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Association between Furosemide Exposure and Patent Ductus Arteriosus in Hospitalized Infants of Very Low Birth Weight.

Publication ,  Journal Article
Thompson, EJ; Greenberg, RG; Kumar, K; Laughon, M; Smith, PB; Clark, RH; Crowell, A; Shaw, L; Harrison, L; Scales, G; Bell, N; Hornik, CP
Published in: J Pediatr
August 2018

OBJECTIVE: To evaluate the association between furosemide exposure and patent ductus arteriosus (PDA) in a large, contemporary cohort of hospitalized infants with very low birth weight (VLBW). STUDY DESIGN: Using the Pediatrix Medical Group Clinical Data Warehouse, we identified all inborn infants of VLBW <37 weeks of gestation discharged from the neonatal intensive care unit after the first postnatal week from 2011 to 2015. We defined PDA as any medical (ibuprofen or indomethacin) or surgical PDA therapy. We collected data up to the day of PDA treatment or postnatal day 18 for infants not diagnosed with PDA. We performed multivariable logistic regression to evaluate the association between PDA and exposure to furosemide. RESULTS: We included 43 576 infants from 337 neonatal intensive care units, of whom 6675 (15%) underwent PDA treatment. Infants with PDA were more premature and more often exposed to mechanical ventilation and inotropes. Furosemide was prescribed to 4055 (9%) infants. On multivariable regression, exposure to furosemide was associated with decreased odds of PDA treatment (OR 0.72; 95% CI 0.65-0.79). Increasing percentage of days with furosemide exposure was not associated with PDA treatment (OR 1.01; 95% CI 0.97-1.06). CONCLUSIONS: Furosemide exposure was not associated with increased odds of PDA treatment in hospitalized infants of VLBW. Further studies are needed to characterize the efficacy and safety of furosemide in premature infants.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

August 2018

Volume

199

Start / End Page

231 / 236

Location

United States

Related Subject Headings

  • Sodium Potassium Chloride Symporter Inhibitors
  • Risk Factors
  • Retrospective Studies
  • Pediatrics
  • Male
  • Logistic Models
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
 

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Thompson, E. J., Greenberg, R. G., Kumar, K., Laughon, M., Smith, P. B., Clark, R. H., … Hornik, C. P. (2018). Association between Furosemide Exposure and Patent Ductus Arteriosus in Hospitalized Infants of Very Low Birth Weight. J Pediatr, 199, 231–236. https://doi.org/10.1016/j.jpeds.2018.03.067
Thompson, Elizabeth J., Rachel G. Greenberg, Karan Kumar, Matthew Laughon, P Brian Smith, Reese H. Clark, Andromeda Crowell, et al. “Association between Furosemide Exposure and Patent Ductus Arteriosus in Hospitalized Infants of Very Low Birth Weight.J Pediatr 199 (August 2018): 231–36. https://doi.org/10.1016/j.jpeds.2018.03.067.
Thompson EJ, Greenberg RG, Kumar K, Laughon M, Smith PB, Clark RH, et al. Association between Furosemide Exposure and Patent Ductus Arteriosus in Hospitalized Infants of Very Low Birth Weight. J Pediatr. 2018 Aug;199:231–6.
Thompson, Elizabeth J., et al. “Association between Furosemide Exposure and Patent Ductus Arteriosus in Hospitalized Infants of Very Low Birth Weight.J Pediatr, vol. 199, Aug. 2018, pp. 231–36. Pubmed, doi:10.1016/j.jpeds.2018.03.067.
Thompson EJ, Greenberg RG, Kumar K, Laughon M, Smith PB, Clark RH, Crowell A, Shaw L, Harrison L, Scales G, Bell N, Hornik CP. Association between Furosemide Exposure and Patent Ductus Arteriosus in Hospitalized Infants of Very Low Birth Weight. J Pediatr. 2018 Aug;199:231–236.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

August 2018

Volume

199

Start / End Page

231 / 236

Location

United States

Related Subject Headings

  • Sodium Potassium Chloride Symporter Inhibitors
  • Risk Factors
  • Retrospective Studies
  • Pediatrics
  • Male
  • Logistic Models
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn