Scholars@Duke publication: Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.

Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.

Publication , Journal Article

Gao, F; Bonsignori, M; Liao, H-X; Kumar, A; Xia, S-M; Lu, X; Cai, F; Hwang, K-K; Song, H; Zhou, T; Lynch, RM; Alam, SM; Moody, MA; Kelsoe, G ...

Published in: Cell

July 31, 2014

Published version (DOI) Link to item

Development of strategies for induction of HIV-1 broadly neutralizing antibodies (bnAbs) by vaccines is a priority. Determining the steps of bnAb induction in HIV-1-infected individuals who make bnAbs is a key strategy for immunogen design. Here, we study the B cell response in a bnAb-producing individual and report cooperation between two B cell lineages to drive bnAb development. We isolated a virus-neutralizing antibody lineage that targeted an envelope region (loop D) and selected virus escape mutants that resulted in both enhanced bnAb lineage envelope binding and escape mutant neutralization-traits associated with increased B cell antigen drive. Thus, in this individual, two B cell lineages cooperated to induce the development of bnAbs. Design of vaccine immunogens that simultaneously drive both helper and broadly neutralizing B cell lineages may be important for vaccine-induced recapitulation of events that transpire during the maturation of neutralizing antibodies in HIV-1-infected individuals.

Duke Scholars

Author Michael Anthony Moody Pediatrics, Infectious Diseases

Author Celia Crane LaBranche Surgery, Surgical Sciences

Author Feng Gao Medicine, Infectious Diseases

Author S. Munir Alam Medicine, Duke Human Vaccine Institute

Author Garnett H. Kelsoe Integrative Immunobiology

Author Barton Ford Haynes Medicine, Duke Human Vaccine Institute

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Published In

Cell

DOI

10.1016/j.cell.2014.06.022

EISSN

1097-4172

Publication Date

July 31, 2014

Volume

158

Issue

Start / End Page

481 / 491

Location

United States

Related Subject Headings

env Gene Products, Human Immunodeficiency Virus
Sequence Alignment
Mutation
Molecular Sequence Data
Models, Molecular
Immune Evasion
HIV-1
HIV Antibodies
Developmental Biology
B-Lymphocytes

Citation

APA

Chicago

ICMJE

MLA

NLM

Gao, F., Bonsignori, M., Liao, H.-X., Kumar, A., Xia, S.-M., Lu, X., … Haynes, B. F. (2014). Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. Cell, 158(3), 481–491. https://doi.org/10.1016/j.cell.2014.06.022

Gao, Feng, Mattia Bonsignori, Hua-Xin Liao, Amit Kumar, Shi-Mao Xia, Xiaozhi Lu, Fangping Cai, et al. “Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.” Cell 158, no. 3 (July 31, 2014): 481–91. https://doi.org/10.1016/j.cell.2014.06.022.

Gao F, Bonsignori M, Liao H-X, Kumar A, Xia S-M, Lu X, et al. Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. Cell. 2014 Jul 31;158(3):481–91.

Gao, Feng, et al. “Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.” Cell, vol. 158, no. 3, July 2014, pp. 481–91. Pubmed, doi:10.1016/j.cell.2014.06.022.

Gao F, Bonsignori M, Liao H-X, Kumar A, Xia S-M, Lu X, Cai F, Hwang K-K, Song H, Zhou T, Lynch RM, Alam SM, Moody MA, Ferrari G, Berrong M, Kelsoe G, Shaw GM, Hahn BH, Montefiori DC, Kamanga G, Cohen MS, Hraber P, Kwong PD, Korber BT, Mascola JR, Kepler TB, Haynes BF. Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. Cell. 2014 Jul 31;158(3):481–491.

Published In

Cell

DOI

10.1016/j.cell.2014.06.022

EISSN

1097-4172

Publication Date

July 31, 2014

Volume

158

Issue

Start / End Page

481 / 491

Location

United States

Related Subject Headings

env Gene Products, Human Immunodeficiency Virus
Sequence Alignment
Mutation
Molecular Sequence Data
Models, Molecular
Immune Evasion
HIV-1
HIV Antibodies
Developmental Biology
B-Lymphocytes