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Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.

Publication ,  Journal Article
Ginsburg, GS; Cavallari, LH; Chakraborty, H; Cooper-DeHoff, RM; Dexter, PR; Eadon, MT; Ferket, BS; Horowitz, CR; Johnson, JA; Kannry, J ...
Published in: Genet Med
July 2021

PURPOSE: A critical gap in the adoption of genomic medicine into medical practice is the need for the rigorous evaluation of the utility of genomic medicine interventions. METHODS: The Implementing Genomics in Practice Pragmatic Trials Network (IGNITE PTN) was formed in 2018 to measure the clinical utility and cost-effectiveness of genomic medicine interventions, to assess approaches for real-world application of genomic medicine in diverse clinical settings, and to produce generalizable knowledge on clinical trials using genomic interventions. Five clinical sites and a coordinating center evaluated trial proposals and developed working groups to enable their implementation. RESULTS: Two pragmatic clinical trials (PCTs) have been initiated, one evaluating genetic risk APOL1 variants in African Americans in the management of their hypertension, and the other to evaluate the use of pharmacogenetic testing for medications to manage acute and chronic pain as well as depression. CONCLUSION: IGNITE PTN is a network that carries out PCTs in genomic medicine; it is focused on diversity and inclusion of underrepresented minority trial participants; it uses electronic health records and clinical decision support to deliver the interventions. IGNITE PTN will develop the evidence to support (or oppose) the adoption of genomic medicine interventions by patients, providers, and payers.

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Published In

Genet Med

DOI

EISSN

1530-0366

Publication Date

July 2021

Volume

23

Issue

7

Start / End Page

1185 / 1191

Location

United States

Related Subject Headings

  • Precision Medicine
  • Pharmacogenomic Testing
  • Humans
  • Genomics
  • Genetics & Heredity
  • Electronic Health Records
  • Decision Support Systems, Clinical
  • Apolipoprotein L1
  • 3105 Genetics
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ginsburg, G. S., Cavallari, L. H., Chakraborty, H., Cooper-DeHoff, R. M., Dexter, P. R., Eadon, M. T., … IGNITE PTN. (2021). Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network. Genet Med, 23(7), 1185–1191. https://doi.org/10.1038/s41436-021-01118-9
Ginsburg, Geoffrey S., Larisa H. Cavallari, Hrishikesh Chakraborty, Rhonda M. Cooper-DeHoff, Paul R. Dexter, Michael T. Eadon, Bart S. Ferket, et al. “Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.Genet Med 23, no. 7 (July 2021): 1185–91. https://doi.org/10.1038/s41436-021-01118-9.
Ginsburg GS, Cavallari LH, Chakraborty H, Cooper-DeHoff RM, Dexter PR, Eadon MT, et al. Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network. Genet Med. 2021 Jul;23(7):1185–91.
Ginsburg, Geoffrey S., et al. “Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.Genet Med, vol. 23, no. 7, July 2021, pp. 1185–91. Pubmed, doi:10.1038/s41436-021-01118-9.
Ginsburg GS, Cavallari LH, Chakraborty H, Cooper-DeHoff RM, Dexter PR, Eadon MT, Ferket BS, Horowitz CR, Johnson JA, Kannry J, Kucher N, Madden EB, Orlando LA, Parker W, Peterson J, Pratt VM, Rakhra-Burris TK, Ramos MA, Skaar TC, Sperber N, Steen-Burrell K-A, Van Driest SL, Voora D, Wiisanen K, Winterstein AG, Volpi S, IGNITE PTN. Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network. Genet Med. 2021 Jul;23(7):1185–1191.

Published In

Genet Med

DOI

EISSN

1530-0366

Publication Date

July 2021

Volume

23

Issue

7

Start / End Page

1185 / 1191

Location

United States

Related Subject Headings

  • Precision Medicine
  • Pharmacogenomic Testing
  • Humans
  • Genomics
  • Genetics & Heredity
  • Electronic Health Records
  • Decision Support Systems, Clinical
  • Apolipoprotein L1
  • 3105 Genetics
  • 1103 Clinical Sciences