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lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.

Publication ,  Journal Article
Wang, Z; Yang, B; Zhang, M; Guo, W; Wu, Z; Wang, Y; Jia, L; Li, S; Cancer Genome Atlas Research Network, ; Xie, W; Yang, D
Published in: Cancer Cell
April 9, 2018

We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island hypermethylation phenotype in cancer, we observed a recurrent hypomethylation of 1,006 lncRNA genes in cancer, including EPIC1 (epigenetically-induced lncRNA1). Overexpression of EPIC1 is associated with poor prognosis in luminal B breast cancer patients and enhances tumor growth in vitro and in vivo. Mechanistically, EPIC1 promotes cell-cycle progression by interacting with MYC through EPIC1's 129-283 nt region. EPIC1 knockdown reduces the occupancy of MYC to its target genes (e.g., CDKN1A, CCNA2, CDC20, and CDC45). MYC depletion abolishes EPIC1's regulation of MYC target and luminal breast cancer tumorigenesis in vitro and in vivo.

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Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

April 9, 2018

Volume

33

Issue

4

Start / End Page

706 / 720.e9

Location

United States

Related Subject Headings

  • Up-Regulation
  • RNA, Long Noncoding
  • Proto-Oncogene Proteins c-myc
  • Promoter Regions, Genetic
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice
  • Humans
  • Gene Expression Regulation, Neoplastic
 

Citation

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Wang, Z., Yang, B., Zhang, M., Guo, W., Wu, Z., Wang, Y., … Yang, D. (2018). lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Cancer Cell, 33(4), 706-720.e9. https://doi.org/10.1016/j.ccell.2018.03.006
Wang, Zehua, Bo Yang, Min Zhang, Weiwei Guo, Zhiyuan Wu, Yue Wang, Lin Jia, et al. “lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.Cancer Cell 33, no. 4 (April 9, 2018): 706-720.e9. https://doi.org/10.1016/j.ccell.2018.03.006.
Wang, Zehua, et al. “lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.Cancer Cell, vol. 33, no. 4, Apr. 2018, pp. 706-720.e9. Pubmed, doi:10.1016/j.ccell.2018.03.006.
Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, Jia L, Li S, Cancer Genome Atlas Research Network, Xie W, Yang D. lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Cancer Cell. 2018 Apr 9;33(4):706-720.e9.

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

April 9, 2018

Volume

33

Issue

4

Start / End Page

706 / 720.e9

Location

United States

Related Subject Headings

  • Up-Regulation
  • RNA, Long Noncoding
  • Proto-Oncogene Proteins c-myc
  • Promoter Regions, Genetic
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice
  • Humans
  • Gene Expression Regulation, Neoplastic