Scholars@Duke
Suhail Kamrudin Mithani

Suhail Kamrudin Mithani

Associate Professor of Surgery
Surgery, Plastic, Maxillofacial, and Oral Surgery

Selected Publications

Two Thumbs Down: A 10-Year Analysis of Crossbow-Related Hand and Digit Injuries in the United States.

Journal Article Hand (N Y) · October 2024 BACKGROUND: Modern crossbow is a popular weapon used throughout the United States for outdoor recreation. Crossbow mechanics place the hand and digits at significant risk of injury while shooting or handling these weapons; however, injury patterns have bee ... Full text Link to item Cite

Contemporary Management of Distal Radius Fractures: What All Plastic Surgeons Should Know.

Journal Article Plast Reconstr Surg · September 4, 2024 Distal radius fractures are extremely common. Plastic surgery trainees and practicing surgeons who encounter these patients should be familiar with the various treatment options. Although the volar locking plate has revolutionized treatment of these fractu ... Full text Link to item Cite

Comparison of Low-Dose Computed Tomography Versus Conventional-Dose Computed Tomography in the Evaluation of Distal Radius Fractures.

Journal Article Hand (N Y) · March 7, 2024 BACKGROUND: Distal radius fractures (DRFs) are common upper extremity fractures and often require surgical fixation when they are intraarticular. Preoperative computed tomography (CT) has emerged as a surgical planning tool to evaluate intraarticular DRFs. ... Full text Link to item Cite

Comparison Between Intramedullary Nail and Percutaneous Pin Fixation in Proximal Phalanx Fractures.

Journal Article Hand (N Y) · February 27, 2024 BACKGROUND: Percutaneous pinning has been the predominant technique for fixation of proximal phalanx fractures, but stiffness is a reported complication. The introduction of intramedullary (IM) nail fixation of proximal phalanx fractures provides a stronge ... Full text Link to item Cite

Soft tissue reconstruction of achilles-tendon-associated wounds

Chapter · February 23, 2024 Soft tissue defects overlying the Achilles tendon pose a distinct challenge for both orthopedic and reconstructive surgeons. Stable soft tissue coverage facilitates proper tendon excursion, prevents desiccation, and provides durable tissue for shoe wearing ... Full text Cite

The mangled upper extremity: a principled approach to management

Journal Article Plastic and Aesthetic Research · January 1, 2024 A mangled upper extremity often involves injury to soft tissue, bone, nerves, and vessels and presents a unique challenge to hand surgeons. The complexity of such injuries requires a multidisciplinary approach to achieve an optimal functional outcome. Afte ... Full text Cite

Underrepresentation of African Americans in Plastic Surgery: Examining Demographics, Specialty Factors, and Medical School Experiences.

Journal Article J Surg Educ · December 2023 BACKGROUND: Racial representation among medical trainees translates into physicians that are able to communicate with diverse patient populations and are perceptive to health disparities. This is important within plastic surgery where an optimal physicianp ... Full text Link to item Cite

Advances in Soft Tissue Injuries Associated with Open Fractures.

Journal Article Hand Clin · November 2023 Management of soft tissue injury is a key component in the overall treatment of upper extremity fractures. Hand surgeons must rely on their armamentarium for treating soft tissue deficits for functional outcomes. Understanding the role of fracture fixation ... Full text Link to item Cite

A Multicenter Prospective Randomized Comparison of Conduits Versus Decellularized Nerve Allograft for Digital Nerve Repairs.

Journal Article J Hand Surg Am · September 2023 PURPOSE: While there are advantages and disadvantages to both processed nerve allografts (PNA) and conduits, a large, well-controlled prospective study is needed to compare the efficacy and to delineate how each of these repair tools can be best applied to ... Full text Link to item Cite

Management of Complex Hand and Wrist Ligament Injuries.

Journal Article Hand Clin · August 2023 Ligamentous injuries in the hand and wrist are often underdiagnosed and can present with significant functional limitations if there is untimely recognition of injury. Adequate repair or reconstruction is critical in restoring joint stability and mobility. ... Full text Link to item Cite

Recalcitrant Neuropathies in the Upper Extremity.

Journal Article J Hand Surg Glob Online · July 2023 Carpal and cubital tunnel syndrome can cause debilitating pain and weakness in the hand and upper extremities. Although most patients have a resolution of their symptoms after primary decompression, managing those with recalcitrant neuropathies is challeng ... Full text Link to item Cite

Variations in Incidence of Trigger Finger and Response to Corticosteroid Injection after Aromatase Inhibitor Therapy for Breast Cancer.

Journal Article Plast Reconstr Surg · May 1, 2023 BACKGROUND: Aromatase inhibitors (AIs), such as letrozole and anastrozole, have been demonstrated to have significant musculoskeletal symptoms in patients. The purpose of this study was to evaluate the effect of specific AI medications on the incidence of ... Full text Link to item Cite

Dermal Regenerative Templates in Orthopaedic Surgery.

Journal Article J Am Acad Orthop Surg · April 1, 2023 Management of soft-tissue injuries is a critical principle in the treatment of orthopaedic trauma. Understanding the options for soft-tissue reconstruction is vital for successful patient outcomes. Application of dermal regenerative templates (DRTs) in tra ... Full text Link to item Cite

Recent Smoking History Is Not Associated with Adverse 30-Day Standardized Postoperative Outcomes following Microsurgical Reconstructive Procedures of the Upper Extremity.

Journal Article Plast Surg (Oakv) · February 2023 Background: Upper extremity (UE) microsurgical reconstruction relies upon proper wound healing for optimal outcomes. Cigarette smoking is associated with wound healing complications, yet conclusions vary regarding impact on microsurgical outcomes (replanta ... Full text Link to item Cite

Relative Increase in Distal Radius Exposure with Extension of the FCR Approach.

Journal Article Arch Bone Jt Surg · 2023 OBJECTIVES: Major surgical approaches for volar plating of the distal radius include the standard flexor carpi radialis (FCR) approach, the extended FCR (eFCR) approach, and the extended FCR approach combined with radial-sided carpal tunnel release (eFCR+C ... Full text Link to item Cite

3D-Printed Total Talus Replacement After Free Vascularized Medial Femoral Condyle Osteocutaneous Flap for Avascular Necrosis of the Talus Leads to Poor Clinical Outcomes: A Case Series.

Journal Article Foot Ankle Spec · December 8, 2022 INTRODUCTION: Avascular necrosis (AVN) of the talus is 1 of the most difficult foot and ankle pathologies to diagnose and manage. The purpose of this study was to report on the functional outcomes of 3D-printed total talus replacement (TTR) in 2 patients w ... Full text Link to item Cite

Addressing Surgical Instrument Oversupply: A Focused Literature Review and Case-Study in Orthopedic Hand Surgery.

Journal Article Hand (N Y) · November 2022 BACKGROUND: Instrument oversupply drives cost in the operating room (OR). We review previously reported methodologies for surgical instrument reduction and report a pilot methodology for optimizing instrument supply via ethnographic instrument tracking of ... Full text Link to item Cite

Intraoperative angiography imaging correlates with wound complications following soft tissue sarcoma resection.

Journal Article J Orthop Res · October 2022 For soft tissue sarcoma patients receiving preoperative radiation therapy, wound complications are common and potentially devastating. The purpose of this study was to assess the feasibility of intraoperative indocyanine green fluorescent angiography (ICGA ... Full text Link to item Cite

Arthroscopic TFCC Ulnar Bone Tunnel Foveal Repair in Adult Patients.

Journal Article Arthrosc Tech · October 2022 Triangular fibrocartilage complex (TFCC) tears may cause persistent ulnar-sided wrist pain, loss of grip strength, and associated loss of function. Although the majority of TFCC tears can be treated nonoperatively, surgical repair is considered when conser ... Full text Link to item Cite

Primary Targeted Muscle Reinnervation after Below-Knee Amputation Is Not Associated with an Increased Risk of Major or Minor Surgical Complications: A Multi-Institutional, Propensity Score-Matched Analysis.

Journal Article Plast Reconstr Surg · September 1, 2022 BACKGROUND: Targeted muscle reinnervation has emerged as a technique to reduce neuroma and phantom limb pain after below-knee amputation; however, the incidence of postoperative complications remains unknown. This multi-institutional study assessed the ris ... Full text Link to item Cite

Outcomes associated with proton pump inhibitors and distal radius fractures: A post-hoc comparative analysis.

Journal Article J Plast Reconstr Aesthet Surg · August 2022 UNLABELLED: Long-term, high-dose, daily proton pump inhibitors (PPI) may impact outcomes associated with distal radius fractures (DRF). The hypothesis was that differences existed in patient demographics, but there existed no differences in injury patterns ... Full text Link to item Cite

Symptom Duration and Diabetic Control Influence Success of Steroid Injection in Trigger Finger.

Journal Article Plast Reconstr Surg · August 1, 2022 BACKGROUND: Trigger finger is one of the most common hand abnormalities, with a prevalence of 2 percent of the general population. Conservative treatment with corticosteroid injections at the A1 pulley has been shown to be a cost-effective first-line treat ... Full text Link to item Cite

Return to Activities After Simultaneous Bilateral Endoscopic Carpal Tunnel Release.

Journal Article Hand (N Y) · July 2022 BACKGROUND: Approximately 56% of patients diagnosed with carpal tunnel syndrome present with bilateral symptoms; however, few studies have investigated bilateral simultaneous endoscopic carpal tunnel release (ECTR) and postoperative effect on return to act ... Full text Link to item Cite

Upper Extremity Free Flap Transfers: An Analysis of the National Surgical Quality Improvement Program Database.

Journal Article J Hand Microsurg · July 2022 Introduction  We evaluated the demographics, flap types, and 30-day complication, readmission, and reoperation rates for upper extremity free flap transfers within the National Surgical Quality Improvement Program (NSQIP) database. Materials and Methods  U ... Full text Link to item Cite

Achilles: Failed Acute Repair.

Journal Article Foot Ankle Clin · June 2022 Acute Achilles tendon ruptures are commonly managed with surgical repair. This particular surgery is prone to rerupture, wound complications, deep vein thrombosis, and sural nerve injuries. In this chapter the authors discuss complications, how to avoid th ... Full text Link to item Cite

A Reliability Study of Multiplanar Radiographs for the Evaluation of SNAC Wrist Arthritis.

Journal Article Hand (N Y) · May 2022 Background: Scaphoid nonunion advanced collapse (SNAC) is a common form of wrist arthritis, the treatment of which depends on the arthritic stage. The Vender classification serves to describe SNAC arthritis based on a single posteroanterior (PA) radiograph ... Full text Link to item Cite

Isolated Scaphoid Dislocation With Radial-Axial Instability: A Treatment Strategy Utilizing Spanning Wrist Plates.

Journal Article J Hand Surg Am · March 2022 Isolated dislocation of the scaphoid is a rare injury with only a few case reports in the literature. We report on 2 complex scaphoid dislocations demonstrating concomitant axial instability with disruption of the capitohamate articulation as well as the l ... Full text Link to item Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Evaluating Treatment Preferences and Perceptions of a Prosthetic Versus a Transplanted Hand: A Conjoint Analysis-Based Study.

Journal Article Ann Plast Surg · January 1, 2022 INTRODUCTION: This study used a conjoint analysis-based survey to assess which factors are most influential when considering treatment with a prosthesis or transplant after a unilateral hand amputation. METHODS: Overall, 469 respondents were recruited usin ... Full text Link to item Cite

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.

Journal Article Br J Anaesth · December 2021 BACKGROUND: Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. METHODS: We enrolled 140 English-speaking patients ≥60 yr old scheduled fo ... Full text Open Access Link to item Cite

Patient Perspectives on the Cost of Hand Surgery.

Journal Article J Bone Joint Surg Am · November 17, 2021 BACKGROUND: Health-care expenditures in the U.S. are continually rising, prompting providers, patients, and payers to search for solutions to reduce costs while maintaining quality. The present study seeks to define the out-of-pocket price that patients un ... Full text Link to item Cite

Autologous Osteoligamentous Reconstruction of Scaphoid Proximal Pole With Metatarsal Head and Collateral Ligament: Cadaver Anatomic Description of Novel Surgical Technique.

Journal Article Hand (N Y) · November 2021 Background: Historically, scaphoid nonunion has been surgically treated with vascularized bone graft taken from multiple different anatomic sites. However, none of these grafts fully recapitulate the unique osteoligamentous anatomy of the proximal pole of ... Full text Link to item Cite

A Cluster of Nontuberculous Mycobacterial Tenosynovitis Following Hurricane Relief Efforts.

Journal Article Clin Infect Dis · June 15, 2021 BACKGROUND: Nontuberculous mycobacteria (NTM) are a rare cause of infectious tenosynovitis of the upper extremity. Using molecular methods, clinical microbiology laboratories are increasingly reporting identification down to the species level. Improved met ... Full text Open Access Link to item Cite

Incidence and Risk Factors for Flap Coverage After Total Ankle Arthroplasty.

Journal Article Foot Ankle Int · June 2021 BACKGROUND: Wound complications following total ankle arthroplasty (TAA) can have a significant impact on patient morbidity, particularly when they require flap coverage. We sought to determine the risk factors associated with the need for flap coverage af ... Full text Link to item Cite

Complications of Low-Profile Plate Fixation of Phalanx Fractures.

