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Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age.

Publication ,  Journal Article
Sarkar, S; Shankaran, S; Barks, J; Do, BT; Laptook, AR; Das, A; Ambalavanan, N; Van Meurs, KP; Bell, EF; Sanchez, PJ; Hintz, SR; Wyckoff, MH ...
Published in: J Pediatr
April 2018

OBJECTIVE: To determine the outcome of preterm infants whose cystic periventricular leukomalacia "disappeared" on serial screening cranial imaging studies. STUDY DESIGN: Infants ≤26 weeks of gestation born between 2002 and 2012 who had cranial imaging studies at least twice, the most abnormal study at <28 days of age and another closest to 36 weeks, were reviewed. The outcome of late death (after 36 weeks postmenstrual age) or neurodevelopmental impairment (NDI) in surviving infants at 18-26 months corrected age was compared between the infants with no cystic periventricular leukomalacia on both studies and cystic periventricular leukomalacia that disappeared (cystic periventricular leukomalacia at <28 days but not at 36 weeks), persisted (cystic periventricular leukomalacia on both studies), or appeared late (cystic periventricular leukomalacia only at 36 weeks). Predictors of NDI were evaluated by logistic regression. RESULTS: Of 7063 eligible infants, 433 (6.1%) had cystic periventricular leukomalacia. Among the 433 infants with cystic periventricular leukomalacia, cystic periventricular leukomalacia disappeared in 76 (18%), persisted in 87 (20%), and 270 (62%) had late cystic periventricular leukomalacia. Loss to follow-up ranged between 3% and 13%. Death or NDI was more common in infants with disappeared cystic periventricular leukomalacia compared with those with no cystic periventricular leukomalacia (38 of 72 [53%] vs 1776 of 6376 [28%]; OR [95% CI] 2.8 [1.8-4.6]). Disappeared, persistent, and late cystic periventricular leukomalacia were all also independently associated with NDI (OR 1.17, 1.21, and 1.16, respectively). CONCLUSIONS: Infants with "disappeared" cystic periventricular leukomalacia are at increased risk of adverse outcome similar to infants with persistent or late cystic periventricular leukomalacia.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

April 2018

Volume

195

Start / End Page

59 / 65.e3

Location

United States

Related Subject Headings

  • Ultrasonography
  • Risk Factors
  • Prospective Studies
  • Pediatrics
  • Neonatal Screening
  • Male
  • Logistic Models
  • Leukomalacia, Periventricular
  • Infant, Newborn
  • Infant, Extremely Premature
 

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Sarkar, S., Shankaran, S., Barks, J., Do, B. T., Laptook, A. R., Das, A., … Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . (2018). Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. J Pediatr, 195, 59-65.e3. https://doi.org/10.1016/j.jpeds.2017.12.010
Sarkar, Subrata, Seetha Shankaran, John Barks, Barbara T. Do, Abbot R. Laptook, Abhik Das, Namasivayam Ambalavanan, et al. “Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age.J Pediatr 195 (April 2018): 59-65.e3. https://doi.org/10.1016/j.jpeds.2017.12.010.
Sarkar S, Shankaran S, Barks J, Do BT, Laptook AR, Das A, et al. Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. J Pediatr. 2018 Apr;195:59-65.e3.
Sarkar, Subrata, et al. “Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age.J Pediatr, vol. 195, Apr. 2018, pp. 59-65.e3. Pubmed, doi:10.1016/j.jpeds.2017.12.010.
Sarkar S, Shankaran S, Barks J, Do BT, Laptook AR, Das A, Ambalavanan N, Van Meurs KP, Bell EF, Sanchez PJ, Hintz SR, Wyckoff MH, Stoll BJ, Carlo WA, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. J Pediatr. 2018 Apr;195:59-65.e3.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

April 2018

Volume

195

Start / End Page

59 / 65.e3

Location

United States

Related Subject Headings

  • Ultrasonography
  • Risk Factors
  • Prospective Studies
  • Pediatrics
  • Neonatal Screening
  • Male
  • Logistic Models
  • Leukomalacia, Periventricular
  • Infant, Newborn
  • Infant, Extremely Premature