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Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.

Publication ,  Journal Article
Ukraintseva, S; Duan, H; Holmes, R; Bagley, O; Wu, D; Yashkin, A; Kulminski, A; Akushevich, I; Whitson, H; Stallard, E; Yashin, A; Arbeev, K
Published in: J Alzheimers Dis
2024

Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and slope of decline in weight, on AD risk. Women with late-onset-AD had lower weight three or more decades before AD onset, and ∼10 years younger AgeMax, compared to AD-free women. APOE4 carriers had younger AgeMax and steeper slope. Older AgeMax and flatter slope predicted lower AD risk. Premature decline in weight could be a sign of accelerated physical aging contributing to AD.

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Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2024

Volume

97

Issue

1

Start / End Page

163 / 170

Location

Netherlands

Related Subject Headings

  • Neurology & Neurosurgery
  • Humans
  • Female
  • Apolipoprotein E4
  • Alzheimer Disease
  • Aging
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Ukraintseva, S., Duan, H., Holmes, R., Bagley, O., Wu, D., Yashkin, A., … Arbeev, K. (2024). Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease. J Alzheimers Dis, 97(1), 163–170. https://doi.org/10.3233/JAD-220998
Ukraintseva, Svetlana, Hongzhe Duan, Rachel Holmes, Olivia Bagley, Deqing Wu, Arseniy Yashkin, Alexander Kulminski, et al. “Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.J Alzheimers Dis 97, no. 1 (2024): 163–70. https://doi.org/10.3233/JAD-220998.
Ukraintseva S, Duan H, Holmes R, Bagley O, Wu D, Yashkin A, et al. Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease. J Alzheimers Dis. 2024;97(1):163–70.
Ukraintseva, Svetlana, et al. “Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.J Alzheimers Dis, vol. 97, no. 1, 2024, pp. 163–70. Pubmed, doi:10.3233/JAD-220998.
Ukraintseva S, Duan H, Holmes R, Bagley O, Wu D, Yashkin A, Kulminski A, Akushevich I, Whitson H, Stallard E, Yashin A, Arbeev K. Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease. J Alzheimers Dis. 2024;97(1):163–170.

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2024

Volume

97

Issue

1

Start / End Page

163 / 170

Location

Netherlands

Related Subject Headings

  • Neurology & Neurosurgery
  • Humans
  • Female
  • Apolipoprotein E4
  • Alzheimer Disease
  • Aging
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences