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Analysis of DNA mismatch repair proteins in human medulloblastoma.

Publication ,  Journal Article
Lee, SE; Johnson, SP; Hale, LP; Li, J; Bullock, N; Fuchs, H; Friedman, A; McLendon, R; Bigner, DD; Modrich, P; Friedman, HS
Published in: Clin Cancer Res
June 1998

During replication, the primary function of the eukaryotic DNA mismatch repair (MMR) system is to recognize and correct mismatched base pairs within the DNA helix. Deficiencies in MMR have been reported previously in cases of hereditary nonpolyposis colorectal cancer and sporadic tumors occurring in a variety of tissues including gliomas. Furthermore, recent evidence indicates that the MMR system may be involved in mediating therapeutic sensitivity to alkylating agents. In this study, 22 neoplastic tissue samples from 22 patients who underwent surgical resection for medulloblastoma, a common cerebellar tumor of childhood, were assayed for the presence or absence of MMR polypeptides using Western blot and immunohistochemical techniques. Results from these experiments indicate that the MMR system is not commonly deficient in medulloblastoma.

Duke Scholars

Published In

Clin Cancer Res

ISSN

1078-0432

Publication Date

June 1998

Volume

4

Issue

6

Start / End Page

1415 / 1419

Location

United States

Related Subject Headings

  • Proto-Oncogene Proteins
  • Proteins
  • Palatine Tonsil
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Neoplasm Recurrence, Local
  • Neoplasm Proteins
  • MutS Homolog 2 Protein
  • MutL Protein Homolog 1
  • Mismatch Repair Endonuclease PMS2
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, S. E., Johnson, S. P., Hale, L. P., Li, J., Bullock, N., Fuchs, H., … Friedman, H. S. (1998). Analysis of DNA mismatch repair proteins in human medulloblastoma. Clin Cancer Res, 4(6), 1415–1419.
Lee, S. E., S. P. Johnson, L. P. Hale, J. Li, N. Bullock, H. Fuchs, A. Friedman, et al. “Analysis of DNA mismatch repair proteins in human medulloblastoma.Clin Cancer Res 4, no. 6 (June 1998): 1415–19.
Lee SE, Johnson SP, Hale LP, Li J, Bullock N, Fuchs H, et al. Analysis of DNA mismatch repair proteins in human medulloblastoma. Clin Cancer Res. 1998 Jun;4(6):1415–9.
Lee, S. E., et al. “Analysis of DNA mismatch repair proteins in human medulloblastoma.Clin Cancer Res, vol. 4, no. 6, June 1998, pp. 1415–19.
Lee SE, Johnson SP, Hale LP, Li J, Bullock N, Fuchs H, Friedman A, McLendon R, Bigner DD, Modrich P, Friedman HS. Analysis of DNA mismatch repair proteins in human medulloblastoma. Clin Cancer Res. 1998 Jun;4(6):1415–1419.

Published In

Clin Cancer Res

ISSN

1078-0432

Publication Date

June 1998

Volume

4

Issue

6

Start / End Page

1415 / 1419

Location

United States

Related Subject Headings

  • Proto-Oncogene Proteins
  • Proteins
  • Palatine Tonsil
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Neoplasm Recurrence, Local
  • Neoplasm Proteins
  • MutS Homolog 2 Protein
  • MutL Protein Homolog 1
  • Mismatch Repair Endonuclease PMS2