CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection.
Publication
, Journal Article
Kwa, S; Sadagopal, S; Shen, X; Hong, JJ; Gangadhara, S; Basu, R; Victor, B; Iyer, SS; LaBranche, CC; Montefiori, DC; Tomaras, GD; Villinger, F ...
Published in: J Virol
April 2015
Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency virus (SIV) vaccine enhances protection against a pathogenic neutralization-resistant mucosal SIV infection, improves long-term viral control, and prevents AIDS. Analyses of serum IgG antibodies to linear peptides of SIV Env revealed a strong response to V2, with targeting of fewer epitopes in the immunodominant region of gp41 (gp41-ID) and the V1 region as a correlate for enhanced protection. Greater expansion of antiviral CD8 T cells in the gut correlated with long-term viral control.
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Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
April 2015
Volume
89
Issue
8
Start / End Page
4690 / 4695
Location
United States
Related Subject Headings
- Virology
- Vaccinia virus
- Simian Acquired Immunodeficiency Syndrome
- SAIDS Vaccines
- Macaca mulatta
- Kaplan-Meier Estimate
- Immunoglobulin G
- Immunity, Cellular
- Epitope Mapping
- CD8-Positive T-Lymphocytes
Citation
APA
Chicago
ICMJE
MLA
NLM
Kwa, S., Sadagopal, S., Shen, X., Hong, J. J., Gangadhara, S., Basu, R., … Amara, R. R. (2015). CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection. J Virol, 89(8), 4690–4695. https://doi.org/10.1128/JVI.03527-14
Kwa, Suefen, Shanmugalakshmi Sadagopal, Xiaoying Shen, Jung Joo Hong, Sailaja Gangadhara, Rahul Basu, Blandine Victor, et al. “CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection.” J Virol 89, no. 8 (April 2015): 4690–95. https://doi.org/10.1128/JVI.03527-14.
Kwa S, Sadagopal S, Shen X, Hong JJ, Gangadhara S, Basu R, et al. CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection. J Virol. 2015 Apr;89(8):4690–5.
Kwa, Suefen, et al. “CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection.” J Virol, vol. 89, no. 8, Apr. 2015, pp. 4690–95. Pubmed, doi:10.1128/JVI.03527-14.
Kwa S, Sadagopal S, Shen X, Hong JJ, Gangadhara S, Basu R, Victor B, Iyer SS, LaBranche CC, Montefiori DC, Tomaras GD, Villinger F, Moss B, Kozlowski PA, Amara RR. CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection. J Virol. 2015 Apr;89(8):4690–4695.
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
April 2015
Volume
89
Issue
8
Start / End Page
4690 / 4695
Location
United States
Related Subject Headings
- Virology
- Vaccinia virus
- Simian Acquired Immunodeficiency Syndrome
- SAIDS Vaccines
- Macaca mulatta
- Kaplan-Meier Estimate
- Immunoglobulin G
- Immunity, Cellular
- Epitope Mapping
- CD8-Positive T-Lymphocytes