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Microcalcification crystallography as a potential marker of DCIS recurrence.

Publication ,  Journal Article
Gosling, SB; Arnold, EL; Davies, SK; Cross, H; Bouybayoune, I; Calabrese, D; Nallala, J; Pinder, SE; Fu, L; Lips, EH; King, L; Marks, J ...
Published in: Sci Rep
June 8, 2023

Ductal carcinoma in-situ (DCIS) accounts for 20-25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

June 8, 2023

Volume

13

Issue

1

Start / End Page

9331

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Neoplasm Recurrence, Local
  • Humans
  • Female
  • Crystallography
  • Carcinoma, Intraductal, Noninfiltrating
  • Carcinoma, Ductal, Breast
  • Calcinosis
  • Breast Neoplasms
 

Citation

APA
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MLA
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Gosling, S. B., Arnold, E. L., Davies, S. K., Cross, H., Bouybayoune, I., Calabrese, D., … Grand Challenge PRECISION Consortium, . (2023). Microcalcification crystallography as a potential marker of DCIS recurrence. Sci Rep, 13(1), 9331. https://doi.org/10.1038/s41598-023-33547-8
Gosling, Sarah B., Emily L. Arnold, Samantha K. Davies, Hannah Cross, Ihssane Bouybayoune, Doriana Calabrese, Jayakrupakar Nallala, et al. “Microcalcification crystallography as a potential marker of DCIS recurrence.Sci Rep 13, no. 1 (June 8, 2023): 9331. https://doi.org/10.1038/s41598-023-33547-8.
Gosling SB, Arnold EL, Davies SK, Cross H, Bouybayoune I, Calabrese D, et al. Microcalcification crystallography as a potential marker of DCIS recurrence. Sci Rep. 2023 Jun 8;13(1):9331.
Gosling, Sarah B., et al. “Microcalcification crystallography as a potential marker of DCIS recurrence.Sci Rep, vol. 13, no. 1, June 2023, p. 9331. Pubmed, doi:10.1038/s41598-023-33547-8.
Gosling SB, Arnold EL, Davies SK, Cross H, Bouybayoune I, Calabrese D, Nallala J, Pinder SE, Fu L, Lips EH, King L, Marks J, Hall A, Grimm LJ, Lynch T, Pinto D, Stobart H, Hwang ES, Wesseling J, Geraki K, Stone N, Lyburn ID, Greenwood C, Rogers KD, Grand Challenge PRECISION Consortium. Microcalcification crystallography as a potential marker of DCIS recurrence. Sci Rep. 2023 Jun 8;13(1):9331.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

June 8, 2023

Volume

13

Issue

1

Start / End Page

9331

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • Neoplasm Recurrence, Local
  • Humans
  • Female
  • Crystallography
  • Carcinoma, Intraductal, Noninfiltrating
  • Carcinoma, Ductal, Breast
  • Calcinosis
  • Breast Neoplasms