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Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.

Publication ,  Journal Article
Liu, Y; Sethi, NS; Hinoue, T; Schneider, BG; Cherniack, AD; Sanchez-Vega, F; Seoane, JA; Farshidfar, F; Bowlby, R; Islam, M; Kim, J; Akbani, R ...
Published in: Cancer Cell
April 9, 2018

We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing of MLH1 in the context of CpG island methylator phenotype, plus tumors with elevated single-nucleotide variants associated with mutations in POLE. Tumors with chromosomal instability were diverse, with gastroesophageal adenocarcinomas harboring fragmented genomes associated with genomic doubling and distinct mutational signatures. We identified a group of tumors in the colon and rectum lacking hypermutation and aneuploidy termed genome stable and enriched in DNA hypermethylation and mutations in KRAS, SOX9, and PCBP1.

Duke Scholars

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Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

April 9, 2018

Volume

33

Issue

4

Start / End Page

721 / 735.e8

Location

United States

Related Subject Headings

  • SOX9 Transcription Factor
  • RNA-Binding Proteins
  • Proto-Oncogene Proteins p21(ras)
  • Polymorphism, Single Nucleotide
  • Poly-ADP-Ribose Binding Proteins
  • Oncology & Carcinogenesis
  • Mutation
  • MutL Protein Homolog 1
  • Microsatellite Instability
  • Male
 

Citation

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Liu, Y., Sethi, N. S., Hinoue, T., Schneider, B. G., Cherniack, A. D., Sanchez-Vega, F., … Laird, P. W. (2018). Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. Cancer Cell, 33(4), 721-735.e8. https://doi.org/10.1016/j.ccell.2018.03.010
Liu, Yang, Nilay S. Sethi, Toshinori Hinoue, Barbara G. Schneider, Andrew D. Cherniack, Francisco Sanchez-Vega, Jose A. Seoane, et al. “Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.Cancer Cell 33, no. 4 (April 9, 2018): 721-735.e8. https://doi.org/10.1016/j.ccell.2018.03.010.
Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, et al. Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. Cancer Cell. 2018 Apr 9;33(4):721-735.e8.
Liu, Yang, et al. “Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.Cancer Cell, vol. 33, no. 4, Apr. 2018, pp. 721-735.e8. Pubmed, doi:10.1016/j.ccell.2018.03.010.
Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatila W, Akbani R, Kanchi RS, Rabkin CS, Willis JE, Wang KK, McCall SJ, Mishra L, Ojesina AI, Bullman S, Pedamallu CS, Lazar AJ, Sakai R, Cancer Genome Atlas Research Network, Thorsson V, Bass AJ, Laird PW. Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. Cancer Cell. 2018 Apr 9;33(4):721-735.e8.

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

April 9, 2018

Volume

33

Issue

4

Start / End Page

721 / 735.e8

Location

United States

Related Subject Headings

  • SOX9 Transcription Factor
  • RNA-Binding Proteins
  • Proto-Oncogene Proteins p21(ras)
  • Polymorphism, Single Nucleotide
  • Poly-ADP-Ribose Binding Proteins
  • Oncology & Carcinogenesis
  • Mutation
  • MutL Protein Homolog 1
  • Microsatellite Instability
  • Male