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Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.

Publication ,  Journal Article
Ge, Z; Leighton, JS; Wang, Y; Peng, X; Chen, Z; Chen, H; Sun, Y; Yao, F; Li, J; Zhang, H; Liu, J; Shriver, CD; Hu, H; Piwnica-Worms, H ...
Published in: Cell Rep
April 3, 2018

Protein ubiquitination is a dynamic and reversible process of adding single ubiquitin molecules or various ubiquitin chains to target proteins. Here, using multidimensional omic data of 9,125 tumor samples across 33 cancer types from The Cancer Genome Atlas, we perform comprehensive molecular characterization of 929 ubiquitin-related genes and 95 deubiquitinase genes. Among them, we systematically identify top somatic driver candidates, including mutated FBXW7 with cancer-type-specific patterns and amplified MDM2 showing a mutually exclusive pattern with BRAF mutations. Ubiquitin pathway genes tend to be upregulated in cancer mediated by diverse mechanisms. By integrating pan-cancer multiomic data, we identify a group of tumor samples that exhibit worse prognosis. These samples are consistently associated with the upregulation of cell-cycle and DNA repair pathways, characterized by mutated TP53, MYC/TERT amplification, and APC/PTEN deletion. Our analysis highlights the importance of the ubiquitin pathway in cancer development and lays a foundation for developing relevant therapeutic strategies.

Duke Scholars

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

April 3, 2018

Volume

23

Issue

1

Start / End Page

213 / 226.e3

Location

United States

Related Subject Headings

  • Ubiquitination
  • Oncogene Proteins
  • Neoplasms
  • Metabolic Networks and Pathways
  • Humans
  • Genomics
  • Genome, Human
  • Gene Expression Regulation, Neoplastic
  • Cell Line, Tumor
  • 31 Biological sciences
 

Citation

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Ge, Z., Leighton, J. S., Wang, Y., Peng, X., Chen, Z., Chen, H., … Liang, H. (2018). Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types. Cell Rep, 23(1), 213-226.e3. https://doi.org/10.1016/j.celrep.2018.03.047
Ge, Zhongqi, Jake S. Leighton, Yumeng Wang, Xinxin Peng, Zhongyuan Chen, Hu Chen, Yutong Sun, et al. “Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.Cell Rep 23, no. 1 (April 3, 2018): 213-226.e3. https://doi.org/10.1016/j.celrep.2018.03.047.
Ge Z, Leighton JS, Wang Y, Peng X, Chen Z, Chen H, et al. Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types. Cell Rep. 2018 Apr 3;23(1):213-226.e3.
Ge, Zhongqi, et al. “Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.Cell Rep, vol. 23, no. 1, Apr. 2018, pp. 213-226.e3. Pubmed, doi:10.1016/j.celrep.2018.03.047.
Ge Z, Leighton JS, Wang Y, Peng X, Chen Z, Chen H, Sun Y, Yao F, Li J, Zhang H, Liu J, Shriver CD, Hu H, Cancer Genome Atlas Research Network, Piwnica-Worms H, Ma L, Liang H. Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types. Cell Rep. 2018 Apr 3;23(1):213-226.e3.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

April 3, 2018

Volume

23

Issue

1

Start / End Page

213 / 226.e3

Location

United States

Related Subject Headings

  • Ubiquitination
  • Oncogene Proteins
  • Neoplasms
  • Metabolic Networks and Pathways
  • Humans
  • Genomics
  • Genome, Human
  • Gene Expression Regulation, Neoplastic
  • Cell Line, Tumor
  • 31 Biological sciences