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Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses.

Publication ,  Journal Article
Moody, MA; Gao, F; Gurley, TC; Amos, JD; Kumar, A; Hora, B; Marshall, DJ; Whitesides, JF; Xia, S-M; Parks, R; Lloyd, KE; Hwang, K-K; Lu, X ...
Published in: Cell Host Microbe
September 9, 2015

The third variable (V3) loop and the CD4 binding site (CD4bs) of the HIV-1 envelope are frequently targeted by neutralizing antibodies (nAbs) in infected individuals. In chronic infection, HIV-1 escape mutants repopulate the plasma, and V3 and CD4bs nAbs emerge that can neutralize heterologous tier 1 easy-to-neutralize but not tier 2 difficult-to-neutralize HIV-1 isolates. However, neutralization sensitivity of autologous plasma viruses to this type of nAb response has not been studied. We describe the development and evolution in vivo of antibodies distinguished by their target specificity for V3 and CD4bs epitopes on autologous tier 2 viruses but not on heterologous tier 2 viruses. A surprisingly high fraction of autologous circulating viruses was sensitive to these antibodies. These findings demonstrate a role for V3 and CD4bs antibodies in constraining the native envelope trimer in vivo to a neutralization-resistant phenotype, explaining why HIV-1 transmission generally occurs by tier 2 neutralization-resistant viruses.

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Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

September 9, 2015

Volume

18

Issue

3

Start / End Page

354 / 362

Location

United States

Related Subject Headings

  • Virus Attachment
  • Sequence Analysis, DNA
  • Selection, Genetic
  • RNA, Viral
  • Mutation
  • Molecular Sequence Data
  • Immunology
  • HIV-1
  • HIV Envelope Protein gp120
  • HIV Antibodies
 

Citation

APA
Chicago
ICMJE
MLA
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Moody, M. A., Gao, F., Gurley, T. C., Amos, J. D., Kumar, A., Hora, B., … Haynes, B. F. (2015). Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses. Cell Host Microbe, 18(3), 354–362. https://doi.org/10.1016/j.chom.2015.08.006
Moody, M Anthony, Feng Gao, Thaddeus C. Gurley, Joshua D. Amos, Amit Kumar, Bhavna Hora, Dawn J. Marshall, et al. “Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses.Cell Host Microbe 18, no. 3 (September 9, 2015): 354–62. https://doi.org/10.1016/j.chom.2015.08.006.
Moody MA, Gao F, Gurley TC, Amos JD, Kumar A, Hora B, et al. Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses. Cell Host Microbe. 2015 Sep 9;18(3):354–62.
Moody, M. Anthony, et al. “Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses.Cell Host Microbe, vol. 18, no. 3, Sept. 2015, pp. 354–62. Pubmed, doi:10.1016/j.chom.2015.08.006.
Moody MA, Gao F, Gurley TC, Amos JD, Kumar A, Hora B, Marshall DJ, Whitesides JF, Xia S-M, Parks R, Lloyd KE, Hwang K-K, Lu X, Bonsignori M, Finzi A, Vandergrift NA, Alam SM, Ferrari G, Shen X, Tomaras GD, Kamanga G, Cohen MS, Sam NE, Kapiga S, Gray ES, Tumba NL, Morris L, Zolla-Pazner S, Gorny MK, Mascola JR, Hahn BH, Shaw GM, Sodroski JG, Liao H-X, Montefiori DC, Hraber PT, Korber BT, Haynes BF. Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses. Cell Host Microbe. 2015 Sep 9;18(3):354–362.
Journal cover image

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

September 9, 2015

Volume

18

Issue

3

Start / End Page

354 / 362

Location

United States

Related Subject Headings

  • Virus Attachment
  • Sequence Analysis, DNA
  • Selection, Genetic
  • RNA, Viral
  • Mutation
  • Molecular Sequence Data
  • Immunology
  • HIV-1
  • HIV Envelope Protein gp120
  • HIV Antibodies