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Infection and inflammation: New perspectives on Alzheimer's disease.

Publication ,  Journal Article
Whitson, HE; Colton, C; El Khoury, J; Gate, D; Goate, A; Heneka, MT; Kaddurah-Daouk, R; Klein, RS; Shinohara, ML; Sisodia, S; Spudich, SS ...
Published in: Brain Behav Immun Health
July 2022

Neuroinflammation has been recognized as a component of Alzheimer's Disease (AD) pathology since the original descriptions by Alois Alzheimer and a role for infections in AD pathogenesis has long been hypothesized. More recently, this hypothesis has gained strength as human genetics and experimental data suggest key roles for inflammatory cells in AD pathogenesis. To review this topic, Duke/University of North Carolina (Duke/UNC) Alzheimer's Disease Research Center hosted a virtual symposium: "Infection and Inflammation: New Perspectives on Alzheimer's Disease (AD)." Participants considered current evidence for and against the hypothesis that AD could be caused or exacerbated by infection or commensal microbes. Discussion focused on connecting microglial transcriptional states to functional states, mouse models that better mimic human immunity, the potential involvement of inflammasome signaling, metabolic alterations, self-reactive T cells, gut microbes and fungal infections, and lessons learned from Covid-19 patients with neurologic symptoms. The content presented in the symposium, and major topics raised in discussions are reviewed in this summary of the proceedings.

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Published In

Brain Behav Immun Health

DOI

EISSN

2666-3546

Publication Date

July 2022

Volume

22

Start / End Page

100462

Location

United States

Related Subject Headings

  • 3204 Immunology
  • 3202 Clinical sciences
 

Citation

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Whitson, H. E., Colton, C., El Khoury, J., Gate, D., Goate, A., Heneka, M. T., … Symposium Planning Committee members, . (2022). Infection and inflammation: New perspectives on Alzheimer's disease. Brain Behav Immun Health, 22, 100462. https://doi.org/10.1016/j.bbih.2022.100462
Whitson, Heather E., Carol Colton, Joseph El Khoury, David Gate, Alison Goate, Michael T. Heneka, Rima Kaddurah-Daouk, et al. “Infection and inflammation: New perspectives on Alzheimer's disease.Brain Behav Immun Health 22 (July 2022): 100462. https://doi.org/10.1016/j.bbih.2022.100462.
Whitson HE, Colton C, El Khoury J, Gate D, Goate A, Heneka MT, et al. Infection and inflammation: New perspectives on Alzheimer's disease. Brain Behav Immun Health. 2022 Jul;22:100462.
Whitson, Heather E., et al. “Infection and inflammation: New perspectives on Alzheimer's disease.Brain Behav Immun Health, vol. 22, July 2022, p. 100462. Pubmed, doi:10.1016/j.bbih.2022.100462.
Whitson HE, Colton C, El Khoury J, Gate D, Goate A, Heneka MT, Kaddurah-Daouk R, Klein RS, Shinohara ML, Sisodia S, Spudich SS, Stevens B, Tanzi R, Ting JP, Garden G, Symposium Planning Committee members. Infection and inflammation: New perspectives on Alzheimer's disease. Brain Behav Immun Health. 2022 Jul;22:100462.

Published In

Brain Behav Immun Health

DOI

EISSN

2666-3546

Publication Date

July 2022

Volume

22

Start / End Page

100462

Location

United States

Related Subject Headings

  • 3204 Immunology
  • 3202 Clinical sciences