Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease.
Publication
, Journal Article
Holmes, ZC; Tang, H; Liu, C; Bush, A; Neubert, BC; Jiao, Y; Covington, M; Cardona, DM; Kirtley, MC; Chen, BJ; Chao, NJ; David, LA; Sung, AD
Published in: Blood
November 24, 2022
Previous studies suggest that gut microbiome disruption induced by chemotherapy, dietary deficiencies, and/or antibiotics are associated with increased incidence of acute graft-versus-host disease (aGVHD) following hematopoietic stem cell transplantation (HSCT). In a murine model of antibiotic-induced gut microbiome disruption, Holmes and colleagues show that oral administration of galactooligosaccharides (GOS) as a prebiotic attenuates lethal aGVHD, highlighting the crosstalk between diet and gut microbiota. Their data encourage clinical trials of GOS prebiotic diets during HSCT.
Duke Scholars
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Published In
Blood
DOI
EISSN
1528-0020
Publication Date
November 24, 2022
Volume
140
Issue
21
Start / End Page
2300 / 2304
Location
United States
Related Subject Headings
- Prebiotics
- Mice
- Immunology
- Graft vs Host Disease
- Gastrointestinal Microbiome
- Animals
- 3213 Paediatrics
- 3201 Cardiovascular medicine and haematology
- 3101 Biochemistry and cell biology
- 1114 Paediatrics and Reproductive Medicine
Citation
APA
Chicago
ICMJE
MLA
NLM
Holmes, Z. C., Tang, H., Liu, C., Bush, A., Neubert, B. C., Jiao, Y., … Sung, A. D. (2022). Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease. Blood, 140(21), 2300–2304. https://doi.org/10.1182/blood.2021015178
Holmes, Zachary C., Helen Tang, Congxiao Liu, Amy Bush, Benjamin C. Neubert, Yiqun Jiao, Megan Covington, et al. “Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease.” Blood 140, no. 21 (November 24, 2022): 2300–2304. https://doi.org/10.1182/blood.2021015178.
Holmes ZC, Tang H, Liu C, Bush A, Neubert BC, Jiao Y, et al. Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease. Blood. 2022 Nov 24;140(21):2300–4.
Holmes, Zachary C., et al. “Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease.” Blood, vol. 140, no. 21, Nov. 2022, pp. 2300–04. Pubmed, doi:10.1182/blood.2021015178.
Holmes ZC, Tang H, Liu C, Bush A, Neubert BC, Jiao Y, Covington M, Cardona DM, Kirtley MC, Chen BJ, Chao NJ, David LA, Sung AD. Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease. Blood. 2022 Nov 24;140(21):2300–2304.
Published In
Blood
DOI
EISSN
1528-0020
Publication Date
November 24, 2022
Volume
140
Issue
21
Start / End Page
2300 / 2304
Location
United States
Related Subject Headings
- Prebiotics
- Mice
- Immunology
- Graft vs Host Disease
- Gastrointestinal Microbiome
- Animals
- 3213 Paediatrics
- 3201 Cardiovascular medicine and haematology
- 3101 Biochemistry and cell biology
- 1114 Paediatrics and Reproductive Medicine