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Preterm Neuroimaging and School-Age Cognitive Outcomes.

Publication ,  Journal Article
Hintz, SR; Vohr, BR; Bann, CM; Taylor, HG; Das, A; Gustafson, KE; Yolton, K; Watson, VE; Lowe, J; DeAnda, ME; Ball, MB; Finer, NN; Pappas, A ...
Published in: Pediatrics
July 2018

BACKGROUND AND OBJECTIVES: Children born extremely preterm are at risk for cognitive difficulties and disability. The relative prognostic value of neonatal brain MRI and cranial ultrasound (CUS) for school-age outcomes remains unclear. Our objectives were to relate near-term conventional brain MRI and early and late CUS to cognitive impairment and disability at 6 to 7 years among children born extremely preterm and assess prognostic value. METHODS: A prospective study of adverse early and late CUS and near-term conventional MRI findings to predict outcomes at 6 to 7 years including a full-scale IQ (FSIQ) <70 and disability (FSIQ <70, moderate-to-severe cerebral palsy, or severe vision or hearing impairment) in a subgroup of Surfactant Positive Airway Pressure and Pulse Oximetry Randomized Trial enrollees. Stepwise logistic regression evaluated associations of neuroimaging with outcomes, adjusting for perinatal-neonatal factors. RESULTS: A total of 386 children had follow-up. In unadjusted analyses, severity of white matter abnormality and cerebellar lesions on MRI and adverse CUS findings were associated with outcomes. In full regression models, both adverse late CUS findings (odds ratio [OR] 27.9; 95% confidence interval [CI] 6.0-129) and significant cerebellar lesions on MRI (OR 2.71; 95% CI 1.1-6.7) remained associated with disability, but only adverse late CUS findings (OR 20.1; 95% CI 3.6-111) were associated with FSIQ <70. Predictive accuracy of stepwise models was not substantially improved with the addition of neuroimaging. CONCLUSIONS: Severe but rare adverse late CUS findings were most strongly associated with cognitive impairment and disability at school age, and significant cerebellar lesions on MRI were associated with disability. Near-term conventional MRI did not substantively enhance prediction of severe early school-age outcomes.

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Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

July 2018

Volume

142

Issue

1

Location

United States

Related Subject Headings

  • Prospective Studies
  • Prognosis
  • Pediatrics
  • Neuroimaging
  • Magnetic Resonance Imaging
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hintz, S. R., Vohr, B. R., Bann, C. M., Taylor, H. G., Das, A., Gustafson, K. E., … SUPPORT study group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . (2018). Preterm Neuroimaging and School-Age Cognitive Outcomes. Pediatrics, 142(1). https://doi.org/10.1542/peds.2017-4058
Hintz, Susan R., Betty R. Vohr, Carla M. Bann, H Gerry Taylor, Abhik Das, Kathryn E. Gustafson, Kimberly Yolton, et al. “Preterm Neuroimaging and School-Age Cognitive Outcomes.Pediatrics 142, no. 1 (July 2018). https://doi.org/10.1542/peds.2017-4058.
Hintz SR, Vohr BR, Bann CM, Taylor HG, Das A, Gustafson KE, et al. Preterm Neuroimaging and School-Age Cognitive Outcomes. Pediatrics. 2018 Jul;142(1).
Hintz, Susan R., et al. “Preterm Neuroimaging and School-Age Cognitive Outcomes.Pediatrics, vol. 142, no. 1, July 2018. Pubmed, doi:10.1542/peds.2017-4058.
Hintz SR, Vohr BR, Bann CM, Taylor HG, Das A, Gustafson KE, Yolton K, Watson VE, Lowe J, DeAnda ME, Ball MB, Finer NN, Van Meurs KP, Shankaran S, Pappas A, Barnes PD, Bulas D, Newman JE, Wilson-Costello DE, Heyne RJ, Harmon HM, Peralta-Carcelen M, Adams-Chapman I, Duncan AF, Fuller J, Vaucher YE, Colaizy TT, Winter S, McGowan EC, Goldstein RF, Higgins RD, SUPPORT study group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Preterm Neuroimaging and School-Age Cognitive Outcomes. Pediatrics. 2018 Jul;142(1).

Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

July 2018

Volume

142

Issue

1

Location

United States

Related Subject Headings

  • Prospective Studies
  • Prognosis
  • Pediatrics
  • Neuroimaging
  • Magnetic Resonance Imaging
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
  • Follow-Up Studies