Journal Article Hand (N Y) · March 2021 Background: Phalanx fractures are common, and plate fixation can be used to treat difficult fractures. Major complications have been reported in up to 64% of phalanx fractures treated with plate fixation, with stiffness being the most common. Low-profile a ... Full text Link to item Cite

The Critical Portions of Carpal Tunnel Surgery: A Comparison Between Opinions of Surgeons and the General Public.

Journal Article J Hand Surg Am · March 2021 PURPOSE: Attending surgeons must participate in critical and key portions of procedures and otherwise be immediately available. However, surgeon-defined standards of the critical and key portions of surgery have been questioned, potentially affecting train ... Full text Link to item Cite

Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.

Journal Article Sci Rep · February 4, 2021 Arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) derived lipids play key roles in initiating and resolving inflammation. Neuro-inflammation is thought to play a causal role in perioperative neurocognitive disorders, yet th ... Full text Open Access Link to item Cite

Complications of Low-Profile Plate Fixation in Metacarpal Fractures.

Journal Article Orthopedics · January 1, 2021 High complication rates have been reported using conventional plating systems to treat metacarpal fractures. This study investigated complication rates in metacarpal fractures treated with low-profile anatomic plates. A retrospective chart review was perfo ... Full text Link to item Cite

Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2021 BACKGROUND: Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1-12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized to result from neuroinflammation; ... Full text Open Access Link to item Cite

Increased Rate of Complications following Trigger Finger Release in Diabetic Patients.

Journal Article Plast Reconstr Surg · October 2020 BACKGROUND: The purpose of this study was to investigate the impact of diabetes on complications after open trigger finger release compared with a cohort matched for age, sex, race, and body mass index class. METHODS: A retrospective chart review was perfo ... Full text Link to item Cite

Surgical Techniques for Revascularization in Abdominal Wall Transplantation.

Journal Article J Reconstr Microsurg · September 2020 BACKGROUND:  Abdominal wall vascularized composite allotransplantation (AW-VCA) can be considered as a technically feasible option for abdominal wall reconstruction in patients whose abdomen cannot be closed using traditional methods. However, successful i ... Full text Open Access Link to item Cite

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Journal Article J Neurol · July 2020 OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort st ... Full text Link to item Cite

Synchronous Abdominal Wall and Small-bowel Transplantation: A 1-year Follow-up.

Journal Article Plast Reconstr Surg Glob Open · July 2020 Abdominal wall-vascularized composite allotransplantation (AW-VCA) has evolved as a technically feasible but challenging option in the rare event of abdominal wall reconstruction in patients whose abdomen cannot be closed by applying conventional methods. ... Full text Open Access Link to item Cite

Hand transplantation in the United States: A review of the Organ Procurement and Transplantation Network/United Network for Organ Sharing Database.

Journal Article Am J Transplant · May 2020 Hand transplantation is the most common application of vascularized composite allotransplantation (VCA). Since July 3, 2014, VCAs were added to the definition of organs covered by federal regulation (the Organ Procurement and Transplantation Network (OPTN) ... Full text Link to item Cite

Integrated Compression Screw Stabilization of the Dorsal Lunate Facet in Intra-Articular Distal Radius Fractures.

Journal Article J Hand Surg Am · April 2020 PURPOSE: To evaluate outcomes of intra-articular distal radius fractures with displaced dorsal lunate facet fragments treated with a combination of volar plating and the use of a dorsal screw that integrates into the plate. METHODS: We reviewed a retrospec ... Full text Link to item Cite

Open Reduction Internal Fixation With Transverse Volar Plating for Unstable Proximal Interphalangeal Fracture-Dislocation: The Seatbelt Procedure.

Journal Article Hand (N Y) · March 2020 Background: Unstable intra-articular proximal interphalangeal (PIP) joint fracture-dislocations present a difficult problem that requires congruous joint reduction and stable internal fixation or distraction. Though fractures with limited articular involve ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.

Journal Article Anesth Analg · November 2019 Animal models suggest postoperative cognitive dysfunction may be caused by brain monocyte influx. To study this in humans, we developed a flow cytometry panel to profile cerebrospinal fluid (CSF) samples collected before and after major noncardiac surgery ... Full text Open Access Link to item Cite

Elevated Preoperative Hemoglobin A1c Associated with Increased Wound Complications in Diabetic Patients Undergoing Primary, Open Carpal Tunnel Release.

Journal Article Plast Reconstr Surg · October 2019 BACKGROUND: An increased rate of complications has been demonstrated with increasing hemoglobin A1c value for a variety of orthopedic procedures, including arthroplasty and spine surgery. The authors investigated the effects of elevated hemoglobin A1c valu ... Full text Link to item Cite

Management of Recalcitrant Carpal Tunnel Syndrome.

Journal Article J Am Acad Orthop Surg · August 1, 2019 Recalcitrant carpal tunnel syndrome presents a clinical challenge. Potential etiologies of persistent or recurrent symptoms after primary carpal tunnel release include incomplete nerve decompression, secondary sites of nerve compression, unrecognized anato ... Full text Link to item Cite

Small bowel and abdominal wall transplantation: A novel technique for synchronous revascularization.

Journal Article Am J Transplant · July 2019 Abdominal wall transplantation (AWT) was introduced in 1999 in the context of reconstruction of complex abdominal wall defects in conjunction with visceral organ transplantation. As of recently, 38 cases of total AWT have been performed worldwide, about ha ... Full text Link to item Cite

The Utilization of Video Technology in Surgical Education: A Systematic Review.

Journal Article J Surg Res · March 2019 BACKGROUND: The use of surgical video has great potential to enhance surgical education, but there exists limited information about how to effectively use surgical videos. We performed a systematic review of video technology in surgical training and provid ... Full text Link to item Cite

Matched Cohort Study of Wound-Healing Complications in Patients With and Without Diabetes Mellitus After Primary Open Carpal Tunnel Release

Journal Article Journal of Hand Surgery Global Online · January 1, 2019 Purpose: Diabetes mellitus (DM)is associated with increased rates of wound complications and reduced improvement in patient-reported outcomes across a wide range of surgical disciplines, although the impact of DM is less known after primary carpal tunnel r ... Full text Cite

Neural Perforasomes of the Upper Extremity.

Journal Article Plast Reconstr Surg · December 2018 BACKGROUND: In the setting of the rapid advancement of integumentary vascular knowledge, the authors hypothesized that the extrinsic blood supply to the major peripheral nerves of the upper extremity could be categorized into discrete neural "perforasomes. ... Full text Link to item Cite

The Sigmoid Notch View for Distal Radius Fractures.

Journal Article J Hand Surg Am · November 2018 PURPOSE: This study defines the sigmoid notch view of the distal radius. Specifically, we tested the null hypothesis that there is no relationship between the subchondral stripe of bone seen on a sigmoid notch view of the distal radius and the articular su ... Full text Link to item Cite

Conjoint Analysis of Treatment Preferences for Nondisplaced Scaphoid Fractures.

Journal Article J Hand Surg Am · July 2018 PURPOSE: We used conjoint analysis to assess the relative importance of factors that influence a patient's decision between surgical or nonsurgical management of a nondisplaced scaphoid fracture. Our hypothesis was that out-of-pocket costs will have a grea ... Full text Link to item Cite

Forearm-Based Turnover Muscle Flaps for Elbow Soft-Tissue Reconstruction: A Comparison of Regional Coverage Based on Distal Flap Perfusion.

Journal Article Plast Reconstr Surg · July 2018 BACKGROUND: Elbow wounds pose a reconstructive challenge. Prior studies have described the vascular anatomy of both the brachioradialis and flexor carpi ulnaris muscle flaps. The goal of this study was to describe the distal flap perfusion of the flexor ca ... Full text Link to item Cite

Management of Achilles Tendon Rupture Complications.

Journal Article Instr Course Lect · February 15, 2018 The management of Achilles tendon rupture complications has always been a challenge. Rerupture, infection, wound problems, suture reaction, weakness as a result of Achilles tendon lengthening, sural nerve injury, and thrombosis are the most common complica ... Link to item Cite

Application of a Modified Pedicled Adipofascial Lateral Arm Flap in the Prevention and Treatment of Radial Nerve Injuries.

Journal Article Tech Hand Up Extrem Surg · December 2017 The fasciocutaneous lateral arm flap is a workhorse flap in upper extremity reconstruction. However, its adipofascial variant is not widely used. The technique can be used in various clinical scenarios. The adipofascial flap can be transposed to circumfere ... Full text Link to item Cite

Outcomes of sympathectomy and vascular bypass for digital ischaemia in connective tissue disorders.

Journal Article J Hand Surg Eur Vol · October 2017 UNLABELLED: All patients (36 hands) with connective tissue disorders who underwent periarterial sympathectomy of the hand alone or in conjunction with vascular bypass at our institution between 1995-2013 were reviewed. The durable resolution of ulcers was ... Full text Link to item Cite

Soft Tissue Reconstruction After Total Ankle Arthroplasty.

Journal Article Foot Ankle Clin · June 2017 Wound complications following total ankle replacement are common. A team approach, including plastic surgeons, should be utilized to manage these wound issues. The handling of the wound, from the index procedure, to a variety of flaps, can be utilized to p ... Full text Link to item Cite

Single-Stage Bipedicle Local Tissue Transfer and Skin Graft for Achilles Tendon Surgery Wound Complications.

Journal Article Foot Ankle Spec · February 2017 INTRODUCTION: Achilles tendon and posterior heel wound complications are difficult to treat. These typically require soft tissue coverage via microvascular free tissue transfer at a tertiary referral center. Here, we describe coverage of a series of poster ... Full text Link to item Cite

Iatrogenic Arteriovenous Fistula With Associated Pseudoaneurysm of Posterior Tibial Artery After Revision Total Ankle Arthroplasty: A Case Report.

Journal Article J Foot Ankle Surg · 2017 Iatrogenic vascular injuries in elective orthopedic surgery are rare. However, these are important complications to recognize early and treat appropriately because the potential sequelae can be devastating. Arteriovenous fistula of the lower extremity afte ... Full text Link to item Cite

Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.

Journal Article Front Syst Neurosci · 2017 Each year over 16 million older Americans undergo general anesthesia for surgery, and up to 40% develop postoperative delirium and/or cognitive dysfunction (POCD). Delirium and POCD are each associated with decreased quality of life, early retirement, incr ... Full text Open Access Link to item Cite

Biomechanical Comparison of Suture-Button Suspensionplasty and LRTI for Basilar Thumb Arthritis.

Journal Article Hand (N Y) · December 2016 Background: The purpose of this study was to compare the initial biomechanical strength of trapeziectomy and suture-button suspensionplasty (SBS) with ligament reconstruction and tendon interposition (LRTI) for thumb carpometacarpal (CMC) arthritis in a ca ... Full text Link to item Cite

Major Peripheral Nerve Injuries After Elbow Arthroscopy.

Journal Article Arthroscopy · June 2016 PURPOSE: To survey the American Society for Surgery of the Hand membership to determine the nature and distribution of nerve injuries treated after elbow arthroscopy. METHODS: An online survey was sent to all members of the American Society for Surgery of ... Full text Link to item Cite

In Situ Venous Bypass for Chronic Hand Ischemia: A Review of 25 Cases in 23 Patients.

Journal Article Ann Plast Surg · June 2016 BACKGROUND: Chronic ischemia of the hand in the setting of atherosclerotic disease is a challenging problem that leads to serial amputations and significant morbidity. Salvage using an in situ venous bypass has been described. In selected cases, leaving th ... Full text Link to item Cite

An outcomes analysis of 2142 breast reduction procedures.

Journal Article Ann Plast Surg · March 2015 BACKGROUND: Breast reduction alleviates macromastia symptoms and facilitates symmetrical breast reconstruction after cancer treatment. We investigated a large series of consecutive breast reductions to study important factors that impact outcomes. METHODS: ... Full text Link to item Cite

A comparison of débridement with and without anconeus muscle flap for treatment of refractory lateral epicondylitis.

Journal Article J Shoulder Elbow Surg · February 2015 BACKGROUND: Lateral epicondylitis is a common condition encountered by orthopedic surgeons. Whereas the majority of patients improve with conservative management, a small percentage will require surgery. The purpose of this study was to compare the clinica ... Full text Link to item Cite

Analysis of radiographically confirmed blunt-mechanism facial fractures.

Journal Article J Craniofac Surg · January 2014 Facial fractures resulting from blunt-mechanism trauma, although common, have been infrequently evaluated in large studies that do not include confirmation of fractures based on author review of available patient radiographic studies. An 8-year review (199 ... Full text Link to item Cite

Facial fractures of the upper craniofacial skeleton predict mortality and occult intracranial injury after blunt trauma: an analysis.

Journal Article J Craniofac Surg · November 2013 PURPOSE: The aim of this article was to assess how regional facial fracture patterns predict mortality and occult intracranial injury after blunt trauma. METHODS: Retrospective chart review was performed for blunt-mechanism craniofacial fracture patients w ... Full text Link to item Cite

Isolated ulnar shortening osteotomy for the treatment of extra-articular distal radius malunion.

Journal Article J Hand Surg Am · June 2013 PURPOSE: To report the clinical outcomes and complications for a cohort of patients who had extra-articular distal radius malunions treated with isolated ulnar-shortening osteotomy (USO). A second purpose was to define the dorsal angulation limit that woul ... Full text Link to item Cite

Increasing age impairs outcomes in breast reduction surgery.

Journal Article Plast Reconstr Surg · December 2011 BACKGROUND: Although multiple breast reduction outcomes studies have been performed, none has specifically identified the impact of advanced age. The authors aimed to study the impact of age on breast reduction outcome. METHODS: Medical records for all pat ... Full text Link to item Cite

Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma.

Journal Article Melanoma Res · August 2011 The objective of this study was to identify novel tumor-suppressor genes in melanoma, using an integrative genomic approach. Data from: (i) earlier reports of DNA loss and gain in malignant melanoma accompanied by comparative genomic hybridization high-def ... Full text Link to item Cite

Soft tissue injuries

Chapter · January 1, 2010 The face is comprised of multiple soft tissue layers, reapproximation of which must be considered in planning of repair: Innervation of the face is provided by cranial nerves V (sensory) and VII (motor). Most motor branches of cranial nerve VII are deep to ... Full text Cite

Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers.

Journal Article ORL J Otorhinolaryngol Relat Spec · 2010 Fanconi anemia (FA) and dyskeratosis congenita (DC) are rare inherited syndromes that cause head and neck squamous cell cancer (HNSCC). Prior studies of inherited forms of cancer have been extremely important in elucidating tumor suppressor genes inactivat ... Full text Link to item Cite

Chronic cigarette smoke extract treatment selects for apoptotic dysfunction and mitochondrial mutations in minimally transformed oral keratinocytes.

Journal Article Int J Cancer · January 1, 2010 Cigarette smoke demonstrates a carcinogenic effect through chronic exposure, not acute exposures. However, current cell line models study only the acute effects of cigarette smoke. Using a cell line model, we compared the effects of acute versus chronic ci ... Full text Link to item Cite

Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands.

Journal Article PLoS One · December 30, 2009 BACKGROUND: The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas. METHODO ... Full text Open Access Link to item Cite

Expression microarray identifies novel markers of free flap failure in a rat model.

Journal Article Ann Plast Surg · September 2009 Clinical detection of free flap failure lacks sensitivity. Failure is likely accompanied by altered gene expression; however, a genomic approach that identifies potential biomarkers and therapeutic targets has not been described. This study identifies gene ... Full text Link to item Cite

Novel integrative methods for gene discovery associated with head and neck squamous cell carcinoma development.

Journal Article Arch Otolaryngol Head Neck Surg · May 2009 OBJECTIVE: To find head and neck squamous cell carcinoma (HNSCC) specific genetic changes using integrative genetics. DESIGN: Genetic analysis. PATIENTS: Three separate cohorts of patients with primary HNSCC were evaluated for expression-microarray of 33 0 ... Full text Link to item Cite

Predictable patterns of intracranial and cervical spine injury in craniomaxillofacial trauma: analysis of 4786 patients.

Journal Article Plast Reconstr Surg · April 2009 BACKGROUND: Patients presenting with traumatic craniomaxillofacial fractures often have occult concomitant injuries. This study was designed to determine whether facial fracture patterns are associated with a particular constellation of concomitant head an ... Full text Link to item Cite

Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer.

Journal Article PLoS One · 2009 BACKGROUND: Epigenetic alterations have been implicated in the pathogenesis of solid tumors, however, proto-oncogenes activated by promoter demethylation have been sporadically reported. We used an integrative method to analyze expression in primary head a ... Full text Open Access Link to item Cite

Microsurgical salvage of the intractable oral vestibule.

Journal Article Plast Reconstr Surg · January 2009 BACKGROUND: The significance of the oral vestibule is often underappreciated in composite craniomaxillofacial reconstruction, and its deficiency results in considerable incompetence. Results of traditional vestibuloplasty techniques are unpredictable when ... Full text Link to item Cite

Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands.

Journal Article PloS one · 2009 BACKGROUND: The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas. METHODO ... Cite

Nonsynonymous somatic mitochondrial mutations occur in the majority of cutaneous melanomas.

Journal Article Melanoma Res · June 2008 Earlier studies of mitochondrial mutations in melanoma have focused on analysis of selected mitochondrial genes and the displacement loop (D-loop) region using conventional sequencing. In this study we use data from a whole mitochondria-sequencing array, t ... Full text Link to item Cite

Recurrent abdominal laxity following interpositional human acellular dermal matrix.

Journal Article Ann Plast Surg · January 2008 Repair of large complex abdominal hernias with significant loss of domain requires component separation in combination with either a synthetic or biologic interpositional material. We previously described an algorithm for complex abdominal hernia repair, w ... Full text Link to item Cite

Mitochondrial resequencing arrays detect tumor-specific mutations in salivary rinses of patients with head and neck cancer.

Journal Article Clin Cancer Res · December 15, 2007 PURPOSE: Alterations of the mitochondrial genome have been identified in multiple solid tumors and in many head and neck squamous cell carcinomas (HNSCC). Identification of mitochondrial mutations in the salivary rinses of patients with HNSCC has potential ... Full text Link to item Cite

DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage.

Journal Article Int J Cancer · October 15, 2007 Epigenetic changes have been implicated in the pathogenesis of solid tumors, including head and neck squamous cell carcinoma (HNSCC). Prior efforts have primarily examined regional promoter hypermethylation as a silencer of tumor suppressor gene expression ... Full text Link to item Cite

Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer.

Journal Article Clin Cancer Res · August 1, 2007 PURPOSE: To determine the timing of mitochondrial mutations in the progression of head and neck squamous cell carcinoma. EXPERIMENTAL DESIGN: Twenty-three mitochondrial mutations were identified in 12 tumors using a high-throughput mitochondrial sequencing ... Full text Link to item Cite

Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.

Journal Article Proc Natl Acad Sci U S A · May 1, 2007 Mitochondrial genomic mutations are found in a variety of human cancers; however, the frequency of mitochondrial DNA (mtDNA) mutations in coding regions remains poorly defined, and the functional effects of mitochondrial mutations found in primary human ca ... Full text Link to item Cite

Molecular genetics of premalignant oral lesions.

Journal Article Oral Dis · March 2007 Oral squamous cell carcinoma (OSCC) is characterized by cellular and subcellular alterations that are associated with a progression towards dedifferentiation and growth. There are several histologically distinct lesions of the oral cavity which have malign ... Full text Link to item Cite

Management of wound complications in spinal surgery

Journal Article Neurosurgery Quarterly · March 1, 2006 Wound complications after spinal surgery are relatively uncommon; however, they can be associated with a significant amount of morbidity. Wound breakdown after spinal surgery is due to a wide variety of causes, ranging from the trivial to life threatening. ... Full text Cite

Laparoscopic resection of a paraganglioma of the organ of Zuckerkandl in a patient with a carotid body tumor.

Journal Article Am Surg · January 2006 Paragangliomas of the organ of Zuckerkandl are rare tumors with only several case reports noted in the literature. Synchronous paraganglioma occur sporadically, and on occasion, in association with several genetic syndromes. Paraganglioma of the organ of Z ... Link to item Cite

Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy.

Journal Article Am Surg · January 2005 Margin status is an important prognostic factor for local recurrence after partial mastectomy for breast malignancy. Options for intraoperative evaluation of margin status include gross examination of the specimen, frozen section, and "touch preparation" c ... Link to item Cite

Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells.

Journal Article J Surg Res · April 2004 BACKGROUND: Smad proteins play a key role in TGF-beta signaling that regulates cell proliferation, differentiation, and apoptosis. Mice deficient in Smad3 develop colonic adenocarcinoma. MATERIALS AND METHODS: We developed a Smad3-deficient colonocyte cell ... Full text Link to item Cite

Over-expression of cyclin D1 regulates Cdk4 protein synthesis.

Journal Article Cell Prolif · December 2003 Increased Cdk4 expression occurs coincident with over-expression of cyclin D1 in many human tumours and tumourigenic mouse models. Here, we investigate both in vivo and in vitro the mechanism by which Cdk4 expression is regulated in the context of cyclin D ... Full text Link to item Cite

Induction of cytotoxicity with proteasome inhibition in hepatocellular carcinoma

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · September 1, 2003 Link to item Cite

Lymphatic mapping and sentinel lymphadenectomy after preoperative therapy for stage II and III breast cancer.

Journal Article Ann Surg Oncol · July 2003 BACKGROUND: We evaluated the accuracy of sentinel lymph node dissection (SLND) in patients with stage II and III breast cancer who had received preoperative therapy. METHODS: A prospective clinical trial evaluated 122 patients who had SLND followed by axil ... Full text Link to item Cite