Scholars@Duke
Uptal Dinesh Patel

Uptal Dinesh Patel

Adjunct Professor in the Department of Medicine
Medicine, Nephrology
uptal.patel@duke.edu
Duke Box 3646, 2400 Pratt Street, Durham, NC 27705
1 Medimmune Way, Gaithersburg, MD 20878-2204

Selected Publications

Selonsertib in Patients with Diabetic Kidney Disease: A Phase 2b Randomized Active Run-In Clinical Trial.

Journal Article J Am Soc Nephrol · December 1, 2024 KEY POINTS: In a randomized, placebo-controlled, phase 2b study, we compared the effects of selonsertib with placebo on eGFR decline in people with type 2 diabetes and CKD. Patients taking selonsertib had slower eGFR decline but were more likely to reach a ... Full text Link to item Cite

Clinical Outcomes Among High-Risk Primary Care Patients With Diabetic Kidney Disease: Methodological Challenges and Results From the STOP-DKD Study.

Journal Article Med Care · October 1, 2024 BACKGROUND/OBJECTIVE: Slowing the progression of diabetic kidney disease (DKD) is critical. We conducted a randomized controlled trial to target risk factors for DKD progression. METHODS: We evaluated the effect of a pharmacist-led intervention focused on ... Full text Open Access Link to item Cite

Felzartamab in Antibody-Mediated Rejection. Reply.

Journal Article N Engl J Med · September 26, 2024 Full text Link to item Cite

Phase 1b/2a Study Assessing the Safety and Efficacy of Felzartamab in Anti-Phospholipase A2 Receptor Autoantibody–Positive Primary Membranous Nephropathy

Journal Article Kidney International Reports · September 1, 2024 Introduction: Primary membranous nephropathy (PMN) is most often caused by autoantibodies to phospholipase A2 receptor (PLA2R). M-PLACE (NCT04145440) is an open-label, phase 1b/2a study that assessed the safety and efficacy of the fully human anti-CD38 mon ... Full text Cite

A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection.

Journal Article N Engl J Med · July 11, 2024 BACKGROUND: Antibody-mediated rejection is a leading cause of kidney-transplant failure. The targeting of CD38 to inhibit graft injury caused by alloantibodies and natural killer (NK) cells may be a therapeutic option. METHODS: In this phase 2, double-blin ... Full text Link to item Cite

Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine.

Journal Article Kidney Int · June 2024 Current classification of chronic kidney disease (CKD) into stages using indirect systemic measures (estimated glomerular filtration rate (eGFR) and albuminuria) is agnostic to the heterogeneity of underlying molecular processes in the kidney thereby limit ... Full text Open Access Link to item Cite

Clinical Trial Considerations in Developing Treatments for Early Stages of Common, Chronic Kidney Diseases: A Scientific Workshop Cosponsored by the National Kidney Foundation and the US Food and Drug Administration.

Conference Am J Kidney Dis · October 2022 In the past decade, advances in the validation of surrogate end points for chronic kidney disease (CKD) progression have heightened interest in evaluating therapies in early CKD. In December 2020, the National Kidney Foundation sponsored a scientific works ... Full text Link to item Cite

Race, Income, and Medical Care Spending Patterns in High-Risk Primary Care Patients: Results From the STOP-DKD (Simultaneous Risk Factor Control Using Telehealth to Slow Progression of Diabetic Kidney Disease) Study.

Journal Article Kidney Med · January 2022 RATIONALE & OBJECTIVE: Little is known about how socioeconomic status (SES) relates to the prioritization of medical care spending over personal expenditures in individuals with multiple comorbid conditions, and whether this relationship differs between Bl ... Full text Open Access Link to item Cite

Urine tricarboxylic acid cycle signatures of early-stage diabetic kidney disease.

Journal Article Metabolomics · December 20, 2021 INTRODUCTION: Urine tricarboxylic acid (TCA) cycle organic anions (OAs) are elevated in diabetes and may be biomarkers for diabetic kidney disease (DKD) progression. OBJECTIVES: We assessed associations of 10 urine TCA cycle OAs with estimated glomerular f ... Full text Open Access Link to item Cite

Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney.

Journal Article J Am Soc Nephrol · March 2021 BACKGROUND: Microscopic analysis of urine sediment is probably the most commonly used diagnostic procedure in nephrology. The urinary cells, however, have not yet undergone careful unbiased characterization. METHODS: Single-cell transcriptomic analysis was ... Full text Link to item Cite

Phase II, randomised, double-blind, multicentre study evaluating the safety and efficacy of filgotinib and lanraplenib in patients with lupus membranous nephropathy.

Journal Article RMD Open · December 2020 OBJECTIVES: Patients with lupus membranous nephropathy (LMN) are at risk for prolonged proteinuria and progressive chronic kidney disease. There are no proven effective treatments for LMN, and controlled trials are lacking. This trial assessed the preferen ... Full text Link to item Cite

Racial Differences in the Effectiveness of a Multifactorial Telehealth Intervention to Slow Diabetic Kidney Disease.

Journal Article Medical care · November 2020 BackgroundAfrican Americans are significantly more likely than non-African Americans to have diabetes, chronic kidney disease, and uncontrolled hypertension, increasing their risk for kidney function decline.ObjectiveThe objective of this ... Full text Open Access Cite

International consensus definitions of clinical trial outcomes for kidney failure: 2020.

Journal Article Kidney Int · October 2020 Kidney failure is an important outcome for patients, clinicians, researchers, healthcare systems, payers, and regulators. However, no harmonized international consensus definitions of kidney failure and key surrogates of progression to kidney failure exist ... Full text Link to item Cite

Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects.

Journal Article Clin Pharmacokinet · September 2020 BACKGROUND: Selonsertib is a first-in-class inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with therapeutic potential for fibrotic diseases. This phase I study evaluated the safety, tolerability, pharmacokinetics (PK), and food effect of selonser ... Full text Link to item Cite

Effects of Selonsertib in Patients with Diabetic Kidney Disease.

Journal Article J Am Soc Nephrol · October 2019 BACKGROUND: Apoptosis signal-regulating kinase 1 (ASK1) activation in glomerular and tubular cells resulting from oxidative stress may drive kidney disease progression. Findings in animal models identified selonsertib, a selective ASK1 inhibitor, as a pote ... Full text Link to item Cite

The relationship between Pittsburgh Sleep Quality Index subscales and diabetes control.

Journal Article Chronic Illn · September 2019 OBJECTIVES:: Data suggest that poor sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) contributes to suboptimal diabetes control. How the subscales comprising the PSQI individually relate to diabetes control is poorly understood. METHO ... Full text Open Access Link to item Cite

Addressing Diabetes and Poorly Controlled Hypertension: Pragmatic mHealth Self-Management Intervention.

Journal Article J Med Internet Res · April 9, 2019 BACKGROUND: Patients with diabetes and poorly controlled hypertension are at increased risk for adverse renal and cardiovascular outcomes. Identifying these patients early and addressing modifiable risk factors is central to delaying renal complications su ... Full text Open Access Link to item Cite

Renal Pre-Competitive Consortium (RPC2): discovering therapeutic targets together.

Journal Article Drug Discov Today · October 2018 Despite significant effort, patients with kidney disease have not seen their outcomes improved significantly over the past two decades. This has motivated clinicians and researchers to consider alternative methods to identifying risk factors, disease progr ... Full text Link to item Cite

Putting patients at the center of kidney care transitions: PREPARE NOW, a cluster randomized controlled trial.

Journal Article Contemp Clin Trials · October 2018 UNLABELLED: Care for patients transitioning from chronic kidney disease to kidney failure often falls short of meeting patients' needs. The PREPARE NOW study is a cluster randomized controlled trial studying the effectiveness of a pragmatic health system i ... Full text Link to item Cite

Simultaneous Risk Factor Control Using Telehealth to slOw Progression of Diabetic Kidney Disease (STOP-DKD) study: Protocol and baseline characteristics of a randomized controlled trial.

Journal Article Contemp Clin Trials · June 2018 UNLABELLED: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) in the United States. Multiple risk factors contribute to DKD development, yet few interventions target more than a single DKD risk factor at a time. This man ... Full text Open Access Link to item Cite

Racial differences in nocturnal dipping status in diabetic kidney disease: Results from the STOP-DKD (Simultaneous Risk Factor Control Using Telehealth to Slow Progression of Diabetic Kidney Disease) study.

Journal Article J Clin Hypertens (Greenwich) · December 2017 While racial variation in ambulatory blood pressure (BP) is known, patterns of diurnal dipping in the context of diabetic kidney disease have not been well defined. The authors sought to determine the association of race with nocturnal dipping status among ... Full text Open Access Link to item Cite

Epidemiology of hypertension in Northern Tanzania: a community-based mixed-methods study.

Journal Article BMJ Open · November 9, 2017 INTRODUCTION: Sub-Saharan Africa is particularly vulnerable to the growing global burden of hypertension, but epidemiological studies are limited and barriers to optimal management are poorly understood. Therefore, we undertook a community-based mixed-meth ... Full text Open Access Link to item Cite

Perspectives from the Kidney Health Initiative on Advancing Technologies to Facilitate Remote Monitoring of Patient Self-Care in RRT.

Journal Article Clin J Am Soc Nephrol · November 7, 2017 Telehealth and remote monitoring of a patient's health status has become more commonplace in the last decade and has been applied to conditions such as heart failure, diabetes mellitus, hypertension, and chronic obstructive pulmonary disease. Conversely, u ... Full text Link to item Cite

Prevalence and Outcomes of Left-Sided Valvular Heart Disease Associated With Chronic Kidney Disease.

Journal Article J Am Heart Assoc · October 11, 2017 BACKGROUND: Chronic kidney disease (CKD) is an adverse prognostic marker for valve intervention patients; however, the prevalence and related outcomes of valvular heart disease in CKD patients is unknown. METHODS AND RESULTS: Included patients underwent ec ... Full text Open Access Link to item Cite

Urinalysis findings and urinary kidney injury biomarker concentrations.

Journal Article BMC Nephrol · July 6, 2017 INTRODUCTION: Urinary biomarkers of kidney injury are presumed to reflect renal tubular damage. However, their concentrations may be influenced by other factors, such as hematuria or pyuria. We sought to examine what non-injury related urinalysis factors a ... Full text Link to item Cite

Comparison of Associations of Reduced Estimated Glomerular Filtration Rate With Stroke Outcomes Between Hypertension and No Hypertension.

Journal Article Stroke · June 2017 BACKGROUND AND PURPOSE: We compared the association of low estimated glomerular filtration rate (eGFR) with stroke outcomes among patients with hypertension and without hypertension. METHODS: We used the China stroke registry to identify patients on discha ... Full text Link to item Cite

Comparative Efficacy of Coronary Revascularization Procedures for Multivessel Coronary Artery Disease in Patients With Chronic Kidney Disease.

Journal Article Am J Cardiol · May 1, 2017 Patients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease and death, yet little data exist regarding the comparative efficacy of coronary revascularization procedures in CKD patients with multivessel disease. We created a c ... Full text Link to item Cite

Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization.

Journal Article Cardiorenal Med · February 2017 BACKGROUND: While the association between APOL1 genetic variants and chronic kidney disease (CKD) has been established, their association with cardiovascular disease (CVD) is unclear. This study sought to understand CKD and cardiovascular risk conferred by ... Full text Link to item Cite

Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial.

Journal Article JAMA · January 10, 2017 IMPORTANCE: Secondary hyperparathyroidism contributes to extraskeletal calcification and is associated with all-cause and cardiovascular mortality. Control is suboptimal in the majority of patients receiving hemodialysis. An intravenously (IV) administered ... Full text Link to item Cite

Effect of Etelcalcetide vs Placebo on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: Two Randomized Clinical Trials.

Journal Article JAMA · January 10, 2017 IMPORTANCE: Secondary hyperparathyroidism contributes to extraskeletal complications in chronic kidney disease. OBJECTIVE: To evaluate the effect of the intravenous calcimimetic etelcalcetide on serum parathyroid hormone (PTH) concentrations in patients re ... Full text Link to item Cite

APOL1 risk alleles among individuals with CKD in Northern Tanzania: A pilot study.

Journal Article PLoS One · 2017 INTRODUCTION: In sub-Saharan Africa, approximately 100 million people have CKD, yet genetic risk factors are not well-understood. Despite the potential importance of understanding APOL1 risk allele status among individuals with CKD, little genetic research ... Full text Link to item Cite

Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients.

Journal Article Ther Drug Monit · October 2016 BACKGROUND: Sirolimus, an immunosuppressive agent used in renal transplantation, can prevent allograft rejection. Identification of the therapeutic index (the ratio of minimum toxic concentration to minimum therapeutic concentration) for immunosuppresants ... Full text Link to item Cite

Traditional medicine practices among community members with diabetes mellitus in Northern Tanzania: an ethnomedical survey.

Journal Article BMC Complement Altern Med · August 11, 2016 BACKGROUND: Diabetes is a growing burden in sub-Saharan Africa where traditional medicines (TMs) remain a primary form of healthcare in many settings. In Tanzania, TMs are frequently used to treat non-communicable diseases, yet little is known about TM pra ... Full text Open Access Link to item Cite

Albuminuria and cardiovascular events in patients with acute coronary syndromes: Results from the TRACER trial.

Journal Article Am Heart J · August 2016 BACKGROUND: Albuminuria is associated with cardiovascular (CV) outcomes. We evaluated albuminuria, alone and in combination with estimated glomerular filtration rate (eGFR), as a predictor of mortality and CV morbidity in 12,944 patients with non-ST-segmen ... Full text Link to item Cite

Association of cardiac biomarkers with acute kidney injury after cardiac surgery: A multicenter cohort study.

Journal Article J Thorac Cardiovasc Surg · July 2016 OBJECTIVE: Acute kidney injury is common after cardiac surgery and associated with postoperative mortality. Perioperative cardiac biomarkers may predict acute kidney injury and mortality. We evaluated whether cardiac biomarkers were associated with severe ... Full text Link to item Cite

Joint Effect of Early Microvascular Damage in the Eye &Kidney on Risk of Cardiovascular Events.

Journal Article Sci Rep · June 8, 2016 Microalbuminuria is associated with an increased risk of cardiovascular disease (CVD), but not all individuals require treatment. Retinal microvascular abnormalities and microalbuminuria reflect early systemic microvascular changes. We examined the joint e ... Full text Link to item Cite

Chronic kidney disease in low- and middle-income countries.

Journal Article Nephrol Dial Transplant · June 2016 Most of the global burden of chronic kidney disease (CKD) is occurring in low- and middle-income countries (LMICs). As a result of rapid urbanization in LMICs, a growing number of populations are exposed to numerous environmental toxins, high infectious di ... Full text Link to item Cite

CKD of Uncertain Etiology: A Systematic Review.

Journal Article Clin J Am Soc Nephrol · March 7, 2016 BACKGROUND AND OBJECTIVES: Epidemics of CKD of uncertain etiology (CKDu) are emerging around the world. Highlighting common risk factors for CKD of uncertain etiology across various regions and populations may be important for health policy and public heal ... Full text Link to item Cite

Neighborhood clustering of non-communicable diseases: results from a community-based study in Northern Tanzania.

Journal Article BMC Public Health · March 5, 2016 BACKGROUND: In order to begin to address the burden of non-communicable diseases (NCDs) in sub-Saharan Africa, high quality community-based epidemiological studies from the region are urgently needed. Cluster-designed sampling methods may be most efficient ... Full text Link to item Cite

Renal failure in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention: Predictors, clinical and angiographic features, and outcomes.

Journal Article Am Heart J · March 2016 BACKGROUND: Among patients presenting with ST-segment elevation myocardial infarction (STEMI) for primary percutaneous coronary intervention (PCI), the associations between clinical outcomes and both baseline renal function and the development of acute kid ... Full text Link to item Cite

Prevalence and correlates of proteinuria in Kampala, Uganda: a cross-sectional pilot study.

Journal Article BMC Res Notes · February 16, 2016 BACKGROUND: Despite the increasing prevalence of chronic kidney disease (CKD) in sub-Saharan Africa, few community-based screenings have been conducted in Uganda. Opportunities to improve the management of CKD in sub-Saharan Africa are limited by low aware ... Full text Open Access Link to item Cite

Knowledge, Attitudes, and Practices Associated with Chronic Kidney Disease in Northern Tanzania: A Community-Based Study.

Journal Article PLoS One · 2016 BACKGROUND: Non-communicable diseases (NCDs) are a leading cause of death among adults in sub-Saharan Africa, and chronic kidney disease (CKD) is a growing public health threat. Understanding knowledge, attitudes, and practices associated with NCDs is vita ... Full text Link to item Cite

Prevalence, Risk Factors, and Complications of Diabetes in the Kilimanjaro Region: A Population-Based Study from Tanzania.

Journal Article PLoS One · 2016 BACKGROUND: In sub-Saharan Africa, diabetes is a growing burden, yet little is known about its prevalence, risk factors, and complications. To address these gaps and help inform public health efforts aimed at prevention and treatment, we conducted a commun ... Full text Link to item Cite

Comparative Effectiveness of CRT-D Versus Defibrillator Alone in HF Patients With Moderate-to-Severe Chronic Kidney Disease.

Journal Article J Am Coll Cardiol · December 15, 2015 BACKGROUND: Patients with moderate-to-severe chronic kidney disease (CKD) are poorly represented in clinical trials of cardiac resynchronization therapy (CRT). OBJECTIVES: This study sought to assess the real-world comparative effectiveness of CRT with def ... Full text Link to item Cite

Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR.

Journal Article Am J Kidney Dis · December 2015 BACKGROUND: The interaction between baseline kidney function and the performance of biomarkers of acute kidney injury (AKI) on the development of AKI is unclear. STUDY DESIGN: Post hoc analysis of prospective cohort study. SETTING & PARTICIPANTS: The 1,219 ... Full text Link to item Cite

Traditional medicine practices among community members with chronic kidney disease in northern Tanzania: an ethnomedical survey.

Journal Article BMC Nephrol · October 23, 2015 BACKGROUND: In sub-Saharan Africa, chronic kidney disease (CKD) is being recognized as a non-communicable disease (NCD) with high morbidity and mortality. In countries like Tanzania, people access many sources, including traditional medicines, to meet thei ... Full text Open Access Link to item Cite

CKD as a Model for Improving Chronic Disease Care through Electronic Health Records.

Journal Article Clin J Am Soc Nephrol · August 7, 2015 Electronic health records have the potential to improve the care of patients with chronic medical conditions. CKD provides a unique opportunity to show this potential: the disease is common in the United States, there is significant room to improve CKD det ... Full text Link to item Cite

Pharmacokinetics, Pharmacodynamics, and Safety of Lisinopril in Pediatric Kidney Transplant Patients: Implications for Starting Dose Selection.

Journal Article Clin Pharmacol Ther · July 2015 Hypertension in pediatric kidney transplant recipients contributes to long-term graft loss, yet treatment options--including angiotensin-converting enzyme inhibitors--are poorly characterized in this vulnerable population. We conducted a multicenter, open- ... Full text Link to item Cite

Impact of automated reporting of estimated glomerular filtration rate in the veterans health administration.

Journal Article Med Care · February 2015 BACKGROUND: Early detection and treatment of chronic kidney disease (CKD) is important for slowing progression to renal failure and preventing cardiovascular events, but CKD is often not recognized and patients are referred to nephrologists too late for ti ... Full text Link to item Cite

Outcomes in kidney transplant recipients from older living donors.

Journal Article Transplantation · February 2015 BACKGROUND: Previous studies demonstrate that graft survival from older living kidney donors (LD; age>60 years) is worse than younger LD but similar to deceased standard criteria donors (SCD). Limited sample size has precluded more detailed analyses of tra ... Full text Link to item Cite

Literature-related discovery and innovation: Chronic kidney disease

Journal Article Technological Forecasting and Social Change · February 1, 2015 Different approaches for preventing, reducing, halting, and reversing chronic kidney disease (CKD) have been described in the medical literature. However, all related factors have not been identified together. To overcome these limitations, we used an LRDI ... Full text Cite

The determinants of traditional medicine use in Northern Tanzania: a mixed-methods study.

Journal Article PLoS One · 2015 INTRODUCTION: Traditional medicines are an important part of healthcare in sub-Saharan Africa, and building successful disease treatment programs that are sensitive to traditional medicine practices will require an understanding of their current use and ro ... Full text Link to item Cite

Development and validation of a cross-cultural knowledge, attitudes, and practices survey instrument for chronic kidney disease in a Swahili-speaking population.

Journal Article PLoS One · 2015 INTRODUCTION: Non-communicable diseases are a growing global burden, and structured surveys can identify critical gaps to address this epidemic. In sub-Saharan Africa, there are very few well-tested survey instruments measuring population attributes relate ... Full text Link to item Cite

The epidemiology of chronic kidney disease in Northern Tanzania: a population-based survey.

Journal Article PLoS One · 2015 BACKGROUND: In sub-Saharan Africa, kidney failure has a high morbidity and mortality. Despite this, population-based estimates of prevalence, potential etiologies, and awareness are not available. METHODS: Between January and June 2014, we conducted a hous ... Full text Link to item Cite

Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study.

Journal Article PLoS One · 2015 BACKGROUND: Higher levels of plasma neutrophil gelatinase-associated lipocalin (pNGAL) are an early marker of acute kidney injury and are associated with increased risk of short-term adverse outcomes. The independent association between pNGAL and long-term ... Full text Link to item Cite

Validated contemporary risk model of acute kidney injury in patients undergoing percutaneous coronary interventions: insights from the National Cardiovascular Data Registry Cath-PCI Registry.

Journal Article J Am Heart Assoc · December 2014 BACKGROUND: We developed risk models for predicting acute kidney injury (AKI) and AKI requiring dialysis (AKI‐D) after percutaneous coronary intervention (PCI) to support quality assessment and the use of preventative strategies. METHODS AND RESULTS: AKI w ... Full text Link to item Cite

Diabetic kidney disease: a report from an ADA Consensus Conference.

Journal Article Am J Kidney Dis · October 2014 The incidence and prevalence of diabetes mellitus have grown significantly throughout the world, due primarily to the increase in type 2 diabetes. This overall increase in the number of people with diabetes has had a major impact on development of diabetic ... Full text Link to item Cite

Diabetic kidney disease: a report from an ADA Consensus Conference.

Journal Article Diabetes Care · October 2014 The incidence and prevalence of diabetes mellitus have grown significantly throughout the world, due primarily to the increase in type 2 diabetes. This overall increase in the number of people with diabetes has had a major impact on development of diabetic ... Full text Link to item Cite

Blood transfusions are associated with urinary biomarkers of kidney injury in cardiac surgery.

Journal Article J Thorac Cardiovasc Surg · August 2014 OBJECTIVE: Cardiac surgery is a major cause of acute kidney injury. In this setting, receipt of blood transfusions seems to be associated with a higher risk of acute kidney injury, as measured using serum creatinine values. We examined this association fur ... Full text Link to item Cite

Serum brain natriuretic peptide and risk of acute kidney injury after cardiac operations in children.

Journal Article Ann Thorac Surg · June 2014 BACKGROUND: Acute kidney injury (AKI) after pediatric cardiac operations is associated with poor outcomes and is difficult to predict. We conducted a prospective study to evaluate whether preoperative brain natriuretic peptide (BNP) levels predict postoper ... Full text Link to item Cite

The landscape of clinical trials in nephrology: a systematic review of Clinicaltrials.gov.

Journal Article Am J Kidney Dis · May 2014 BACKGROUND: Well-designed trials are of paramount importance in improving the delivery of care to patients with kidney disease. However, it remains unknown whether contemporary clinical trials within nephrology are of sufficient quality and quantity to mee ... Full text Link to item Cite

Cardiovascular complications of diabetic kidney disease.

Journal Article Adv Chronic Kidney Dis · May 2014 Diabetic nephropathy is the most common cause of CKD and represents a large and ominous public health problem. Patients with diabetic kidney disease have exceptionally high rates of cardiovascular morbidity and mortality. In fact, the excess mortality amon ... Full text Link to item Cite

Urinary biomarkers of AKI and mortality 3 years after cardiac surgery.

Journal Article J Am Soc Nephrol · May 2014 Urinary biomarkers of AKI provide prognostic value for in-hospital outcomes, but little is known about their association with longer-term mortality after surgery. We sought to assess the association between kidney injury biomarkers and all-cause mortality ... Full text Link to item Cite

The epidemiology of chronic kidney disease in sub-Saharan Africa: a systematic review and meta-analysis.

Journal Article Lancet Glob Health · March 2014 BACKGROUND: Amid rapid urbanisation, the HIV epidemic, and increasing rates of non-communicable diseases, people in sub-Saharan Africa are especially vulnerable to kidney disease. Little is known about the epidemiology of chronic kidney disease (CKD) in su ... Full text Link to item Cite

Contemporary incidence, predictors, and outcomes of acute kidney injury in patients undergoing percutaneous coronary interventions: insights from the NCDR Cath-PCI registry.

Journal Article JACC Cardiovasc Interv · January 2014 OBJECTIVES: This study sought to examine the contemporary incidence, predictors and outcomes of acute kidney injury in patients undergoing percutaneous coronary interventions. BACKGROUND: Acute kidney injury (AKI) is a serious and potentially preventable c ... Full text Link to item Cite

Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet.

Journal Article J Hypertens (Los Angel) · 2014 OBJECTIVES: Although the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure in adults with hypertension, how kidney function impacts this effect is not known. We evaluated whether Estimated Glomerular Filtration Rate (eGFR) modifies ... Full text Open Access Link to item Cite

Recognition of CKD after the introduction of automated reporting of estimated GFR in the Veterans Health Administration.

Journal Article Clin J Am Soc Nephrol · January 2014 BACKGROUND AND OBJECTIVES: Early detection of CKD is important for slowing progression to renal failure and preventing cardiovascular events. Automated laboratory reporting of estimated GFR (eGFR) has been introduced in many health systems to improve CKD r ... Full text Link to item Cite

New models of chronic kidney disease care including pharmacists: improving medication reconciliation and medication management.

Journal Article Curr Opin Nephrol Hypertens · November 2013 PURPOSE OF REVIEW: Patients with chronic kidney disease (CKD) are complex, have many medication-related problems (MRPs) and high rates of medication nonadherence, and are less adherent to some medications than patients with higher levels of kidney function ... Full text Link to item Cite

Renal transplant imaging using magnetic resonance angiography with a nonnephrotoxic contrast agent.

Journal Article Transplantation · July 15, 2013 BACKGROUND: In renal allograft recipients presenting with graft dysfunction, it is critical to determine the patency of the transplant vasculature to guide clinical management. Conventional modalities such as Doppler ultrasound, contrast-enhanced computed ... Full text Link to item Cite

Impact of 5-year weight change on blood pressure: results from the Weight Loss Maintenance trial.

Journal Article J Clin Hypertens (Greenwich) · July 2013 In this secondary analysis of the Weight Loss Maintenance trial, the authors assessed the relationship between blood pressure (BP) change and weight change in overweight and obese adults with hypertension and/or dyslipidemia who were randomized to 1 of 3 w ... Full text Open Access Link to item Cite

Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery.

Journal Article Clin J Am Soc Nephrol · July 2013 BACKGROUND AND OBJECTIVES: AKI is common and novel biomarkers may help provide earlier diagnosis and prognosis of AKI in the postoperative period. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a prospective, multicenter cohort study involving 121 ... Full text Link to item Cite

The quality of cardiovascular disease care for adolescents with kidney disease: a Midwest Pediatric Nephrology Consortium study.

Journal Article Pediatr Nephrol · June 2013 BACKGROUND: Cardiovascular disease is the leading cause of increased mortality for adolescents with advanced kidney disease. The quality of preventive cardiovascular care may impact long-term outcomes for these patients. METHODS: We reviewed the records of ... Full text Link to item Cite

Urinary cystatin C and acute kidney injury after cardiac surgery.

Journal Article Am J Kidney Dis · May 2013 BACKGROUND: Acute kidney injury (AKI) is common after cardiac surgery and is associated with adverse patient outcomes. Urinary cystatin C (CysC) level is a biomarker of proximal tubule function and may increase earlier in AKI than serum creatinine level. S ... Full text Link to item Cite

Screening for chronic kidney disease.

Journal Article Ann Intern Med · March 5, 2013 Full text Link to item Cite

Comparison of outcomes for veterans receiving dialysis care from VA and non-VA providers.

Journal Article BMC Health Serv Res · January 18, 2013 BACKGROUND: Demand for dialysis treatment exceeds its supply within the Veterans Health Administration (VA), requiring VA to outsource dialysis care by purchasing private sector dialysis for veterans on a fee-for-service basis. It is unclear whether outcom ... Full text Link to item Cite

Cardiovascular toxicity of epoetin-alfa in patients with chronic kidney disease.

Journal Article Am J Nephrol · 2013 BACKGROUND: Recombinant erythropoietin has become a routine component of care of patients with chronic kidney disease reducing the need for blood transfusions but raising the risks for cardiovascular events. We undertook this secondary analysis of subjects ... Full text Link to item Cite

Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis.

Journal Article N Engl J Med · December 27, 2012 BACKGROUND: Disorders of mineral metabolism, including secondary hyperparathyroidism, are thought to contribute to extraskeletal (including vascular) calcification among patients with chronic kidney disease. It has been hypothesized that treatment with the ... Full text Link to item Cite

Serum cystatin C- versus creatinine-based definitions of acute kidney injury following cardiac surgery: a prospective cohort study.

Journal Article Am J Kidney Dis · December 2012 BACKGROUND: The primary aim of this study was to compare the sensitivity and rapidity of acute kidney injury (AKI) detection by cystatin C level relative to creatinine level after cardiac surgery. STUDY DESIGN: Prospective cohort study. SETTINGS & PARTICIP ... Full text Link to item Cite

Association of postoperative proteinuria with AKI after cardiac surgery among patients at high risk.

Journal Article Clin J Am Soc Nephrol · November 2012 BACKGROUND AND OBJECTIVES: Preoperative proteinuria is associated with a higher incidence of postoperative AKI. Whether the same is true for postoperative proteinuria is uncertain. This study tested the hypothesis that increased proteinuria after cardiac s ... Full text Link to item Cite

Effect of hemoglobin target on progression of kidney disease: a secondary analysis of the CHOIR (Correction of Hemoglobin and Outcomes in Renal Insufficiency) trial.

Journal Article Am J Kidney Dis · September 2012 BACKGROUND: Conflicting relationships have been described between anemia correction using erythropoiesis-stimulating agents and progression of chronic kidney disease (CKD). This study was undertaken to examine the impact of target hemoglobin level on progr ... Full text Link to item Cite

Impact of higher hemoglobin targets on blood pressure and clinical outcomes: a secondary analysis of CHOIR.

Journal Article Nephrol Dial Transplant · September 2012 BACKGROUND: Targeting a higher hemoglobin in patients with chronic kidney disease leads to adverse cardiovascular outcomes, yet the reasons remain unclear. Herein, we sought to determine whether changes in erythropoiesis-stimulating agent (ESA) dose and in ... Full text Link to item Cite

Implementation of automated reporting of estimated glomerular filtration rate among Veterans Affairs laboratories: a retrospective study.

Journal Article BMC Med Inform Decis Mak · July 12, 2012 Featured Publication BACKGROUND: Automated reporting of estimated glomerular filtration rate (eGFR) is a recent advance in laboratory information technology (IT) that generates a measure of kidney function with chemistry laboratory results to aid early detection of chronic kid ... Full text Open Access Link to item Cite

Updated report on comparative effectiveness of ACE inhibitors, ARBs, and direct renin inhibitors for patients with essential hypertension: much more data, little new information.

Journal Article J Gen Intern Med · June 2012 OBJECTIVES: A 2007 systematic review compared angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) in patients with hypertension. Direct renin inhibitors (DRIs) have since been introduced, and significant new research ... Full text Link to item Cite

Biomarkers predict progression of acute kidney injury after cardiac surgery.

Journal Article J Am Soc Nephrol · May 2012 Being able to predict whether AKI will progress could improve monitoring and care, guide patient counseling, and assist with enrollment into trials of AKI treatment. Using samples from the Translational Research Investigating Biomarker Endpoints in AKI stu ... Full text Link to item Cite

Discussions of the kidney disease trajectory by elderly patients and nephrologists: a qualitative study.

Journal Article Am J Kidney Dis · April 2012 Featured Publication BACKGROUND: Elderly patients with advanced kidney disease experience considerable disability, morbidity, and mortality. Little is known about the impact of physician-patient interactions on patient preparation for the illness trajectory. We sought to descr ... Full text Link to item Cite

Preoperative serum brain natriuretic peptide and risk of acute kidney injury after cardiac surgery.

Journal Article Circulation · March 20, 2012 Featured Publication BACKGROUND: Acute kidney injury (AKI) after cardiac surgery is associated with poor outcomes and is difficult to predict. We conducted a prospective study to evaluate whether preoperative brain natriuretic peptide (BNP) levels predict postoperative AKI amo ... Full text Link to item Cite

Association between high-dose erythropoiesis-stimulating agents, inflammatory biomarkers, and soluble erythropoietin receptors.

Journal Article BMC Nephrol · December 12, 2011 BACKGROUND: High-dose erythropoiesis-stimulating agents (ESA) for anemia of chronic kidney disease (CKD) have been associated with adverse clinical outcomes and do not always improve erythropoiesis. We hypothesized that high-dose ESA requirement would be a ... Full text Link to item Cite

Safety and efficacy of drug-eluting stents in older patients with chronic kidney disease: a report from the linked CathPCI Registry-CMS claims database.

Journal Article J Am Coll Cardiol · October 25, 2011 OBJECTIVES: The purpose of this study was to determine the safety and efficacy of drug-eluting stents (DES) compared with bare-metal stents (BMS) in older patients with chronic kidney disease (CKD). BACKGROUND: DES may be associated with late death and myo ... Full text Link to item Cite

Longitudinal analysis of market factors associated with provision of peritoneal dialysis services.

Journal Article Med Care Res Rev · October 2011 Despite the appeal of peritoneal dialysis (PD) among patients, payers, and providers, its use in the United States has been limited and declining. Prior research has found that patient factors explain little variation in PD utilization, and little is known ... Full text Link to item Cite

Relationship of the time interval between cardiac catheterization and elective coronary artery bypass surgery with postprocedural acute kidney injury.

Journal Article Circulation · September 13, 2011 BACKGROUND: Some prior studies have suggested that the time to cardiac surgery after cardiac catheterization is inversely related to postoperative acute kidney injury (AKI). However, these studies, because of the small number of patients, were unable to ad ... Full text Link to item Cite

Presurgical serum cystatin C and risk of acute kidney injury after cardiac surgery.

Journal Article Am J Kidney Dis · September 2011 BACKGROUND: Acute kidney injury (AKI) after cardiac surgery is associated with poor outcomes, but is challenging to predict from information available before surgery. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: The TRIBE-AKI (Translatio ... Full text Link to item Cite

Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery.

Journal Article J Am Soc Nephrol · September 2011 Featured Publication Acute kidney injury (AKI) is a frequent complication of cardiac surgery and increases morbidity and mortality. The identification of reliable biomarkers that allow earlier diagnosis of AKI in the postoperative period may increase the success of therapeutic ... Full text Link to item Cite

Device therapy in heart failure patients with chronic kidney disease.

Journal Article J Am Coll Cardiol · August 23, 2011 Heart failure (HF) and chronic kidney disease (CKD) both carry significant risk for sudden cardiac death, hospitalization, and mortality; when combined, however, they markedly increase the risk of morbidity and mortality. Device therapies such as implantab ... Full text Link to item Cite

The chronic kidney disease model: a general purpose model of disease progression and treatment.

Journal Article BMC Med Inform Decis Mak · June 16, 2011 Featured Publication BACKGROUND: Chronic kidney disease (CKD) is the focus of recent national policy efforts; however, decision makers must account for multiple therapeutic options, comorbidities and complications. The objective of the Chronic Kidney Disease model is to provid ... Full text Open Access Link to item Cite

Impact of estimated GFR reporting on patients, clinicians, and health-care systems: a systematic review.

Journal Article Am J Kidney Dis · April 2011 Featured Publication BACKGROUND: Many laboratories now report estimated glomerular filtration rate (eGFR) when a serum creatinine measurement is ordered. A summary of the impact of eGFR reporting in health care systems around the world for which it has been adopted is lacking. ... Full text Link to item Cite

Management of coronary artery disease in end-stage renal disease.

Journal Article Semin Dial · 2011 Despite a substantial number of patients with end-stage renal disease who have coronary artery disease, the comparative effectiveness of revascularization procedures such as coronary artery bypass grafting and percutaneous coronary intervention remain uncl ... Full text Link to item Cite

Veterans more likely to start hemodialysis with an arteriovenous fistula.

Journal Article Semin Dial · 2011 Hemodialysis via arteriovenous fistulas (AVFs) is associated with reduced morbidity and mortality when compared to alternative vascular accesses, yet few patients in the United States start dialysis with AVFs. Recent studies have demonstrated higher qualit ... Full text Link to item Cite

Impact of recovery of renal function on long-term mortality after coronary artery bypass grafting.

Journal Article Am J Cardiol · December 15, 2010 Whether prognosis differs in acute renal failure (ARF) after coronary artery bypass grafting (CABG) in patients with and without recovery of renal function is not known. We studied patients who had CABG at Duke University Medical Center (1995 to 2008). ARF ... Full text Link to item Cite

Associations between worsening renal function and 30-day outcomes among Medicare beneficiaries hospitalized with heart failure.

Journal Article Am Heart J · July 2010 Featured Publication BACKGROUND: Kidney disease is common among patients with heart failure, but relationships between worsening renal function (WRF) and outcomes after hospitalization for heart failure are poorly understood, especially among patients with preserved systolic f ... Full text Link to item Cite

Perioperative outcomes among patients with end-stage renal disease following coronary artery bypass surgery in the USA.

Journal Article Nephrol Dial Transplant · July 2010 Featured Publication BACKGROUND: Patients with end-stage renal disease (ESRD) requiring chronic haemodialysis who undergo coronary artery bypass graft surgery (CABG) are at significant risk for perioperative mortality. However, the impact of changes in ESRD patient volume and ... Full text Link to item Cite

Geographic and temporal trends in peritoneal dialysis services in the United States between 1995 and 2003.

Journal Article Am J Kidney Dis · June 2010 BACKGROUND: Peritoneal dialysis (PD) is the preferred dialysis modality for many patients with end-stage renal disease (ESRD) in the United States. However, in sharp contrast to the high rates of PD use in other industrialized countries, PD use in the Unit ... Full text Link to item Cite

Impact of early renal recovery on survival after cardiac surgery-associated acute kidney injury.

Journal Article Ann Thorac Surg · April 2010 BACKGROUND: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a major postoperative complication. Although some early recovery is common, its effect on long-term outcomes is unclear. We tested the hypothesis that early renal recovery after CSA-AK ... Full text Link to item Cite

A secondary analysis of the CHOIR trial shows that comorbid conditions differentially affect outcomes during anemia treatment.

Journal Article Kidney Int · February 2010 The CHOIR trial in anemic patients with chronic kidney disease compared epoetin-alfa treatment with low (11.3 g/l) and high (13.5 g/l) hemoglobin targets on the composite end point of death, hospitalization for heart failure, stroke, and myocardial infarct ... Full text Link to item Cite

Fetal origins of renal disparities.

Journal Article Semin Nephrol · January 2010 Featured Publication Epidemiologic studies of populations continue to emerge showing that early-life factors influence the risk of developing several chronic diseases of adulthood. Susceptibility to environmental factors is particularly problematic during renal development, wh ... Full text Link to item Cite

Association of blood pressure increases during hemodialysis with 2-year mortality in incident hemodialysis patients: a secondary analysis of the Dialysis Morbidity and Mortality Wave 2 Study.

Journal Article Am J Kidney Dis · November 2009 BACKGROUND: Intradialytic increases in blood pressure (BP) can complicate the management of hypertension in hemodialysis (HD) patients. However, the long-term consequences are uncertain. Thus, we sought to determine whether BP increases during HD were asso ... Full text Link to item Cite

Decreased pulse pressure during hemodialysis is associated with improved 6-month outcomes.

Journal Article Kidney Int · November 2009 Pulse pressure is a well established marker of vascular stiffness and is associated with increased mortality in hemodialysis patients. Here we sought to determine if a decrease in pulse pressure during hemodialysis was associated with improved outcomes usi ... Full text Link to item Cite

Increasing healthcare resource utilization after coronary artery bypass graft surgery in the United States.

Journal Article Circ Cardiovasc Qual Outcomes · July 2009 BACKGROUND: Despite declining lengths of stay, postdischarge healthcare resource utilization may be increasing because of shifts to nonacute care settings. Although changes in hospital stay after coronary artery bypass graft (CABG) surgery have been descri ... Full text Link to item Cite

Searching for genes that matter in acute kidney injury: a systematic review.

Journal Article Clin J Am Soc Nephrol · June 2009 BACKGROUND AND OBJECTIVES: Identifying patients who may develop acute kidney injury (AKI) remains challenging, as clinical determinants explain only a portion of individual risk. Another factor that likely affects risk is intrinsic genetic variability. The ... Full text Link to item Cite

Hospital performance and differences by kidney function in the use of recommended therapies after non-ST-elevation acute coronary syndromes.

Journal Article Am J Kidney Dis · March 2009 Featured Publication BACKGROUND: Chronic kidney disease (CKD) is associated with an increased risk of cardiac events and death; however, underuse of guideline-recommended therapies is widespread. The extent to which hospital performance affects the care of patients with CKD an ... Full text Link to item Cite

Recommendations for a clinical decision support for the management of individuals with chronic kidney disease.

Journal Article Clin J Am Soc Nephrol · February 2009 Featured Publication BACKGROUND AND OBJECTIVES: Care for advanced CKD patients is suboptimal. CKD practice guidelines aim to close gaps in care, but making providers aware of guidelines is an ineffective implementation strategy. The Institute of Medicine has endorsed the use o ... Full text Link to item Cite

Mortality trends associated with acute renal failure requiring dialysis after CABG surgery in the United States.

Journal Article Blood Purif · 2009 BACKGROUND/AIMS: Acute renal failure is associated with a high risk of mortality when it complicates coronary artery bypass graft (CABG) surgery. We examined a large nationwide database from 1988 to 2003 and hypothesized that mortality in CABG-associated a ... Full text Link to item Cite

Trends in cardiac surgery-associated acute renal failure in the United States: a disproportionate increase after heart transplantation.

Journal Article Ren Fail · 2009 Acute renal failure (ARF) is common after cardiac surgery and more frequent after complex cardiac surgery. While the incidence of ARF is increasing after coronary artery bypass graft (CABG) surgery, trends in other forms of cardiac surgery remain unclear. ... Full text Link to item Cite

Emerging concepts in acute kidney injury following cardiac surgery.

Journal Article Semin Cardiothorac Vasc Anesth · December 2008 Featured Publication Acute kidney injury (AKI) remains a significant cause of morbidity and mortality following cardiac surgery. Through a more thorough understanding of perioperative genomics and the evolving role of early biomarkers of AKI, the authors seek to improve meanin ... Full text Link to item Cite

Negative trials in nephrology: what can we learn?

Journal Article Kidney Int · November 2008 Chronic kidney disease is assuming epidemic proportions, and an increasing number of clinical trials are testing treatments developed to improve morbidity and mortality. Surprisingly, however, a large proportion of these trials have had negative or neutral ... Full text Link to item Cite

Chronic kidney disease after hematopoietic cell transplantation: a systematic review.

Journal Article Am J Transplant · November 2008 Featured Publication Advances in hematopoietic cell transplantation (HCT) have broadened its indications for use and resulted in more long-term HCT survivors. Some survivors develop chronic kidney disease (CKD); however, the incidence and risk factors are unclear. We performed ... Full text Link to item Cite

Impact of anemia on physical function and survival among patients with coronary artery disease.

Journal Article Clin Cardiol · November 2008 BACKGROUND: Anemia is a purported risk factor for adverse outcomes, particularly among patients with cardiac disease. Although anemia at the time of discharge has been associated with poor functional status and survival, its impact over time is not clear. ... Full text Link to item Cite

Quality of care and outcomes among patients with heart failure and chronic kidney disease: A Get With the Guidelines -- Heart Failure Program study.

