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Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas.

Publication ,  Journal Article
Moghrabi, A; Friedman, HS; Ashley, DM; Bottom, KS; Kerby, T; Stewart, E; Bruggers, C; Provenzale, JM; Champagne, M; Hershon, L; Watral, M ...
Published in: Neurosurg Focus
April 15, 1998

In this study, the authors sought to investigate the response rate and toxicity of carboplatin in patients with progressive low-grade glioma (LGG). Thirty-two patients with progressive LGG were treated with carboplatin at a dosage of 560 mg/m(2). Treatment was given at 4-week intervals and continued until the disease progressed, unacceptable toxicity supervened, or for 12 additional courses after achieving maximal response. Patients with stable disease were treated with a total of 12 cycles. All patients were treated as outpatients. Patients were evaluated for response to treatment and toxicity. All patients received a minimum of two cycles of carboplatin, and were examined for response. A partial response was achieved in nine patients (28%) and a minimal response in two (6%), for an overall response rate of 34% (11 of 32 patients). Eighteen patients (56%) had stable disease. A partial response was achieved in the nine patients after a median of six cycles (range 4-11 cycles), a minimal response was achieved in the two patients after five cycles. Glioma progression was noted in three patients after three, five, and five cycles, respectively. The 11 patients in whom some response was achieved had either an optic pathway tumor or a juvenile pilocytic astrocytoma. Twenty-six of the 32 patients had those characteristics, making the response rate in that group 42% (11 of 26 patients). Thirty-two patients received a total of 387 cycles of chemotherapy. Hematological toxicity was moderate. Twenty-one patients developed thrombocytopenia (platelet count < 50,000/microl); three patients required one platelet transfusion each. Nine patients developed neutropenia (absolute neutrophil count < 500/microl); one developed fever and required administration of antibiotic agents. One dose adjustment in each of the patients prevented further thrombocytopenia and neutropenia. Two patients with stable disease died of respiratory complications. One patient developed Grade III ototoxicity after receiving five cycles, one patient developed hypersensitivity to carboplatin, and none developed nephrotoxicity. Carboplatin given at a dosage of 560 mg/m(2) every 4 weeks has activity in patients with progressive LGG. This drug regimen is relatively simple and well tolerated. Further investigation and longer follow-up study are warranted.

Duke Scholars

Published In

Neurosurg Focus

DOI

ISSN

1092-0684

Publication Date

April 15, 1998

Volume

4

Issue

4

Start / End Page

e3

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • 3209 Neurosciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Moghrabi, A., Friedman, H. S., Ashley, D. M., Bottom, K. S., Kerby, T., Stewart, E., … Longee, D. C. (1998). Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas. Neurosurg Focus, 4(4), e3. https://doi.org/10.3171/foc.1998.4.4.6
Moghrabi, A., H. S. Friedman, D. M. Ashley, K. S. Bottom, T. Kerby, E. Stewart, C. Bruggers, et al. “Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas.Neurosurg Focus 4, no. 4 (April 15, 1998): e3. https://doi.org/10.3171/foc.1998.4.4.6.
Moghrabi A, Friedman HS, Ashley DM, Bottom KS, Kerby T, Stewart E, et al. Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas. Neurosurg Focus. 1998 Apr 15;4(4):e3.
Moghrabi, A., et al. “Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas.Neurosurg Focus, vol. 4, no. 4, Apr. 1998, p. e3. Pubmed, doi:10.3171/foc.1998.4.4.6.
Moghrabi A, Friedman HS, Ashley DM, Bottom KS, Kerby T, Stewart E, Bruggers C, Provenzale JM, Champagne M, Hershon L, Watral M, Ryan J, Rasheed K, Lovell S, Korones D, Fuchs H, George T, McLendon RE, Friedman AH, Buckley E, Longee DC. Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas. Neurosurg Focus. 1998 Apr 15;4(4):e3.

Published In

Neurosurg Focus

DOI

ISSN

1092-0684

Publication Date

April 15, 1998

Volume

4

Issue

4

Start / End Page

e3

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • 3209 Neurosciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences