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Repeat lumbar punctures in infants with meningitis in the neonatal intensive care unit.

Publication ,  Journal Article
Greenberg, RG; Benjamin, DK; Cohen-Wolkowiez, M; Clark, RH; Cotten, CM; Laughon, M; Smith, PB
Published in: J Perinatol
June 2011

OBJECTIVE: The purpose of this study is to examine the results of repeat lumbar puncture in infants with initial positive cerebrospinal fluid (CSF) cultures in order to determine the clinical characteristics and outcomes of infants with repeat positive cultures. STUDY DESIGN: Cohort study of infants with an initial positive CSF culture undergoing repeat lumbar puncture between 1997 and 2004 at 150 neonatal intensive care units managed by the Pediatrix Medical group. We compared the clinical outcomes of infants with repeat positive cultures and infants with repeat negative cultures. RESULT: We identified 118 infants with repeat CSF cultures. Of these, 26 infants had repeat positive cultures. A higher proportion with repeat positive cultures died compared with those with repeat negative cultures, 6/23 (26%) vs. 6/81 (7%), respectively (P=0.02). CONCLUSION: Among infants with a positive CSF culture, a repeat positive CSF culture is common. The presence of a second positive culture is associated with increased mortality.

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

June 2011

Volume

31

Issue

6

Start / End Page

425 / 429

Location

United States

Related Subject Headings

  • Spinal Puncture
  • Prognosis
  • Pediatrics
  • Meningitis, Fungal
  • Meningitis, Bacterial
  • Male
  • Kaplan-Meier Estimate
  • Intensive Care Units, Neonatal
  • Infant, Newborn
  • Humans
 

Citation

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Greenberg, R. G., Benjamin, D. K., Cohen-Wolkowiez, M., Clark, R. H., Cotten, C. M., Laughon, M., & Smith, P. B. (2011). Repeat lumbar punctures in infants with meningitis in the neonatal intensive care unit. J Perinatol, 31(6), 425–429. https://doi.org/10.1038/jp.2010.142
Greenberg, R. G., D. K. Benjamin, M. Cohen-Wolkowiez, R. H. Clark, C. M. Cotten, M. Laughon, and P. B. Smith. “Repeat lumbar punctures in infants with meningitis in the neonatal intensive care unit.J Perinatol 31, no. 6 (June 2011): 425–29. https://doi.org/10.1038/jp.2010.142.
Greenberg RG, Benjamin DK, Cohen-Wolkowiez M, Clark RH, Cotten CM, Laughon M, et al. Repeat lumbar punctures in infants with meningitis in the neonatal intensive care unit. J Perinatol. 2011 Jun;31(6):425–9.
Greenberg, R. G., et al. “Repeat lumbar punctures in infants with meningitis in the neonatal intensive care unit.J Perinatol, vol. 31, no. 6, June 2011, pp. 425–29. Pubmed, doi:10.1038/jp.2010.142.
Greenberg RG, Benjamin DK, Cohen-Wolkowiez M, Clark RH, Cotten CM, Laughon M, Smith PB. Repeat lumbar punctures in infants with meningitis in the neonatal intensive care unit. J Perinatol. 2011 Jun;31(6):425–429.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

June 2011

Volume

31

Issue

6

Start / End Page

425 / 429

Location

United States

Related Subject Headings

  • Spinal Puncture
  • Prognosis
  • Pediatrics
  • Meningitis, Fungal
  • Meningitis, Bacterial
  • Male
  • Kaplan-Meier Estimate
  • Intensive Care Units, Neonatal
  • Infant, Newborn
  • Humans