Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.

Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and slope of decline in weight, on AD risk. Women with late-onset-AD had lower weight three or more decades before AD onset, and ∼10 years younger AgeMax, compared to AD-free women. APOE4 carriers had younger AgeMax and steeper slope. Older AgeMax and flatter slope predicted lower AD risk. Premature decline in weight could be a sign of accelerated physical aging contributing to AD.

Duke Scholars

Author Alexander Kulminski Social Science Research Institute

Author Konstantin Arbeev Social Science Research Institute

Author Arseniy Yashkin Social Science Research Institute

Author Heather Elizabeth Whitson Medicine, Geriatrics and Palliative Care

Author Dequing Wu  

Author Svetlana Ukraintseva Social Science Research Institute

Author Rachel Holmes