Journal Article Am Heart J · October 2008 Featured Publication BACKGROUND: Both heart failure (HF) and chronic kidney disease (CKD) are highly prevalent conditions that often coexist; however, the quality of care received by hospitalized patients with both is not known. METHODS: The Get With the Guidelines - HF regist ... Full text Link to item Cite

Systematic review of CT and MR perfusion imaging for assessment of acute cerebrovascular disease.

Journal Article AJNR Am J Neuroradiol · September 2008 BACKGROUND AND PURPOSE: Perfusion imaging sequences are an important part of imaging studies designed to provide information to guide therapy for treatment of cerebrovascular disease. The purpose of this study was to perform a meta-analysis of the medical ... Full text Link to item Cite

Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes.

Journal Article Kidney Int · September 2008 Trials of anemia correction in chronic kidney disease have found either no benefit or detrimental outcomes of higher targets. We did a secondary analysis of patients with chronic kidney disease enrolled in the Correction of Hemoglobin in the Outcomes in Re ... Full text Link to item Cite

Intensity of renal support in critically ill patients with acute kidney injury.

Journal Article N Engl J Med · July 3, 2008 BACKGROUND: The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial. METHODS: We randomly assigned critically ill patients with acute kidney injury and failure of at least one nonrenal organ o ... Full text Link to item Cite

Acute kidney injury and chronic kidney disease after cardiac surgery.

Journal Article Adv Chronic Kidney Dis · July 2008 Kidney dysfunction is common after cardiac surgery and predicts mortality risk and poorer long-term outcome, particularly when acute injury superimposes upon chronic kidney disease. Numerous insults contribute to perioperative renal impairment including ma ... Full text Link to item Cite

Mortality, kidney disease and cardiac procedures following acute coronary syndrome.

Journal Article Nephrol Dial Transplant · March 2008 BACKGROUND: Cardiac interventions are underutilized in patients with chronic kidney disease (CKD) following acute coronary syndrome (ACS) partly due to nephrotoxicity concerns. METHODS: We analyzed outcomes of 4631 subjects with ACS enrolled in the Blockad ... Full text Link to item Cite

Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension.

Journal Article Ann Intern Med · January 1, 2008 Featured Publication BACKGROUND: The relative effectiveness of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) for lowering blood pressure is unknown. PURPOSE: To compare the benefits and harms of ACE inhibitors versus ARBs for treati ... Full text Link to item Cite

Risk for cardiovascular outcomes among subjects with atherosclerotic cardiovascular disease and greater-than-normal estimated glomerular filtration rate.

Journal Article Clin J Am Soc Nephrol · November 2007 BACKGROUND AND OBJECTIVES: Estimating equations for calculating glomerular filtration rate (eGFR) occasionally identify patients with elevated eGFR, yet the prognostic significance remains to be determined. This study sought to define the association of an ... Full text Link to item Cite

Trends in acute renal failure associated with coronary artery bypass graft surgery in the United States.

Journal Article Crit Care Med · October 2007 OBJECTIVE: Acute renal failure remains a major complication of coronary artery bypass graft surgery that is strongly associated with in-hospital mortality. Based on similar observations in other clinical settings, we tested the hypothesis that the diagnosi ... Full text Link to item Cite

Relationship between interdialytic weight gain and blood pressure among prevalent hemodialysis patients.

Journal Article Am J Kidney Dis · July 2007 BACKGROUND: Hypertension is common in hemodialysis patients; however, the relationship between interdialytic weight gain (IDWG) and blood pressure (BP) is incompletely characterized. This study seeks to define the relationship between IDWG and BP in preval ... Full text Link to item Cite

Association of intradialytic blood pressure changes with hospitalization and mortality rates in prevalent ESRD patients.

Journal Article Kidney Int · March 2007 The relationship between blood pressure (BP) and clinical outcomes among hemodialysis patients is complex and incompletely understood. This study sought to assess the relationship between blood pressure changes with hemodialysis and clinical outcomes durin ... Full text Link to item Cite

Hematopoietic stem-cell transplantation.

Journal Article N Engl J Med · September 7, 2006 Full text Link to item Cite

Falling into the doughnut hole: drug spending among beneficiaries with end-stage renal disease under Medicare Part D plans.

Journal Article J Am Soc Nephrol · September 2006 Featured Publication The Medicare Part D prescription drug benefit may facilitate provision of medications by subsidizing drug costs. However, beneficiaries with higher drug utilization may face higher out-of-pocket (OOP) costs under the benefit's "doughnut hole" provisions th ... Full text Link to item Cite

Physicians' attitudes and practices regarding adherence to medical regimens by patients with chronic illness.

Journal Article Clin Pediatr (Phila) · June 2006 Featured Publication Health professionals often do not detect nonadherence despite substantial adverse impacts on health-care delivery and costs. We sought to determine how physicians assess and manage adherence among patients with chronic illness, and whether approaches to no ... Full text Link to item Cite

Chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes.

Journal Article Am J Med · March 2006 PURPOSE: Chronic kidney disease has been linked to high mortality rates in patients with ST-segment elevation myocardial infarction but has not been well described for patients with non-ST-segment elevation acute coronary syndromes. We examined the treatme ... Full text Link to item Cite

CKD progression and mortality among older patients with diabetes.

Journal Article Am J Kidney Dis · September 2005 Featured Publication BACKGROUND: Chronic kidney disease (CKD) is clearly associated with an increased risk for adverse outcomes; however, the cumulative impact of renal and cardiac complications in high-risk populations is not known. In addition, little is known about patterns ... Full text Link to item Cite

Clinical problem-solving. Index of suspicion.

Journal Article N Engl J Med · May 6, 2004 Full text Link to item Cite

Delayed compared with immediate use of peritoneal catheter in pediatric peritoneal dialysis.

Journal Article Adv Perit Dial · 2001 Delayed use of the peritoneal catheter may be one method of reducing catheter-related complications in chronic peritoneal dialysis (PD); however, the risks and benefits of immediate as compared with delayed use have not been examined in children. We retros ... Link to item Cite

Are physicians aware of which of their patients have indwelling urinary catheters?

Journal Article Am J Med · October 15, 2000 PURPOSE: Although infections associated with indwelling urinary catheters are common, costly, and morbid, the use of these catheters is unnecessary in more than one-third of patients. We sought to assess whether attending physicians, medical residents, and ... Full text Link to item Cite