Skip to main content

Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.

Publication ,  Journal Article
Schildkraut, JM; Murphy, SK; Palmieri, RT; Iversen, E; Moorman, PG; Huang, Z; Halabi, S; Calingaert, B; Gusberg, A; Marks, JR; Berchuck, A
Published in: Cancer Epidemiol Biomarkers Prev
March 2007

INTRODUCTION: Androgens may play a role in the development of ovarian cancers. Two trinucleotide repeat polymorphisms have been described in exon 1 of the androgen receptor (AR) gene that may affect its function. Previous studies of ovarian cancer and AR repeat polymorphisms have been inconsistent. METHODS: We analyzed CAG and GGC repeat length polymorphisms in the AR gene using data from a population-based case-control study of ovarian cancer that included 594 cases and 681 controls. Repeat lengths were determined by fluorescent DNA fragment analysis using ABI GeneScan software. Change point models were used to determine appropriate repeat length cutoff points by race (African American versus Caucasian) for both the shorter and longer CAG and GGC repeats. RESULTS: No relationship was observed between CAG repeat length and ovarian cancer among Caucasians. Among African Americans, having a short repeat length on either allele was associated with a 2-fold increase in ovarian cancer risk (age-adjusted odds ratio, 2.2; 95% confidence interval, 1.1-4.1). Having short CAG repeat lengths for both alleles was associated with a 5-fold increased risk for developing ovarian cancer (age-adjusted odds ratio, 5.4; 95% confidence interval, 1.4-1.7). No relationship with the GGC repeat length polymorphisms was observed. CONCLUSION: These results suggest that having a short CAG repeat length in AR increases ovarian cancer risk in African Americans. The failure to observe this relationship in Caucasians may be due to the rarity of such short CAG alleles in this population or could reflect racial differences in disease etiology.

Duke Scholars

Published In

Cancer Epidemiol Biomarkers Prev

DOI

ISSN

1055-9965

Publication Date

March 2007

Volume

16

Issue

3

Start / End Page

473 / 480

Location

United States

Related Subject Headings

  • White People
  • Trinucleotide Repeats
  • Risk Factors
  • Registries
  • Receptors, Androgen
  • Population Surveillance
  • Polymorphism, Genetic
  • Ovarian Neoplasms
  • North Carolina
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schildkraut, J. M., Murphy, S. K., Palmieri, R. T., Iversen, E., Moorman, P. G., Huang, Z., … Berchuck, A. (2007). Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev, 16(3), 473–480. https://doi.org/10.1158/1055-9965.EPI-06-0868
Schildkraut, Joellen M., Susan K. Murphy, Rachel T. Palmieri, Edwin Iversen, Patricia G. Moorman, Zhiqing Huang, Susan Halabi, et al. “Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.Cancer Epidemiol Biomarkers Prev 16, no. 3 (March 2007): 473–80. https://doi.org/10.1158/1055-9965.EPI-06-0868.
Schildkraut JM, Murphy SK, Palmieri RT, Iversen E, Moorman PG, Huang Z, et al. Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):473–80.
Schildkraut, Joellen M., et al. “Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.Cancer Epidemiol Biomarkers Prev, vol. 16, no. 3, Mar. 2007, pp. 473–80. Pubmed, doi:10.1158/1055-9965.EPI-06-0868.
Schildkraut JM, Murphy SK, Palmieri RT, Iversen E, Moorman PG, Huang Z, Halabi S, Calingaert B, Gusberg A, Marks JR, Berchuck A. Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):473–480.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

ISSN

1055-9965

Publication Date

March 2007

Volume

16

Issue

3

Start / End Page

473 / 480

Location

United States

Related Subject Headings

  • White People
  • Trinucleotide Repeats
  • Risk Factors
  • Registries
  • Receptors, Androgen
  • Population Surveillance
  • Polymorphism, Genetic
  • Ovarian Neoplasms
  • North Carolina
  • Middle Aged