ohio) during hyperba ... Cite

Recompression treatment should only be administered in a hospital-based facility

Journal Article South Pacific Underwater Medicine Society Journal · September 1, 2000 In an ideal world all divers with decompression illness would receive immediate expert assessment and recompression treatment with or without the necessary adjunctive therapy to maintain blood pressure and ensure appropriate pulmonary gas exchange. However ... Cite

All divers with decompression illness require recompression

Journal Article South Pacific Underwater Medicine Society Journal · September 1, 2000 Cite

Recompression treatments should be to a pressure equivalent to 18 m depth

Journal Article South Pacific Underwater Medicine Society Journal · September 1, 2000 It is conceivable that, under some circumstances, shallower recompression depths, or even surface treatment, may achieve a similar degree of success. But, because 18 m recompression is so successful, the burden of proof remains on the side of individuals s ... Cite

Mechanisms of acute postoperative hypomagnesemia

Journal Article ANESTHESIOLOGY · September 1, 2000 Link to item Cite

Outcome analysis in patients with primary necrotizing fasciitis of the male genitalia.

Journal Article Urology · July 2000 OBJECTIVES: To characterize patients with primary necrotizing fasciitis of the male genitalia (Fournier's gangrene) and to identify risk factors and prognostic variables of survival. METHODS: Fifty consecutive patients with primary necrotizing fasciitis of ... Full text Link to item Cite

Laryngeal radionecrosis and hyperbaric oxygen therapy: report of 18 cases and review of the literature.

Journal Article Ann Otol Rhinol Laryngol · June 2000 Laryngeal radionecrosis is a difficult late complication of radiotherapy. It is associated with hoarseness, edema, pain, weight loss, and upper airway obstruction. The medical treatment options are limited, and in severe cases, the patient may require trac ... Full text Link to item Cite

The natural progression of decompression illness and development of recompression procedures

Journal Article South Pacific Underwater Medicine Society Journal · March 1, 2000 The initial observations in the 19th century of DCS in compressed air workers and divers revealed a disease that could cause severe neurological injury and death, but would often surprisingly resolve spontaneously. The standard of care for this illness tod ... Cite

Hyperbaric oxygen in the treatment of life-threatening soft-tissue infections.

Journal Article Respir Care Clin N Am · June 1999 Necrotizing soft-tissue infections are rapidly spreading bacterial infections that account for a relatively small proportion of infections, but are aggressive in nature and nearly uniformly fatal if left untreated. Prompt recognition, antibiotic therapy, a ... Link to item Cite

Treatment of diving emergencies.

Journal Article Crit Care Clin · April 1999 Recognition of condition attributable to the environmental changes experienced by divers will facilitate appropriate treatment. The diagnosis of these conditions rarely requires sophisticated imaging or electrophysiologic testing. Divers who have suspected ... Full text Link to item Cite

Hyperbaric oxygen therapy: from the nineteenth to the twenty-first century.

Journal Article Respir Care Clin N Am · March 1999 Hyperbaric oxygen technology now occupies a legitimate place in modern medical practice, and the number of clinically active hyperbaric facilities has grown. We estimate that more than 200 monoplace (single-patient) chambers and over two dozen multiplace f ... Link to item Cite

Treatment of decompression illness and latrogenic gas embolism.

Journal Article Respir Care Clin N Am · March 1999 The mainstay of treatment of gas bubble disease is therapeutic recompression while the patient is breathing oxygen. The patient should be recompressed as soon as possible; however, patients should be considered for recompression even after several days' de ... Link to item Cite

Operational use and patient monitoring in a multiplace hyperbaric chamber.

Journal Article Respir Care Clin N Am · March 1999 Multiplace hyperbaric chambers can be used to deliver patient care with enormous flexibility. Standard critical care techniques, such as mechanical ventilation, endotracheal suctioning, hemodynamic monitoring, blood gas measurement, and emergency therapy s ... Link to item Cite

Adjunctive therapy in decompression illness: Present and future

Journal Article South Pacific Underwater Medicine Society Journal · January 1, 1999 Surface oxygen appears to be efficacious, at least whenever there is some delay to recompression treatment. First aid measures should ideally include airway management and assuring adequacy of ventilation, fluid resuscitation and maintenance of blood press ... Cite

The spums policy on the initial management of diving injuries and illnesses

Journal Article South Pacific Underwater Medicine Society Journal · December 1, 1998 Cite

The effect of hyperbaric oxygen on pulmonary vascular tone.

Journal Article ANESTHESIOLOGY · September 1, 1998 Link to item Cite

Chronic osteomyelitis of the tibia: treatment with hyperbaric oxygen and autogenous microsurgical muscle transplantation.

Journal Article J South Orthop Assoc · 1998 To establish the success rate of combined therapy for tibial osteomyelitis, we reviewed all cases of this infection treated with surgery, antibiotics, and hyperbaric oxygen (HBO) between 1974 and 1991 at Duke University Medical Center. The median delay fro ... Link to item Cite

Changes in the lung after prolonged positive pressure ventilation in normal baboons.

Journal Article J Crit Care · June 1997 PURPOSE: The effects of prolonged positive pressure ventilation on lung ultrastructure are not well defined in primates. This study was designed to measure cardiopulmonary and morphological responses to 4 days of positive pressure ventilation in normal bab ... Full text Link to item Cite

Guidelines for treatment of decompression illness.

Journal Article Aviat Space Environ Med · March 1997 Link to item Cite

Brown recluse spider envenomation: a prospective trial of hyperbaric oxygen therapy.

Journal Article Acad Emerg Med · March 1997 OBJECTIVES: Loxosceles reclusa (brown recluse) spider bites can produce severe skin lesions that may necessitate extensive surgical repair. This study delineated the effects of hyperbaric oxygen (HBO) therapy on these lesions by performing a prospective co ... Full text Link to item Cite

VA/Q abnormalities during gram negative sepsis.

Journal Article Respir Physiol · August 1996 Hypoxemia in bacterial sepsis develops by mechanisms which are incompletely understood. In this study, we measured pulmonary gas exchange in eight baboons to determine the causes of hypoxemia after infusion of live Escherichia coli (1 x 10(10) CFU/kg) foll ... Full text Link to item Cite

[Hyperbaric oxygenation: therapy with oxygen using hyperbaric pressure].

Journal Article Anasthesiol Intensivmed Notfallmed Schmerzther · March 1996 Full text Link to item Cite

[Indications for primary or initial use of hyperbaric oxygenation].

Journal Article Anasthesiol Intensivmed Notfallmed Schmerzther · March 1996 Full text Link to item Cite

Artificial surfactant attenuates hyperoxic lung injury in primates. I. Physiology and biochemistry.

Journal Article J Appl Physiol (1985) · May 1995 Prolonged exposure to O2 causes diffuse alveolar damage and surfactant dysfunction that contribute to the pathophysiology of hyperoxic lung injury. We hypothesized that exogenous surfactant would improve lung function during O2 exposure in primates. Sixtee ... Full text Link to item Cite

Fasting Before Surgery

Journal Article JAMA: The Journal of the American Medical Association · April 19, 1995 Full text Cite

Fasting before surgery.

Journal Article JAMA · April 19, 1995 Full text Link to item Cite

Treatment of cervical necrotizing fasciitis with hyperbaric oxygen therapy.

Journal Article Otolaryngol Head Neck Surg · February 1995 Hyperbaric oxygen therapy has significantly improved the management of necrotizing fasciitis of the extremities and trunk. Its role in cervical necrotizing fasciitis has not been fully evaluated. Historically, necrotizing fasciitis has been associated with ... Full text Link to item Cite

The physiology of decompression illness

Journal Article Scientific American · January 1, 1995 Cite

Cerebral imaging of decompression injury patients with 18-F-2-fluoro-2-deoxyglucose positron emission tomography.

Journal Article Undersea Hyperb Med · June 1994 The objective assessment of the extent of cerebral insult and the effects of therapy in decompression injury patients has proven to be difficult by most imaging modalities. In this pilot study we evaluated the ability of 18-F-2-fluoro-2-deoxyglucose (FDG) ... Link to item Cite

Natural surfactant and hyperoxic lung injury in primates. I. Physiology and biochemistry.

Journal Article J Appl Physiol (1985) · March 1994 Surfactant dysfunction contributes to the pathophysiology of adult respiratory distress syndrome (ARDS), and we hypothesized that surfactant treatment would improve experimental ARDS produced by continuous exposure to hyperoxia. Twelve healthy male baboons ... Full text Link to item Cite

Effects of clenbuterol hydrochloride on pulmonary gas exchange and hemodynamics in anesthetized horses.

Journal Article Am J Vet Res · May 1993 We evaluated the effects of clenbuterol HCl (0.8 micrograms/kg, of body weight, IV), a beta 2 agonist, on ventilation-perfusion matching and hemodynamic variables in anesthetized (by IV route), laterally recumbent horses. The multiple inert gas elimination ... Link to item Cite

EVOLUTION OF HEMODYNAMICS AND V(A)/Q-DISTRIBUTIONS IN GRAM-NEGATIVE SEPSIS IN NONHUMAN-PRIMATES

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · April 1, 1993 Link to item Cite

WHAT IS THE RISK OF PULMONARY BAROTRAUMA(PBT) DUE TO ASTHMA(A) IN SCUBA-DIVERS

Conference JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY · January 1, 1993 Link to item Cite

FLOW AUGMENTATION IN THE FENHOLLOWAY RIVER BASIN

Conference ENGINEERING HYDROLOGY - PROCEEDINGS OF THE SYMPOSIUM · January 1, 1993 Link to item Cite

Embolism caused by sudden environmental pressure changes

Journal Article Anesthesiology Clinics of North America · January 1, 1993 Cite

Warehouse workers' headache.

Journal Article J Occup Med · September 1992 Link to item Cite

WAREHOUSE WORKERS HEADACHE - REPLY

Journal Article JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE · September 1, 1992 Link to item Cite

Renal responses during a dry saturation dive to 450 msw.

Journal Article Undersea Biomed Res · July 1992 Four subjects were compressed to a simulated depth of 450 msw (46 bar) for 37 days in the main research chamber of the German underwater simulator diving facility at the GKSS Research Center, Geesthacht. The ambient gas was trimix. Urine was collected at 0 ... Link to item Cite

Platelet count in deep saturation diving.

Journal Article Undersea Biomed Res · July 1992 Platelet counts were measured in 10 divers during the course of 4 experimental deep dives (450 and 600 m) and different anticoagulants were tested. The use of sodium citrate as an anticoagulant was associated with artifactual thrombocytopenia, whereas ethy ... Link to item Cite

Urinary vasopressin and aldosterone and plasma volume during a saturation dive to 450 m.

Journal Article Undersea Biomed Res · July 1992 Urinary vasopressin (VP), aldosterone (ALDO), osmotic substances, sodium excretion, and plasma volume were assessed in 4 healthy male divers during 2 predive control days, 2 compression days, 6 days at 46 atm abs, and 26 days of decompression with stops at ... Link to item Cite

Warehouse workers’ headache: The author replies

Journal Article Journal of Occupational Medicine · January 1, 1992 Cite

Warehouse workers' headache. Carbon monoxide poisoning from propane-fueled forklifts.

Journal Article J Occup Med · January 1992 We reviewed over 220 cases of acute carbon monoxide (CO) poisoning and now report on 17 patients whose poisoning occurred from the indoor use of propane-fueled forklifts. All patients in this series presented with neurologic symptoms or persistent headache ... Link to item Cite

MRI of absent left pulmonary artery.

Journal Article J Comput Assist Tomogr · 1992 Unilateral absence of a pulmonary artery, more accurately referred to as unilateral proximal interruption of a pulmonary artery, is a rare congenital anomaly that may occur as an isolated lesion or in association with other congenital cardiovascular abnorm ... Full text Link to item Cite

Preoperative evaluation

Journal Article Problems in Urology · January 1, 1992 Patients at increased risk of perioperative complications can almost always be identified by history and physical examination. Batteries of routine preoperative tests generally are unhelpful. Common preoperative problems have been discussed and relevant so ... Cite

Initial treatment of patients with extensive trauma.

Journal Article N Engl J Med · November 14, 1991 Full text Link to item Cite

Venous gas emboli and complement activation after deep repetitive air diving.

Journal Article Undersea Biomed Res · July 1991 Complement activity has been linked to decompression sickness (DCS), but the effects of intravascular bubbles on complement activation are poorly understood. We have investigated intravascular complement activation by measuring red blood cell (RBC)-bound C ... Link to item Cite

Extubation after transsternal thymectomy for myasthenia gravis: a prospective analysis.

Journal Article South Med J · June 1991 Recommendations concerning postoperative extubation after thymectomy for myasthenia gravis are presently based upon retrospective chart reviews. We present the results of a prospective investigation of time to extubation after thymectomy for 14 patients ov ... Full text Link to item Cite

Cerebral oxygen availability by NIR spectroscopy during transient hypoxia in humans.

Journal Article J Appl Physiol (1985) · September 1990 The effects of mild hypoxia on brain oxyhemoglobin, cytochrome a,a3 redox status, and cerebral blood volume were studied using near-infrared spectroscopy in eight healthy volunteers. Incremental hypoxia reaching 70% arterial O2 saturation was produced in n ... Full text Link to item Cite

Initial table treatment of decompression sickness and arterial gas embolism.

Journal Article Aviat Space Environ Med · August 1990 This descriptive, nonrandomized, multicenter-based study compares the treatment outcomes of two major categories of recompression treatment tables for recreational sport SCUBA divers suffering from decompression sickness and/or arterial gas embolism. Strat ... Link to item Cite

Barotrauma and air embolism in hyperbaric oxygen therapy.

Journal Article Am J Forensic Med Pathol · June 1990 A 69-year-old woman underwent hyperbaric oxygen therapy because of a nonhealing ulcer of her foot. During decompression, she developed a left-sided hemiplegia and confusion. Recompression resulted in transient neurologic improvement, but she eventually bec ... Full text Link to item Cite

Hyperbaric medicine: an integral part of trauma care.

Journal Article Crit Care Clin · January 1990 In conclusion, HBO constitutes an important therapeutic tool in managing a variety of syndromes associated with trauma and is thought to possess potential benefits for the management of others. Because its therapeutic efficacy and limitations are as yet in ... Link to item Cite

EMERGENCY TREATMENT OF DIVING CASUALTIES IN REMOTE AREAS

Journal Article MARINE TECHNOLOGY SOCIETY JOURNAL · December 1, 1989 Link to item Cite

Patent foramen ovale and decompression sickness in divers.

Journal Article Lancet · March 11, 1989 30 patients with a history of decompression sickness were examined for the presence of patent foramen ovale by bubble contrast, two-dimensional echocardiography and colour flow doppler imaging. With bubble contrast, 11 (37%) of the patients had right-to-le ... Full text Link to item Cite

Effect of epidural lidocaine on spinal cord blood flow.

Journal Article Anesth Analg · March 1989 The effect of epidural lidocaine on spinal cord blood flow (SCBF) was measured in mongrel dogs. Spinal evoked potentials were used to measure spinal cord conduction and enabled us to time the measurement of SCBF associated with maximum reduction in latency ... Link to item Cite

Should hyperbaric oxygen be used to treat the pregnant patient for acute carbon monoxide poisoning? A case report and literature review.

Journal Article JAMA · February 17, 1989 Carbon monoxide (CO) is the leading cause of death due to poisoning. Although uncommon, CO poisoning does occur during pregnancy and can result in fetal mortality and neurological malformations in fetuses who survive to term. Uncertainty arises regarding t ... Full text Link to item Cite

Neuroimaging of scuba diving injuries to the CNS.

Journal Article AJR Am J Roentgenol · November 1988 Diving accidents related to barotrauma constitute a unique subset of ischemic insults to the CNS. Victims may demonstrate components of arterial gas embolism, which has a propensity for cerebral involvement, and/or decompression sickness, with primarily sp ... Full text Link to item Cite

Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis.

