Scholars@Duke
Wuwei Feng

Selected Publications

External validation of the predictive swallow score for dysphagia in stroke patients.

Journal Article J Stroke Cerebrovasc Dis · April 2026 INTRODUCTION: Post-stroke dysphagia (PSD) is a common complication following acute ischemic stroke (AIS). Predicting the recovery of swallow function remains challenging. The Predictive Swallow Score (PRESS) model, derived and validated in a Swiss cohort, ... Full text Link to item Cite

Stroke Risk After Bioprosthetic Aortic Valve Replacement in Aortic Stenosis: Systematic Review and Meta-Analysis.

Journal Article Stroke · March 20, 2026 BACKGROUND: Stroke is a possible complication after bioprosthetic aortic valve replacement (AVR) for severe aortic stenosis (AS), impacting morbidity and mortality. Accurate estimates of the proportion of individuals who experience stroke within and beyond ... Full text Link to item Cite

Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational study.

Journal Article Lancet Digit Health · January 2026 BACKGROUND: Stroke leads to complex chronic structural and functional brain changes that specifically affect motor outcomes. The brain predicted age difference (PAD) has emerged as a sensitive biomarker of both sensorimotor and cognitive function after str ... Full text Link to item Cite

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies.

Journal Article J Vis Exp · December 12, 2025 Transcranial ultrasonic stimulation (TUS) is emerging as a non-invasive neuromodulatory technique capable of delivering millimeter-precision stimulation at whole-brain depths. Research efforts have increasingly focused on its translational potential. Promi ... Full text Link to item Cite

Updates on vascular dementia.

Journal Article Stroke Vasc Neurol · October 27, 2025 Vascular dementia (VaD) is the second leading cause of dementia after Alzheimer's disease (AD). In comparison to AD, there is a decline in the incidence of VaD due to recent improvements in cardiovascular risk factors. Brain hypoperfusion and hypoxia due t ... Full text Open Access Link to item Cite

Comparative analysis of burden of topmost disorders requiring rehabilitation services: a systematic review and meta-analysis.

Journal Article J Transl Med · September 25, 2025 BACKGROUND: Rehabilitation is an essential health service that should be available for all with health conditions affecting functioning in daily life. Initiatives for equitable distribution of scarce and limited rehabilitation resources are frequently guid ... Full text Link to item Cite

Authors' reply

Journal Article LANCET NEUROLOGY · August 2025 Open Access Link to item Cite

Cerebrovascular Management Considerations in Patients on AATs.

Journal Article J Clin Med · May 14, 2025 The prevalence of Alzheimer's Disease (AD) is increasing worldwide, with more emergency providers and neurologists expecting to encounter these patients. The paradigm of management of AD is expected to change given the recent approval of anti-amyloid thera ... Full text Open Access Link to item Cite

Safety and efficacy of transcranial direct current stimulation in addition to constraint-induced movement therapy for post-stroke motor recovery (TRANSPORT2): a phase 2, multicentre, randomised, sham-controlled triple-blind trial.

Journal Article Lancet Neurol · May 2025 BACKGROUND: Motor impairments contribute substantially to long-term disability following stroke. Studies of transcranial direct current stimulation (tDCS), combined with various rehabilitation therapies, have shown promising results in reducing motor impai ... Full text Link to item Cite

Association that Neuroimaging and Clinical Measures Have with Change in Arm Impairment in a Phase 3 Stroke Recovery Trial.

Journal Article Ann Neurol · April 2025 OBJECTIVE: Vagus nerve stimulation (VNS) paired with rehabilitation therapy improved motor status compared to rehabilitation alone in the phase III VNS-REHAB stroke trial, but treatment response was variable and not associated with any clinical measures ac ... Full text Link to item Cite

Minorities are under-reported and females are under-represented in stroke motor recovery trials.

Journal Article Top Stroke Rehabil · March 2025 BACKGROUND: Inclusion of diverse patient populations in stroke rehabilitation clinical trials is key for generalizability and detecting differences in subgroups. The aim of this study was to assess the reporting and inclusion of race, ethnicity, and sex in ... Full text Link to item Cite

Normobaric hyperoxia combined with endovascular treatment for acute ischaemic stroke in China (OPENS-2 trial): a multicentre, randomised, single-blind, sham-controlled trial.

