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Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study.

Publication ,  Journal Article
Gupta, A; Saraiya, V; Deveaux, A; Oyekunle, T; Jackson, KD; Salako, O; Daramola, A; Hall, A; Alatise, O; Ogun, G; Adeniyi, A; Ayandipo, O ...
Published in: Sci Rep
June 23, 2022

There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of lipid biomarkers-total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides-with odds of BC overall and by subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC) for 296 newly diagnosed BC cases and 116 healthy controls in Nigeria. Each unit standard deviation (SD) increase in triglycerides was associated with 39% increased odds of BC in fully adjusted models (aOR: 1.39; 95% CI: 1.03, 1.86). Among post-menopausal women, higher total cholesterol (aOR: 1.65; 95% CI: 1.06, 2.57), LDL cholesterol (aOR: 1.59; 95% CI: 1.04, 2.41), and triglycerides (aOR: 1.91; 95% CI: 1.21, 3.01) were associated with increased odds of BC. Additionally, each unit SD increase in LDL was associated with 64% increased odds of Luminal B BC (aOR 1.64; 95% CI: 1.06, 2.55). Clinically low HDL was associated with 2.7 times increased odds of TNBC (aOR 2.67; 95% CI: 1.10, 6.49). Among post-menopausal women, higher LDL cholesterol and triglycerides were significantly associated with increased odds of Luminal B BC and HER2 BC, respectively. In conclusion, low HDL and high LDL are associated with increased odds of TN and Luminal B BC, respectively, among African women. Future prospective studies can definitively characterize this association and inform clinical approaches targeting HDL as a BC prevention strategy.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

June 23, 2022

Volume

12

Issue

1

Start / End Page

10631

Location

England

Related Subject Headings

  • Triple Negative Breast Neoplasms
  • Triglycerides
  • Risk Factors
  • Prospective Studies
  • Humans
  • Female
  • Cholesterol, LDL
  • Cholesterol, HDL
  • Breast Neoplasms
  • Biomarkers
 

Citation

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Gupta, A., Saraiya, V., Deveaux, A., Oyekunle, T., Jackson, K. D., Salako, O., … Akinyemiju, T. (2022). Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study. Sci Rep, 12(1), 10631. https://doi.org/10.1038/s41598-022-13740-x
Gupta, Anjali, Veeral Saraiya, April Deveaux, Taofik Oyekunle, Klarissa D. Jackson, Omolola Salako, Adetola Daramola, et al. “Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study.Sci Rep 12, no. 1 (June 23, 2022): 10631. https://doi.org/10.1038/s41598-022-13740-x.
Gupta A, Saraiya V, Deveaux A, Oyekunle T, Jackson KD, Salako O, et al. Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study. Sci Rep. 2022 Jun 23;12(1):10631.
Gupta, Anjali, et al. “Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study.Sci Rep, vol. 12, no. 1, June 2022, p. 10631. Pubmed, doi:10.1038/s41598-022-13740-x.
Gupta A, Saraiya V, Deveaux A, Oyekunle T, Jackson KD, Salako O, Daramola A, Hall A, Alatise O, Ogun G, Adeniyi A, Ayandipo O, Olajide T, Olasehinde O, Arowolo O, Adisa A, Afuwape O, Olusanya A, Adegoke A, Tollefsbol TO, Arnett D, Muehlbauer MJ, Newgard CB, H3 Africa Kidney Research Network, Akinyemiju T. Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study. Sci Rep. 2022 Jun 23;12(1):10631.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

June 23, 2022

Volume

12

Issue

1

Start / End Page

10631

Location

England

Related Subject Headings

  • Triple Negative Breast Neoplasms
  • Triglycerides
  • Risk Factors
  • Prospective Studies
  • Humans
  • Female
  • Cholesterol, LDL
  • Cholesterol, HDL
  • Breast Neoplasms
  • Biomarkers