Scholars@Duke

Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.

Publication ,  Journal Article
Somarelli, JA; Schaeffer, D; Marengo, MS; Bepler, T; Rouse, D; Ware, KE; Hish, AJ; Zhao, Y; Buckley, AF; Epstein, JI; Armstrong, AJ ...
Published in: Oncogene
August 18, 2016
Published version (DOI) Open Access Copy (Duke) Link to item

The cascade that culminates in macrometastases is thought to be mediated by phenotypic plasticity, including epithelial-mesenchymal and mesenchymal-epithelial transitions (EMT and MET). Although there is substantial support for the role of EMT in driving cancer cell invasion and dissemination, much less is known about the importance of MET in the later steps of metastatic colonization. We created novel reporters, which integrate transcriptional and post-transcriptional regulation, to test whether MET is required for metastasis in multiple in vivo cancer models. In a model of carcinosarcoma, metastasis occurred via an MET-dependent pathway; however, in two prostate carcinoma models, metastatic colonization was MET independent. Our results provide evidence for both MET-dependent and MET-independent metastatic pathways.

Duke Scholars

Jason Andrew Somarelli
Author Jason Andrew Somarelli Medicine, Medical Oncology
Anne Frances Buckley
Author Anne Frances Buckley Pathology
Andrew John Armstrong
Author Andrew John Armstrong Medicine, Medical Oncology
David Marc Virshup
Author David Marc Virshup Pediatrics

Published In

Oncogene

DOI

10.1038/onc.2015.497

EISSN

1476-5594

Publication Date

August 18, 2016

Volume

35

Issue

33

Start / End Page

4302 / 4311

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Neoplasm Metastasis
  • Mice, Inbred BALB C
  • Mice
  • Humans
  • Female
  • Epithelial-Mesenchymal Transition
  • Cell Proliferation
  • Animals
 

Citation

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Somarelli, J. A., Schaeffer, D., Marengo, M. S., Bepler, T., Rouse, D., Ware, K. E., … Garcia-Blanco, M. A. (2016). Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. Oncogene, 35(33), 4302–4311. https://doi.org/10.1038/onc.2015.497
Somarelli, J. A., D. Schaeffer, M. S. Marengo, T. Bepler, D. Rouse, K. E. Ware, A. J. Hish, et al. “Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.” Oncogene 35, no. 33 (August 18, 2016): 4302–11. https://doi.org/10.1038/onc.2015.497.
Somarelli JA, Schaeffer D, Marengo MS, Bepler T, Rouse D, Ware KE, et al. Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. Oncogene. 2016 Aug 18;35(33):4302–11.
Somarelli, J. A., et al. “Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.” Oncogene, vol. 35, no. 33, Aug. 2016, pp. 4302–11. Pubmed, doi:10.1038/onc.2015.497.
Somarelli JA, Schaeffer D, Marengo MS, Bepler T, Rouse D, Ware KE, Hish AJ, Zhao Y, Buckley AF, Epstein JI, Armstrong AJ, Virshup DM, Garcia-Blanco MA. Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. Oncogene. 2016 Aug 18;35(33):4302–4311.

Published In

Oncogene

DOI

10.1038/onc.2015.497

EISSN

1476-5594

Publication Date

August 18, 2016

Volume

35

Issue

33

Start / End Page

4302 / 4311

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Neoplasm Metastasis
  • Mice, Inbred BALB C
  • Mice
  • Humans
  • Female
  • Epithelial-Mesenchymal Transition
  • Cell Proliferation
  • Animals