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Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa.

Publication ,  Journal Article
Gray, GE; Huang, Y; Grunenberg, N; Laher, F; Roux, S; Andersen-Nissen, E; De Rosa, SC; Flach, B; Randhawa, AK; Jensen, R; Swann, EM; Innes, C ...
Published in: Sci Transl Med
September 18, 2019

One of the most successful HIV vaccines to date, the RV144 vaccine tested in Thailand, demonstrated correlates of protection including cross-clade V1V2 immunoglobulin G (IgG) breadth, Env-specific CD4+ T cell polyfunctionality, and antibody-dependent cellular cytotoxicity (ADCC) in vaccinees with low IgA binding. The HIV Vaccine Trials Network (HVTN) 097 trial evaluated this vaccine regimen in South Africa, where clade C HIV-1 predominates. We compared cellular and humoral responses at peak and durability immunogenicity time points in HVTN 097 and RV144 vaccinee samples, and evaluated vaccine-matched and cross-clade immune responses. At peak immunogenicity, HVTN 097 vaccinees exhibited significantly higher cellular and humoral immune responses than RV144 vaccinees. CD4+ T cell responses were more frequent in HVTN 097 irrespective of age and sex, and CD4+ T cell Env-specific functionality scores were higher in HVTN 097. Env-specific CD40L+ CD4+ T cells were more common in HVTN 097, with individuals having this pattern of expression demonstrating higher median antibody responses to HIV-1 Env. IgG and IgG3 binding antibody rates and response magnitude to gp120 vaccine- and V1V2 vaccine-matched antigens were higher or comparable in HVTN 097 than in RV144 ADCC, and ADCP functional antibody responses were elicited in HVTN 097. Env-specific IgG and CD4+ Env responses declined significantly over time in both trials. Overall, cross-clade immune responses associated with protection were better than expected in South Africa, suggesting wider applicability of this regimen.

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Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

September 18, 2019

Volume

11

Issue

510

Location

United States

Related Subject Headings

  • Young Adult
  • Vaccination
  • Thailand
  • T-Lymphocytes
  • South Africa
  • Principal Component Analysis
  • Placebos
  • Phagocytosis
  • Neutralization Tests
  • Male
 

Citation

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MLA
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Gray, G. E., Huang, Y., Grunenberg, N., Laher, F., Roux, S., Andersen-Nissen, E., … Corey, L. (2019). Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa. Sci Transl Med, 11(510). https://doi.org/10.1126/scitranslmed.aax1880
Gray, Glenda E., Ying Huang, Nicole Grunenberg, Fatima Laher, Surita Roux, Erica Andersen-Nissen, Stephen C. De Rosa, et al. “Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa.Sci Transl Med 11, no. 510 (September 18, 2019). https://doi.org/10.1126/scitranslmed.aax1880.
Gray GE, Huang Y, Grunenberg N, Laher F, Roux S, Andersen-Nissen E, et al. Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa. Sci Transl Med. 2019 Sep 18;11(510).
Gray, Glenda E., et al. “Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa.Sci Transl Med, vol. 11, no. 510, Sept. 2019. Pubmed, doi:10.1126/scitranslmed.aax1880.
Gray GE, Huang Y, Grunenberg N, Laher F, Roux S, Andersen-Nissen E, De Rosa SC, Flach B, Randhawa AK, Jensen R, Swann EM, Bekker L-G, Innes C, Lazarus E, Morris L, Mkhize NN, Ferrari G, Montefiori DC, Shen X, Sawant S, Yates N, Hural J, Isaacs A, Phogat S, DiazGranados CA, Lee C, Sinangil F, Michael NL, Robb ML, Kublin JG, Gilbert PB, McElrath MJ, Tomaras GD, Corey L. Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa. Sci Transl Med. 2019 Sep 18;11(510).

Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

September 18, 2019

Volume

11

Issue

510

Location

United States

Related Subject Headings

  • Young Adult
  • Vaccination
  • Thailand
  • T-Lymphocytes
  • South Africa
  • Principal Component Analysis
  • Placebos
  • Phagocytosis
  • Neutralization Tests
  • Male