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Progress in HIV-1 vaccine development.

Publication ,  Journal Article
Haynes, BF; Moody, MA; Alam, M; Bonsignori, M; Verkoczy, L; Ferrari, G; Gao, F; Tomaras, GD; Liao, H-X; Kelsoe, G
Published in: J Allergy Clin Immunol
July 2014

The past 2 years have seen a number of basic and translational science advances in the quest for development of an effective HIV-1 vaccine. These advances include discovery of new envelope targets of potentially protective antibodies, demonstration that CD8(+) T cells can control HIV-1 infection, development of immunogens to overcome HIV-1 T-cell epitope diversity, identification of correlates of transmission risk in an HIV-1 efficacy trial, and mapping of the coevolution of HIV-1 founder envelope mutants in infected subjects with broad neutralizing antibodies, thereby defining broad neutralizing antibody developmental pathways. Despite these advances, a promising HIV-1 vaccine efficacy trial published in 2013 did not prevent infection, and the HIV-1 vaccine field is still years away from deployment of an effective vaccine. This review summarizes what some of the scientific advances have been, what roadblocks still remain, and what the most promising approaches are for progress in design of successful HIV-1 vaccine candidates.

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Published In

J Allergy Clin Immunol

DOI

EISSN

1097-6825

Publication Date

July 2014

Volume

134

Issue

1

Start / End Page

3 / 10

Location

United States

Related Subject Headings

  • Viral Envelope Proteins
  • Models, Molecular
  • Macaca mulatta
  • Immunization
  • Humans
  • HIV-1
  • HIV Infections
  • Epitopes, T-Lymphocyte
  • Epitope Mapping
  • Clinical Trials as Topic
 

Citation

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Haynes, B. F., Moody, M. A., Alam, M., Bonsignori, M., Verkoczy, L., Ferrari, G., … Kelsoe, G. (2014). Progress in HIV-1 vaccine development. J Allergy Clin Immunol, 134(1), 3–10. https://doi.org/10.1016/j.jaci.2014.04.025
Haynes, Barton F., M Anthony Moody, Munir Alam, Mattia Bonsignori, Laurent Verkoczy, Guido Ferrari, Feng Gao, Georgia D. Tomaras, Hua-Xin Liao, and Garnett Kelsoe. “Progress in HIV-1 vaccine development.J Allergy Clin Immunol 134, no. 1 (July 2014): 3–10. https://doi.org/10.1016/j.jaci.2014.04.025.
Haynes BF, Moody MA, Alam M, Bonsignori M, Verkoczy L, Ferrari G, et al. Progress in HIV-1 vaccine development. J Allergy Clin Immunol. 2014 Jul;134(1):3–10.
Haynes, Barton F., et al. “Progress in HIV-1 vaccine development.J Allergy Clin Immunol, vol. 134, no. 1, July 2014, pp. 3–10. Pubmed, doi:10.1016/j.jaci.2014.04.025.
Haynes BF, Moody MA, Alam M, Bonsignori M, Verkoczy L, Ferrari G, Gao F, Tomaras GD, Liao H-X, Kelsoe G. Progress in HIV-1 vaccine development. J Allergy Clin Immunol. 2014 Jul;134(1):3–10.
Journal cover image

Published In

J Allergy Clin Immunol

DOI

EISSN

1097-6825

Publication Date

July 2014

Volume

134

Issue

1

Start / End Page

3 / 10

Location

United States

Related Subject Headings

  • Viral Envelope Proteins
  • Models, Molecular
  • Macaca mulatta
  • Immunization
  • Humans
  • HIV-1
  • HIV Infections
  • Epitopes, T-Lymphocyte
  • Epitope Mapping
  • Clinical Trials as Topic