External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.
Publication
, Journal Article
Ge, S; Beechinor, RJ; Hornik, CP; Standing, JF; Zimmerman, K; Cohen-Wolkowiez, M; Laughon, MM; Clark, R; Gonzalez, D
Published in: Antimicrob Agents Chemother
September 2018
Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses was to evaluate the feasibility of using a national electronic health record (EHR) database for further external evaluation of this model. Our results suggest that, with proper data capture procedures, EHR data can serve as a potential data source for external evaluation of PK models.
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Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
September 2018
Volume
62
Issue
9
Location
United States
Related Subject Headings
- Models, Biological
- Microbiology
- Male
- Infant, Newborn
- Infant
- Humans
- Gentamicins
- Female
- Electronic Health Records
- Databases, Factual
Citation
APA
Chicago
ICMJE
MLA
NLM
Ge, S., Beechinor, R. J., Hornik, C. P., Standing, J. F., Zimmerman, K., Cohen-Wolkowiez, M., … Gonzalez, D. (2018). External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database. Antimicrob Agents Chemother, 62(9). https://doi.org/10.1128/AAC.00669-18
Ge, Shufan, Ryan J. Beechinor, Christoph P. Hornik, Joseph F. Standing, Kanecia Zimmerman, Michael Cohen-Wolkowiez, Matthew M. Laughon, Reese Clark, and Daniel Gonzalez. “External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.” Antimicrob Agents Chemother 62, no. 9 (September 2018). https://doi.org/10.1128/AAC.00669-18.
Ge S, Beechinor RJ, Hornik CP, Standing JF, Zimmerman K, Cohen-Wolkowiez M, et al. External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database. Antimicrob Agents Chemother. 2018 Sep;62(9).
Ge, Shufan, et al. “External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.” Antimicrob Agents Chemother, vol. 62, no. 9, Sept. 2018. Pubmed, doi:10.1128/AAC.00669-18.
Ge S, Beechinor RJ, Hornik CP, Standing JF, Zimmerman K, Cohen-Wolkowiez M, Laughon MM, Clark R, Gonzalez D. External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database. Antimicrob Agents Chemother. 2018 Sep;62(9).
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
September 2018
Volume
62
Issue
9
Location
United States
Related Subject Headings
- Models, Biological
- Microbiology
- Male
- Infant, Newborn
- Infant
- Humans
- Gentamicins
- Female
- Electronic Health Records
- Databases, Factual