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ApolipoproteinE mimetic peptides improve outcome after focal ischemia.

Publication ,  Journal Article
Wang, H; Anderson, LG; Lascola, CD; James, ML; Venkatraman, TN; Bennett, ER; Acheson, SK; Vitek, MP; Laskowitz, DT
Published in: Exp Neurol
March 2013
Published version (DOI) Link to item

Growing clinical evidence implicates isoform-specific effects of apolipoprotein E (apoE) in reducing neuroinflammation and mediating adaptive responses following ischemic and traumatic brain injury. However, the intact apoE holoprotein does not cross the blood-brain barrier and thus has limited therapeutic potential. We have created a small peptide, COG1410 (acetyl-AS-Aib-LRKL-Aib-KRLL-amide), derived from the apoE receptor-binding region. COG1410 retains the anti-inflammatory and neuroprotective biological properties of the intact holoprotein and penetrates the blood-brain barrier. In the current study, we utilized a murine model of transient focal cerebral ischemia and reperfusion to demonstrate that intravenous (IV) administration of COG1410 reduces infarct volume and radiographic progression of infarct, and improves functional outcome as assessed by rotarod when delivered up to 4h after ischemia onset.

Duke Scholars

Haichen Wang
Author Haichen Wang Neurology, Neurocritical Care
Christopher David Lascola
Author Christopher David Lascola Radiology, Neuroradiology
Michael Lucas James
Author Michael Lucas James Anesthesiology, Neuroanesthesia
Ellen Ruth Bennett
Author Ellen Ruth Bennett Neurology, Neurocritical Care
Michael P. Vitek
Author Michael P. Vitek Neurology, Behavioral Neurology
Daniel Todd Laskowitz
Author Daniel Todd Laskowitz Neurology, Neurocritical Care

Published In

Exp Neurol

DOI

10.1016/j.expneurol.2012.11.027

EISSN

1090-2430

Publication Date

March 2013

Volume

241

Start / End Page

67 / 74

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Time Factors
  • Recovery of Function
  • RNA, Messenger
  • Neurology & Neurosurgery
  • Movement Disorders
  • Mice, Inbred C57BL
  • Mice
  • Mass Spectrometry
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, H., Anderson, L. G., Lascola, C. D., James, M. L., Venkatraman, T. N., Bennett, E. R., … Laskowitz, D. T. (2013). ApolipoproteinE mimetic peptides improve outcome after focal ischemia. Exp Neurol, 241, 67–74. https://doi.org/10.1016/j.expneurol.2012.11.027
Wang, Haichen, Lauren G. Anderson, Christopher D. Lascola, Michael L. James, Talaignair N. Venkatraman, Ellen R. Bennett, Shawn K. Acheson, Michael P. Vitek, and Daniel T. Laskowitz. “ApolipoproteinE mimetic peptides improve outcome after focal ischemia.” Exp Neurol 241 (March 2013): 67–74. https://doi.org/10.1016/j.expneurol.2012.11.027.
Wang H, Anderson LG, Lascola CD, James ML, Venkatraman TN, Bennett ER, et al. ApolipoproteinE mimetic peptides improve outcome after focal ischemia. Exp Neurol. 2013 Mar;241:67–74.
Wang, Haichen, et al. “ApolipoproteinE mimetic peptides improve outcome after focal ischemia.” Exp Neurol, vol. 241, Mar. 2013, pp. 67–74. Pubmed, doi:10.1016/j.expneurol.2012.11.027.
Wang H, Anderson LG, Lascola CD, James ML, Venkatraman TN, Bennett ER, Acheson SK, Vitek MP, Laskowitz DT. ApolipoproteinE mimetic peptides improve outcome after focal ischemia. Exp Neurol. 2013 Mar;241:67–74.
Journal cover image

Published In

Exp Neurol

DOI

10.1016/j.expneurol.2012.11.027

EISSN

1090-2430

Publication Date

March 2013

Volume

241

Start / End Page

67 / 74

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Time Factors
  • Recovery of Function
  • RNA, Messenger
  • Neurology & Neurosurgery
  • Movement Disorders
  • Mice, Inbred C57BL
  • Mice
  • Mass Spectrometry
  • Male