Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.
Published
Journal Article
Development of strategies for induction of HIV-1 broadly neutralizing antibodies (bnAbs) by vaccines is a priority. Determining the steps of bnAb induction in HIV-1-infected individuals who make bnAbs is a key strategy for immunogen design. Here, we study the B cell response in a bnAb-producing individual and report cooperation between two B cell lineages to drive bnAb development. We isolated a virus-neutralizing antibody lineage that targeted an envelope region (loop D) and selected virus escape mutants that resulted in both enhanced bnAb lineage envelope binding and escape mutant neutralization-traits associated with increased B cell antigen drive. Thus, in this individual, two B cell lineages cooperated to induce the development of bnAbs. Design of vaccine immunogens that simultaneously drive both helper and broadly neutralizing B cell lineages may be important for vaccine-induced recapitulation of events that transpire during the maturation of neutralizing antibodies in HIV-1-infected individuals.
Full Text
Duke Authors
- Alam, S. Munir
- Bonsignori, Mattia
- Ferrari, Guido
- Gao, Feng
- Haynes, Barton Ford
- Kelsoe, Garnett H.
- Liao, Hua-Xin
- Montefiori, David Charles
- Moody, Michael Anthony
Cited Authors
- Gao, F; Bonsignori, M; Liao, H-X; Kumar, A; Xia, S-M; Lu, X; Cai, F; Hwang, K-K; Song, H; Zhou, T; Lynch, RM; Alam, SM; Moody, MA; Ferrari, G; Berrong, M; Kelsoe, G; Shaw, GM; Hahn, BH; Montefiori, DC; Kamanga, G; Cohen, MS; Hraber, P; Kwong, PD; Korber, BT; Mascola, JR; Kepler, TB; Haynes, BF
Published Date
- July 24, 2014
Published In
Volume / Issue
- 158 / 3
Start / End Page
- 481 - 491
PubMed ID
- 25065977
Pubmed Central ID
- 25065977
Electronic International Standard Serial Number (EISSN)
- 1097-4172
International Standard Serial Number (ISSN)
- 0092-8674
Digital Object Identifier (DOI)
- 10.1016/j.cell.2014.06.022
Language
- eng