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Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

Publication ,  Journal Article
Hoadley, KA; Yau, C; Hinoue, T; Wolf, DM; Lazar, AJ; Drill, E; Shen, R; Taylor, AM; Cherniack, AD; Thorsson, V; Akbani, R; Bowlby, R ...
Published in: Cell
April 5, 2018

We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chromosome-arm-level aneuploidy, DNA hypermethylation, mRNA, and miRNA expression levels and reverse-phase protein arrays, of which all, except for aneuploidy, revealed clustering primarily organized by histology, tissue type, or anatomic origin. The influence of cell type was evident in DNA-methylation-based clustering, even after excluding sites with known preexisting tissue-type-specific methylation. Integrative clustering further emphasized the dominant role of cell-of-origin patterns. Molecular similarities among histologically or anatomically related cancer types provide a basis for focused pan-cancer analyses, such as pan-gastrointestinal, pan-gynecological, pan-kidney, and pan-squamous cancers, and those related by stemness features, which in turn may inform strategies for future therapeutic development.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

April 5, 2018

Volume

173

Issue

2

Start / End Page

291 / 304.e6

Location

United States

Related Subject Headings

  • RNA, Messenger
  • Neoplasms
  • Neoplasm Proteins
  • Mutation
  • MicroRNAs
  • Humans
  • Developmental Biology
  • Databases, Factual
  • DNA Methylation
  • CpG Islands
 

Citation

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Hoadley, K. A., Yau, C., Hinoue, T., Wolf, D. M., Lazar, A. J., Drill, E., … Laird, P. W. (2018). Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer. Cell, 173(2), 291-304.e6. https://doi.org/10.1016/j.cell.2018.03.022
Hoadley, Katherine A., Christina Yau, Toshinori Hinoue, Denise M. Wolf, Alexander J. Lazar, Esther Drill, Ronglai Shen, et al. “Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.Cell 173, no. 2 (April 5, 2018): 291-304.e6. https://doi.org/10.1016/j.cell.2018.03.022.
Hoadley KA, Yau C, Hinoue T, Wolf DM, Lazar AJ, Drill E, et al. Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer. Cell. 2018 Apr 5;173(2):291-304.e6.
Hoadley, Katherine A., et al. “Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.Cell, vol. 173, no. 2, Apr. 2018, pp. 291-304.e6. Pubmed, doi:10.1016/j.cell.2018.03.022.
Hoadley KA, Yau C, Hinoue T, Wolf DM, Lazar AJ, Drill E, Shen R, Taylor AM, Cherniack AD, Thorsson V, Akbani R, Bowlby R, Wong CK, Wiznerowicz M, Sanchez-Vega F, Robertson AG, Schneider BG, Lawrence MS, Noushmehr H, Malta TM, Cancer Genome Atlas Network, Stuart JM, Benz CC, Laird PW. Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer. Cell. 2018 Apr 5;173(2):291-304.e6.

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

April 5, 2018

Volume

173

Issue

2

Start / End Page

291 / 304.e6

Location

United States

Related Subject Headings

  • RNA, Messenger
  • Neoplasms
  • Neoplasm Proteins
  • Mutation
  • MicroRNAs
  • Humans
  • Developmental Biology
  • Databases, Factual
  • DNA Methylation
  • CpG Islands