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Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures.

Publication ,  Journal Article
Cohen-Wolkowiez, M; Smith, PB; Mangum, B; Steinbach, WJ; Alexander, BD; Cotten, CM; Clark, RH; Walsh, TJ; Benjamin, DK
Published in: J Perinatol
February 2007

OBJECTIVE: The purpose of this study was to examine the frequency of normal cerebrospinal fluid (CSF) parameters in Candida meningitis and the proportion of candidemia associated with Candida meningitis. STUDY DESIGN: We evaluated the initial lumbar puncture results from infants discharged from 150 Neonatal Intensive Care Units between 1997 and 2004. Candida meningitis was diagnosed by a positive CSF culture or positive Gram stain for yeast. We calculated two-tailed P-values using non-parametric testing, Mann-Whitney, Kruskal-Wallis or Fisher's exact tests where appropriate. RESULTS: Twenty infants had culture-positive Candida meningitis. Normal CSF parameters were found in 43% (3/7) of the infants with Candida meningitis and only 37% (7/19) of them had positive blood cultures for Candida. CONCLUSION: Normal CSF parameters do not exclude the diagnosis of neonatal Candida meningitis. The majority of infants in this cohort with Candida meningitis did not have evidence of candidemia at the time of diagnosis.

Duke Scholars

Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

February 2007

Volume

27

Issue

2

Start / End Page

97 / 100

Location

United States

Related Subject Headings

  • Sepsis
  • Pediatrics
  • Meningitis, Bacterial
  • Male
  • Leukocyte Count
  • Infant, Newborn
  • Humans
  • Female
  • Candidiasis
  • Blood Glucose
 

Citation

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ICMJE
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Cohen-Wolkowiez, M., Smith, P. B., Mangum, B., Steinbach, W. J., Alexander, B. D., Cotten, C. M., … Benjamin, D. K. (2007). Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures. J Perinatol, 27(2), 97–100. https://doi.org/10.1038/sj.jp.7211628
Cohen-Wolkowiez, M., P. B. Smith, B. Mangum, W. J. Steinbach, B. D. Alexander, C. M. Cotten, R. H. Clark, T. J. Walsh, and D. K. Benjamin. “Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures.J Perinatol 27, no. 2 (February 2007): 97–100. https://doi.org/10.1038/sj.jp.7211628.
Cohen-Wolkowiez M, Smith PB, Mangum B, Steinbach WJ, Alexander BD, Cotten CM, et al. Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures. J Perinatol. 2007 Feb;27(2):97–100.
Cohen-Wolkowiez, M., et al. “Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures.J Perinatol, vol. 27, no. 2, Feb. 2007, pp. 97–100. Pubmed, doi:10.1038/sj.jp.7211628.
Cohen-Wolkowiez M, Smith PB, Mangum B, Steinbach WJ, Alexander BD, Cotten CM, Clark RH, Walsh TJ, Benjamin DK. Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures. J Perinatol. 2007 Feb;27(2):97–100.

Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

February 2007

Volume

27

Issue

2

Start / End Page

97 / 100

Location

United States

Related Subject Headings

  • Sepsis
  • Pediatrics
  • Meningitis, Bacterial
  • Male
  • Leukocyte Count
  • Infant, Newborn
  • Humans
  • Female
  • Candidiasis
  • Blood Glucose