Skip to main content

Differential impact of inhibitory and activating Killer Ig-Like Receptors (KIR) on high-risk patients with myeloid and lymphoid malignancies undergoing reduced intensity transplantation from haploidentical related donors.

Publication ,  Journal Article
Chen, D-F; Prasad, VK; Broadwater, G; Reinsmoen, NL; DeOliveira, A; Clark, A; Sullivan, KM; Chute, JP; Horwitz, ME; Gasparetto, C; Long, GD ...
Published in: Bone Marrow Transplant
June 2012

The impact of activating KIR (aKIR) and inhibitory KIR (iKIR) on OS, relapse-related mortality (RRM) and acute GVHD (aGVHD) was prospectively studied in 84 adults with high-risk hematologic malignancies receiving reduced intensity conditioning (RIC) T-cell depleted hematopoietic SCT (HSCT) from haploidentical related donors. In this clinical model, freedom from RRM is dependent on GVL effect. Patients were divided into myeloid (n=49) and lymphoid (n=35) malignancy groups. KIR-ligand and ligand-ligand models were studied in both GVH and rejection directions and statistically correlated with outcome measures. In the myeloid group, OS was higher (P=0.009) and RRM was lower (P=0.036) in patients missing HLA-C group2 ligand to donor iKIR. OS was higher if patients had >1 missing ligand (P=0.018). In lymphoid malignancy, missing ligand to donor KIR had no impact on OS or RRM. However, OS was better with donor aKIR 2DS2 (P=0.028). There was a trend towards shorter OS in recipient with KIR 2DS1, 2DS5 and 3DS1, although sample sizes were too small to provide inferential statistics. Findings in lymphoid malignancy patients should be further studied. These results suggest that the absence of appropriate HLA ligands in the recipient to donor iKIR may induce GVL without aGVHD in myeloid malignancy patients undergoing TCD-RIC transplants.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Bone Marrow Transplant

DOI

EISSN

1476-5365

Publication Date

June 2012

Volume

47

Issue

6

Start / End Page

817 / 823

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Conditioning
  • Survival Rate
  • Risk Factors
  • Retrospective Studies
  • Receptors, KIR
  • Peripheral Blood Stem Cell Transplantation
  • Middle Aged
  • Male
  • Living Donors
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, D.-F., Prasad, V. K., Broadwater, G., Reinsmoen, N. L., DeOliveira, A., Clark, A., … Rizzieri, D. A. (2012). Differential impact of inhibitory and activating Killer Ig-Like Receptors (KIR) on high-risk patients with myeloid and lymphoid malignancies undergoing reduced intensity transplantation from haploidentical related donors. Bone Marrow Transplant, 47(6), 817–823. https://doi.org/10.1038/bmt.2011.181
Chen, D. -. F., V. K. Prasad, G. Broadwater, N. L. Reinsmoen, A. DeOliveira, A. Clark, K. M. Sullivan, et al. “Differential impact of inhibitory and activating Killer Ig-Like Receptors (KIR) on high-risk patients with myeloid and lymphoid malignancies undergoing reduced intensity transplantation from haploidentical related donors.Bone Marrow Transplant 47, no. 6 (June 2012): 817–23. https://doi.org/10.1038/bmt.2011.181.
Chen D-F, Prasad VK, Broadwater G, Reinsmoen NL, DeOliveira A, Clark A, Sullivan KM, Chute JP, Horwitz ME, Gasparetto C, Long GD, Yang Y, Chao NJ, Rizzieri DA. Differential impact of inhibitory and activating Killer Ig-Like Receptors (KIR) on high-risk patients with myeloid and lymphoid malignancies undergoing reduced intensity transplantation from haploidentical related donors. Bone Marrow Transplant. 2012 Jun;47(6):817–823.

Published In

Bone Marrow Transplant

DOI

EISSN

1476-5365

Publication Date

June 2012

Volume

47

Issue

6

Start / End Page

817 / 823

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Conditioning
  • Survival Rate
  • Risk Factors
  • Retrospective Studies
  • Receptors, KIR
  • Peripheral Blood Stem Cell Transplantation
  • Middle Aged
  • Male
  • Living Donors