Scholars@Duke

Autologous stem cell transplant for severe, progressive juvenile systemic sclerosis.

Publication ,  Journal Article
Alqahtani, S; Cacace, F; Bauchat, A; DePriest, BP; Driscoll, TA; Bonfim, C; Kurtzberg, J; Larrier, N; Dvergsten, J; Mahadeo, KM
Published in: Stem Cells Transl Med
March 23, 2026
Published version (DOI) Link to item

Juvenile systemic sclerosis (jSSc) is a rare, chronic, autoimmune disease in children/adolescents and is associated with significant morbidity, skin thickening/hardening (scleroderma), organ toxicity and sub-optimal therapeutic options. In this report, autologous stem cell transplantation is associated with clinical improvement in a 17-year-old with refractory jSSc.

Duke Scholars

Jeffrey Arthur Dvergsten
Author Jeffrey Arthur Dvergsten Pediatrics, Rheumatology
Kris Mahadeo
Author Kris Mahadeo Pediatrics, Transplant and Cellular Therapy
Timothy Alan Driscoll
Author Timothy Alan Driscoll Pediatrics, Transplant and Cellular Therapy
Nicole A. Larrier
Author Nicole A. Larrier Radiation Oncology
Joanne Kurtzberg
Author Joanne Kurtzberg Pediatrics, Transplant and Cellular Therapy
B. Paige DePriest
Author B. Paige DePriest Pediatrics, Transplant and Cellular Therapy

Published In

Stem Cells Transl Med

DOI

10.1093/stcltm/szag005

EISSN

2157-6580

Publication Date

March 23, 2026

Volume

15

Issue

4

Location

England

Related Subject Headings

  • Transplantation, Autologous
  • Stem Cell Transplantation
  • Scleroderma, Systemic
  • Male
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Female
  • Adolescent
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Alqahtani, S., Cacace, F., Bauchat, A., DePriest, B. P., Driscoll, T. A., Bonfim, C., … Mahadeo, K. M. (2026). Autologous stem cell transplant for severe, progressive juvenile systemic sclerosis. Stem Cells Transl Med, 15(4). https://doi.org/10.1093/stcltm/szag005
Alqahtani, Shaikha, Fabiana Cacace, Andrea Bauchat, Brittany Paige DePriest, Timothy Alan Driscoll, Carmem Bonfim, Joanne Kurtzberg, Nicole Larrier, Jeffery Dvergsten, and Kris Michael Mahadeo. “Autologous stem cell transplant for severe, progressive juvenile systemic sclerosis.” Stem Cells Transl Med 15, no. 4 (March 23, 2026). https://doi.org/10.1093/stcltm/szag005.
Alqahtani S, Cacace F, Bauchat A, DePriest BP, Driscoll TA, Bonfim C, et al. Autologous stem cell transplant for severe, progressive juvenile systemic sclerosis. Stem Cells Transl Med. 2026 Mar 23;15(4).
Alqahtani, Shaikha, et al. “Autologous stem cell transplant for severe, progressive juvenile systemic sclerosis.” Stem Cells Transl Med, vol. 15, no. 4, Mar. 2026. Pubmed, doi:10.1093/stcltm/szag005.
Alqahtani S, Cacace F, Bauchat A, DePriest BP, Driscoll TA, Bonfim C, Kurtzberg J, Larrier N, Dvergsten J, Mahadeo KM. Autologous stem cell transplant for severe, progressive juvenile systemic sclerosis. Stem Cells Transl Med. 2026 Mar 23;15(4).

Published In

Stem Cells Transl Med

DOI

10.1093/stcltm/szag005

EISSN

2157-6580

Publication Date

March 23, 2026

Volume

15

Issue

4

Location

England

Related Subject Headings

  • Transplantation, Autologous
  • Stem Cell Transplantation
  • Scleroderma, Systemic
  • Male
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Female
  • Adolescent
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology