Skip to main content

Steven Bache

Assistant Consulting Professor in the Department of Radiology
Radiology
Department of Radiology, DUMC 3808, Durham, NC 27710
Department of Radiology, 3808 DUMC, Durham, NC 27710

Selected Publications


A systematic task-based image quality assessment of photon-counting and energy integrating CT as a function of reconstruction kernel and phantom size.

Journal Article Med Phys · February 2024 BACKGROUND: Image quality of photon-counting and energy integrating CT scanners changes with object size, dose to the object, and kernel selection. PURPOSE: To comprehensively compare task-generic image quality of photon-counting CT (PCCT) and energy integ ... Full text Link to item Cite

A comparative study on the utility and choice parameters of photon-counting CT for bone quantification

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 The measurements of bone macro- and microstructures provide major insight into bone health and risk fracture. The accuracy of these measurements is limited when Conventional CT is used. However, CT technology has advanced with the introduction of photon-co ... Full text Cite

Performance assessment of photon counting versus energy integrated CT: concordance of in vivo and phantom measurements

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 Photon-counting CT (PCCT) and energy-integrating CT (EICT) system offer differing image quality attributes, but it is uncertain if such attributes manifest themselves differently across phantom vs patients. This study investigated if image quality assessme ... Full text Cite

Exploration of the pulse pileup effects in a clinical CdTe-based photon-counting computed tomography.

Journal Article Med Phys · November 2023 BACKGROUND: High tube current generates a high flux of x-rays to photon counting detectors (PCDs) that can potentially result in the piling up of pulses formed by concurrent photons, which can cause count loss and energy resolution degradation. PURPOSE: To ... Full text Link to item Cite

Quantitative performance of photon-counting CT at low dose: Virtual monochromatic imaging and iodine quantification.

Journal Article Med Phys · September 2023 BACKGROUND: Quantitative imaging techniques, such as virtual monochromatic imaging (VMI) and iodine quantification (IQ), have proven valuable diagnostic methods in several specific clinical tasks such as tumor and tissue differentiation. Recently, a new ge ... Full text Link to item Cite

A methodology for incorporating a photon-counting CT system into routine clinical use.

Journal Article J Appl Clin Med Phys · August 2023 Photon-counting computed tomography (PCCT) systems are increasingly available in the U.S. following Food and Drug Administration (FDA) approval of the first clinical PCCT system in Fall 2021. Consequently, there will be a need to incorporate PCCTs into exi ... Full text Link to item Cite

Pediatric Applications of Photon-Counting Detector CT.

Journal Article AJR Am J Roentgenol · April 2023 Photon-counting detector (PCD) CT represents the most recent generational advance in CT technology. PCD CT has the potential to reduce image noise, improve spatial resolution and contrast resolution, and provide multispectral capability, all of which may b ... Full text Link to item Cite

Effect of tube current on computed tomography radiomic features.

Journal Article Scientific reports · February 2018 Variability in the x-ray tube current used in computed tomography may affect quantitative features extracted from the images. To investigate these effects, we scanned the Credence Cartridge Radiomics phantom 12 times, varying the tube current from 25 to 30 ... Full text Cite

Quantitation of tumor uptake with molecular breast imaging.

Journal Article Medical physics · September 2017 PurposeWe developed scatter and attenuation-correction techniques for quantifying images obtained with Molecular Breast Imaging (MBI) systems.MethodsTo investigate scatter correction, energy spectra of a 99m Tc point source wer ... Full text Cite

Quantitation of clinical feedback on image quality differences between two CT scanner models.

Journal Article Journal of applied clinical medical physics · March 2017 The aim of this work was to quantitate differences in image quality between two GE CT scanner models - the LightSpeed VCT ("VCT") and Discovery HD750 ("HD") - based upon feedback from radiologists at our institution. First, 3 yrs of daily QC images of the ... Full text Cite

TH‐CD‐207B‐12: Quantification of Clinical Feedback On Image Quality Differences Between Two CT Scanner Models

Conference Medical Physics · June 2016 Purpose:This work sought to quantify a radiology team's assessment of image quality differences between two CT scanner models currently in clinical use, with emphasis on noise and low‐contrast detectability (LCD). ... Full text Cite

SU‐G‐206‐08: How Should Focal Spot Be Chosen for Optimized CT Imaging with Dose Modulation?

Conference Medical Physics · June 2016 Purpose:To choose the preferred focal spot for achieving optimized CT image quality with balanced tube heating considerations.Methods:An anthropomorph ... Full text Cite

SU‐G‐206‐02: Impact of Focal Spot Sizes On CT Image Quality

Conference Medical Physics · June 2016 Purpose:To quantify a radiology team's assessment of image quality differences between two CT scanner models currently in clinical use, with emphasis on spatial resolution that could be impacted by focal spot size ... Full text Cite

Optical-CT 3D Dosimetry Using Fresnel Lenses with Minimal Refractive-Index Matching Fluid.

Journal Article PLoS One · 2016 Telecentric optical computed tomography (optical-CT) is a state-of-the-art method for visualizing and quantifying 3-dimensional dose distributions in radiochromic dosimeters. In this work a prototype telecentric system (DFOS-Duke Fresnel Optical-CT Scanner ... Full text Open Access Link to item Cite

Quantification of tumor uptake with molecular breast imaging (MBI)

Conference EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING · 2016 Cite

A systematic task-based image quality assessment of photon-counting and energy integrating CT as a function of reconstruction kernel and phantom size.

Journal Article Med Phys · February 2024 BACKGROUND: Image quality of photon-counting and energy integrating CT scanners changes with object size, dose to the object, and kernel selection. PURPOSE: To comprehensively compare task-generic image quality of photon-counting CT (PCCT) and energy integ ... Full text Link to item Cite

A comparative study on the utility and choice parameters of photon-counting CT for bone quantification

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 The measurements of bone macro- and microstructures provide major insight into bone health and risk fracture. The accuracy of these measurements is limited when Conventional CT is used. However, CT technology has advanced with the introduction of photon-co ... Full text Cite

Performance assessment of photon counting versus energy integrated CT: concordance of in vivo and phantom measurements

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2024 Photon-counting CT (PCCT) and energy-integrating CT (EICT) system offer differing image quality attributes, but it is uncertain if such attributes manifest themselves differently across phantom vs patients. This study investigated if image quality assessme ... Full text Cite

Exploration of the pulse pileup effects in a clinical CdTe-based photon-counting computed tomography.

Journal Article Med Phys · November 2023 BACKGROUND: High tube current generates a high flux of x-rays to photon counting detectors (PCDs) that can potentially result in the piling up of pulses formed by concurrent photons, which can cause count loss and energy resolution degradation. PURPOSE: To ... Full text Link to item Cite

Quantitative performance of photon-counting CT at low dose: Virtual monochromatic imaging and iodine quantification.

Journal Article Med Phys · September 2023 BACKGROUND: Quantitative imaging techniques, such as virtual monochromatic imaging (VMI) and iodine quantification (IQ), have proven valuable diagnostic methods in several specific clinical tasks such as tumor and tissue differentiation. Recently, a new ge ... Full text Link to item Cite

A methodology for incorporating a photon-counting CT system into routine clinical use.

Journal Article J Appl Clin Med Phys · August 2023 Photon-counting computed tomography (PCCT) systems are increasingly available in the U.S. following Food and Drug Administration (FDA) approval of the first clinical PCCT system in Fall 2021. Consequently, there will be a need to incorporate PCCTs into exi ... Full text Link to item Cite

Pediatric Applications of Photon-Counting Detector CT.

Journal Article AJR Am J Roentgenol · April 2023 Photon-counting detector (PCD) CT represents the most recent generational advance in CT technology. PCD CT has the potential to reduce image noise, improve spatial resolution and contrast resolution, and provide multispectral capability, all of which may b ... Full text Link to item Cite

Effect of tube current on computed tomography radiomic features.

Journal Article Scientific reports · February 2018 Variability in the x-ray tube current used in computed tomography may affect quantitative features extracted from the images. To investigate these effects, we scanned the Credence Cartridge Radiomics phantom 12 times, varying the tube current from 25 to 30 ... Full text Cite

Quantitation of tumor uptake with molecular breast imaging.

Journal Article Medical physics · September 2017 PurposeWe developed scatter and attenuation-correction techniques for quantifying images obtained with Molecular Breast Imaging (MBI) systems.MethodsTo investigate scatter correction, energy spectra of a 99m Tc point source wer ... Full text Cite

Quantitation of clinical feedback on image quality differences between two CT scanner models.

Journal Article Journal of applied clinical medical physics · March 2017 The aim of this work was to quantitate differences in image quality between two GE CT scanner models - the LightSpeed VCT ("VCT") and Discovery HD750 ("HD") - based upon feedback from radiologists at our institution. First, 3 yrs of daily QC images of the ... Full text Cite

TH‐CD‐207B‐12: Quantification of Clinical Feedback On Image Quality Differences Between Two CT Scanner Models

Conference Medical Physics · June 2016 Purpose:This work sought to quantify a radiology team's assessment of image quality differences between two CT scanner models currently in clinical use, with emphasis on noise and low‐contrast detectability (LCD). ... Full text Cite

SU‐G‐206‐08: How Should Focal Spot Be Chosen for Optimized CT Imaging with Dose Modulation?

Conference Medical Physics · June 2016 Purpose:To choose the preferred focal spot for achieving optimized CT image quality with balanced tube heating considerations.Methods:An anthropomorph ... Full text Cite

SU‐G‐206‐02: Impact of Focal Spot Sizes On CT Image Quality

Conference Medical Physics · June 2016 Purpose:To quantify a radiology team's assessment of image quality differences between two CT scanner models currently in clinical use, with emphasis on spatial resolution that could be impacted by focal spot size ... Full text Cite

Optical-CT 3D Dosimetry Using Fresnel Lenses with Minimal Refractive-Index Matching Fluid.

Journal Article PLoS One · 2016 Telecentric optical computed tomography (optical-CT) is a state-of-the-art method for visualizing and quantifying 3-dimensional dose distributions in radiochromic dosimeters. In this work a prototype telecentric system (DFOS-Duke Fresnel Optical-CT Scanner ... Full text Open Access Link to item Cite

Quantification of tumor uptake with molecular breast imaging (MBI)

Conference EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING · 2016 Cite

SU‐E‐I‐22: A Comprehensive Investigation of Noise Variations Between the GE Discovery CT750 HD and GE LightSpeed VCT

Conference Medical Physics · June 2015 Purpose:To quantify and compare the noise properties between two GE CT models‐the Discovery CT750 HD (aka HD750) and LightSpeed VCT, with the overall goal of assessing the impact in clinical diagnostic practice. Full text Cite

Investigating the accuracy of microstereotactic-body-radiotherapy utilizing anatomically accurate 3D printed rodent-morphic dosimeters.

Journal Article Med Phys · February 2015 PURPOSE: Sophisticated small animal irradiators, incorporating cone-beam-CT image-guidance, have recently been developed which enable exploration of the efficacy of advanced radiation treatments in the preclinical setting. Microstereotactic-body-radiation- ... Full text Link to item Cite

Investigation of a low-cost optical-CT system with minimal refractive index-matching fluid

Conference Journal of Physics: Conference Series · January 1, 2015 Optical computed tomography (optical-CT) is a method for visualizing 3dimensional dose distributions in radiochromic dosimeters. Projection images are acquired by collimating a visible light point source into parallel-beam geometry and imaging differential ... Full text Cite

SU-C-BRE-04: Microbeam-Radiation-Therapy (MRT): Characterizing a Novel MRT Device Using High Resolution 3D Dosimetry.

Journal Article Med Phys · June 2014 PURPOSE: The feasibility of MRT has recently been demonstrated utilizing a new technology of Carbon-Nano-Tube(CNT) field emission x-ray sources. This approach can deliver very high dose(10's of Gy) in narrow stripes(sub-mm) of radiation which enables the s ... Full text Link to item Cite

WE-F-16A-04: Micro-Irradiator Treatment Verification with High-Resolution 3D-Printed Rodent-Morphic Dosimeters.

Journal Article Med Phys · June 2014 PURPOSE: Pre-clinical micro-radiation therapy studies often utilize very small beams (∼0.5-5mm), and require accurate dose delivery in order to effectively investigate treatment efficacy. Here we present a novel high-resolution absolute 3D dosimetry proced ... Full text Link to item Cite

SU-E-J-164: An Investigation of a Low-Cost 'dry' Optical-CT Scanning System for 3D Dosimetry.

Journal Article Med Phys · June 2014 PURPOSE: To characterize and explore the efficacy of a novel low-cost, lowfluid, broad-beam optical-CT system for 3D-dosimetry in radiochromic Presage dosimeters. Leading current optical-CT systems incorporate expensive glass-based telecentric lens technol ... Full text Link to item Cite

Investigating end-to-end accuracy of image guided radiation treatment delivery using a micro-irradiator.

Journal Article Phys Med Biol · November 7, 2013 There is significant interest in delivering precisely targeted small-volume radiation treatments, in the pre-clinical setting, to study dose-volume relationships with tumour control and normal tissue damage. For these studies it is vital that image guidanc ... Full text Link to item Cite

WE-E-108-09: An Investigation of the Feasibility of Rodentmorphic 3D Dosimeters for Verification of Precision Micro-Irradiator Treatment.

Journal Article Med Phys · June 2013 PURPOSE: To evaluate the feasibility of novel rodentmorphic 3D dosimeters for comprehensive high-resolution verification of the treatment accuracy of a state-of-the-art micro-irradiator equipped with on-line cone-beam-CT guidance. METHODS: Anatomically acc ... Full text Link to item Cite