Journal Article Lancet · February 8, 2025 BACKGROUND: Endovascular treatment improves the recanalisation rate for patients with acute ischaemic stroke; however, even with endovascular treatment, approximately half of patients do not have a favourable functional outcome. We aimed to evaluate the ef ... Full text Open Access Link to item Cite

Three Pillars of Recovery After Aneurysmal Subarachnoid Hemorrhage: A Narrative Review.

Journal Article Transl Stroke Res · February 2025 Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating neurologic disease with high mortality and disability. There have been global improvements in survival, which has contributed to the prevalence of patients living with long-term sequelae related to ... Full text Link to item Cite

Low intensity focused ultrasound stimulation in stroke: A phase I safety & feasibility trial.

Journal Article Brain Stimul · 2025 OBJECTIVE: We aimed to determine the maximum safe spatial-peak pulse-average intensity (ISPPA) of low-intensity focused ultrasound stimulation (LIFUS) in stroke patients and explore its effect on motor learning and corticospinal excitability. METHODS: We a ... Full text Link to item Cite

Intravenous thrombolysis in a stroke patient with a repaired aortic dissection.

Journal Article BMJ Case Rep · December 18, 2024 Acute aortic dissection is considered a contraindication to the use of intravenous thrombolysis in patients presenting with acute ischaemic stroke, but less has been described about previously repaired dissections. We present a case of a woman in her 50s p ... Full text Link to item Cite

Propranolol or Beta-Blockers for Cerebral Cavernous Malformation: a Systematic Review and Meta-analysis of Literature in Both Preclinical and Clinical Studies.

Journal Article Transl Stroke Res · December 2024 Cerebral cavernous malformation (CCM), either sporadic or familial, is a devastating vascular malformation affecting the central nervous system that can present with intracerebral hemorrhage, seizure, and new focal neurologic deficits resulting in substant ... Full text Link to item Cite

Epidemiology, Pathophysiology, and Management of Cancer-Associated Ischemic Stroke.

Journal Article Cancers (Basel) · November 29, 2024 Cancer and stroke are leading causes of global disability and mortality. With improvements in cancer-associated mortality and advancements in treatment of active malignancy, it is more common to encounter patients with ischemic stroke and active malignancy ... Full text Open Access Link to item Cite

Effects of different types of high-definition transcranial electrical stimulation on visual working memory and contralateral delayed activity.

Journal Article J Neuroeng Rehabil · November 8, 2024 BACKGROUND AND PURPOSE: Working memory is critical for individuals and has been found to be improved by electrical stimulation of the left dorsolateral prefrontal cortex (DLPFC). However, the effects of different types of transcranial electrical stimulatio ... Full text Open Access Link to item Cite

Flexible Ultrasonic Transducers for Wearable Biomedical Applications: A Review on Advanced Materials, Structural Designs, and Future Prospects.

Journal Article IEEE Trans Ultrason Ferroelectr Freq Control · July 2024 Due to the rapid developments in materials science and fabrication techniques, wearable devices have recently received increased attention for biomedical applications, particularly in medical ultrasound (US) imaging, sensing, and therapy. US is ubiquitous ... Full text Open Access Link to item Cite

Safety and Real-World Dosing of OnabotulinumtoxinA for the Treatment of Adult Spasticity: Post Hoc Analysis of the Adult Spasticity International Registry Study.

Journal Article Am J Phys Med Rehabil · July 1, 2024 OBJECTIVE: The aim of the study is to evaluate the safety of onabotulinumtoxinA treatment for spasticity across dose ranges in real-world practice. DESIGN: Adult Spasticity International Registry was a multicenter, prospective, observational study (NCT0193 ... Full text Link to item Cite

Effects of Tirofiban on Neurological Deterioration in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial.

Journal Article JAMA Neurol · June 1, 2024 IMPORTANCE: Evidence supports using antiplatelet therapy in patients with acute ischemic stroke. However, neurological deterioration remains common under the currently recommended antiplatelet regimen, leading to poor clinical outcomes. OBJECTIVE: To deter ... Full text Link to item Cite

Botulinum toxin for post-stroke limb spasticity

Chapter · April 23, 2024 Stroke mortality has declined steadily in recent years. As a result, an increasing number of individuals survive but are left with various residual physical and cognitive deficits. Of these deficits, post-stroke limb spasticity (PSLS) generally occurs with ... Full text Cite

Lateral Medullary Syndrome With Ipsilateral Upper Motor Neuron Facial Palsy.

Journal Article Neurohospitalist · April 2024 Lateral medullary syndrome is a common presentation of posterior circulation ischemia that presents with ipsilateral Horner syndrome, ipsilateral facial numbness, contralateral body numbness, vestibular symptoms, ataxia, dysphagia, and dysarthria. Here, we ... Full text Open Access Link to item Cite

Choice and Timing of Antithrombotic after Ischemic Stroke, Intracerebral Hemorrhage or Cerebral Venous Thrombosis.

Journal Article CNS Neurol Disord Drug Targets · 2024 Stroke is a multifactorial vascular disease and remains a leading cause of disability in the United States. Strokes can be ischemic or hemorrhagic in nature and secondary to arterial or venous disease, making determining the etiology and secondary preventi ... Full text Link to item Cite

Thrombolysis with Recombinant Human Prourokinase 4.5-6 h After Acute Ischemic Stroke: A Phase IIa, Randomized, and Open-Label Multicenter Clinical Trial.

Journal Article CNS Drugs · January 2024 BACKGROUND: Ischemic stroke is a major cause of disability and death worldwide. A narrow therapeutic window profoundly constrained the utilization of alteplase. OBJECTIVES: To investigate therapeutic effects and safety of intravenous recombinant human prou ... Full text Open Access Link to item Cite

Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities.

Journal Article Transl Stroke Res · December 2023 Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are man ... Full text Link to item Cite

Neuromodulation for Post-Stroke Motor Recovery: a Narrative Review of Invasive and Non‑Invasive Tools.

Journal Article Curr Neurol Neurosci Rep · December 2023 PURPOSE OF REVIEW: Stroke remains a leading disabling condition, and many survivors have permanent disability despite acute stroke treatment and subsequent standard-of-care rehabilitation therapies. Adjunctive neuromodulation is an emerging frontier in the ... Full text Link to item Cite

Efficacy and Safety of Recombinant Human Prourokinase in the Treatment of Acute Ischemic Stroke Within 4.5 Hours of Stroke Onset: A Phase 3 Randomized Clinical Trial.

Journal Article JAMA Netw Open · July 3, 2023 IMPORTANCE: Recombinant human prourokinase (rhPro-UK) is a thrombolytic agent that has shown promising findings in a phase 2 clinical trial in patients with acute ischemic stroke (AIS). OBJECTIVE: To evaluate the efficacy and safety of rhPro-UK thrombolysi ... Full text Link to item Cite

Vagus Nerve Stimulation Paired With Rehabilitation for Upper Limb Motor Impairment and Function After Chronic Ischemic Stroke: Subgroup Analysis of the Randomized, Blinded, Pivotal, VNS-REHAB Device Trial.

Journal Article Neurorehabil Neural Repair · June 2023 BACKGROUND: Vagus Nerve Stimulation (VNS) paired with rehabilitation improved upper extremity impairment and function in a recent pivotal, randomized, triple-blind, sham-controlled trial in people with chronic arm weakness after stroke. OBJECTIVE: We aimed ... Full text Link to item Cite

Intra-arterial Thrombolysis for Acute Retinal Ischemia: A Retrospective, Observational, Cohort Study.

Journal Article J Neuroophthalmol · June 1, 2023 BACKGROUND: To determine whether intra-arterial thrombolysis (IAT) within 16 hours after the onset of symptoms is feasible and associated with better visual outcomes in patients with acute retinal ischemia (ARI). METHODS: The retrospective cohort study was ... Full text Link to item Cite

Global synergistic actions to improve brain health for human development.

Journal Article Nat Rev Neurol · June 2023 The global burden of neurological disorders is substantial and increasing, especially in low-resource settings. The current increased global interest in brain health and its impact on population wellbeing and economic growth, highlighted in the World Healt ... Full text Open Access Link to item Cite

Association of Brain Age, Lesion Volume, and Functional Outcome in Patients With Stroke.

Journal Article Neurology · May 16, 2023 BACKGROUND AND OBJECTIVES: Functional outcomes after stroke are strongly related to focal injury measures. However, the role of global brain health is less clear. In this study, we examined the impact of brain age, a measure of neurobiological aging derive ... Full text Open Access Link to item Cite

Complications of Intravenous Tenecteplase Versus Alteplase for the Treatment of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Journal Article Stroke · May 2023 BACKGROUND: Prior systematic reviews have compared the efficacy of intravenous tenecteplase and alteplase in acute ischemic stroke, assigning their relative complications as a secondary objective. The objective of the present study is to determine whether ... Full text Link to item Cite

Incidence of post-stroke cognitive impairment in patients with first-ever ischemic stroke: a multicenter cross-sectional study in China.

Journal Article Lancet Reg Health West Pac · April 2023 BACKGROUND: Post-stroke cognitive impairment (PSCI) is a common sequela after stroke. China has a large population of stroke survivors, but a large-scale survey on the incidence and risk factors for PSCI has not been undertaken. We aimed to calculate the i ... Full text Open Access Link to item Cite

Transcranial Direct Current Stimulation for Chronic Stroke: Is Neuroimaging the Answer to the Next Leap Forward?

Journal Article J Clin Med · March 30, 2023 During rehabilitation, a large proportion of stroke patients either plateau or begin to lose motor skills. By priming the motor system, transcranial direct current stimulation (tDCS) is a promising clinical adjunct that could augment the gains acquired dur ... Full text Open Access Link to item Cite

Numerical and experimental evaluation of low-intensity transcranial focused ultrasound wave propagation using human skulls for brain neuromodulation.

Journal Article Med Phys · January 2023 BACKGROUND: Low-intensity transcranial focused ultrasound (tFUS) has gained considerable attention as a promising noninvasive neuromodulatory technique for human brains. However, the complex morphology of the skull hinders scholars from precisely predictin ... Full text Open Access Link to item Cite

Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke: A Phase IIa Randomized Clinical Trial.

Journal Article Transl Stroke Res · December 2022 Recombinant human prourokinase (rhPro-UK) is a novel thrombolytic that has been approved to treat patients with acute myocardial infarction. However, the safety and efficacy of intravenous rhPro-UK in patients with acute ischemic stroke (AIS) has not been ... Full text Link to item Cite

The hypereosinophilic syndrome - an unusual cause of myocarditis and cardioembolic strokes.

Journal Article Am J Med Sci · November 2022 Hypereosinophilic syndrome is a rare disorder characterized by excessive peripheral eosinophilia and eosinophil associated end-organ damage. Clinical presentations are heterogenous and can involve skin, pulmonary, cardiac and neurologic dysfunction. Eosino ... Full text Link to item Cite

Bridging thrombolysis in atrial fibrillation stroke is associated with increased hemorrhagic complications without improved outcomes.

Journal Article J Neurointerv Surg · October 2022 BACKGROUND: Atrial fibrillation (AF) associated ischemic stroke is associated with worse functional outcomes, less effective recanalization, and increased rates of hemorrhagic complications after intravenous thrombolysis (IVT). Conversely, AF is not associ ... Full text Link to item Cite

Automated multimodal segmentation of acute ischemic stroke lesions on clinical MR images.

Journal Article Magn Reson Imaging · October 2022 Magnetic resonance (MR) imaging (MRI) is commonly used to diagnose, assess and monitor stroke. Accurate and timely segmentation of stroke lesions provides the anatomico-structural information that can aid physicians in predicting prognosis, as well as in d ... Full text Open Access Link to item Cite

Microdermabrasion facilitates direct current stimulation by lowering skin resistance.

Journal Article Skin Health Dis · September 2022 BACKGROUND: Transcranial direct current stimulation (tDCS) is reported to induce irritating skin sensations and occasional skin injuries, which limits the applied tDCS dose. Additionally, tDCS hardware safety profile prevents high current delivery when ski ... Full text Open Access Link to item Cite

Analysis of Prescriptions for Dual Antiplatelet Therapy After Acute Ischemic Stroke.

Journal Article JAMA Netw Open · July 1, 2022 IMPORTANCE: After the publication of the CHANCE (Clopidogrel in High Risk Patients With Acute Nondisabling Cerebrovascular Events) and POINT (Platelet-Oriented Inhibition in New Transient Ischemic Attack and Minor Ischemic Stroke) clinical trials, the Amer ... Full text Link to item Cite

A large, curated, open-source stroke neuroimaging dataset to improve lesion segmentation algorithms.

Journal Article Sci Data · June 16, 2022 Accurate lesion segmentation is critical in stroke rehabilitation research for the quantification of lesion burden and accurate image processing. Current automated lesion segmentation methods for T1-weighted (T1w) MRIs, commonly used in stroke research, la ... Full text Open Access Link to item Cite

Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis.

Journal Article J Am Heart Assoc · May 17, 2022 Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the contex ... Full text Link to item Cite

Advances in the management of cardioembolic stroke associated with patent foramen ovale.

Journal Article BMJ · February 9, 2022 Patent foramen ovale (PFO) describes a valve in the interatrial septum that permits shunting of blood or thrombotic material between the atria. PFOs are present in approximately 25% of the healthy population and are not associated with any pathology in the ... Full text Link to item Cite

Hyperglycemia, Risk of Subsequent Stroke, and Efficacy of Dual Antiplatelet Therapy: A Post Hoc Analysis of the POINT Trial.

Journal Article J Am Heart Assoc · February 2022 Background One-quarter of all strokes are subsequent events. It is not known whether higher levels of blood glucose are associated with an increased risk of subsequent stroke after high-risk transient ischemic attack or minor ischemic stroke. Methods and R ... Full text Link to item Cite

In vivo Measurements of Electric Fields During Cranial Electrical Stimulation in the Human Brain.

Journal Article Front Hum Neurosci · 2022 Cranial electrical stimulation (CES) has been applied at various current levels in both adults and children with neurological conditions with seemingly promising but somewhat inconsistent results. Stimulation-induced spatial electric fields (EFs) within a ... Full text Open Access Link to item Cite

Operant down-conditioning of the soleus H-reflex in people after stroke.

Journal Article Front Rehabil Sci · 2022 Through operant conditioning, spinal reflex behaviors can be changed. Previous studies in rats indicate that the sensorimotor cortex and corticospinal tract are essential in inducing and maintaining reflex changes induced through conditioning. In people wi ... Full text Open Access Link to item Cite

Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke.

Journal Article Front Neurosci · 2022 Acoustically detecting the optical absorption contrast, photoacoustic imaging (PAI) is a highly versatile imaging modality that can provide anatomical, functional, molecular, and metabolic information of biological tissues. PAI is highly scalable and can p ... Full text Open Access Link to item Cite

Intracranial Electric Field Recording During Multichannel Transcranial Electrical Stimulation

Journal Article · December 21, 2021 AbstractBackground Multichannel transcranial electrical stimulation (tES) modeling and optimization have been wid ... Full text Cite

Impact of the pandemic of COVID-19 on emergency attendance for stroke and acute myocardial infarction in Beijing, China.

Journal Article J Thromb Thrombolysis · November 2021 To estimate the impact on emergency attendance for stroke and acute myocardial infarction (AMI) during the pandemic of COVID-19 in Beijing, China. Based on 17,123 and 8693 emergency attendance for stroke and AMI, an interrupted time-series (ITS) study was ... Full text Link to item Cite

Real-World Adherence to OnabotulinumtoxinA Treatment for Spasticity: Insights From the ASPIRE Study.

Journal Article Arch Phys Med Rehabil · November 2021 OBJECTIVE: To identify baseline characteristics and treatment-related variables that affect adherence to onabotulinumtoxinA treatment from the Adult Spasticity International Registry (ASPIRE) study. DESIGN: Prospective, observational registry (NCT01930786) ... Full text Link to item Cite

Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Language Recovery in Poststroke Survivors With Aphasia: An Updated Meta-analysis.

Journal Article Neurorehabil Neural Repair · August 2021 The effects of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) on treating poststroke aphasia (PSA) remain inconclusive. We aimed to evaluate the efficacy and safety of LF-rTMS on language function poststroke and determine potential fa ... Full text Open Access Link to item Cite

Detection of Atrial Fibrillation After Central Retinal Artery Occlusion.

Journal Article Stroke · August 2021 BACKGROUND: Central retinal artery occlusion (CRAO) causes sudden, irreversible blindness and is a form of acute ischemic stroke. In this study, we sought to determine the proportion of patients in whom atrial fibrillation (AF) is detected by extended card ... Full text Open Access Link to item Cite

Structural and Functional Imaging of the Retina in Central Retinal Artery Occlusion - Current Approaches and Future Directions.

Journal Article J Stroke Cerebrovasc Dis · July 2021 Central retinal artery occlusion (CRAO) is a form of acute ischemic stroke which affects the retina. Intravenous thrombolysis is emerging as a compelling therapeutic approach. However, it is not known which patients may benefit from this therapy because th ... Full text Link to item Cite

Thrombolytic therapy for wake-up stroke: A systematic review and meta-analysis.

Journal Article Eur J Neurol · June 2021 BACKGROUND AND PURPOSE: According to evidence-based clinical practice guidelines, patients presenting with disabling stroke symptoms should be treated with intravenous tissue plasminogen activator (IV tPA) within 4.5 h of time last known well. However, 25% ... Full text Link to item Cite

Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial.

Journal Article Lancet · April 24, 2021 BACKGROUND: Long-term loss of arm function after ischaemic stroke is common and might be improved by vagus nerve stimulation paired with rehabilitation. We aimed to determine whether this strategy is a safe and effective treatment for improving arm functio ... Full text Link to item Cite

Use of a Smartphone Platform to Help With Emergency Management of Acute Ischemic Stroke: Observational Study.

Journal Article JMIR Mhealth Uhealth · February 9, 2021 BACKGROUND: To improve the outcomes of acute ischemic stroke (AIS), timely thrombolytic therapy is crucial. Series strategies were recommended to reduce door-to-needle (DTN) time for AIS. Mobile technologies are feasible and have been used in stroke manage ... Full text Link to item Cite

Characteristics of strokes associated with centrifugal flow left ventricular assist devices.

Journal Article Sci Rep · January 18, 2021 Stroke is a devastating complication of left ventricular assist device (LVAD) therapy. Understanding the characteristics, risk factors and outcomes of strokes associated with the centrifugal flow LVADs is important to devise better strategies for managemen ... Full text Link to item Cite

Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review.

Journal Article Front Neurosci · 2021 Background: Although low-intensity transcranial ultrasound stimulation (LI-TUS) has received more recognition for its neuromodulation potential, there remains a crucial knowledge gap regarding the neuromodulatory effects of LI-TUS and its potential for tra ... Full text Link to item Cite

Direct Communication Between Brains: A Systematic PRISMA Review of Brain-To-Brain Interface.

Journal Article Front Neurorobot · 2021 This paper aims to review the current state of brain-to-brain interface (B2BI) technology and its potential. B2BIs function via a brain-computer interface (BCI) to read a sender's brain activity and a computer-brain interface (CBI) to write a pattern to a ... Full text Open Access Link to item Cite

Repetitive Transcranial Magnetic Stimulation on the Affected Hemisphere Enhances Hand Functional Recovery in Subacute Adult Stroke Patients: A Randomized Trial.

Journal Article Front Aging Neurosci · 2021 Objectives: Either motor training or repetitive transcranial magnetic stimulation (rTMS) could modulate the neural plasticity after stroke. Therefore, synchronizing the two interventions may optimize the efficiency of recovery. In the present study, we aim ... Full text Open Access Link to item Cite

Biosafety of low-intensity pulsed transcranial focused ultrasound brain stimulation - A human skull study

Conference Proceedings of SPIE the International Society for Optical Engineering · January 1, 2021 Among a variety of existing modalities for noninvasive brain stimulation (NIBS), low-intensity pulsed transcranial focused ultrasound (tFUS) is a promising technique to precisely stimulate deep brain structures due to its high spatial specificity and super ... Full text Cite

Ipsilateral internal carotid artery web and acute ischemic stroke: A cohort study, systematic review and meta-analysis.

Journal Article PLoS One · 2021 INTRODUCTION: The carotid web is a compelling potential mechanism of embolic ischemic stroke. In this study, we aim to determine the prevalence of ipsilateral carotid web in a cohort of ischemic stroke patients and to perform a systematic review and meta-a ... Full text Open Access Link to item Cite

Preventing Ischemic Cerebrovascular Events in High-Risk Patients With Non-disabling Ischemic Cerebrovascular Events Using Remote Ischemic Conditioning: A Single-Arm Study.

Journal Article Front Neurol · 2021 Background: Secondary stroke prevention after a high-risk, non-disabling ischemic cerebrovascular event needs to be enhanced. The study was conducted to investigate whether remote ischemic conditioning (RIC) is effective in preventing recurrent ischemic ev ... Full text Open Access Link to item Cite

Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide.

Journal Article Brain Commun · 2021 Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of ... Full text Link to item Cite

Estimating minimal clinically important differences for two scales in patients with chronic traumatic brain injury.

