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Host immunity associated with spontaneous suppression of viremia in therapy-naïve young rhesus macaques following neonatal SHIV infection.

Publication ,  Journal Article
Evangelous, TD; Berry, M; Venkatayogi, S; LeMaster, C; Geanes, ES; De Naeyer, N; DeMarco, T; Shen, X; Li, H; Hora, B; Solomonis, N; Lewis, MG ...
Published in: J Virol
November 30, 2023

Despite the advent of highly active anti-retroviral therapy, people are still dying from HIV-related causes, many of whom are children, and a protective vaccine or cure is needed to end the HIV pandemic. Understanding the nature and activation states of immune cell subsets during infection will provide insights into the immunologic milieu associated with viremia suppression that can be harnessed via therapeutic strategies to achieve a functional cure, but these are understudied in pediatric subjects. We evaluated humoral and adaptive host immunity associated with suppression of viremia in rhesus macaques infected soon after birth with a pathogenic SHIV. The results from our study provide insights into the immune cell subsets and functions associated with viremia control in young macaques that may translate to pediatric subjects for the design of future anti-viral strategies in HIV-1-infected infants and children and contribute to an understudied area of HIV-1 pathogenesis in pediatric subjects.

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Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

November 30, 2023

Volume

97

Issue

11

Start / End Page

e0109423

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Macaca mulatta
  • Humans
  • HIV Infections
  • HIV
  • Disease Models, Animal
 

Citation

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Evangelous, T. D., Berry, M., Venkatayogi, S., LeMaster, C., Geanes, E. S., De Naeyer, N., … Williams, W. B. (2023). Host immunity associated with spontaneous suppression of viremia in therapy-naïve young rhesus macaques following neonatal SHIV infection. J Virol, 97(11), e0109423. https://doi.org/10.1128/jvi.01094-23
Evangelous, Tyler D., Madison Berry, Sravani Venkatayogi, Cas LeMaster, Eric S. Geanes, Nicole De Naeyer, Todd DeMarco, et al. “Host immunity associated with spontaneous suppression of viremia in therapy-naïve young rhesus macaques following neonatal SHIV infection.J Virol 97, no. 11 (November 30, 2023): e0109423. https://doi.org/10.1128/jvi.01094-23.
Evangelous TD, Berry M, Venkatayogi S, LeMaster C, Geanes ES, De Naeyer N, et al. Host immunity associated with spontaneous suppression of viremia in therapy-naïve young rhesus macaques following neonatal SHIV infection. J Virol. 2023 Nov 30;97(11):e0109423.
Evangelous, Tyler D., et al. “Host immunity associated with spontaneous suppression of viremia in therapy-naïve young rhesus macaques following neonatal SHIV infection.J Virol, vol. 97, no. 11, Nov. 2023, p. e0109423. Pubmed, doi:10.1128/jvi.01094-23.
Evangelous TD, Berry M, Venkatayogi S, LeMaster C, Geanes ES, De Naeyer N, DeMarco T, Shen X, Li H, Hora B, Solomonis N, Misamore J, Lewis MG, Denny TN, Montefiori D, Shaw GM, Wiehe K, Bradley T, Williams WB. Host immunity associated with spontaneous suppression of viremia in therapy-naïve young rhesus macaques following neonatal SHIV infection. J Virol. 2023 Nov 30;97(11):e0109423.

Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

November 30, 2023

Volume

97

Issue

11

Start / End Page

e0109423

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Macaca mulatta
  • Humans
  • HIV Infections
  • HIV
  • Disease Models, Animal