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Comparative efficacy and safety of late surfactant preparations: a retrospective study.

Publication ,  Journal Article
Lane, MD; Kishnani, S; Udemadu, O; Danquah, SE; Treadway, RM; Langman, A; Balevic, S; Jackson, WM; Laughon, M; Hornik, CP; Greenberg, RG ...
Published in: J Perinatol
November 2021

OBJECTIVE: Characterize the use, efficacy, and safety of poractant alfa and calfactant surfactants compared to beractant in preterm infants receiving late surfactant. STUDY DESIGN: We included infants <37 weeks gestational age (GA) discharged from Pediatrix Medical Group-managed neonatal intensive care units (1997-2017). Efficacy and safety outcomes of interest were analyzed. RESULTS: Of 184,770 infants administered surfactant at any time, 7846 (4.23%) received late surfactant at a median (25th, 75th percentile) PNA of 8 days (3, 22); specifically, 2976 received poractant alfa (38%), 2890 beractant (37%), and 1936 calfactant (25%). We identified no significant differences in composite efficacy or safety outcomes between surfactants in the primary analysis, but 33-36 week GA infants administered poractant alfa had significantly greater odds of developing a safety event. CONCLUSIONS: Compared to beractant, there is no evidence of overall superior efficacy or safety of poractant alfa.

Duke Scholars

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

November 2021

Volume

41

Issue

11

Start / End Page

2639 / 2644

Location

United States

Related Subject Headings

  • Surface-Active Agents
  • Retrospective Studies
  • Respiratory Distress Syndrome, Newborn
  • Pulmonary Surfactants
  • Phospholipids
  • Pediatrics
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Biological Products
 

Citation

APA
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ICMJE
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Lane, M. D., Kishnani, S., Udemadu, O., Danquah, S. E., Treadway, R. M., Langman, A., … Zimmerman, K. O. (2021). Comparative efficacy and safety of late surfactant preparations: a retrospective study. J Perinatol, 41(11), 2639–2644. https://doi.org/10.1038/s41372-021-01142-2

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

November 2021

Volume

41

Issue

11

Start / End Page

2639 / 2644

Location

United States

Related Subject Headings

  • Surface-Active Agents
  • Retrospective Studies
  • Respiratory Distress Syndrome, Newborn
  • Pulmonary Surfactants
  • Phospholipids
  • Pediatrics
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Biological Products