Journal Article Curr Med Res Opin · December 2020 BACKGROUND: This study aimed to establish the minimal clinically important difference (MCID) for the Fugl-Meyer Motor Scale (FMMS) and the Disability Rating Scale (DRS) to evaluate interventions in patients with motor deficits in the chronic phase after tr ... Full text Link to item Cite

Use of a Smartphone Platform to Help With Emergency Management of Acute Ischemic Stroke: Observational Study (Preprint)

Journal Article · November 4, 2020 BACKGROUND To improve the outcomes of acute ischemic stroke (AIS), timely thrombolytic therapy is crucial. Series strategies were recommended to reduce door-to-needle (DTN) time for AIS. ... Full text Cite

Thrombectomy Technique Predicts Outcome in Posterior Circulation Stroke-Insights from the STAR Collaboration.

Journal Article Neurosurgery · October 15, 2020 BACKGROUND: Randomized controlled trials evaluating mechanical thrombectomy (MT) for acute ischemic stroke predominantly studied anterior circulation patients. Both procedural and clinical predictors of outcome in posterior circulation patients have not be ... Full text Link to item Cite

Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke.

Journal Article Brain Res · August 15, 2020 The nitric oxide (NO) metabolome and the NO metabolite-based neurovascular protective pathways are dysregulated after stroke. The major NO metabolite S-nitrosoglutahione (GSNO) is essential for S-nitrosylation-based signaling events and the inhibition of S ... Full text Link to item Cite

An Animal Trial on the Optimal Time and Intensity of Exercise after Stroke.

Journal Article Med Sci Sports Exerc · August 2020 INTRODUCTION: Although exercise is a safe, cost-effective, and therapeutic poststroke therapy, the proper time window and dosage of exercise are still unknown. We aim to determine the optimal combination of time window and intensity of exercise by assessin ... Full text Link to item Cite

Effects of transcranial direct current stimulation with virtual reality on upper limb function in patients with ischemic stroke: a randomized controlled trial.

Journal Article J Neuroeng Rehabil · June 15, 2020 BACKGROUND: Non-invasive brain stimulation techniques have been shown in several studies to improve the motor recovery of the affected upper-limbs in stroke patients. This study aims to investigate whether or not cathodal transcranial direct current stimul ... Full text Link to item Cite

Investigation of S-Nitrosoglutathione in stroke: A systematic review and meta-analysis of literature in pre-clinical and clinical research.

Journal Article Exp Neurol · June 2020 BACKGROUND: S-Nitrosoglutathione (GSNO) is a nitric oxide donor that has been investigated for neuroprotective and neuro-recovery effect. We aimed to conduct a systematic review on the published literatures using GSNO in both pre-clinical and clinical stro ... Full text Link to item Cite

Complement-Dependent Synaptic Uptake and Cognitive Decline after Stroke and Reperfusion Therapy.

Journal Article J Neurosci · May 13, 2020 Despite the success of reperfusion therapy in significantly reducing the extent of infarct expansion after stroke, the effect of revascularization on poststroke neuroinflammation and the role of anti-inflammatory strategies in postreperfusion era are yet t ... Full text Link to item Cite

Phase I Safety Trial: Extended Daily Peripheral Sensory Stimulation Using a Wrist-Worn Vibrator in Stroke Survivors.

Journal Article Transl Stroke Res · April 2020 Peripheral sensory stimulation augments post-stroke upper extremity rehabilitation outcomes. Most sensory stimulations interfere with natural hand tasks and the stimulation duration is limited. We developed TheraBracelet, low-level random-frequency vibrati ... Full text Link to item Cite

Safety and Outcomes of Intravenous tPA in Acute Ischemic Stroke Patients With Prior Stroke Within 3 Months: Findings From Get With The Guidelines-Stroke.

Journal Article Circ Cardiovasc Qual Outcomes · January 2020 Background Guidelines recommend against the use of intravenous tPA (tissue-type plasminogen activator; IV tPA) in acute ischemic stroke patients with prior ischemic stroke within 3 months. However, there are limited data on the safety of IV tPA in this pop ... Full text Link to item Cite

Reductions in Hospital Admissions and Delays in Acute Stroke Care During the Pandemic of COVID-19.

