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Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units.

Publication ,  Journal Article
Hornik, CP; Fort, P; Clark, RH; Watt, K; Benjamin, DK; Smith, PB; Manzoni, P; Jacqz-Aigrain, E; Kaguelidou, F; Cohen-Wolkowiez, M
Published in: Early Hum Dev
May 2012

BACKGROUND: Very-low-birth-weight (VLBW, <1500 g birth weight) infants are at high risk for both early- and late-onset sepsis. Prior studies have observed a predominance of Gram-negative organisms as a cause of early-onset sepsis and Gram-positive organisms as a cause of late-onset sepsis. These reports are limited to large, academic neonatal intensive care units (NICUs) and may not reflect findings in other units. The purpose of this study was to determine the risk factors for sepsis, the causative organisms, and mortality following infection in a large and diverse sample of NICUs. METHODS: We analysed the results of all cultures obtained from VLBW infants admitted to 313 NICUs from 1997 to 2010. RESULTS: Over 108,000 VLBW infants were admitted during the study period. Early-onset sepsis occurred in 1032 infants, and late-onset sepsis occurred in 12,204 infants. Gram-negative organisms were the most commonly isolated pathogens in early-onset sepsis, and Gram-positive organisms were most commonly isolated in late-onset sepsis. Early- and late-onset sepsis were associated with increased risk of death controlling for other confounders (odds ratio 1.45 [95% confidence interval [CI] 1.21,1.73], and OR 1.30 [95%CI 1.21, 1.40], respectively). CONCLUSIONS: This is the largest report of sepsis in VLBW infants to date. Incidence for early-onset sepsis and late-onset sepsis has changed little over this 14-year period, and overall mortality in VLBW infants with early- and late-onset sepsis is higher than in infants with negative cultures.

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Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

May 2012

Volume

88 Suppl 2

Issue

Suppl 2

Start / End Page

S69 / S74

Location

Ireland

Related Subject Headings

  • Sepsis
  • Risk Factors
  • Pediatrics
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Humans
 

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Hornik, C. P., Fort, P., Clark, R. H., Watt, K., Benjamin, D. K., Smith, P. B., … Cohen-Wolkowiez, M. (2012). Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. Early Hum Dev, 88 Suppl 2(Suppl 2), S69–S74. https://doi.org/10.1016/S0378-3782(12)70019-1
Hornik, C. P., P. Fort, R. H. Clark, K. Watt, D. K. Benjamin, P. B. Smith, P. Manzoni, E. Jacqz-Aigrain, F. Kaguelidou, and M. Cohen-Wolkowiez. “Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units.Early Hum Dev 88 Suppl 2, no. Suppl 2 (May 2012): S69–74. https://doi.org/10.1016/S0378-3782(12)70019-1.
Hornik CP, Fort P, Clark RH, Watt K, Benjamin DK, Smith PB, et al. Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. Early Hum Dev. 2012 May;88 Suppl 2(Suppl 2):S69–74.
Hornik, C. P., et al. “Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units.Early Hum Dev, vol. 88 Suppl 2, no. Suppl 2, May 2012, pp. S69–74. Pubmed, doi:10.1016/S0378-3782(12)70019-1.
Hornik CP, Fort P, Clark RH, Watt K, Benjamin DK, Smith PB, Manzoni P, Jacqz-Aigrain E, Kaguelidou F, Cohen-Wolkowiez M. Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. Early Hum Dev. 2012 May;88 Suppl 2(Suppl 2):S69–S74.
Journal cover image

Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

May 2012

Volume

88 Suppl 2

Issue

Suppl 2

Start / End Page

S69 / S74

Location

Ireland

Related Subject Headings

  • Sepsis
  • Risk Factors
  • Pediatrics
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Humans