Skip to main content
Journal cover image

The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach.

Publication ,  Journal Article
Jonassaint, CR; Ashley-Koch, A; Whitfield, KE; Hoyle, RH; Richman, LS; Siegler, IC; Royal, CD; Williams, R
Published in: Biol Psychol
September 2012

Here we examine the effects of both self-reported and independent observer-reported environmental risk indices, the serotonin transporter gene promoter (5HTTLPR) polymorphism, and their interaction on self-esteem. This trait was assessed during early and mid adolescence (mean age=14 and 16.5, respectively) and young adulthood (mean age=21.8) in a prospective cohort of 1214 unrelated participants in the Longitudinal Study of Adolescent Health (Add Health). Using structural equation modeling we identified a gene-environment (G×E) interaction using observer-report but not self-report measures of environmental stress exposure during adolescence: 5HTTLPR genotype and observer-reports of home and neighborhood quality (HNQ) during adolescence interacted to predict self-esteem levels in young adulthood (p<.004). Carriers of the s allele who lived in poor HNQ conditions during adolescence reported lower self-esteem in young adulthood than those with a good HNQ during adolescence. In contrast, among individuals with the l/l genotype, adolescent HNQ did not predict adulthood self-esteem. Genes may moderate the effect of adolescent environmental conditions on adulthood self-esteem.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Biol Psychol

DOI

EISSN

1873-6246

Publication Date

September 2012

Volume

91

Issue

1

Start / End Page

111 / 119

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Social Environment
  • Serotonin Plasma Membrane Transport Proteins
  • Self Concept
  • Psychology, Adolescent
  • Polymorphism, Genetic
  • Male
  • Longitudinal Studies
  • Humans
  • Genotype
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jonassaint, C. R., Ashley-Koch, A., Whitfield, K. E., Hoyle, R. H., Richman, L. S., Siegler, I. C., … Williams, R. (2012). The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach. Biol Psychol, 91(1), 111–119. https://doi.org/10.1016/j.biopsycho.2012.05.004
Jonassaint, Charles R., Allison Ashley-Koch, Keith E. Whitfield, Rick H. Hoyle, Laura Smart Richman, Ilene C. Siegler, Charmaine D. Royal, and Redford Williams. “The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach.Biol Psychol 91, no. 1 (September 2012): 111–19. https://doi.org/10.1016/j.biopsycho.2012.05.004.
Jonassaint, Charles R., et al. “The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach.Biol Psychol, vol. 91, no. 1, Sept. 2012, pp. 111–19. Pubmed, doi:10.1016/j.biopsycho.2012.05.004.
Jonassaint CR, Ashley-Koch A, Whitfield KE, Hoyle RH, Richman LS, Siegler IC, Royal CD, Williams R. The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach. Biol Psychol. 2012 Sep;91(1):111–119.
Journal cover image

Published In

Biol Psychol

DOI

EISSN

1873-6246

Publication Date

September 2012

Volume

91

Issue

1

Start / End Page

111 / 119

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Social Environment
  • Serotonin Plasma Membrane Transport Proteins
  • Self Concept
  • Psychology, Adolescent
  • Polymorphism, Genetic
  • Male
  • Longitudinal Studies
  • Humans
  • Genotype