Scholars@Duke
Satyanarayana Achanta

Satyanarayana Achanta

Assistant Professor in Anesthesiology
Anesthesiology

Selected Publications

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death.

Journal Article J Vis Exp · June 6, 2025 The number of advanced heart failure patients who can receive a heart transplant is limited by a shortage of suitable organ donors. In efforts to expand the donor pool, alternative donation and procurement methods have been developed, including heart trans ... Full text Link to item Cite

Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury.

Journal Article Am J Physiol Lung Cell Mol Physiol · April 1, 2024 Chlorine gas (Cl2) has been repeatedly used as a chemical weapon, first in World War I and most recently in Syria. Life-threatening Cl2 exposures frequently occur in domestic and occupational environments, and in transportation accidents. Modeling the huma ... Full text Link to item Cite

Pharmacologic Inhibition of Transient Receptor Potential Ion Channel Ankyrin 1 Counteracts 2-Chlorobenzalmalononitrile Tear Gas Agent-Induced Cutaneous Injuries.

Journal Article J Pharmacol Exp Ther · January 17, 2024 Deployment of the tear gas agent 2-chlorobenzalmalononitrile (CS) for riot control has significantly increased in recent years. The effects of CS have been believed to be transient and benign. However, CS induces severe pain, blepharospasm, lachrymation, a ... Full text Link to item Cite

Interatrial Shunt Devices.

Journal Article Heart Fail Clin · January 2024 Elevated left atrial pressure during exercise is a hallmark of heart failure (HF) and is associated with adverse left atrial remodeling and poor outcomes. To decompress the pressure-overloaded left atrium in patients with HF, several device-based approache ... Full text Link to item Cite

Development and evaluation of a mechanical ventilator-sharing system

Journal Article Frontiers in Medicine · January 1, 2024 Background: During the COVID-19 pandemic surge in the hospitalization of critically ill patients and the global demand for mechanical ventilators, alternative strategies for device sharing were explored. We developed and assessed the performance of a syste ... Full text Cite

Development of a Pleural Pressure Catheter via Continuous Fiberoptic Esophageal Pressure Measurements.

Conference Annu Int Conf IEEE Eng Med Biol Soc · July 2022 There is growing research showing the importance of measuring esophageal pressure as a surrogate for pleural pressure for patients on mechanical ventilators. The most common measurement method uses a balloon catheter, whose accuracy can vary based on patie ... Full text Link to item Cite

Protocol for non-invasive assessment of spontaneous movements of group-housed animals using remote video monitoring.

Journal Article STAR Protoc · June 17, 2022 Frequent monitoring of laboratory animals is critical for ensuring animal welfare and experimental data collection. To minimize the adverse and confounding effects caused by current monitoring protocols and human presence, we developed a low-cost, non-inva ... Full text Link to item Cite

Toxic effects of chlorine gas and potential treatments: a literature review.

Journal Article Toxicol Mech Methods · May 2021 Chlorine gas is one of the highly produced chemicals in the USA and around the world. Chlorine gas has several uses in water purification, sanitation, and industrial applications; however, it is a toxic inhalation hazard agent. Inhalation of chlorine gas, ... Full text Link to item Cite

Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets.

Journal Article Ann N Y Acad Sci · November 2020 The lung is highly sensitive to chemical injuries caused by exposure to threat agents in industrial or transportation accidents, occupational exposures, or deliberate use as weapons of mass destruction (WMD). There are no antidotes for the majority of the ... Full text Link to item Cite

Exposure biomarkers in a pig model of chlorine inhalation injury

Conference Occupational and environmental health · September 7, 2020 Full text Cite

TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation.

Journal Article Toxicol Lett · September 1, 2018 The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard (SM) that initiates a delayed injury response characterized by erythema, inflammation and severe vesication (blistering). Although SM poses a continuing threat, used ... Full text Link to item Cite

TRPA1: Acrolein meets its target.

