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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.

Publication ,  Journal Article
Ricketts, CJ; De Cubas, AA; Fan, H; Smith, CC; Lang, M; Reznik, E; Bowlby, R; Gibb, EA; Akbani, R; Beroukhim, R; Bottaro, DP; Choueiri, TK ...
Published in: Cell Rep
April 3, 2018
Published version (DOI) Link to item

Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival.

Duke Scholars

Quinn Ostrom
Author Quinn Ostrom Neurosurgery, Neuro-Oncology
Andrew Berchuck
Author Andrew Berchuck Obstetrics and Gynecology, Gynecologic Oncology
Jeffrey R. Marks
Author Jeffrey R. Marks Surgery, Surgical Sciences
Shannon Jones McCall
Author Shannon Jones McCall Pathology
Roger Edwin McLendon
Author Roger Edwin McLendon Pathology
Angeles Alvarez Secord
Author Angeles Alvarez Secord Obstetrics and Gynecology, Gynecologic Oncology
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Published In

Cell Rep

DOI

10.1016/j.celrep.2018.03.075

EISSN

2211-1247

Publication Date

April 3, 2018

Volume

23

Issue

1

Start / End Page

313 / 326.e5

Location

United States

Related Subject Headings

  • Ubiquitin Thiolesterase
  • Tumor Suppressor Proteins
  • Transcription Factors
  • Survival Analysis
  • Phenotype
  • PTEN Phosphohydrolase
  • Nuclear Proteins
  • Metabolic Networks and Pathways
  • Kidney Neoplasms
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ricketts, C. J., De Cubas, A. A., Fan, H., Smith, C. C., Lang, M., Reznik, E., … Linehan, W. M. (2018). The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell Rep, 23(1), 313-326.e5. https://doi.org/10.1016/j.celrep.2018.03.075
Ricketts, Christopher J., Aguirre A. De Cubas, Huihui Fan, Christof C. Smith, Martin Lang, Ed Reznik, Reanne Bowlby, et al. “The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.” Cell Rep 23, no. 1 (April 3, 2018): 313-326.e5. https://doi.org/10.1016/j.celrep.2018.03.075.
Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, et al. The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell Rep. 2018 Apr 3;23(1):313-326.e5.
Ricketts, Christopher J., et al. “The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.” Cell Rep, vol. 23, no. 1, Apr. 2018, pp. 313-326.e5. Pubmed, doi:10.1016/j.celrep.2018.03.075.
Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, Hakimi AA, Henske EP, Hsieh JJ, Ho TH, Kanchi RS, Krishnan B, Kwiatkowski DJ, Liu W, Merino MJ, Mills GB, Myers J, Nickerson ML, Reuter VE, Schmidt LS, Shelley CS, Shen H, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Vincent BG, Vocke CD, Wheeler DA, Yang L, Kim WY, Robertson AG, Cancer Genome Atlas Research Network, Spellman PT, Rathmell WK, Linehan WM. The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell Rep. 2018 Apr 3;23(1):313-326.e5.
Journal cover image

Published In

Cell Rep

DOI

10.1016/j.celrep.2018.03.075

EISSN

2211-1247

Publication Date

April 3, 2018

Volume

23

Issue

1

Start / End Page

313 / 326.e5

Location

United States

Related Subject Headings

  • Ubiquitin Thiolesterase
  • Tumor Suppressor Proteins
  • Transcription Factors
  • Survival Analysis
  • Phenotype
  • PTEN Phosphohydrolase
  • Nuclear Proteins
  • Metabolic Networks and Pathways
  • Kidney Neoplasms
  • Humans