Journal Article Rev Infect Dis · 1988 The therapy of rhinocerebral mucormycosis includes aggressive surgical debridement, administration of high-dose amphotericin B, and control of underlying predisposing conditions, especially diabetes and immunosuppression or immunodeficiency. Hyperbaric oxy ... Full text Link to item Cite

Neuroimaging of scuba diving injuries to the CNS

Journal Article American Journal of Neuroradiology · January 1, 1988 Diving accidents related to barotrauma constitute a unique subset of ischemic insults to the CNS. Victims may demonstrate components of arterial gas embolism, which has a propensity for cerebral involvement, and/or decompression sickness, with primarily sp ... Cite

VENTILATORY RESPONSE TO HYPOXIA AFTER MORPHINE OR BUTORPHANOL

Journal Article FEDERATION PROCEEDINGS · March 1, 1987 Link to item Cite

ATRIOPEPTIN AND HYPERBARIC-INDUCED DIURESIS

Journal Article CIRCULATION · October 1, 1986 Link to item Cite

Pulmonary gas exchange in humans exercising at sea level and simulated altitude.

Journal Article J Appl Physiol (1985) · July 1986 In a previous study of normal subjects exercising at sea level and simulated altitude, ventilation-perfusion (VA/Q) inequality and alveolar-end-capillary O2 diffusion limitation (DIFF) were found to increase on exercise at altitude, but at sea level the ch ... Full text Link to item Cite

Monaghan 225 ventilator use under hyperbaric conditions.

Journal Article Chest · June 1986 The Monaghan 225 ventilator was tested to ambient pressures of 6 atmospheres absolute (ATA) in a hyperbaric chamber. The ventilator would function with delivered tidal volume which was independent of ambient pressure. Ventilatory rate declined in an expone ... Full text Link to item Cite

MAGNETIC-RESONANCE-IMAGING OF DIVING INJURIES TO THE BRAIN

Conference AMERICAN JOURNAL OF NEURORADIOLOGY · May 1, 1986 Link to item Cite

SUPPORT OF ARTERIAL OXYGENATION WITH HYPERBARIC-OXYGEN DURING THERAPEUTIC LUNG LAVAGE

Journal Article AMERICAN REVIEW OF RESPIRATORY DISEASE · April 1, 1986 Link to item Cite

Accidental epidural overdose of hydromorphone.

Journal Article Anesthesiology · August 1985 Full text Link to item Cite

Diffusion limitation in normal humans during exercise at sea level and simulated altitude.

Journal Article J Appl Physiol (1985) · March 1985 The relative roles of ventilation-perfusion (VA/Q) inequality, alveolar-capillary diffusion resistance, postpulmonary shunt, and gas phase diffusion limitation in determining arterial PO2 (PaO2) were assessed in nine normal unacclimatized men at rest and d ... Full text Link to item Cite

Ventilation-perfusion inequality in normal humans during exercise at sea level and simulated altitude.

Journal Article J Appl Physiol (1985) · March 1985 To investigate the effects of both exercise and acute exposure to high altitude on ventilation-perfusion (VA/Q) relationships in the lungs, nine young men were studied at rest and at up to three different levels of exercise on a bicycle ergometer. Altitude ... Full text Link to item Cite

The oxygen available to exercising muscles during respiratory loads

Journal Article Federation Proceedings · January 1, 1985 Cite

THE OXYGEN AVAILABLE TO EXERCISING MUSCLES DURING RESPIRATORY LOADS

Journal Article FEDERATION PROCEEDINGS · January 1, 1985 Link to item Cite

Physiological responses to exercise at 47 and 66 ATA.

Journal Article J Appl Physiol Respir Environ Exerc Physiol · October 1984 Five male volunteers served as subjects for exercise studies during three dives to pressures of 47 and 66 ATA while breathing gases containing 0.5 ATA PO2 and varying amounts of N2 and He. The inspired gas density ranged from 1.1 g/l (BTPS) at the surface ... Full text Link to item Cite

Effects of saturation diving on respiratory systems

Conference Developments in Diving Technology: Proceedings of an International Conference, DIVETECH 1984 · January 1, 1984 Cite

ENDOTRACHEAL ARTIFICIAL LARYNX.

Journal Article Digest of Papers - Canadian Medical and Biological Engineering Conference · December 1, 1982 Cite

CONSIDERATIONS IN THE DESIGN OF AN AIRFLOW-ACTIVATED SOUND SOURCE FOR AN ENDOTRACHEAL ARTIFICIAL LARYNX

Journal Article ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY · January 1, 1982 Link to item Cite

DESIGN OF THE ENDOTRACHEAL ARTIFICIAL LARYNX

Journal Article ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY · January 1, 1982 Link to item Cite

EVALUATION OF THE ENDOTRACHEAL ARTIFICIAL LARYNX

Journal Article ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY · January 1, 1982 Link to item Cite

Endotracheal artificial larynx.

Journal Article Ann Otol Rhinol Laryngol Suppl · 1982 Link to item Cite

Considerations in the design of an airflow-activated sound source for an endotracheal artificial larynx

Journal Article Annals of Otology, Rhinology and Laryngology · January 1, 1982 A bench test apparatus has been described that can measure the frequency spectra of isolated human larynges and reed sound sources within an artificial larynx. Objective criteria have been stated, whenever possible, by which artificial sound sources may be ... Cite

Design of the endotracheal artificial larynx

Journal Article Annals of Otology, Rhinology and Laryngology · January 1, 1982 We have presented the specifications for an endotracheal artificial larynx and discussed the design alternatives we considered to meet these specifications. We have described the basic construction of our larynx and discussed the electronic design in detai ... Cite

Evaluation of the endotracheal artificial larynx

Journal Article Annals of Otology, Rhinology and Laryngology · January 1, 1982 This article deals with the evaluation of the effectiveness of the artificial larynx in preventing aspiration, and the assessment of tissue reaction caused by it. ... Cite

Endotracheal artificial larynx -- preliminary report.

Journal Article J Otolaryngol · February 1981 In experimental animals a one stage surgical procedure has been developed which at laryngectomy allows for the creation of a wide and patent tracheopharyngeal fistula. An endotracheal artificial larynx has been developed which has been found effective in p ... Link to item Cite

Application of queueing theory to pharmacokinetics.

Journal Article J Pharm Sci · May 1980 This paper considers the steady-state plasma drug concentration in a one-compartment, open pharmacokinetic model with multiple doses and first-order kinetics using a classical deterministic technique as well as a queueing theoretical stochastic analysis. T ... Full text Link to item Cite

Human-like reasoning capability in a medical diagnostic system: The application of fuzzy set theory to computerized diagnosis

Journal Article Journal of Clinical Computing · January 1, 1979 The rationale, theory and outline of a medical diagnostic system based on fuzzy set theory have been presented. The hope is that such a system, when fully developed, will be able to simulate non-quantitative human reasoning. Preliminary computer runs have ... Cite

Radical radiotherapy versus abdominoperineal resection.

Journal Article Can Med Assoc J · February 18, 1978 Link to item Cite

Hyperbaric treatment of air or gas embolism: current recommendations.

Journal Article Undersea Hyperb Med Gas can enter arteries (arterial gas embolism, AGE) due to alveolar-capillary disruption (caused by pulmonary over-pressurization, e.g. breath-hold ascent by divers) or veins (venous gas embolism, VGE) as a result of tissue bubble formation due to decompre ... Link to item Cite

Hyperbaric treatment for decompression sickness: current recommendations.

Journal Article Undersea Hyperb Med Decompression sickness (DCS, "bends") is caused by formation of bubbles in tissues and/or blood when the sum of dissolved gas pressures exceeds ambient pressure (supersaturation). This may occur when ambient pressure is reduced during any of the following: ... Link to item Cite

Immersion pulmonary edema: drowning from the inside.

Journal Article Undersea Hyperb Med Immersion pulmonary (IPE, also known as swimming-induced pulmonary edema, SIPE) is a condition in which pulmonary edema develops rapidly during a dive or vigorous swim. Symptoms include dyspnea and hemoptysis. Physical exam reveals typical signs of bilater ... Link to item Cite