Journal Article Toxicol Appl Pharmacol · June 1, 2017 Full text Link to item Cite

Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol.

Journal Article Br J Pharmacol · May 2017 BACKGROUND AND PURPOSE: Eucalyptol (1,8-cineol), the major ingredient in the essential oil of eucalyptus leaves and other medicinal plants, has long been known for its anti-inflammatory properties. Eucalyptol interacts with the TRP cation channels among ot ... Full text Link to item Cite

Effect of Multi Drug Resistance Protein 4 (MRP4) Inhibition on the Pharmacokinetics and Pharmacodynamics of Ciprofloxacin in Normal and Rats with LPS-Induced Inflammation.

Journal Article Eur J Drug Metab Pharmacokinet · December 2016 BACKGROUND AND OBJECTIVES: Infection and inflammation are known to cause wide variability in disposition of drugs through modulation of drug transporters. However, the effects of inhibition of multidrug resistance protein 4 (MRP4) on pharmacokinetics and p ... Full text Link to item Cite

IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy.

Journal Article Proc Natl Acad Sci U S A · November 22, 2016 Poison ivy-induced allergic contact dermatitis (ACD) is the most common environmental allergic condition in the United States. Case numbers of poison ivy ACD are increasing due to growing biomass and geographical expansion of poison ivy and increasing cont ... Full text Link to item Cite

Tear gas: an epidemiological and mechanistic reassessment.

Journal Article Ann N Y Acad Sci · August 2016 Deployments of tear gas and pepper spray have rapidly increased worldwide. Large amounts of tear gas have been used in densely populated cities, including Cairo, Istanbul, Rio de Janeiro, Manama (Bahrain), and Hong Kong. In the United States, tear gas was ... Full text Link to item Cite

Anatomical and physiological basis for the allometric scaling of cisplatin clearance in dogs.

Journal Article J Vet Pharmacol Ther · June 2016 Cisplatin is a platinum-containing cytotoxic drug indicated for the treatment of solid tumors in veterinary and human patients. Several of the algorithms used to standardize the doses of cytotoxic drugs utilize allometry, or the nonproportional relationshi ... Full text Link to item Cite

Reaction phenotyping of vinblastine metabolism in dogs.

Journal Article Vet Comp Oncol · June 2016 Vinblastine is a vinca alkaloid used either as a single agent or in combination therapy for the treatment of canine mast cell tumours and lymphomas. The objective of this study was to determine which isoform of cytochrome P450 enzyme is responsible for the ... Full text Link to item Cite

Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice.

Journal Article PLoS One · 2016 Oxidation products of the naturally occurring phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphatidylcholine (PAPC), which are known as OxPAPC, accumulate in atherosclerotic lesions and at other sites of inflammation in conditions such as septic ... Full text Link to item Cite

Comparison of Glucosamine Absorption After Administration of Oral Liquid, Chewable, and Tablet Formulations to Dogs.

Journal Article J Am Anim Hosp Assoc · 2016 Glucosamine (GS) is commonly administered as a nutritional supplement to support joint function. Although many supplements are available, the effect of formulation on oral absorption in dogs is unknown. The purpose of this study was to determine the relati ... Full text Link to item Cite

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.

Journal Article Am J Physiol Lung Cell Mol Physiol · July 15, 2014 The treatment of acute lung injury caused by exposure to reactive chemicals remains challenging because of the lack of mechanism-based therapeutic approaches. Recent studies have shown that transient receptor potential vanilloid 4 (TRPV4), an ion channel e ... Full text Link to item Cite

Simultaneous quantification of vinblastine and desacetylvinblastine concentrations in canine plasma and urine samples using LC-APCI-MS/MS.

Journal Article J Chromatogr B Analyt Technol Biomed Life Sci · January 15, 2013 A highly sensitive and specific liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (LC/APCI-MS/MS) method has been developed and validated for simultaneous quantification of vinblastine and its metabolite, desacetylvinblastine ... Full text Link to item Cite