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Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and Afghanistan war veterans.

Publication ,  Journal Article
Morey, RA; Haswell, CC; Selgrade, ES; Massoglia, D; Liu, C; Weiner, J; Marx, CE; MIRECC Work Group, ; Cernak, I; McCarthy, G
Published in: Hum Brain Mapp
November 2013

Mild traumatic brain injury (TBI) is a common source of morbidity from the wars in Iraq and Afghanistan. With no overt lesions on structural MRI, diagnosis of chronic mild TBI in military veterans relies on obtaining an accurate history and assessment of behavioral symptoms that are also associated with frequent comorbid disorders, particularly posttraumatic stress disorder (PTSD) and depression. Military veterans from Iraq and Afghanistan with mild TBI (n = 30) with comorbid PTSD and depression and non-TBI participants from primary (n = 42) and confirmatory (n = 28) control groups were assessed with high angular resolution diffusion imaging (HARDI). White matter-specific registration followed by whole-brain voxelwise analysis of crossing fibers provided separate partial volume fractions reflecting the integrity of primary fibers and secondary (crossing) fibers. Loss of white matter integrity in primary fibers (P < 0.05; corrected) was associated with chronic mild TBI in a widely distributed pattern of major fiber bundles and smaller peripheral tracts including the corpus callosum (genu, body, and splenium), forceps minor, forceps major, superior and posterior corona radiata, internal capsule, superior longitudinal fasciculus, and others. Distributed loss of white matter integrity correlated with duration of loss of consciousness and most notably with "feeling dazed or confused," but not diagnosis of PTSD or depressive symptoms. This widespread spatial extent of white matter damage has typically been reported in moderate to severe TBI. The diffuse loss of white matter integrity appears consistent with systemic mechanisms of damage shared by blast- and impact-related mild TBI that involves a cascade of inflammatory and neurochemical events.

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Published In

Hum Brain Mapp

DOI

EISSN

1097-0193

Publication Date

November 2013

Volume

34

Issue

11

Start / End Page

2986 / 2999

Location

United States

Related Subject Headings

  • Young Adult
  • Veterans
  • Unconsciousness
  • Stress Disorders, Post-Traumatic
  • Regression Analysis
  • Neuropsychological Tests
  • Nerve Fibers
  • Middle Aged
  • Male
  • Iraq War, 2003-2011
 

Citation

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Morey, R. A., Haswell, C. C., Selgrade, E. S., Massoglia, D., Liu, C., Weiner, J., … McCarthy, G. (2013). Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and Afghanistan war veterans. Hum Brain Mapp, 34(11), 2986–2999. https://doi.org/10.1002/hbm.22117
Morey, Rajendra A., Courtney C. Haswell, Elizabeth S. Selgrade, Dino Massoglia, Chunlei Liu, Jonathan Weiner, Christine E. Marx, Christine E. MIRECC Work Group, Ibolja Cernak, and Gregory McCarthy. “Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and Afghanistan war veterans.Hum Brain Mapp 34, no. 11 (November 2013): 2986–99. https://doi.org/10.1002/hbm.22117.
Morey RA, Haswell CC, Selgrade ES, Massoglia D, Liu C, Weiner J, et al. Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and Afghanistan war veterans. Hum Brain Mapp. 2013 Nov;34(11):2986–99.
Morey, Rajendra A., et al. “Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and Afghanistan war veterans.Hum Brain Mapp, vol. 34, no. 11, Nov. 2013, pp. 2986–99. Pubmed, doi:10.1002/hbm.22117.
Morey RA, Haswell CC, Selgrade ES, Massoglia D, Liu C, Weiner J, Marx CE, MIRECC Work Group, Cernak I, McCarthy G. Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and Afghanistan war veterans. Hum Brain Mapp. 2013 Nov;34(11):2986–2999.
Journal cover image

Published In

Hum Brain Mapp

DOI

EISSN

1097-0193

Publication Date

November 2013

Volume

34

Issue

11

Start / End Page

2986 / 2999

Location

United States

Related Subject Headings

  • Young Adult
  • Veterans
  • Unconsciousness
  • Stress Disorders, Post-Traumatic
  • Regression Analysis
  • Neuropsychological Tests
  • Nerve Fibers
  • Middle Aged
  • Male
  • Iraq War, 2003-2011