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Generation, validation, and benchmarking of a commercial independent Monte Carlo calculation beam model for multi-target SRS.

Publication ,  Journal Article
Adamson, J; Erickson, BG; Wang, C; Cui, Y; Alber, M; Kirkpatrick, J; Yin, F-F
Published in: Z Med Phys
September 7, 2023

BACKGROUND: Dosimetric validation of single isocenter multi-target radiosurgery plans is difficult due to conditions of electronic disequilibrium and the simultaneous irradiation of multiple off-axis lesions dispersed throughout the volume. Here we report the benchmarking of a customizable Monte Carlo secondary dose calculation algorithm specific for multi-target radiosurgery which future users may use to guide their commissioning and clinical implementation. PURPOSE: To report the generation, validation, and clinical benchmarking of a volumetric Monte Carlo (MC) dose calculation beam model for single isocenter radiosurgery of intracranial multi-focal disease. METHODS: The beam model was prepared within SciMoCa (ScientificRT, Munich Germany), a commercial independent dose calculation software, with the aim of broad availability via the commercial software for use with single isocenter radiosurgery. The process included (1) definition & acquisition of measurement data required for beam modeling, (2) tuning model parameters to match measurements, (3) validation of the beam model via independent measurements and end-to-end testing, and finally, (4) clinical benchmarking and validation of beam model utility in a patient specific QA setting. We utilized a 6X Flattening-Filter-Free photon beam from a TrueBeam STX linear accelerator (Siemens Healthineers, Munich Germany). RESULTS: In addition to the measured data required for standard IMRT/VMAT (depth dose, central axis profiles & output factors, leaf gap), beam modeling and validation for single-isocenter SRS required central axis and off axis (5 cm & 9 cm) small field output factors and comparison between measurement and simulation of backscatter with aperture for jaw much greater than MLCs. Validation end-to-end measurements included SRS MapCHECK in StereoPHAN geometry (2%/1 mm Gamma = 99.2% ± 2.2%), and OSL & scintillator measurements in anthropomorphic STEEV phantom (6 targets, volume = 0.1-4.1cc, distance from isocenter = 1.2-7.9 cm) for which mean difference was -1.9% ± 2.2%. For 10 patient cases, MC for individual PTVs was -0.8% ± 1.5%, -1.3% ± 1.7%, and -0.5% ± 1.8% for mean dose, D95%, and D1%, respectively. This corresponded to custom passing rates action limits per AAPM TG-218 guidelines of ±5.2%, ±6.4%, and ±6.3%, respectively. CONCLUSIONS: The beam modeling, validation, and clinical action criteria outlined here serves as a benchmark for future users of the customized beam model within SciMoCa for single isocenter radiosurgery of multi-focal disease.

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Published In

Z Med Phys

DOI

EISSN

1876-4436

Publication Date

September 7, 2023

Location

Germany

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 3211 Oncology and carcinogenesis
 

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Adamson, J., Erickson, B. G., Wang, C., Cui, Y., Alber, M., Kirkpatrick, J., & Yin, F.-F. (2023). Generation, validation, and benchmarking of a commercial independent Monte Carlo calculation beam model for multi-target SRS. Z Med Phys. https://doi.org/10.1016/j.zemedi.2023.08.004
Adamson, Justus, Brett G. Erickson, Chunhao Wang, Yunfeng Cui, Markus Alber, John Kirkpatrick, and Fang-Fang Yin. “Generation, validation, and benchmarking of a commercial independent Monte Carlo calculation beam model for multi-target SRS.Z Med Phys, September 7, 2023. https://doi.org/10.1016/j.zemedi.2023.08.004.
Adamson J, Erickson BG, Wang C, Cui Y, Alber M, Kirkpatrick J, et al. Generation, validation, and benchmarking of a commercial independent Monte Carlo calculation beam model for multi-target SRS. Z Med Phys. 2023 Sep 7;
Adamson, Justus, et al. “Generation, validation, and benchmarking of a commercial independent Monte Carlo calculation beam model for multi-target SRS.Z Med Phys, Sept. 2023. Pubmed, doi:10.1016/j.zemedi.2023.08.004.
Adamson J, Erickson BG, Wang C, Cui Y, Alber M, Kirkpatrick J, Yin F-F. Generation, validation, and benchmarking of a commercial independent Monte Carlo calculation beam model for multi-target SRS. Z Med Phys. 2023 Sep 7;
Journal cover image

Published In

Z Med Phys

DOI

EISSN

1876-4436

Publication Date

September 7, 2023

Location

Germany

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 3211 Oncology and carcinogenesis