Journal Article Front Neurol · 2020 Background: Rapid and effective medical care for stroke is paramount to achieve maximal functional recovery. Because of the wide spreading of the coronavirus disease in 2019 (COVID-19), acute stroke care is negatively impacted. How much acute care for stro ... Full text Link to item Cite

Urinary tract infection after stroke: A narrative review.

Journal Article J Neurol Sci · August 15, 2019 BACKGROUND: Urinary tract infection (UTI) is one of the most common infections seen in patients hospitalized for acute stroke, resulting in greater utilization of hospital resources in addition to patient discomfort. Although post-stroke infections (PSIs) ... Full text Link to item Cite

Diabetes and Stroke: The Role of Glucose Regulation

Chapter · January 1, 2019 The relationship between stroke and diabetes mellitus (DM) though complex is undeniable. Numerous studies have delineated a clear correlate between prediabetes, diabetes mellitus type 1, and diabetes mellitus type 2 as they relate to cerebrovascular diseas ... Full text Cite

Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research.

Journal Article Cell Transplant · December 2018 Exogenous stem cell therapy (SCT) has been recognized recently as a promising neuroregenerative strategy to augment recovery in stroke survivors. Mesenchymal stem cells (MSCs) are the primary source of stem cells used in the majority of both pre-clinical a ... Full text Link to item Cite

Transcranial Direct Current Stimulation for Poststroke Motor Recovery: Challenges and Opportunities.

Journal Article PM R · September 2018 There has been a renewed research interest in transcranial direct current stimulation (tDCS) as an adjunctive tool for poststroke motor recovery as it has a neuro-modulatory effect on the human cortex. However, there are barriers towards its successful app ... Full text Link to item Cite

The network of Shanghai Stroke Service System (4S): A public health-care web-based database using automatic extraction of electronic medical records.

Journal Article Int J Stroke · July 2018 Background Several stroke outcome and quality control projects have demonstrated the success in stroke care quality improvement through structured process. However, Chinese health-care systems are challenged with its overwhelming numbers of patients, limit ... Full text Link to item Cite

Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo.

Journal Article Brain Stimul · 2018 BACKGROUND: Transcranial direct current stimulation (tDCS) is a promising brain modulation technique for several disease conditions. With this technique, some portion of the current penetrates through the scalp to the cortex and modulates cortical excitabi ... Full text Open Access Link to item Cite

Mobile health as a viable strategy to enhance stroke risk factor control: A systematic review and meta-analysis.

Journal Article J Neurol Sci · July 15, 2017 BACKGROUND: With the rapid growth worldwide in cell-phone use, Internet connectivity, and digital health technology, mobile health (mHealth) technology may offer a promising approach to bridge evidence-treatment gaps in stroke prevention. We aimed to evalu ... Full text Link to item Cite

Diffusional Kurtosis Imaging and Motor Outcome in Acute Ischemic Stroke.

Journal Article AJNR Am J Neuroradiol · July 2017 BACKGROUND AND PURPOSE: Motor impairment is the most common deficit after stroke. Our aim was to evaluate whether diffusional kurtosis imaging can detect corticospinal tract microstructural changes in the acute phase for patients with first-ever ischemic s ... Full text Link to item Cite

Safety and tolerability of transcranial direct current stimulation to stroke patients - A phase I current escalation study.

Journal Article Brain Stimul · 2017 BACKGROUND AND OBJECTIVE: A prior meta-analysis revealed that higher doses of transcranial direct current stimulation (tDCS) have a better post-stroke upper-extremity motor recovery. While this finding suggests that currents greater than the typically used ... Full text Link to item Cite

Transcranial Direct Current Stimulation Post-Stroke Upper Extremity Motor Recovery Studies Exhibit a Dose-Response Relationship.

Journal Article Brain Stimul · 2016 BACKGROUND AND PURPOSE: Transcranial direct current stimulation (tDCS) has shown mixed results in post-stroke motor recovery, possibly because of tDCS dose differences. The purpose of this meta-analysis was to explore whether the outcome has a dose-respons ... Full text Link to item Cite

Corticospinal tract lesion load: An imaging biomarker for stroke motor outcomes.

Journal Article Ann Neurol · December 2015 OBJECTIVE: The aim of this work was to investigate whether an imaging measure of corticospinal tract (CST) injury in the acute phase can predict motor outcome at 3 months in comparison to clinical assessment of initial motor impairment. METHODS: A two-site ... Full text Link to item Cite