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Risk factors for cardiovascular disease among individuals with hepatic steatosis.

Publication ,  Journal Article
Karády, J; Ferencik, M; Mayrhofer, T; Meyersohn, NM; Bittner, DO; Staziaki, PV; Szilveszter, B; Hallett, TR; Lu, MT; Puchner, SB; Simon, TG ...
Published in: Hepatol Commun
December 2022

Cardiovascular disease (CVD) is the leading cause of mortality in adults with hepatic steatosis (HS). However, risk factors for CVD in HS are unknown. We aimed to identify factors associated with coronary artery disease (CAD) and incident major adverse cardiovascular events (MACE) in individuals with HS. We performed a nested cohort study of adults with HS detected on coronary computed tomography in the PROspective Multicenter Imaging Study for Evaluation of chest pain (PROMISE) trial. Obstructive CAD was defined as ≥50% coronary stenosis. MACE included hospitalization for unstable angina, nonfatal myocardial infarction, or all-cause death. Multivariate modeling, adjusted for age, sex, atherosclerotic CVD (ASCVD) risk score and body mass index, identified factors associated with obstructive CAD. Cox regression, adjusted for ASCVD risk score, determined the predictors of MACE. A total of 959 of 3,756 (mean age 59.4 years, 55.0% men) had HS. Obstructive CAD was present in 15.2% (145 of 959). Male sex (adjusted odds ratio [aOR] = 1.83, 95% confidence interval [CI] 1.18-1.2.84; p = 0.007), ASCVD risk score (aOR = 1.05, 95% CI 1.03-1.07; p < 0.001), and n-terminal pro-b-type natriuretic peptide (NT-proBNP; aOR = 1.90, 95% CI 1.38-2.62; p < 0.001) were independently associated with obstructive CAD. In the 25-months median follow-up, MACE occurred in 4.4% (42 of 959). Sedentary lifestyle (adjusted hazard ratio [aHR] = 2.53, 95% CI 1.27-5.03; p = 0.008) and NT-proBNP (aOR = 1.50, 95% CI 1.01-2.25; p = 0.046) independently predicted MACE. Furthermore, the risk of MACE increased by 3% for every 1% increase in ASCVD risk score (aHR = 1.03, 95% CI 1.01-1.05; p = 0.02). Conclusion: In individuals with HS, male sex, NT-pro-BNP, and ASCVD risk score are associated with obstructive CAD. Furthermore, ASCVD, NT-proBNP, and sedentary lifestyle are independent predictors of MACE. These factors, with further validation, may help risk-stratify adults with HS for incident CAD and MACE.

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Published In

Hepatol Commun

DOI

EISSN

2471-254X

Publication Date

December 2022

Volume

6

Issue

12

Start / End Page

3406 / 3420

Location

United States

Related Subject Headings

  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Heart Disease Risk Factors
  • Female
  • Coronary Artery Disease
  • Coronary Angiography
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Karády, J., Ferencik, M., Mayrhofer, T., Meyersohn, N. M., Bittner, D. O., Staziaki, P. V., … Corey, K. E. (2022). Risk factors for cardiovascular disease among individuals with hepatic steatosis. Hepatol Commun, 6(12), 3406–3420. https://doi.org/10.1002/hep4.2090
Karády, Julia, Maros Ferencik, Thomas Mayrhofer, Nandini M. Meyersohn, Daniel O. Bittner, Pedro V. Staziaki, Balint Szilveszter, et al. “Risk factors for cardiovascular disease among individuals with hepatic steatosis.Hepatol Commun 6, no. 12 (December 2022): 3406–20. https://doi.org/10.1002/hep4.2090.
Karády J, Ferencik M, Mayrhofer T, Meyersohn NM, Bittner DO, Staziaki PV, et al. Risk factors for cardiovascular disease among individuals with hepatic steatosis. Hepatol Commun. 2022 Dec;6(12):3406–20.
Karády, Julia, et al. “Risk factors for cardiovascular disease among individuals with hepatic steatosis.Hepatol Commun, vol. 6, no. 12, Dec. 2022, pp. 3406–20. Pubmed, doi:10.1002/hep4.2090.
Karády J, Ferencik M, Mayrhofer T, Meyersohn NM, Bittner DO, Staziaki PV, Szilveszter B, Hallett TR, Lu MT, Puchner SB, Simon TG, Foldyna B, Ginsburg GS, McGarrah RW, Voora D, Shah SH, Douglas PS, Hoffmann U, Corey KE. Risk factors for cardiovascular disease among individuals with hepatic steatosis. Hepatol Commun. 2022 Dec;6(12):3406–3420.

Published In

Hepatol Commun

DOI

EISSN

2471-254X

Publication Date

December 2022

Volume

6

Issue

12

Start / End Page

3406 / 3420

Location

United States

Related Subject Headings

  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Heart Disease Risk Factors
  • Female
  • Coronary Artery Disease
  • Coronary Angiography
  • Cohort Studies